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Gene Dmel\morgue

General Information
Symbol	Dmel\morgue	Species	D. melanogaster
Name	modifier of rpr and grim, ubiquitously expressed	Annotation symbol	CG15437
Feature type	protein_coding_gene	FlyBase ID	FBgn0027609
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24F2-24F2	Sequence location	2L:4,442,870..4,444,677 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene modifier of rpr and grim, ubiquitously expressed is referred to in FlyBase by the symbol Dmel\morgue (CG15437, FBgn0027609). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: apoptotic process; induction of compound eye retinal cell programmed cell death. 15 alleles are reported. The phenotypes of these alleles are annotated with: leg; chaeta; tergite; melanotic mass; anterior pupal spiracle. It has one annotated transcript and one annotated polypeptide. Protein features are: F-box domain, Skp2-like; F-box domain, cyclin-like; Ubiquitin-conjugating enzyme, E2; Ubiquitin-conjugating enzyme/RWD-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval/adult salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1629221_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of morgue. Gene sequence location is 2L:4442870..4444677.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Alleles morgue[Scer\UAS.T:Avic\GFP] morgue[126] morgue[100] morgue[457] Transgenic Constructs P{UAS-GFP-morgue} Sequence features HFA00264 BKN24418 References Schreader et al., 2010, Int. J. Dev. Biol. 54(10): 1425--1433
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24F2-24F2   Limits computationally determined from genome sequence between P{lacW}Tps1k08903&P{EP}morgueEP1184 and P{lacW}l(2)k10004k10004&P{EP}CG3036EP963
Experimentally Determined Cytological Location
Cytogenetic map Notes References 24F3-24F3     (Nambu, 2002.2.8)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\morgue for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) morgue-RA FBtr0077457  NM_134989   1746   491
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein morgue-PA   FBpp0077147   55.9   491   4.38     NP_608833   AAF51013
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-conjugating enzyme, E2 (IPR000608) F-box domain, cyclin-like (IPR001810) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) F-box domain, Skp2-like (IPR022364)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA802247   AA803169   AE014134 AAF51013   AF145603 AAD38578   AI063025   AI401862   AQ025048   AY078386 AAL83648   AY231883   BF492977   BF492978   BF496480   BI171613   BI216428   BI564074   BI566692   BI567039   BI567831   BI621767   BI636833   BP551897   BP551898   BT003599 AAO39602   CO295898   DN154249   EC087123   EC235748   EC261656
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q86NX0 Q9Y165
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Wing et al., 2002) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Hays et al., 2002, Wing et al., 2002) pupal stage   tertiary pigment cell   (Hays et al., 2002) secondary pigment cell   (Hays et al., 2002) pupal stage -- adult stage   primary pigment cell   (Hays et al., 2002) adult stage | male   head   (Wing et al., 2002) adult stage | female   head   (Wing et al., 2002) ovary   (Wing et al., 2002)
Additional Descriptive Data
	Reverse-transcriptase PCR assays show that morgue is expressed throughout development. During embryonic development maximal expression is observed at 4-8 hr. After this time expression is low until third instar, beyond which it is expressed at high levels. Sexually dimorphic expression levels are observed with higher expression levels in male head and body versus female. During the period of apoptosis in the developing ommatidia, morgue is initially high in secondary and tertiary pigment cells after which it declines and is not detectable in the mature eye in these cells. In contrast, expression remains high in the primary pigment cells. Expression was not detected in cone or bristle cells at any stage of development. (Hays et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027609    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027609 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027609 expression level Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2273) embryo 02-04hr  (631) embryo 04-06hr  (1544) embryo 06-08hr  (1711) embryo 08-10hr  (1345) embryo 10-12hr  (1462) embryo 12-14hr  (1016) embryo 14-16hr  (809) embryo 16-18hr  (581) embryo 18-20hr  (577) embryo 20-22hr  (474) embryo 22-24hr  (469) larva L1  (608) larva L2  (512) larva L3 12hr old  (476) larva L3 puffstage 1-2  (587) larva L3 puffstage 3-6  (788) larva L3 puffstage 7-9  (1033) white prepupae new  (1028) white prepupae 12hr  (1172) white