FlyBase Gene Report: Dmel\cindr

General Information

Symbol

Dmel\cindr

Species

D. melanogaster

Name

CIN85 and CD2AP related

Annotation Symbol

CG31012

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027598

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Snapshot

CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

BcDNA:GH03163 , CIN85 and CD2AP orthologue, CD2AP

Key Links

Genomic Location

Cytogenetic map

100A6-100A6

Sequence location

3R:30,808,617..30,827,005 [+]

Recombination map

3-101

RefSeq locus

NT_033777 REGION:30808617..30827005

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables cell adhesion molecule binding

inferred from physical interaction with FLYBASE:rst; FB:FBgn0003285

(Johnson et al., 2012)

inferred from physical interaction with FLYBASE:hbs; FB:FBgn0029082

(Johnson et al., 2012)

enables GTPase activating protein binding

inferred from physical interaction with UniProtKB:A1Z7A6

(assigned by UniProt )

(Johnson et al., 2011)

inferred from physical interaction with UniProtKB:Q9VNS2

(assigned by UniProt )

(Johnson et al., 2011)

enables SH3 domain binding

inferred from direct assay

(Quinones et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (8 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in actin filament organization

inferred from mutant phenotype

(Johnson et al., 2008)

involved_in adherens junction assembly

inferred from mutant phenotype

(Johnson et al., 2008)

involved_in border follicle cell migration

inferred from mutant phenotype

(Quinones et al., 2010)

involved_in compound eye development

inferred from mutant phenotype

(Johnson and Cagan, 2009)

involved_in compound eye morphogenesis

inferred from genetic interaction with UniProtKB:E1JIT7

(assigned by UniProt )

(Johnson et al., 2011)

inferred from genetic interaction with UniProtKB:Q7KTX2

(assigned by UniProt )

(Johnson et al., 2011)

inferred from genetic interaction with UniProtKB:Q9VNS2

(assigned by UniProt )

(Johnson et al., 2011)

inferred from mutant phenotype

(Johnson et al., 2008)

involved_in intercellular bridge organization

inferred from mutant phenotype

(Haglund et al., 2010)

involved_in positive regulation of receptor-mediated endocytosis

inferred from genetic interaction with FLYBASE:mim; FB:FBgn0053558

(Quinones et al., 2010)

involved_in regulation of cytokinesis

inferred from mutant phenotype

(Haglund et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Johnson et al., 2008)

located_in cleavage furrow

inferred from direct assay

(Haglund et al., 2010)

located_in fusome

inferred from direct assay

(assigned by CACAO )

(Eikenes et al., 2013)

located_in intercellular bridge

inferred from direct assay

(Haglund et al., 2010)

located_in midbody

inferred from direct assay

(Haglund et al., 2010)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cindr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cindr-RA

FBtr0085707

NM_170527

2071

545

cindr-RB

FBtr0085706

NM_143570

2307

537

cindr-RC

FBtr0085704

NM_170526

3817

882

cindr-RD

FBtr0085705

NM_170528

2799

635

cindr-RE

FBtr0310068

NM_001276195

3897

848

cindr-RF

FBtr0310069

NM_001276196

2970

692

cindr-RG

FBtr0310070

NM_001276197

2976

694

cindr-RH

FBtr0310071

NM_001276198

2281

537

cindr-RI

FBtr0310072

NM_001276199

2225

537

cindr-RJ

FBtr0310424

NM_001276200

4440

941

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

cindr-PA

FBpp0085069

57.3

545

10.48

NP_733406

AAF57088

cindr-PB

FBpp0085068

56.1

537

10.32

NP_651827

AAF57089

cindr-PC

FBpp0085066

92.4

882

9.60

NP_733405

AAF57087

cindr-PD

FBpp0085067

67.1

635

9.99

NP_733407

AAN14260

cindr-PE

FBpp0301769

88.5

848

9.94

NP_001263124

AGB96503

cindr-PF

FBpp0301770

73.0

692

10.35

NP_001263125

AGB96504

cindr-PG

FBpp0301771

73.2

694

10.35

NP_001263126

AGB96505

cindr-PH

FBpp0301772

56.1

537

10.32

NP_001263127

AGB96506

cindr-PI

FBpp0301773

56.1

537

10.32

NP_001263128

AGB96507

cindr-PJ

FBpp0302572

98.5

941

10.03

NP_001263129

AGB96508

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

537 aa isoforms: cindr-PB, cindr-PH, cindr-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cindr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6 -- P7

ommatidium

(Johnson et al., 2008)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

follicle cell

• intercellular bridge

(Haglund et al., 2010)

larval stage

disc epithelium proper

• intercellular bridge

(Haglund et al., 2010)

imaginal disc

• intercellular bridge

(Haglund et al., 2010)

pupal stage P6 -- P7

primary pigment cell

(Johnson et al., 2008)

secondary pigment cell

(Johnson et al., 2008)

tertiary pigment cell

(Johnson et al., 2008)

cone cell

(Johnson et al., 2008)

photoreceptor cell

(Johnson et al., 2008)

interommatidial bristle

(Johnson et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

wing disc

(Johnson et al., 2008)

