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Gene Dmel\cindr

General Information
Symbol	Dmel\cindr	Species	D. melanogaster
Name	CIN85 and CD2AP orthologue	Annotation symbol	CG31012
Feature type	protein_coding_gene	FlyBase ID	FBgn0027598
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	CG11316, BcDNA:GH03163, CD2AP
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100A6-100A6	Sequence location	3R:26,634,339..26,652,727 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene CIN85 and CD2AP orthologue is referred to in FlyBase by the symbol Dmel\cindr (CG31012, FBgn0027598). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: SH3 domain binding. There is experimental evidence that it is involved in the biological process: positive regulation of receptor-mediated endocytosis; border follicle cell migration; compound eye development; lateral inhibition; intercellular bridge organization; cytokinesis; actin filament organization; compound eye morphogenesis. 24 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system; organ system subdivision; peripheral nervous system; portion of tissue; adult; epithelial cell; intercellular bridge; organelle; actin cytoskeleton; extracellular region; sense organ; primary pigment cell. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Neutrophil cytosol factor 2 p67phox; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval salivary gland. Gene sequence location is 3R:26634339..26652727.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100A6-100A6   Limits computationally determined from genome sequence between P{lacW}l(3)s2500s2500 and P{PZ}Aph-407028&P{PZ}dcorK215
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cindr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43 Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cindr-RA FBtr0085707  NM_170527   2071   545 cindr-RB FBtr0085706  NM_143570   2307   537 cindr-RC FBtr0085704  NM_170526   3817   882 cindr-RD FBtr0085705  NM_170528   2799   635 cindr-RE FBtr0310068  NM_001276195   3897   848 cindr-RF FBtr0310069  NM_001276196   2970   692 cindr-RG FBtr0310070  NM_001276197   2976   694 cindr-RH FBtr0310071  NM_001276198   2281   537 cindr-RI FBtr0310072  NM_001276199   2225   537 cindr-RJ FBtr0310424  NM_001276200   4440   941
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cindr-PA   FBpp0085069   57.3   545   10.48     NP_733406   AAF57088 cindr-PB   FBpp0085068   56.1   537   10.32     NP_651827   AAF57089 cindr-PC   FBpp0085066   92.4   882   9.60     NP_733405   AAF57087 cindr-PD   FBpp0085067   67.1   635   9.99     NP_733407   AAN14260 cindr-PE   FBpp0301769   88.5   848   9.94     NP_001263124   AGB96503 cindr-PF   FBpp0301770   73.0   692   10.35     NP_001263125   AGB96504 cindr-PG   FBpp0301771   73.2   694   10.35     NP_001263126   AGB96505 cindr-PH   FBpp0301772   56.1   537   10.32     NP_001263127   AGB96506 cindr-PI   FBpp0301773   56.1   537   10.32     NP_001263128   AGB96507 cindr-PJ   FBpp0302572   98.5   941   10.03     NP_001263129   AGB96508
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Variant SH3 (IPR011511)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141604   AA697526   AE014297 AAF57087   AE014297 AAF57088   AE014297 AAF57089   AE014297 AAN14260   AF145614 AAD38589   AE014297 AGB96503   AE014297 AGB96504   AE014297 AGB96505   AE014297 AGB96506   AE014297 AGB96507   AE014297 AGB96508   AI063388   AI260850   AI292730   AI389234   AI401901   AI402593   AI514284   AI542410   BF495509   BG632903   BH840596   BI163831   BI228933   BI232539   BI234893   BI234918   BI236151   BI237321   BI564692   BI566736   BI567954   BI568016   BI569616   BI570129   BI570422   BI572680   BI581902   BI581927   BI582299   BI590121   BI592258   BI606345   BI607300   BI612151   BI613428   BI626538   BI634822   BI635790   BP543335   BP543336   BT009935 AAQ22404   CK657379   CK659927   CK659939   CO177309   CO186480   CO188267   CO190318   CO264113   CO271076   CO279030   CO288264   CO298002   CO303851   CO305082   CO308864   CO309063   CO311766   CO315334   CO320153   CO321212   CO321543   CO322208   CO322304   CO323131   CO335487   CO337938   CO339008   CO342449   CO342689   CO343748   CZ466877   CZ467635   CZ483562   CZ487875   EC063056   EC066305   EC067786   EC072912   EC195691   EC200576   EC203804   EC206920   EC221593   EC227550   EC231909   EC239441   EC243163   EC249110   EC253802   EC254846   EC256082   EC258717   EC263138   EC266172   ES690338   EV579224   EV586430   EV586894   EV588658   GH953176   GH957378   GH960357   GH967497   GH973867   GH982085
