FB2021_05, released October 15, 2021

Gene: Dmel\cindr

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General Information
Symbol
Dmel\cindr
Species
D. melanogaster
Name
CIN85 and CD2AP related
Annotation Symbol
CG31012
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027598
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BcDNA:GH03163 , CD2AP, CIN85 and CD2AP orthologue

Key Links
Genomic Location
Cytogenetic map
100A6-100A6
Sequence location
Recombination map
3-101
RefSeq locus
NT_033777 REGION:30808617..30827005
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables cell adhesion molecule binding
inferred from physical interaction with FLYBASE:rst; FB:FBgn0003285, FLYBASE:hbs; FB:FBgn0287864
(Johnson et al., 2012)
enables GTPase activating protein binding
inferred from physical interaction with UniProtKB:A1Z7A6
(assigned by UniProt )
(Johnson et al., 2011)
inferred from physical interaction with UniProtKB:Q9VNS2
(assigned by UniProt )
(Johnson et al., 2011)
enables SH3 domain binding
inferred from direct assay
(Quinones et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (8 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from mutant phenotype
(Johnson et al., 2008)
involved_in adherens junction assembly
inferred from mutant phenotype
(Johnson et al., 2008)
involved_in border follicle cell migration
inferred from mutant phenotype
(Quinones et al., 2010)
involved_in compound eye development
inferred from mutant phenotype
(Johnson and Cagan, 2009)
involved_in compound eye morphogenesis
inferred from genetic interaction with UniProtKB:E1JIT7
(assigned by UniProt )
(Johnson et al., 2011)
inferred from genetic interaction with UniProtKB:Q7KTX2
(assigned by UniProt )
(Johnson et al., 2011)
inferred from genetic interaction with UniProtKB:Q9VNS2
(assigned by UniProt )
(Johnson et al., 2011)
inferred from mutant phenotype
(Johnson et al., 2008)
involved_in intercellular bridge organization
inferred from mutant phenotype
(Haglund et al., 2010)
involved_in positive regulation of receptor-mediated endocytosis
inferred from genetic interaction with FLYBASE:mim; FB:FBgn0053558
(Quinones et al., 2010)
involved_in regulation of cytokinesis
inferred from mutant phenotype
(Haglund et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
is_active_in apical cortex
inferred from direct assay
(Johnson et al., 2008)
located_in cleavage furrow
inferred from direct assay
(Haglund et al., 2010)
located_in fusome
inferred from direct assay
(assigned by CACAO )
(Eikenes et al., 2013)
located_in intercellular bridge
inferred from direct assay
(Haglund et al., 2010)
located_in midbody
inferred from direct assay
(Haglund et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis. [Date last reviewed: 2019-03-07]
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
8

Please see the JBrowse view of Dmel\cindr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cindr-RA
FBtr0085707
NM_170527
2071
545
cindr-RB
FBtr0085706
NM_143570
2307
537
cindr-RC
FBtr0085704
NM_170526
3817
882
cindr-RD
FBtr0085705
NM_170528
2799
635
cindr-RE
FBtr0310068
NM_001276195
3897
848
cindr-RF
FBtr0310069
NM_001276196
2970
692
cindr-RG
FBtr0310070
NM_001276197
2976
694
cindr-RH
FBtr0310071
NM_001276198
2281
537
cindr-RI
FBtr0310072
NM_001276199
2225
537
cindr-RJ
FBtr0310424
NM_001276200
4440
941
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
cindr-PA
FBpp0085069
57.3
545
10.48
NP_733406
AAF57088
cindr-PB
FBpp0085068
56.1
537
10.32
NP_651827
AAF57089
cindr-PC
FBpp0085066
92.4
882
9.60
NP_733405
AAF57087
cindr-PD
FBpp0085067
67.1
635
9.99
NP_733407
AAN14260
cindr-PE
FBpp0301769
88.5
848
9.94
NP_001263124
AGB96503
cindr-PF
FBpp0301770
73.0
692
10.35
NP_001263125
AGB96504
cindr-PG
FBpp0301771
73.2
694
10.35
NP_001263126
AGB96505
cindr-PH
FBpp0301772
56.1
537
10.32
NP_001263127
AGB96506
cindr-PI
FBpp0301773
56.1
537
10.32
NP_001263128
AGB96507
cindr-PJ
FBpp0302572
98.5
941
10.03
NP_001263129
AGB96508
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