Additional Descriptive Data

cindr protein colocalizes with scra protein at stable somatic intercellular bridges in egg chamber follicle cells and imaginal disc epithelia.

(Haglund et al., 2010)

cindr protein is detected in primary, secondary, and tertiary pigment cells. Levels are high in photoreceptor neurons, cone cells and sensory bristles.

(Johnson et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical cortex

inferred from direct assay

(Johnson et al., 2008)

located_in cleavage furrow

inferred from direct assay

(Haglund et al., 2010)

located_in fusome

inferred from direct assay

(assigned by CACAO )

(Eikenes et al., 2013)

located_in intercellular bridge

inferred from direct assay

(Haglund et al., 2010)

located_in midbody

inferred from direct assay

(Haglund et al., 2010)

Expression Deduced from Reporters

Reporter: PBac{681.P.FSVS-1}cindr^CPTI001695

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult optic lobe | restricted

(Knowles-Barley, 2011.8.24)

posterior ventrolateral protocerebrum

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cindr in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cindr

View exonic expression by tissue for Dmel\cindr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027598

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31012-RA;CG31012-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31012

Flygut - An atlas of the Drosophila adult midgut

FBgn0027598

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cindr

Transgenic constructs containing regulatory region of cindr

Deletions and Duplications ( 1 )

Disrupted in

Df(3R)Exel8194

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage, with Scer\GAL4^Tub.PU

lethal | first instar larval stage, with Scer\GAL4^Tub.PU

partially lethal - majority die (with Df(3R)Exel6217)

cindr¹

partially lethal - majority die | recessive

cindr¹

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cindr^GD8679

viable, with Scer\GAL4^Mef2.PR

cindr^GD8679

viable, with Scer\GAL4^pnr-MD237

cindr^GD8679

viable, with Scer\GAL4^tin.CΔ4

cindr^GD8679

Other Phenotypes

Allele

exocytosis defective | larval stage (with Df(3R)Exel6217)

cindr¹

increased cell number | pupal stage

cindr^{dsRNA.PC.PD.UAS}

neuroanatomy defective | larval stage (with Df(3R)Exel6217)

cindr¹

neuroanatomy defective | larval stage | recessive

cindr¹

neurophysiology defective | larval stage | chemical conditional (with Df(3R)Exel6217)

cindr¹

neurophysiology defective | larval stage | recessive | chemical conditional

cindr¹

planar polarity defective, with Scer\GAL4^GMR.PF

short lived, with Scer\GAL4^Ugt36A1.PK

short lived (with Df(3R)Exel6217)

cindr¹

visible, with Scer\GAL4^pnr-MD237

cindr^GD8679

Phenotype manifest in

Allele

actin cytoskeleton, with Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

actin cytoskeleton, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

adult pericardial cell, with Scer\GAL4^sns.GCN

cindr^{dsRNA.UAS.cUa}

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

border follicle cell, with Scer\GAL4³⁰⁶

chaeta | supernumerary, with Scer\GAL4^pnr-MD237

cindr^GD8679

cone cell, with Scer\GAL4^GMR.PF

cindr^{dsRNA.PC.PD.UAS}

cone cell, with Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

cone cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

embryonic/larval neuromuscular junction

cindr¹

embryonic/larval neuromuscular junction (with Df(3R)Exel6217)

cindr¹

eye | pupal stage, with Scer\GAL4^GMR.PF

cindr^{dsRNA.PC.PD.UAS}

follicle cell, with Scer\GAL4^GR1, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

follicle cell, with Scer\GAL4^GR1, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

intercellular bridge, with Scer\GAL4^GR1, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

intercellular bridge, with Scer\GAL4^GR1, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

interommatidial precursor cell, with Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

interommatidial precursor cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

macrochaeta, with Scer\GAL4^ap-md544

cindr^{dsRNA.PC.PD.UAS}

mitochondrion | larval stage (with Df(3R)Exel6217)

