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Gene Dmel\CG10249

General Information
Symbol	Dmel\CG10249	Species	D. melanogaster
Name		Annotation symbol	CG10249
Feature type	protein_coding_gene	FlyBase ID	FBgn0027596
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51D2-51D2	Sequence location	2R:10,788,980..10,815,930 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG10249 (FBgn0027596). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neuron projection morphogenesis. 5 alleles are reported. No phenotypic data is available. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Kank N-terminal motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, inseminated spermatheca, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, virgin spermatheca, adult male accessory gland, adult carcass. Gene sequence location is 2R:10788980..10815930.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51D2-51D2   Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG10249 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG10249-RA FBtr0087430  NM_137161   4221   1224 CG10249-RB FBtr0087431  NM_166074   3648   1042 CG10249-RC FBtr0087429  NM_166073   4551   1301 CG10249-RD FBtr0112929  NM_001103848   4880   1339 CG10249-RE FBtr0301334  NM_001169684   3652   934 CG10249-RF FBtr0303756  NM_001202003   4522   1063 CG10249-RG FBtr0303757  NM_001202004   5340   1294 CG10249-RI FBtr0332856  NM_001274054   4059   1039 CG10249-RJ FBtr0303758  NM_001202005   1942   446
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG10249-PA   FBpp0086560   133.6   1224   9.54     NP_611005   AAF58182 CG10249-PB   FBpp0086561   113.7   1042   9.62     NP_725427   AAF58183 CG10249-PC   FBpp0086559   142.7   1301   9.09     NP_725426   AAM68539 CG10249-PD   FBpp0111842   146.8   1339   9.14     NP_001097318   ABV53801 CG10249-PE   FBpp0290549   102.0   934   9.95     NP_001163155   ACZ94427 CG10249-PF   FBpp0292768   116.2   1063   9.70     NP_001188932   ADV37178 CG10249-PG   FBpp0292769   141.6   1294   9.15     NP_001188933   ADV37179 CG10249-PI   FBpp0305078   113.5   1039   9.53     NP_001260983   AGB93515 CG10249-PJ   FBpp0292770   48.6   446   6.51     NP_001188934   ADV37180
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683) Kank N-terminal motif (IPR021939)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140916   AA140917   AE013599 AAF58182   AE013599 AAF58183   AE013599 AAM68539   AE013599 ABV53801   AE013599 ACZ94427   AE013599 ADV37178   AE013599 ADV37179   AE013599 ADV37180   AF145616 AAD38591   AE013599 AGB93515   AI062076   AI063587   AI106971   AI134357   AI238463   AI388218   AI401914   AI405575   BF486661   BF488382   BF489776   BF490416   BF494294   BF500361   BF501296   BH759253   BH759254   BI167481   BI353949   BI624003   BT011145   BT021323 AAX33471   BT082049   BT126188   CO153331   CO155631   CO177031   CO265701   CO280408   CO280785   CO287131   CO288971   CO305958   CO326645   CO327231   CO327649   CO329942   CO330679   CO336912   CO337741   CO339306   CO345555   EC062468   EC081071   EC083483   EC084817   EC198884   EC228742   EC241571   EC242904   EC243643   EC246721   EC250750   EC256857   EC256930   EC258663   EC262950   EC265138   EC266155   EC266341   EL871667   EL871787   EW713219   FE862706   FE862722   FE862811   FE862834   FE862970   FE863010   FE863053   FE863109   FE863214   FE863285   FE863329   GH739168   GH741984   GH742908   GH743342   GO254366   GO254441   GO254522
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KMM8 A1Z9W7 A1Z9W5 A8DYE0 E1JH70 Q5BIA1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   midline primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) dorsal sensory complex proper primordium   (Fisher et al., 2012) Comment:reported as dorsal/lateral sensory complexes embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, inseminated spermatheca, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult thoracico-abdominal ganglion, larval/adult midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, virgin spermatheca, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (63) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male  (63) accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    3 central nervous system, pupae P8    5 head, virgin 1-day female    11 head, virgin 4-day female    7 head, virgin 20-day female    6 head, mated 1-day female    8 head, mated 4-day female    5 head, mated 20-day female    6 head, mated 1-day male    10 head, mated 4-day male    8 head, mated 20-day male    8 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    8 digestive system, 4-day adult    7 digestive system, 20-day adult    8 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    13 