537 aa isoforms: cindr-PB, cindr-PH, cindr-PI
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cindr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage P6 -- P7
ommatidium
(Johnson et al., 2008)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
disc epithelium proper
(Haglund et al., 2010)
imaginal disc
(Haglund et al., 2010)
pupal stage P6 -- P7
primary pigment cell
(Johnson et al., 2008)
secondary pigment cell
(Johnson et al., 2008)
tertiary pigment cell
(Johnson et al., 2008)
cone cell
(Johnson et al., 2008)
photoreceptor cell
(Johnson et al., 2008)
interommatidial bristle
(Johnson et al., 2008)
oogenesis
follicle cell
(Haglund et al., 2010)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
wing disc
(Johnson et al., 2008)
Additional Descriptive Data

cindr protein colocalizes with scra protein at stable somatic intercellular bridges in egg chamber follicle cells and imaginal disc epithelia.

(Haglund et al., 2010)

cindr protein is detected in primary, secondary, and tertiary pigment cells. Levels are high in photoreceptor neurons, cone cells and sensory bristles.

(Johnson et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in apical cortex
inferred from direct assay
(Johnson et al., 2008)
located_in cleavage furrow
inferred from direct assay
(Haglund et al., 2010)
located_in fusome
inferred from direct assay
(assigned by CACAO )
(Eikenes et al., 2013)
located_in intercellular bridge
inferred from direct assay
(Haglund et al., 2010)
located_in midbody
inferred from direct assay
(Haglund et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cindr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cindr
Transgenic constructs containing regulatory region of cindr
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel8194
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | embryonic stage, with Scer\GAL4Tub.PU
lethal | first instar larval stage, with Scer\GAL4Tub.PU
partially lethal - majority die (with Df(3R)Exel6217)
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal neuroanatomy | larval stage (with Df(3R)Exel6217)
abnormal neuroanatomy | larval stage | recessive
abnormal neurophysiology | larval stage | chemical conditional (with Df(3R)Exel6217)
abnormal neurophysiology | larval stage | recessive | chemical conditional
abnormal planar polarity, with Scer\GAL4GMR.PF
increased cell number | pupal stage
short lived, with Scer\GAL4Ugt36A1.PK
short lived (with Df(3R)Exel6217)
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
actin cytoskeleton, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.UAS
actin cytoskeleton, with Scer\GAL4GMR.PF, cindrdsRNA.UAS
adult pericardial cell, with Scer\GAL4sns.GCN
adult pericardial cell, with Scer\GAL4Ugt36A1.PK
border follicle cell, with Scer\GAL4306
chaeta | increased number, with Scer\GAL4pnr-MD237
cone cell, with Scer\GAL4GMR.PF
cone cell, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.UAS
cone cell, with Scer\GAL4GMR.PF, cindrdsRNA.UAS
embryonic/larval neuromuscular junction
embryonic/larval neuromuscular junction (with Df(3R)Exel6217)
eye, with Scer\GAL4GMR.PF
eye | pupal stage, with Scer\GAL4GMR.PF
follicle cell, with Scer\GAL4GR1, cindrdsRNA.PC.PD.UAS
follicle cell, with Scer\GAL4GR1, cindrdsRNA.UAS
intercellular bridge, with Scer\GAL4GR1, cindrdsRNA.PC.PD.UAS
intercellular bridge, with Scer\GAL4GR1, cindrdsRNA.UAS
interommatidial cell | P-stage, with Scer\GAL4GMR.PF
interommatidial precursor cell, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.UAS
interommatidial precursor cell, with Scer\GAL4GMR.PF, cindrdsRNA.UAS
macrochaeta, with Scer\GAL4ap-md544
mitochondrion | larval stage (with Df(3R)Exel6217)
nephrocyte diaphragm | adult stage, with Scer\GAL4Ugt36A1.PK
ommatidium, with Scer\GAL4GMR.PF
ommatidium | somatic clone, with Scer\GAL4FRT.Act5C
ommatidium | somatic clone, with Scer\GAL4FRT.Act5C, cindrdsRNA.PC.PD.UAS
ommatidium | somatic clone, with Scer\GAL4FRT.Act5C, cindrdsRNA.UAS
pigment cell, with Scer\GAL4GMR.PF
primary pigment cell, with Scer\GAL4GMR.PF, cindrdsRNA.PC.PD.UAS
primary pigment cell, with Scer\GAL4GMR.PF, cindrdsRNA.UAS
primary pigment cell | pupal stage | increased number, with Scer\GAL4GMR.PU
retina | P-stage, with Scer\GAL4GMR.PF
retina | pupal stage, with Scer\GAL4GMR.PU
secondary pigment cell, with Scer\GAL4GMR.PF
subsynaptic reticulum | larval stage (with Df(3R)Exel6217)
synaptic vesicle | larval stage (with Df(3R)Exel6217)
terminal bouton | larval stage
terminal bouton | larval stage (with Df(3R)Exel6217)
tertiary pigment cell, with Scer\GAL4GMR.PF
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SH3KBP1
11 of 15
Yes
Yes
1  
Hsap\CD2AP
8 of 15
No
Yes
 