cindr¹

nephrocyte diaphragm | adult stage, with Scer\GAL4^Ugt36A1.PK

cindr^TRiP.cUa

ommatidium, with Scer\GAL4^GMR.PF

ommatidium | somatic clone, with Scer\GAL4^FRT.Act5C

ommatidium | somatic clone, with Scer\GAL4^FRT.Act5C, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

ommatidium | somatic clone, with Scer\GAL4^FRT.Act5C, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

pigment cell, with Scer\GAL4^GMR.PF

primary pigment cell, with Scer\GAL4^GMR.PF, cindr^{dsRNA.PC.PD.UAS}

cindr^dsRNA.UAS

primary pigment cell, with Scer\GAL4^GMR.PF, cindr^dsRNA.UAS

cindr^{dsRNA.PC.PD.UAS}

primary pigment cell | pupal stage | supernumerary, with Scer\GAL4^GMR.PU

cindr^{dsRNA.PC.PD.UAS}

retina | pupal stage, with Scer\GAL4^GMR.PU

cindr^{dsRNA.PC.PD.UAS}

secondary pigment cell, with Scer\GAL4^GMR.PF

cindr^{dsRNA.PC.PD.UAS}

subsynaptic reticulum | larval stage (with Df(3R)Exel6217)

cindr¹

synaptic vesicle | larval stage (with Df(3R)Exel6217)

cindr¹

terminal bouton | larval stage

cindr¹

terminal bouton | larval stage (with Df(3R)Exel6217)

cindr¹

tertiary pigment cell, with Scer\GAL4^GMR.PF

cindr^{dsRNA.PC.PD.UAS}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SH3KBP1

11 of 15

Yes

Hsap\CD2AP

8 of 15

Yes

Hsap\SH3D21

4 of 15

Yes

Hsap\SH3D19

1 of 15

Hsap\SH3PXD2A

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Sh3kbp1

11 of 15

Yes

Mmus\Cd2ap

8 of 15

Yes

Mmus\Sh3d21

3 of 15

Yes

Mmus\Sh3d19

1 of 15

Mmus\Sh3pxd2a

1 of 15

Yes

Rattus norvegicus (Norway rat) (5)

Rnor\Cd2ap

7 of 13

Yes

Rnor\Sh3kbp1

7 of 13

Yes

Rnor\Sh3d21

4 of 13

Yes

Rnor\Sh3d19

1 of 13

Yes

Rnor\Sh3pxd2a

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\cd2ap

6 of 12

Yes

Xtro\sh3kbp1

5 of 12

Yes

Xtro\sh3d21

1 of 12

Yes

Xtro\sh3pxd2a

1 of 12

Yes

Danio rerio (Zebrafish) (4)

Drer\cd2ap

9 of 15

Yes

Drer\sh3kbp1

9 of 15

Yes

Drer\sh3d21

5 of 15

Yes

Drer\si:dkey-71d15.2

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\cdap-2

9 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\AT1G31440

1 of 9

Yes

Atha\AT4G18060

1 of 9

Yes

Atha\AT4G34660

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\sfp47

1 of 12

Yes

Spom\SPBC800.10c

1 of 12

Yes

Spom\ucp8

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904MA )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26879

Drosophila persimilis

Dper\GL13518

Drosophila persimilis

Dper\GL13519

Drosophila willistoni

Dwil\GK14156

Drosophila virilis

Dvir\GJ24244

Drosophila mojavensis

Dmoj\GI22122

Drosophila grimshawi

Dgri\GH14216

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503NP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17009174

Glossina morsitans

Tsetse fly

Gmor\GMOY010085

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00446

Mayetiola destructor

Hessian fly

Mdes\Mdes011294

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001009

Anopheles darlingi

American malaria mosquito

Adar\ADAC006538

Anopheles gambiae

Malaria mosquito

Agam\AGAP004211

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007375

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CMT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002456

Danaus plexippus

Monarch butterfly

Dple\DPOGS208886-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL008900

Apis florea

Little honeybee

Aflo\2193035940

Apis mellifera

Western honey bee

Amel\GB42478

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23089

Bombus terrestris

Buff-tailed bumblebee

Bter\15214007

Linepithema humile

Argentine ant

Lhum\LH15334

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000c49

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008904

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06496

Tribolium castaneum

Red flour beetle

Tcas\TC034557

Pediculus humanus

Human body louse

Phum\PHUM597170

Rhodnius prolixus

Kissing bug

Rpro\RPRC010615

Cimex lectularius

Bed bug

Clec\CLEC006078

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004543

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI089499

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_07752

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05MW )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013526