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    6 carcass, 20-day adult    8 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    63 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr  (35) embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr  26 pupae 2d postWPP  (37) pupae 3d postWPP  (28) pupae 4d postWPP  (39) adult male 01day  (28) adult male 05day  (33) adult male 30day  (32) adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr  (35) embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr  26 pupae 2d postWPP  (37) pupae 3d postWPP  28 pupae 4d postWPP  (39) adult male 01day  28 adult male 05day  (33) adult male 30day  32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    4 embryo 04-06hr    8 embryo 06-08hr    19 embryo 08-10hr    16 embryo 10-12hr    15 embryo 12-14hr    11 embryo 14-16hr    18 embryo 16-18hr    25 embryo 18-20hr    35 embryo 20-22hr    24 embryo 22-24hr    23 larva L1    16 larva L2    15 larva L3 12hr old    18 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    12 white prepupae 24hr    26 pupae 2d postWPP    37 pupae 3d postWPP    28 pupae 4d postWPP    39 adult male 01day    28 adult male 05day    33 adult male 30day    32 adult female 01day    10 adult female 05day    5 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS  (27) ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS  27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    12 embryonic Kc167    9 embryonic S1    0 embryonic S3    1 leg disc CME L1    1 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    9 ovary fGS/OSS    27 ovary OSC    21 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    3 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    8 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    15 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • GH03482 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027596 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10249-RC;HDC06480 FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG10249 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG10249GD6584 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG10249 Class Mutagen Stocks Known lesion CG10249KG00643 P-element activity 1 -- CG10249MI05636 1 -- CG10249NP6204 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG10249 Class Mutagen Stocks Known lesion CG10249GD6584 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG10249HMS00319 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6584} NA P{TRiP.HMS00319} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}CG10249NP6204 No miscellaneous insertions Mi{MIC}CG10249MI05636 NA P{SUPor-P}CG10249KG00643 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data on: 2012-10-22)
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neuron projection morphogenesis inferred from mutant phenotype (Sepp et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG10249 - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - CG18178 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Cypl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Eb1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - GlyP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Klp31E experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG10249 - Liprin-β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Nurf-38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - SC35 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - ctp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG10249 - α-Spec anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG10249 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62410 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027596 DroID - A comprehensive database of gene and protein interactions. • FBgn0027596 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36668
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6256C4 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG67PW1S Arthropod inclusive ortholog search EOG6DBRVH Metazoa inclusive ortholog search EOG6XDGHS