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86PF3 Q9VA35 Q9VA36 Q9Y154 Q7YU85
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cleavage furrow inferred from direct assay (Haglund et al., 2010) intercellular bridge inferred from direct assay (Haglund et al., 2010) midbody inferred from direct assay (Haglund et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, larval salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (27) central nervous system, larvae L3  26 central nervous system, pupae P8    19 head, virgin 1-day female  (27) head, virgin 4-day female  (32) head, virgin 20-day female    22 head, mated 1-day female  (32) head, mated 4-day female  26 head, mated 20-day female    20 head, mated 1-day male  (43) head, mated 4-day male  (40) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (45) digestive system, 1-day adult    24 digestive system, 4-day adult  (28) digestive system, 20-day adult  (35) fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8  (35) carcass, larvae L3 wandering  (33) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female  (33) ovary, mated 4-day female  (40) testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  27 central nervous system, larvae L3  26 central nervous system, pupae P8    19 head, virgin 1-day female  27 head, virgin 4-day female  32 head, virgin 20-day female    22 head, mated 1-day female  32 head, mated 4-day female  26 head, mated 20-day female    20 head, mated 1-day male  (43) head, mated 4-day male  (40) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (45) digestive system, 1-day adult    24 digestive system, 4-day adult  28 digestive system, 20-day adult  (35) fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8  (35) carcass, larvae L3 wandering  (33) carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female  (33) ovary, mated 4-day female  (40) testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    26 central nervous system, pupae P8    19 head, virgin 1-day female    27 head, virgin 4-day female    32 head, virgin 20-day female    22 head, mated 1-day female    32 head, mated 4-day female    26 head, mated 20-day female    20 head, mated 1-day male    43 head, mated 4-day male    40 head, mated 20-day male    43 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    24 digestive system, 4-day adult    28 digestive system, 20-day adult    35 fat body, larvae L3 wandering    9 fat body, white prepupae    19 fat body, pupae P8    35 carcass, larvae L3 wandering    33 carcass, 1-day adult    13 carcass, 4-day adult    14 carcass, 20-day adult    15 ovary, virgin 4-day female    33 ovary, mated 4-day female    40 testis, mated 4-day male    21 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (28) embryo 02-04hr    17 embryo 04-06hr  (39) embryo 06-08hr  (41) embryo 08-10hr  (43) embryo 10-12hr  (42) embryo 12-14hr  (30) embryo 14-16hr    23 embryo 16-18hr  (27) embryo 18-20hr  (42) embryo 20-22hr  (30) embryo 22-24hr  (34) larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (27) white prepupae new  (30) white prepupae 12hr  (74) white prepupae 24hr  (34) pupae 2d postWPP  (31) pupae 3d postWPP    18 pupae 4d postWPP  (36) adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  28 embryo 02-04hr    17 embryo 04-06hr  (39) embryo 06-08hr  (41) embryo 08-10hr  (43) embryo 10-12hr  (42) embryo 12-14hr  30 embryo 14-16hr    23 embryo 16-18hr  27 embryo 18-20hr  (42) embryo 20-22hr  30 embryo 22-24hr  (34) larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  27 white prepupae new  30 white prepupae 12hr  (74) white prepupae 24hr  (34) pupae 2d postWPP  31 pupae 3d postWPP    18 pupae 4d postWPP  (36) adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    28 embryo 02-04hr    17 embryo 04-06hr    39 embryo 06-08hr    41 embryo 08-10hr    43 embryo 