Strigamia maritima

European centipede

Smar\SMAR008278

Ixodes scapularis

Black-legged tick

Isca\ISCW020520

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70631.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur38g00340

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_332604

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08MZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000021783

Ciona intestinalis

Vase tunicate

Cint\LOC100186262

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

2 of 10

CAP

1 of 10

EndoA

1 of 10

POSH

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 5 )

Allele

Disease

Evidence

References

cindr^GLV21035

model of nephrotic syndrome

CEA

(Fu et al., 2017)

cindr^HMS01795

model of nephrotic syndrome

CEA

(Fu et al., 2017)

cindr^HMS01892

model of nephrotic syndrome

CEA

(Fu et al., 2017)

cindr^TRiP.cUa

model of nephrotic syndrome

CEA

(Fu et al., 2017)

cindr¹

model of tauopathy

CEA

(Ojelade et al., 2019)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SH3KBP1; SH3 domain containing kinase binding protein 1

model of immunodeficiency 61

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SH3KBP1; SH3 domain containing kinase binding protein 1

11 of 15

300374

IMMUNODEFICIENCY 61; IMD61

immunodeficiency 61

CD2AP; CD2 associated protein

8 of 15

604241

FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO; FSGS3

SH3D21; SH3 domain containing 21

4 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

cindr

Hsap\CD2AP

(Fu et al., 2017)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cindr - 14-3-3ζ

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Ojelade et al., 2019)

cindr - Actin

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Ojelade et al., 2019)

cindr - ArfGAP3

pull down, anti tag western blot

(Johnson et al., 2011)

cindr - Asap

pull down, anti tag western blot

(Johnson et al., 2011)

cindr - Dsor1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - Fbxl7

anti tag coimmunoprecipitation, anti tag western blot

(Bosch et al., 2014)

cindr - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - Nedd4

pull down, peptide massfingerprinting

(Safi et al., 2016)

cindr - PMCA

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry

(Ojelade et al., 2019)

cindr - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - Ras85D

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - RasGAP1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - Rpt5

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Ojelade et al., 2019)

cindr - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - Syn

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Ojelade et al., 2019)

cindr - Syt1

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot

(Ojelade et al., 2019)

cindr - Tsc1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - bsk

anti bait coimmunoprecipitation, western blot

(Yasin et al., 2016)

cindr - cnk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - cpa

anti bait coimmunoprecipitation, peptide massfingerprinting

(Johnson et al., 2008)

cindr - cpb

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Johnson et al., 2008)

cindr - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - drk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - ds

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

cindr - en

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

cindr - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - hb

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

cindr - hbs

anti bait coimmunoprecipitation, anti tag western blot, pull down, western blot

(Johnson et al., 2012)

cindr - ksr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

cindr - nsl1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Raja et al., 2010)

cindr - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - rst

anti bait coimmunoprecipitation, anti tag western blot, pull down, western blot

(Johnson et al., 2012)

cindr - scra

pull down, anti tag western blot

(Haglund et al., 2010)

cindr - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

cindr - tsh

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cindr

enhanceable

Abl

(Johnson et al., 2008)

cindr

enhanceable

Arf51F

(Johnson et al., 2011)

cindr

enhanceable

ArfGAP3

(Johnson et al., 2011)

cindr

suppressible

ArfGAP3

(Johnson et al., 2011)

cindr

suppressible

Arp3

(Johnson et al., 2008)

cindr

enhanceable

Asap

(Johnson et al., 2011)

cindr

enhanceable

Cbl

(Johnson et al., 2012)

cindr

enhanceable

chic

(Johnson et al., 2008)

cindr

enhanceable

cpa

(Johnson et al., 2008)

cindr

enhanceable

cpb

(Johnson et al., 2008)

cindr

enhanceable

Efa6

(Johnson et al., 2011)

cindr

enhanceable

ena

(Johnson and Cagan, 2009)

cindr

suppressible

hbs

(Johnson et al., 2008)

cindr

suppressible

mim

(Quinones et al., 2010)

cindr

enhanceable

Mtl|Rac1|Rac2

(Johnson et al., 2008)

cindr

enhanceable

Rho1

(Johnson et al., 2008)

cindr

suppressible

rst

(Johnson et al., 2008)

cindr

suppressible

shg

(Johnson et al., 2008)

cindr

enhanceable

shg

(Johnson et al., 2008)

cindr

enhanceable

siz

(Johnson et al., 2011)

cindr

enhanceable

tsr

(Johnson et al., 2008)

cindr

enhanceable

Vav

(Martín-Bermudo et al., 2015)

cindr

enhanceable

WASp

(Johnson et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Fbxl7

suppressible

cindr

(Bosch et al., 2014)

mim

suppressible

cindr

(Quinones et al., 2010)

RacGAP84C

enhanceable

cindr

(Raymond et al., 2004)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68504

DroID - A comprehensive database of gene and protein interactions.