prepupae 24hr  (1576) pupae 2d postWPP  (1383) pupae 3d postWPP  (730) pupae 4d postWPP  (618) adult male 01day  (691) adult male 05day  (827) adult male 30day  (922) adult female 01day  (1034) adult female 05day  (1375) adult female 30day  (1507) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2273) embryo 02-04hr    631 embryo 04-06hr  (1544) embryo 06-08hr  (1711) embryo 08-10hr    1345 embryo 10-12hr  1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr  (1576) pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day  1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027609 expression level Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2273) embryo 02-04hr  (631) embryo 04-06hr  (1544) embryo 06-08hr  (1711) embryo 08-10hr  (1345) embryo 10-12hr  (1462) embryo 12-14hr  (1016) embryo 14-16hr  (809) embryo 16-18hr  (581) embryo 18-20hr  (577) embryo 20-22hr  (474) embryo 22-24hr  (469) larva L1  (608) larva L2  (512) larva L3 12hr old  (476) larva L3 puffstage 1-2  (587) larva L3 puffstage 3-6  (788) larva L3 puffstage 7-9  (1033) white prepupae new  (1028) white prepupae 12hr  (1172) white prepupae 24hr  (1576) pupae 2d postWPP  (1383) pupae 3d postWPP  (730) pupae 4d postWPP  (618) adult male 01day  (691) adult male 05day  (827) adult male 30day  (922) adult female 01day  (1034) adult female 05day  (1375) adult female 30day  (1507) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2273 embryo 02-04hr    631 embryo 04-06hr  1544 embryo 06-08hr  1711 embryo 08-10hr    1345 embryo 10-12hr  1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr  1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day  1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2273 embryo 02-04hr    631 embryo 04-06hr    1544 embryo 06-08hr    1711 embryo 08-10hr    1345 embryo 10-12hr    1462 embryo 12-14hr    1016 embryo 14-16hr    809 embryo 16-18hr    581 embryo 18-20hr    577 embryo 20-22hr    474 embryo 22-24hr    469 larva L1    608 larva L2    512 larva L3 12hr old    476 larva L3 puffstage 1-2    587 larva L3 puffstage 3-6    788 larva L3 puffstage 7-9    1033 white prepupae new    1028 white prepupae 12hr    1172 white prepupae 24hr    1576 pupae 2d postWPP    1383 pupae 3d postWPP    730 pupae 4d postWPP    618 adult male 01day    691 adult male 05day    827 adult male 30day    922 adult female 01day    1034 adult female 05day    1375 adult female 30day    1507 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027609    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027609 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult Malpighian tubules, larval/adult salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027609 expression level Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027609 expression level Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    154.3 Larval Midgut    60 Larval Hindgut    73.6 Larval Malpighian Tubules    88 Larval Fat Body    83.5 Larval Salivary Gland    199.5 Larval Trachea    85.85 Larval Carcass    78.2 Adult Head    84.8 Adult Eye    105.875 Adult Brain    218.4 Adult Thoracic-Abdominal Ganglion    211 Adult Crop    80.6 Adult Midgut    52.9 Adult Hindgut    61.9 Adult Malpighian Tubules    101.2 Adult Fat Body    49.5 Adult Salivary Gland    125.7 Adult Heart    48.2 Adult VirginFemale Spermatheca    76.7 Adult InseminatedFemale Spermatheca    68.9 Adult Ovary    151.4 Adult Testis    99.3 Adult Male Accessory Gland    90.2 Adult Carcass    60.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.8   NA  Eye    105.875   NA  Brain    218.4   154.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    211   NA  Crop    80.6   60  Midgut    52.9   73.6  Hindgut    61.9   88  Malpighian Tubules    101.2   83.5  Fat Body    49.5   199.5  Salivary Gland    125.7   NA  Heart    48.2   85.85  Trachea    NA   NA  VirginFemale Spermatheca    76.7   NA  InseminatedFemale Spermatheca    68.9   NA  Ovary    151.4   NA  Testis    99.3   NA  Male Accessory Gland    90.2   78.2  Carcass    60.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027609 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15437-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal (with Df(2L)dp-h25), with Scer\GAL4[-]: morgueEP1184 viable morgue126 morgue457 morgueE290 viable, with Scer\GAL4[-]: morgueEP1184 morgueEP2367 viable, with Scer\GAL4pnr-MD237 morgueGD1215 viable (with morgue19) morgue126 morgue457 viable (with morgue126) morgue19 viable (with morgue457) morgue19 Other Phenotypes Allele decreased cell death | recessive morgueE290 decreased cell death | recessive, with Scer\GAL4[-]: morgueEP1184 morgueEP2367 hypoactive | adult stage morgue126 morgue457 melanotic mass phenotype, with Scer\GAL4[-]: morgueEP1184 visible morgue126 morgue457 