10-12hr    42 embryo 12-14hr    30 embryo 14-16hr    23 embryo 16-18hr    27 embryo 18-20hr    42 embryo 20-22hr    30 embryo 22-24hr    34 larva L1    15 larva L2    12 larva L3 12hr old    10 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    27 white prepupae new    30 white prepupae 12hr    74 white prepupae 24hr    34 pupae 2d postWPP    31 pupae 3d postWPP    18 pupae 4d postWPP    36 adult male 01day    18 adult male 05day    21 adult male 30day    21 adult female 01day    20 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    222 Schneider line 2 Sg4    98 embryonic 1182-4H    111 embryonic GM2    89 embryonic Kc167    85 embryonic S1    202 embryonic S3    28 leg disc CME L1    118 wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11    130 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    208 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (222) Schneider line 2 Sg4  (98) embryonic 1182-4H  (111) embryonic GM2  (89) embryonic Kc167  (85) embryonic S1  (202) embryonic S3  (28) leg disc CME L1  (118) wing disc CME-W2  (86) wing disc ML-DmD8  (32) wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  (91) wing disc ML-DmD21  (49) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (73) eye-antennal disc ML-DmD11  (130) antennal disc ML-DmD20-c5  (51) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (208) CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (87) ovary fGS/OSS  (33) ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (222) Schneider line 2 Sg4    98 embryonic 1182-4H  (111) embryonic GM2    89 embryonic Kc167    85 embryonic S1  (202) embryonic S3    28 leg disc CME L1  (118) wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9  (159) wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11  (130) antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1  (208) CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    222 Schneider line 2 Sg4    98 embryonic 1182-4H    111 embryonic GM2    89 embryonic Kc167    85 embryonic S1    202 embryonic S3    28 leg disc CME L1    118 wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11    130 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    208 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    222 Schneider line 2 Sg4    98 embryonic 1182-4H    111 embryonic GM2    89 embryonic Kc167    85 embryonic S1    202 embryonic S3    28 leg disc CME L1    118 wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11    130 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    208 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (222) Schneider line 2 Sg4  (98) embryonic 1182-4H  (111) embryonic GM2  (89) embryonic Kc167  (85) embryonic S1  (202) embryonic S3  28 leg disc CME L1  (118) wing disc CME-W2  (86) wing disc ML-DmD8  32 wing disc ML-DmD9  (159) wing disc ML-DmD16-c3  (91) wing disc ML-DmD21  (49) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (73) eye-antennal disc ML-DmD11  (130) antennal disc ML-DmD20-c5  (51) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (208) CNS ML-DmBG2-c2  (35) tumorous blood cells mbn2  (87) ovary fGS/OSS  (33) ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (222) Schneider line 2 Sg4    98 embryonic 1182-4H  111 embryonic GM2    89 embryonic Kc167    85 embryonic S1  (202) embryonic S3    28 leg disc CME L1  118 wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9  (159) wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32  142 haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11  130 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1  (208) CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    222 Schneider line 2 Sg4    98 embryonic 1182-4H    111 embryonic GM2    89 embryonic Kc167    85 embryonic S1    202 embryonic S3    28 leg disc CME L1    118 wing disc CME-W2    86 wing disc ML-DmD8    32 wing disc ML-DmD9    159 wing disc ML-DmD16-c3    91 wing disc ML-DmD21    49 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    73 eye-antennal disc ML-DmD11    130 antennal disc ML-DmD20-c5    51 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    208 CNS ML-DmBG2-c2    35 tumorous blood cells mbn2    87 ovary fGS/OSS    33 ovary OSC    18 