4  
Hsap\SH3D21
4 of 15
No
Yes
Hsap\SH3D19
1 of 15
No
No
Hsap\SH3PXD2A
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Sh3kbp1
11 of 15
Yes
Yes
Mmus\Cd2ap
8 of 15
No
Yes
Mmus\Sh3d21
3 of 15
No
Yes
Mmus\Sh3d19
1 of 15
No
No
Mmus\Sh3pxd2a
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Cd2ap
7 of 13
Yes
Yes
Rnor\Sh3kbp1
7 of 13
Yes
Yes
Rnor\Sh3d21
4 of 13
No
Yes
Rnor\Sh3d19
1 of 13
No
Yes
Rnor\Sh3pxd2a
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\cd2ap
6 of 12
Yes
Yes
Xtro\sh3kbp1
5 of 12
No
Yes
Xtro\sh3d21
1 of 12
No
Yes
Xtro\sh3pxd2a
1 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\cd2ap
9 of 15
Yes
Yes
Drer\sh3kbp1
9 of 15
Yes
Yes
Drer\sh3d21
5 of 15
No
Yes
Drer\si:dkey-71d15.2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\cdap-2
9 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT1G31440
1 of 9
Yes
No
Atha\AT4G18060
1 of 9
Yes
No
Atha\AT4G34660
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\sfp47
1 of 12
Yes
No
Spom\SPBC800.10c
1 of 12
Yes
No
Spom\ucp8
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904MA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012016
Drosophila simulans
Dsim\GD21548
Drosophila sechellia
Dsec\GM12908
Drosophila erecta
Dere\GG11778
Drosophila yakuba
Dyak\GE10904
Drosophila ananassae
Dana\GF22925
Drosophila pseudoobscura pseudoobscura
Dpse\GA26879
Drosophila persimilis
Dper\GL13518
Drosophila persimilis
Dper\GL13519
Drosophila willistoni
Dwil\GK14156
Drosophila virilis
Dvir\GJ24244
Drosophila mojavensis
Dmoj\GI22122
Drosophila grimshawi
Dgri\GH14216
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503NP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009174
Glossina morsitans
Tsetse fly
Gmor\GMOY010085
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00446
Mayetiola destructor
Hessian fly
Mdes\Mdes011294
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001009
Anopheles darlingi
American malaria mosquito
Adar\ADAC006538
Anopheles gambiae
Malaria mosquito
Agam\AGAP004211
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007375
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CMT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002456
Danaus plexippus
Monarch butterfly
Dple\DPOGS208886-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008900
Apis florea
Little honeybee
Aflo\2193035940
Apis mellifera
Western honey bee
Amel\GB42478
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23089
Bombus terrestris
Buff-tailed bumblebee
Bter\15214007
Linepithema humile
Argentine ant
Lhum\LH15334
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000c49
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008904
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06496
Tribolium castaneum
Red flour beetle
Tcas\TC034557
Pediculus humanus
Human body louse
Phum\PHUM597170
Rhodnius prolixus
Kissing bug
Rpro\RPRC010615
Cimex lectularius
Bed bug
Clec\CLEC006078
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004543
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI089499
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07752
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05MW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013526
Strigamia maritima
European centipede
Smar\SMAR008278
Ixodes scapularis
Black-legged tick
Isca\ISCW020520
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70631.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur38g00340
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_332604
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G08MZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000021783
Ciona intestinalis
Vase tunicate
Cint\LOC100186262
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Nost
2 of 10
CAP
1 of 10
EndoA
1 of 10
POSH
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 5 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SH3KBP1; SH3 domain containing kinase binding protein 1
11 of 15
300374
 