Orthologs in Drosophila Species (EOG6256C4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG10249     Drosophila simulans   Dsim\GD25644 Y   Drosophila sechellia   Dsec\GM20166 Y   Drosophila erecta   Dere\GG22383 Y   Drosophila yakuba   Dyak\GE12273 Y   Drosophila ananassae   Dana\GF12634 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA24244 Y   Drosophila persimilis   Dper\GL11708 Y   Drosophila willistoni   Dwil\GK21805 Y   Drosophila virilis   Dvir\GJ20623 Y   Drosophila mojavensis   Dmoj\GI20892 Y   Drosophila grimshawi   Dgri\GH20804 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG67PW1S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB52432   Apis mellifera Western honey bee  Amel\GB54695   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000877   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17833   Atta cephalotes Leafcutter ant  Acep\ACEP21597   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18191   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19508   Linepithema humile Argentine ant  Lhum\LH17329   Linepithema humile Argentine ant  Lhum\LH17330   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14588   Solenopsis invicta Red fire ant  Sinv\SINV16740   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005220   Pediculus humanus Human body louse  Phum\PHUM524820   Tribolium castaneum Red flour beetle  Tcas\TC004585
Orthologs in non-Insect Arthropods (EOG6DBRVH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_98029   Ixodes scapularis Deer tick  Isca\ISCW014698
Orthologs in non-Arthropod Metazoa (EOG6XDGHS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:dkey-226m8.9
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25644 Drosophila sechellia Dsec\GM20166 Drosophila erecta Dere\GG22383 Drosophila yakuba Dyak\GE12273 Drosophila ananassae Dana\GF12634 Drosophila pseudoobscura pseudoobscura Dpse\GA24244 Drosophila persimilis Dper\GL11708 Drosophila willistoni Dwil\GK21805 Drosophila virilis Dvir\GJ20623 Drosophila mojavensis Dmoj\GI20892 Drosophila grimshawi Dgri\GH20804
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	42097 y1 w*; Mi{MIC}CG10249MI05636 33432 y1 sc* v1; P{TRiP.HMS00319}attP2 13549 y1 w67c23; P{SUPor-P}CG10249KG00643
Kyoto	105146 y* w*; P{GawB}CG10249NP6204 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v15009 w1118; P{GD6584}v15009
Genomic Clones ( 1 )
	BACR01L16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03482 GH25621 RE07880 RE07910 RE68833
Other clones	DPiM_GH03482
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02743 AT15225 AT16580 AT21129 AT23639 AT25928 AT26874 GH01141 GH06243 GH11802 GH14510 GH19041 GM25688 RH56375
Other clones	2168 12300 32964 41647 54110 65903 191728 214289.74 214343.78 214545.70 522297 525069 561974 569588 CK01.1A.H6 CK01.64B.D3 CK01.64B.D5 CK01.88C.H2 CK00563 EK052212 EK065014 EK069761 EK143425 EK154005 EK154848 EK249905 EK294218 EK295902 EN01747 EN06447 EN13457 EN15213 EP01603 EP04358 EP06512 EP07812 EP22256 IP03735 IP03835 RM05896 RM05996 RM06496 RM06596 RM06601 RM06701 RM06901 RM07001 RM07101 RM07201 RM07301 RP01159 RP01423 RP01554 RP001013333 RP001015537 RP001045851 RP001052365
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027596 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36668
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG10249 BEST:GH19041 (Rana, 2004.7.8)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137161 NM_166073 NM_166074 NM_001103848 NM_001169684 NM_001202003 NM_001202004 NM_001202005 NM_001274054 RefSeq (Proteins) • NP_611005 NP_725426 NP_725427 NP_001097318 NP_001163155 NP_001188932 NP_001188933 NP_001188934 NP_001260983 DDBJ / EMBL / GenBank • AAD38591 AAF58182 AAF58183 AAM68539 AAX33471 ABV53801 ACZ94427 ADV37178 ADV37179 ADV37180 AF145616 AGB93515 AI063587 AI388218 AI401914 AI405575 BH759253 BH759254 BI167481 BT021323 Entrez Gene - A searchable database of RefSeq genes. • 36668 UniProtKB/TrEMBL • A1Z9W5 A1Z9W7 A8DYE0 E1JH70 Q5BIA1 Q7KMM8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683) Kank N-terminal motif (IPR021939) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH03482
Linkouts
	BioGRID - A database of protein and genetic interactions • 62410 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027596 DroID - A comprehensive database of gene and protein interactions. • FBgn0027596 DRSC - Results from RNAi screens. • FBgn0027596 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027596 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10249-RC;HDC06480 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027596 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36668 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36668 modMine - Data generated by the modENCODE project. • FBgn0027596
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:GH03482   BEST:GH19041   CG10249 (Lebo et al., 2009, Ni et al., 2010.12.1, Wasbrough et al., 2010, Garelli et al., 2012, Sepp et al., 2008)
Name Synonym
Secondary FlyBase IDs
	FBgn0043818
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 4 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Garelli et al., 2012, Science 336(6081): 579--582 Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. [FBrf0218214] Spasic et al., 2012, PLoS Genet. 8(1): e1002433 Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm. [FBrf0217189] Show all research papers ...