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  (31) heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult  (29) Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (41) cold shock, 4-day adult  31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult  (40) Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult  29 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    41 cold shock, 4-day adult    31 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    40 Copper 0.5 mM 12 hrs, larvae L3    24 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    23 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    29 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31012-RA;CG31012-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4tub.PU cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS lethal | first instar larval stage, with Scer\GAL4tub.PU cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS viable cindrCA06686 cindrCA06810 viable, with Scer\GAL4pnr-MD237 cindrGD8679 Other Phenotypes Allele planar polarity defective, with Scer\GAL4GMR.PF cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.PC.Scer\UAS cindrdsRNA.Scer\UAS visible, with Scer\GAL4pnr-MD237 cindrGD8679 Phenotype manifest in Allele actin cytoskeleton, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS actin cytoskeleton, with Scer\GAL4GMR.PF, cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS border follicle cell, with Scer\GAL4306 cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS chaeta | supernumerary, with Scer\GAL4pnr-MD237 cindrGD8679 cone cell, with Scer\GAL4GMR.PF cindrdsRNA.PC.PD.Scer\UAS eye | pupal stage, with Scer\GAL4GMR.PF cindrdsRNA.Scer\UAS follicle cell, with Scer\GAL4GR1, cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS follicle cell, with Scer\GAL4GR1, cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS intercellular bridge, with Scer\GAL4GR1, cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS intercellular bridge, with Scer\GAL4GR1, cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS macrochaeta, with Scer\GAL4ap-md544 cindrdsRNA.PC.PD.Scer\UAS ommatidium, with Scer\GAL4GMR.PF cindrdsRNA.Scer\UAS cindrdsRNA.PC.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS ommatidium | somatic clone, with Scer\GAL4Scer\FRT.Act5C cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS ommatidium | somatic clone, with Scer\GAL4Scer\FRT.Act5C, cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS ommatidium | somatic clone, with Scer\GAL4Scer\FRT.Act5C, cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS pigment cell, with Scer\GAL4GMR.PF cindrdsRNA.Scer\UAS cindrdsRNA.PC.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS primary pigment cell, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.Scer\UAS cindrdsRNA.Scer\UAS primary pigment cell, with Scer\GAL4GMR.PF, cindrdsRNA.Scer\UAS cindrdsRNA.PC.PD.Scer\UAS secondary pigment cell, with Scer\GAL4GMR.PF cindrdsRNA.PC.PD.Scer\UAS tertiary pigment cell, with Scer\GAL4GMR.PF cindrdsRNA.PC.PD.Scer\UAS
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of cindr Class Mutagen Stocks Known lesion cindrc01086 piggyBac transposase 1 -- cindrEY02524 P-element activity 1 -- cindrf01073 piggyBac transposase 1 -- cindrf05244 piggyBac transposase 1 -- cindrKG05741 P-element activity 1 -- cindrMI05938 1 -- cindrNP6530 1 -- cindrNP6642 1 -- cindrNP7424 1 -- cindrc02040 piggyBac transposase 0 -- cindrCA06686 P-element activity 0 Yes cindrCA06810 P-element activity 0 Yes cindrCPTI001695 piggyBac transposase 0 Yes cindrCPTI002324 piggyBac transposase 0 Yes cindrEP3700 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cindr Class Mutagen Stocks Known lesion cindrGD8679 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cindrGLV21035 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cindrHMS01795 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cindrHMS01892 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cindrdsRNA.PC.PD.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cindrdsRNA.PC.