FBgn0027598

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43654

MIST (genetic) - An integrated Molecular Interaction Database

cindr

MIST (protein-protein) - An integrated Molecular Interaction Database

cindr

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-101

Cytogenetic map

100A6-100A6

Sequence location

3R:30,808,617..30,827,005 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100A6-100A6

Limits computationally determined from genome sequence between P{lacW}l(3)s2500^s2500 and P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-101

(FlyBase, 2016)

3-98.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Bloomington

81437

y¹ v¹; P{TKO.GS04670}attP40

40244

y¹ w^*; Mi{MIC}cindr^MI05938

50802

y¹ w^*; P{PTT-GA}cindr^CA06686

15869

y¹ w^67c23; P{EPgy2}cindr^EY02524

85616

w¹¹¹⁸; PBac{WH}cindr^f01073/TM6B, Tb¹

38328

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01795}attP2

14211

y¹ w^67c23; ry⁵⁰⁶ P{SUPor-P}cindr^KG05741

Kyoto

115543

w¹¹¹⁸; PBac{544.SVS-1}cindr^CPTI002324

115233

w¹¹¹⁸; PBac{681.P.FSVS-1}cindr^CPTI001695

114282

w^*; P{GawB}cindr^NP7424 / TM6, P{UAS-lacZ.UW23-1}UW23-1

VDRC

v330422

P{VSH330422}attP40

v38854

w¹¹¹⁸; P{GD8679}v38854

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (92)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027598

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027598

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43654

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Haglund et al., 2010, Johnson et al., 2008)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: BcDNA:GH03163 CG1408

(Yao, 1999.11)

Source for identity of: cindr CG31012

(Johnson et al., 2008)

Source for database merge of

Additional comments

Annotations CG11316, CG1408 merged as CG31012 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 82 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43654

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027598

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31012

Flygut - An atlas of the Drosophila adult midgut

FBgn0027598

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43654

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034557

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG31012

modMine - A data warehouse for the modENCODE project

FBgn0027598

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7YU85

Linkouts

BioGRID - A database of protein and genetic interactions.

68504

DPiM - Drosophila Protein interaction map

FBgn0027598

DroID - A comprehensive database of gene and protein interactions.

FBgn0027598

DRSC - Results frm RNAi screens

FBgn0027598

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027598

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG31012-RA;CG31012-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027598

FlyMine - An integrated database for Drosophila genomics

FBgn0027598

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43654

MIST (genetic) - An integrated Molecular Interaction Database

cindr

MIST (protein-protein) - An integrated Molecular Interaction Database

cindr

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BcDNA:GH03163

(Mukherjee et al., 2014, Kim et al., 2005, Stanyon et al., 2004, Giot et al., 2003)

CD2AP

(Johnson et al., 2011, Quinones et al., 2010)

CG11316

(Raymond et al., 2004, Brody et al., 2002)

CG1408

CG31012

(Meadows, 2017.9.14, Safi et al., 2016, Ashwal-Fluss et al., 2014, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Haglund et al., 2010, Ni et al., 2010.12.1, Raja et al., 2010, Wasbrough et al., 2010, Liu et al., 2009, Weavers et al., 2009, Font-Burgada et al., 2008, Johnson et al., 2008, Buszczak et al., 2007, Kim et al., 2005, Park et al., 2005, Raymond et al., 2004)

Cindir

(Finegan and Bergstralh, 2020)

Cindr

(Yu et al., 2020, Carrasco-Rando et al., 2019, Bushnell et al., 2018, Loyer and Januschke, 2018, Fu et al., 2017, Helmstädter and Simons, 2017, Yasin et al., 2016, Eikenes et al., 2015, Menon and Gaestel, 2015, Na et al., 2015, Sopko et al., 2015, Eikenes et al., 2013, Johnson et al., 2008)

Name Synonyms

CD2AP and CIN85 orthologue

(Johnson et al., 2011)

CIN85 and CD2AP orthologue

(Johnson et al., 2008)

CIN85 and CD2AP related

Cindr

(Johnson et al., 2008)

Secondary FlyBase IDs

FBgn0039803
FBgn0051012

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (97)

The following external sites may use different assemblies or annotations than FlyBase.

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