visible (with Df(2L)dp-h25), with Scer\GAL4[-]: morgueEP1184 Phenotype manifest in Allele anterior pupal spiracle morgue126 morgue457 chaeta (with Df(2L)dp-h25), with Scer\GAL4[-]: morgueEP1184 leg (with Df(2L)dp-h25), with Scer\GAL4[-]: morgueEP1184 melanotic mass, with Scer\GAL4[-]: morgueEP1184 midline glial cell | embryonic stage 16 morgue126 morgue457 midline glial cell | embryonic stage 16 | supernumerary morgue126 peripheral glial cell 3 of ISN | embryonic stage 16 morgueunspecified pigment cell | supernumerary morgueE290 morgueunspecified pigment cell | supernumerary (with morgueEP1184), with Scer\GAL4[-]: morgueEP2367 pigment cell | supernumerary (with morgueEP2367), with Scer\GAL4[-]: morgueEP1184 support cell of the dorsal bipolar dendritic cell | embryonic stage 16 morgueunspecified tergite morgue126 morgue457
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of morgue Class Mutagen Stocks Known lesion morgueEP1184 hypomorphic allele - genetic evidence P-element activity 2 Yes morgueKG05280 1 -- morgue100 P-element activity 0 Yes morgue126 P-element activity 0 Yes morgue19 Delta2-3 0 Yes morgue457 P-element activity 0 Yes morgueE290 hypomorphic allele - genetic evidence ethyl nitrosourea 0 -- morgueEP2367 hypomorphic allele - genetic evidence P-element activity 0 Yes morgueunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of morgue Class Mutagen Stocks Known lesion morgueGD1215 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morgueJF01507 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes morguecWa in vitro construct 0 Yes morgueMtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes morgueScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes morgueΔUBC.MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)dp-h25 (Wing et al., 2002) Df(2L)Exel8011 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1215} NA P{TRiP.JF01507} NA P{UAS-GFP-morgue} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}morgueEP1184 NA P{EP}morgueEP2367 NA miscellaneous insertions P{SUPor-P}morgueKG05280 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process inferred from mutant phenotype (Hays et al., 2002) induction of compound eye retinal cell programmed cell death inferred from mutant phenotype (Hays et al., 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
small conjugating protein ligase activity traceable author statement (Bergmann et al., 2003) ubiquitin-protein ligase activity inferred from sequence or structural similarity with Saccharomyces UBC4 (FlyBase, 1992-) non-traceable author statement (Ditzel and Meier, 2002, Nambu, 2002.2.8, Hays et al., 2002)
Biological Process
CV term Evidence References
apoptotic process non-traceable author statement (Nambu, 2002.2.8) induction of apoptosis non-traceable author statement (Ditzel and Meier, 2002) protein ubiquitination traceable author statement (Bergmann et al., 2003) regulation of retinal cell programmed cell death non-traceable author statement (Brachmann and Cagan, 2003)
Cellular Component
CV term Evidence References
SCF ubiquitin ligase complex non-traceable author statement (Ou et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions morgue allele Gene References morgueEP1184 grim (Hays et al., 2002) rpr (Hays et al., 2002) W (Hays et al., 2002) morgueEP2367 rpr (Wing et al., 2002) rst (Hays et al., 2002) morgueunspecified th (Hays et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59842 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027609 DroID - A comprehensive database of gene and protein interactions. • FBgn0027609 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33648
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24066 Dere\GG24379 Dgri\GH11661 Dmoj\GI17963 Dper\GL15422 Dpse\GA13727 Dsec\GM18094 Dsim\GD22710 Dvir\GJ17736 Dwil\GK24680 Dyak\morgue
Curated drosophilid orthologs	Dpse\GA13727   Dyak\morgue
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006413-PA Aedes aegypti (mosquito) AGAP008941-PA Anopheles gambiae (mosquito) XP_395429.2 Apis mellifera (honey bee) XP_001943662.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001951-PA Bombyx mori (silk worm) CBP11218 Caenorhabditis briggsae (nematode) CPIJ004186 Culex pipens (mosquito) 220586 Capitella spl (polychaete worm) 203669 Daphnia pulex (daphnia) 97921 Hypsipyla robusta (cedar shoot borer) ISCW009130-PA Ixodes scapularis (deer tick) 124502 Lottia gigantea (owl limpet) XP_001599676.1 Nasonia vitripennis (wasp) PHUM004840-PA Pediculus humanus (human body louse) ENSRNOP00000000750 Rattus norvegicus (norway rat) Smp_082820 Schistosoma mansoni (trematode parasite) XP_001198432.1 Strongylocentrotus purpuratus (purple sea urchin) XP_972196.1 Tribolium castaneum (red flour beetle) 224.m00037 Tetrahymena thermophila (ciliate protozoa) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16405 NV50563 NV18926 LH11985 ISCW009130 FBgn0067945 FBgn0226640 FBgn0204905 FBgn0194107 FBgn0173001 JGI_V11_203669 FBgn0073763 FBgn0153026 FBgn0140703 FBgn0119141 FBgn0116511 FBgn0101060 CPIJ004186 BGIBMGA001951 ACYPI000647 GB12017 AGAP008941 AAEL006413 PHUM044580 GLEAN_10856