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cindrdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cindrNIG.1408R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cindrNIG.31012R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel8194 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.1408R} NA P{NIG.31012R} NA P{TRiP.GLV21035} NA P{TRiP.HMS01795} NA P{TRiP.HMS01892} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}cindrEP3700 NA P{EPgy2}cindrEY02524 NA insertion of enhancer trap binary system P{GawB}cindrNP6530 No P{GawB}cindrNP6642 No P{GawB}cindrNP7424 No miscellaneous insertions Mi{MIC}cindrMI05938 NA P{PTT-GA}cindrCA06686 NA P{PTT-GA}cindrCA06810 NA P{SUPor-P}cindrKG05741 NA PBac{544.SVS-1}cindrCPTI002324 NA PBac{681.P.FSVS-1}cindrCPTI001695 NA PBac{PB}cindrc01086 NA PBac{PB}cindrc02040 NA PBac{WH}cindrf01073 NA PBac{WH}cindrf05244 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
SH3 domain binding inferred from direct assay (Quinones et al., 2010)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Johnson et al., 2008) border follicle cell migration inferred from mutant phenotype (Quinones et al., 2010) compound eye development inferred from mutant phenotype (Johnson and Cagan, 2009) compound eye morphogenesis inferred from mutant phenotype (Johnson et al., 2008) cytokinesis inferred from mutant phenotype (Haglund et al., 2010) intercellular bridge organization inferred from mutant phenotype (Haglund et al., 2010) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) positive regulation of receptor-mediated endocytosis inferred from genetic interaction with mim (Quinones et al., 2010)
Cellular Component
CV term Evidence References
cleavage furrow inferred from direct assay (Haglund et al., 2010) intercellular bridge inferred from direct assay (Haglund et al., 2010) midbody inferred from direct assay (Haglund et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
SH3/SH2 adaptor activity inferred from sequence or structural similarity with EMBL:AF077003 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cindr - ArfGAP3 pull down, anti tag western blot (Johnson et al., 2011) cindr - Asap1 pull down, anti tag western blot (Johnson et al., 2011) cindr - cpa anti bait coimmunoprecipitation, peptide massfingerprinting (Johnson et al., 2008) cindr - cpb anti bait coimmunoprecipitation, western blot, peptide massfingerprinting (Johnson et al., 2008)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cindr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68504 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027598 DroID - A comprehensive database of gene and protein interactions. • FBgn0027598 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43654 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7YU85
Orthologs
OrthoDB Orthologs (8) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6ZW5XS Dipteran inclusive ortholog search EOG6B8JNP Insect inclusive ortholog search EOG6X0KNQ Arthropod inclusive ortholog search EOG6VX0MH Metazoa inclusive ortholog search EOG6SZ155
Orthologs in Drosophila Species (EOG6ZW5XS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cindr     Drosophila simulans   Dsim\GD21548 Y   Drosophila erecta   Dere\GG11778 Y   Drosophila yakuba   Dyak\GE10904 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26879 Y   Drosophila persimilis   Dper\GL13519     Drosophila willistoni   Dwil\GK14156 Y   Drosophila mojavensis   Dmoj\GI22123
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21548 Drosophila erecta Dere\GG11778 Drosophila yakuba Dyak\GE10904 Drosophila ananassae Dana\GF22925 Drosophila pseudoobscura pseudoobscura Dpse\GA26879 Drosophila willistoni Dwil\GK14156 Drosophila virilis Dvir\GJ24244 Drosophila grimshawi Dgri\GH14216
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	40244 y1 w*; Mi{MIC}cindrMI05938 15869 y1 w67c23; P{EPgy2}cindrEY02524 38328 y1 sc* v1; P{TRiP.HMS01795}attP2 38976 y1 sc* v1; P{TRiP.HMS01892}attP40 14211 y1 w67c23; ry506 P{SUPor-P}cindrKG05741 35670 y1 sc* v1; P{TRiP.GLV21035}attP2/TM3, Sb1
Harvard	- PBac{PB}cindrc01086 - PBac{WH}cindrf01073 - PBac{WH}cindrf05244
Kyoto	114282 w*; P{GawB}cindrNP7424 / TM6, P{UAS-lacZ.UW23-1}UW23-1 105244 y* w*; P{GawB}cindrNP6530 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v38854 w1118; P{GD8679}v38854
	More stocks available...