CD2AP; CD2 associated protein
8 of 15
604241
 
SH3D21; SH3 domain containing 21
4 of 15
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      cindr
      Hsap\CD2AP
      (Fu et al., 2017)
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      cindr - 14-3-3ζ
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - Actin
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - ArfGAP3
      pull down, anti tag western blot
      (Johnson et al., 2011)
      cindr - Asap
      pull down, anti tag western blot
      (Johnson et al., 2011)
      cindr - Dsor1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - Fbxl7
      anti tag coimmunoprecipitation, anti tag western blot
      (Bosch et al., 2014)
      cindr - Myc
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - Nedd4
      pull down, peptide massfingerprinting
      (Safi et al., 2016)
      cindr - PMCA
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - Pdk1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - Ras85D
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - RasGAP1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - Rpt5
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - S6kII
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - Syn
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - Syt1
      anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry
      (Ojelade et al., 2019)
      cindr - Tsc1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - bsk
      anti bait coimmunoprecipitation, western blot
      (Yasin et al., 2016)
      cindr - cnk
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - cpa
      anti bait coimmunoprecipitation, peptide massfingerprinting
      (Johnson et al., 2008)
      cindr - cpb
      anti bait coimmunoprecipitation, western blot, peptide massfingerprinting
      (Johnson et al., 2008)
      cindr - dos
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - drk
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - ds
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      cindr - en
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      cindr - foxo
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - gig
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - hb
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      cindr - hbs
      pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot
      (Johnson et al., 2012)
      cindr - ksr
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Friedman et al., 2011)
      cindr - nsl1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Raja et al., 2010)
      cindr - rictor
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - rst
      anti bait coimmunoprecipitation, anti tag western blot, pull down, western blot
      (Johnson et al., 2012)
      cindr - scra
      pull down, anti tag western blot
      (Haglund et al., 2010)
      cindr - sima
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      cindr - tsh
      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      cindr
      enhanceable
      Abl
      (Johnson et al., 2008)
      cindr
      enhanceable
      Arf51F
      (Johnson et al., 2011)
      cindr
      enhanceable
      ArfGAP3
      (Johnson et al., 2011)
      cindr
      suppressible
      ArfGAP3
      (Johnson et al., 2011)
      cindr
      suppressible
      ari-1
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Arp3
      (Johnson et al., 2008)
      cindr
      enhanceable
      Asap
      (Johnson et al., 2011)
      cindr
      enhanceable
      bsk
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Cbl
      (Ketosugbo et al., 2017, Johnson et al., 2012)
      cindr
      enhanceable
      CG1909
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG4238
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      CG5555
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      CG6923
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG7376
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG7694
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG8419
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG10916
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG12362
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG12477
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      CG17721
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      CG32369
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      CG32486
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      chic
      (Johnson et al., 2008)
      cindr
      enhanceable
      cpa
      (Johnson et al., 2008)
      cindr
      enhanceable
      cpb
      (Johnson et al., 2008)
      cindr
      enhanceable
      Cul1
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Cul2
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Cul2
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Cul3
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Cul6
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      dgrn
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Efa6
      (Johnson et al., 2011)
      cindr
      enhanceable
      ena
      (Johnson and Cagan, 2009)
      cindr
      enhanceable
      Hakai
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      hbs
      (Johnson et al., 2008)
      cindr
      suppressible
      Herc4
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Kpc1
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Ltn1
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Ltn1
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      mim
      (Quinones et al., 2010)
      cindr
      enhanceable
      Mrgn1
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Mtl|Rac1|Rac2
      (Johnson et al., 2008)
      cindr
      enhanceable
      mura
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      nopo
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      nopo
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Nse1
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      park
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      park
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      poe
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Prp19
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      puc
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Rchy1
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Rho1
      (Johnson et al., 2008)
      cindr
      suppressible
      Rnf146
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      roq
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      rst
      (Johnson et al., 2008)
      cindr
      suppressible
      rswl
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      shg
      (Johnson et al., 2008)
      cindr
      enhanceable
      shg
      (Johnson et al., 2008)
      cindr
      enhanceable
      sina
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      sinah
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      siz
      (Johnson et al., 2011)
      cindr
      enhanceable
      slpr
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      sordd1
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      tn
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Topors
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Traf4
      (Ketosugbo et al., 2017)
      cindr
      suppressible
      Traf6
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      tsr
      (Johnson et al., 2008)
      cindr
      enhanceable
      Uev1A
      (Ketosugbo et al., 2017)
      cindr
      enhanceable
      Vav
      (Martín-Bermudo et al., 2015)
      cindr
      enhanceable
      WASp
      (Johnson et al., 2008)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Fbxl7
      suppressible
      cindr
      (Bosch et al., 2014)
      mim
      suppressible
      cindr
      (Quinones et al., 2010)
      RacGAP84C
      enhanceable
      cindr
      (Raymond et al., 2004)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-101
      Cytogenetic map
      100A6-100A6
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      100A6-100A6
      Limits computationally determined from genome sequence between P{lacW}l(3)s2500s2500 and P{PZ}Aph-407028&P{PZ}dcorK215
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-101