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31059 y1 v1; P{TRiP.JF01507}attP2 16996 w1118; P{EP}morgueEP1184/CyO 14109 y1 w67c23; P{SUPor-P}morgueKG05280
Kyoto	114443 yd2 w1118 P{ey-FLP.N}2; P{EP}morgueEP1184 P{neoFRT}40A/CyO y+
VDRC	v11090 w1118; P{GD1215}v11090
Genomic Clones ( 1 )
	BACR28K16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02435 GM10337
Other clones	DPiM_GH02435 yak-em_BcDNA:GH02435
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10410 GM04077 RE13427 RE23555 RH35757 RH36410 RH36866 RH38529 RH53168 SD18658
Other clones	AT01362 EK204013 EK212127 FGM215E02
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027609 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33648
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: morgue BcDNA:GH02435 (Hay, 2002.3.20, FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of morgue BcDNA:GH02435 was sequence comparison (date:020313). (FlyBase, 1996-)
Other Comments
	Identification: in a screen for genes involved in retinal apoptosis. (Hays et al., 2002) morgue hypomorphs have extra lattice cells in the adult eye due to insufficient cell death during development. (Hays et al., 2002) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and ClkJrk background. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134989 RefSeq (Proteins) • NP_608833 DDBJ / EMBL / GenBank • AA803169 AAD38578 AAF51013 AAL83648 AAO39602 AF145603 AI063025 AI401862 AQ025048 AY078386 BT003599 Entrez Gene - A searchable database of RefSeq genes. • 33648 UniProtKB/TrEMBL • Q9Y165 Q86NX0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-conjugating enzyme, E2 (IPR000608) F-box domain, cyclin-like (IPR001810) Ubiquitin-conjugating enzyme/RWD-like (IPR016135) F-box domain, Skp2-like (IPR022364)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59842 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027609 DroID - A comprehensive database of gene and protein interactions. • FBgn0027609 DRSC - Results from RNAi screens. • FBgn0027609 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027609 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15437-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027609 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33648 InParanoid A subset of ortholog calls from InParanoid. • AAEL006413-PA Aedes aegypti (mosquito) AGAP008941-PA Anopheles gambiae (mosquito) XP_395429.2 Apis mellifera (honey bee) XP_001943662.1 Acyrthosiphon pisum (pea aphid) BGIBMGA001951-PA Bombyx mori (silk worm) CBP11218 Caenorhabditis briggsae (nematode) CPIJ004186 Culex pipens (mosquito) 220586 Capitella spl (polychaete worm) 203669 Daphnia pulex (daphnia) 97921 Hypsipyla robusta (cedar shoot borer) ISCW009130-PA Ixodes scapularis (deer tick) 124502 Lottia gigantea (owl limpet) XP_001599676.1 Nasonia vitripennis (wasp) PHUM004840-PA Pediculus humanus (human body louse) ENSRNOP00000000750 Rattus norvegicus (norway rat) Smp_082820 Schistosoma mansoni (trematode parasite) XP_001198432.1 Strongylocentrotus purpuratus (purple sea urchin) XP_972196.1 Tribolium castaneum (red flour beetle) 224.m00037 Tetrahymena thermophila (ciliate protozoa) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33648 modMine - Data generated by the modENCODE project. • FBgn0027609 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16405 NV50563 NV18926 LH11985 ISCW009130 FBgn0067945 FBgn0226640 FBgn0204905 FBgn0194107 FBgn0173001 JGI_V11_203669 FBgn0073763 FBgn0153026 FBgn0140703 FBgn0119141 FBgn0116511 FBgn0101060 CPIJ004186 BGIBMGA001951 ACYPI000647 GB12017 AGAP008941 AAEL006413 PHUM044580 GLEAN_10856
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	BcDNA:GH02435 (Hay, 2002.3.20, ) CG15437 (Wing et al., 2002, Das et al., 2002, Claridge-Chang et al., 2001, Ni et al., 2008) morgue (Murad et al., 2007, Kuo et al., 2006, Dworkin et al., 2009, Dubruille et al., 2009, Schreader et al., 2010) Morgue (Zhou and Nambu, 2008)
Name Synonym	modifier of rpr and grim, ubiquitously expressed (Wing et al., 2002) morgue (Zhou and Nambu, 2008, Sathyanarayanan et al., 2008)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 3 ) Review  ( 9 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Schreader et al., 2010, Int. J. Dev. Biol. 54(10): 1425--1433 Drosophila morgue influences cell numbers and positions in the embryonic nervous system. [FBrf0212937] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...