Genomic Clones ( 1 )
	BACR48I02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH03163 SD08724
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04451 GH20360 GH21841 GH27382 HL02716 LP04838 LP18068 LP18085 LP23604 RE03345 RE26593 RE28623 RE30663 RE30692 RE32165 RE33534 RH01722 RH02384 RH02745 RH03696 RH08284 RH09904 RH19729 RH19762 RH20267 RH36469 RH39063 RH39269 RH39347 RH40557 RH42578 RH62077 RH67513 RH72683 RH74336 SD17274
Other clones	19070 33772 62164 62592 125337 156384 156565 177423 192193 214277.64 214345.20 214353.26 214377.26 275048 569792 CK01.58D.C8 CK01.65B.G3 CK01.126D.D1 CK01.133B.E1 CK02075 Dmel_dig_011527_0603_2312 Dmel_neb_014686_0130_0827 Dmel_neb_015181_0175_2762 Dmel_neb_015220_0122_1519 EK020205 EK038847 EK047744 EK053126 EK068112 EK101917 EK133316 EK137522 EK171106 EK185902 EK187544 EK187844 EK189804 EK226244 EK242951 EK247256 EK259537 EK260041 EK261057 EK282535 EK290517 EN10547 EN15624 EP00616 EP14933 EP15337 EP17946 FGC019H09 GH15696 RP004060346 RP004133694 RP004225354 RP004374325 RP004466601 RP004546292
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43654
Antibody Information
	polyclonal (Johnson et al., 2008, Haglund et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: BcDNA:GH03163 CG1408 (Yao, 1999.11) Source for identity of: cindr CG31012 (Johnson et al., 2008)
Source for database merge of
Additional comments	Annotations CG11316, CG1408 merged as CG31012 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143570 NM_170526 NM_170527 NM_170528 NM_001276195 NM_001276196 NM_001276197 NM_001276198 NM_001276199 NM_001276200 RefSeq (Proteins) • NP_651827 NP_733405 NP_733406 NP_733407 NP_001263124 NP_001263125 NP_001263126 NP_001263127 NP_001263128 NP_001263129 DDBJ / EMBL / GenBank • AAD38589 AAF57087 AAF57088 AAF57089 AAN14260 AAQ22404 AF145614 AGB96503 AGB96504 AGB96505 AGB96506 AGB96507 AGB96508 AI063388 AI401901 AI542410 BH840596 BT009935 CZ466877 CZ467635 CZ483562 CZ487875 Entrez Gene - A searchable database of RefSeq genes. • 43654 UniProtKB/TrEMBL • Q7YU85 Q9VA35 Q9VA36 Q9Y154 Q86PF3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Neutrophil cytosol factor 2 p67phox (IPR000108) Src homology-3 domain (IPR001452) Variant SH3 (IPR011511)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68504 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027598 DroID - A comprehensive database of gene and protein interactions. • FBgn0027598 DRSC - Results from RNAi screens. • FBgn0027598 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027598 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31012-RA;CG31012-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027598 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43654 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43654 modMine - Data generated by the modENCODE project. • FBgn0027598 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7YU85
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BcDNA:GH03163 (Giot et al., 2003, Kim et al., 2005) CD2AP (Johnson et al., 2011, Quinones et al., 2010) CG1408   CG11316 (Brody et al., 2002, Raymond et al., 2004) CG31012 (Haglund et al., 2010, Park et al., 2005, Buszczak et al., 2007, Johnson et al., 2008, Raymond et al., 2004, Font-Burgada et al., 2008, Weavers et al., 2009, Liu et al., 2009, Kim et al., 2005, Wasbrough et al., 2010, Ni et al., 2011.7.19, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1) cindr (Johnson et al., 2011, Haglund et al., 2010, Johnson and Cagan, 2009, Quinones et al., 2010) Cindr (Johnson et al., 2008)
Name Synonym	CD2AP and CIN85 orthologue (Johnson et al., 2011) CIN85 and CD2AP orthologue (Johnson et al., 2008, ) Cindr (Johnson et al., 2008)
Secondary FlyBase IDs
	FBgn0039803 FBgn0051012
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 4 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 2 )
Recent research papers ( 2 )
	Bai et al., 2011, BMC Biol. 9: 54 Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. [FBrf0216297] Johnson et al., 2011, Mol. Biol. Cell 22(23): 4513--4526 Role for a Cindr-Arf6 axis in patterning emerging epithelia. [FBrf0216708] Show all research papers ...