      (FlyBase, 2016)

      3-98.7

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (17)
      Genomic Clones (18)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (92)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Haglund et al., 2010, Johnson et al., 2008)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: BcDNA:GH03163 CG1408

        (Yao, 1999.11)

        Source for identity of: cindr CG31012

        (Johnson et al., 2008)
        Source for database merge of
        Additional comments

        Annotations CG11316, CG1408 merged as CG31012 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 83 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Reported As
        Symbol Synonym
        BcDNA:GH03163
        (Mukherjee et al., 2014, Kim et al., 2005, Stanyon et al., 2004, Giot et al., 2003)
        CD2AP
        (Johnson et al., 2011, Quinones et al., 2010)
        CG11316
        (Raymond et al., 2004, Brody et al., 2002)
        CG1408
        CG31012
        (Meadows, 2017.9.14, Safi et al., 2016, Ashwal-Fluss et al., 2014, Christis and Munro, 2012, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Haglund et al., 2010, Ni et al., 2010.12.1, Raja et al., 2010, Wasbrough et al., 2010, Liu et al., 2009, Weavers et al., 2009, Font-Burgada et al., 2008, Johnson et al., 2008, Buszczak et al., 2007, Kim et al., 2005, Park et al., 2005, Raymond et al., 2004)
        Cindir
        (Finegan and Bergstralh, 2020)
        Cindr
        (Garrett and Korstanje, 2020, Yu et al., 2020, Carrasco-Rando et al., 2019, Bushnell et al., 2018, Loyer and Januschke, 2018, Fu et al., 2017, Helmstädter and Simons, 2017, Yasin et al., 2016, Eikenes et al., 2015, Menon and Gaestel, 2015, Na et al., 2015, Sopko et al., 2015, Eikenes et al., 2013, Johnson et al., 2008)
        cindr
        (Yu and Hyun, 2021, Bolus et al., 2020, Rech et al., 2019, Tossidou et al., 2019, Bushnell et al., 2018, Hermle et al., 2017, Ketosugbo et al., 2017, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2015-, Martín-Bermudo et al., 2015, Bosch et al., 2014, Shulman et al., 2014, Beckett et al., 2013, Kockmann et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Johnson et al., 2012, Friedman et al., 2011, Johnson et al., 2011, Haglund et al., 2010, Quinones et al., 2010, Johnson and Cagan, 2009)
        Name Synonyms
        CD2AP and CIN85 orthologue
        (Johnson et al., 2011)
        CIN85 and CD2AP orthologue
        (Johnson et al., 2008)
        CIN85 and CD2AP related
        Cindr
        (Johnson et al., 2008)
        Secondary FlyBase IDs
        • FBgn0039803
        • FBgn0051012
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (101)