• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\LM408

General Information
Symbol	Dmel\LM408	Species	D. melanogaster
Name	Lysosomal α-mannosidase	Annotation symbol	CG6206
Feature type	protein_coding_gene	FlyBase ID	FBgn0027611
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	BcDNA:GH02419, dLM
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31E5-31E5	Sequence location	2L:10,457,658..10,462,472 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lysosomal α-mannosidase is referred to in FlyBase by the symbol Dmel\LM408 (CG6206, FBgn0027611). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: alpha-mannosidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: mannose metabolic process. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Galactose mutarotase-like domain; Glycoside hydrolase 38/57, N-terminal domain; Glycoside hydrolase family 38, N-terminal domain; Glycoside hydrolase, family 38, central domain; Glycoside hydrolase/deacetylase, beta/alpha-barrel; Glycosyl hydrolase family 38, C-terminal; Glycosyl hydrolase, family 13, all-beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval/adult midgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, larval trachea, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1635125_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG6206. Gene sequence location is 2L:10457658..10462472.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles LM408[MI08174]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31E5-31E5   Limits computationally determined from genome sequence between P{lacW}KdelRk00311 and P{lacW}l(2)k09116k09116&P{lacW}Fatpk10307
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\LM408 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) LM408-RA FBtr0080030  NM_135564   3499   1080 LM408-RB FBtr0080031  NM_164929   3499   1080
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein LM408-PA   FBpp0079620   122.7   1080   5.63     NP_609408   AAF52958 LM408-PB   FBpp0079621   122.7   1080   5.49     NP_723591   AAN10754
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase family 38, N-terminal domain (IPR000602) Galactose mutarotase-like domain (IPR011013) Glycosyl hydrolase family 38, C-terminal (IPR011682) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330) Glycoside hydrolase, family 38, central domain (IPR015341) Glycoside hydrolase 38/57, N-terminal domain (IPR027291) Glycosyl hydrolase, family 13, all-beta (IPR013780)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141696   AA246616   AA246935   AA440745   AA538856   AA538875   AA540471   AA802832   AA941918   AE014134 AAF52958   AE014134 AAN10754   AF145601 AAD38576   AI063010   AI063568   AI063808   AI064584   AI106938   AI107136   AI107793   AI134757   AI238245   AI257637   AI258215   AI258266   AI260551   AI387893   AI401859   AI404121   AI404192   AI404869   AI456497   AI514199   AI516551   BF494816   BG639327   BG641312   BI169336   BI171265   BI173611   BI213143   BI239136   BI363140   BI368804   BI375145   BI483016   BI484156   BI484977   BI604431   BI606157   BI613456   BI624373   BI635643   BI635746   CK657585   CK658450   CO190439   CO191456   CO193524   CO196591   CO268712   CO268825   CO269453   CO282635   CO304040   CO318910   CO319725   CO320271   CO344244   CZ474613   CZ479407   CZ479408   EC059730   EC064804   EC082524   EC202831   EC204550   EC205651   EC205789   EC210949   EC213247   EC238041   EC241350   EC256277   GH756867   GH943482   GH943577   GH944569   GH944691   GH947286   GH955424   GH962881   GH967706   GH967952   GH969367   GH970466   GH976616   GH977206   GH981698
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IPB7 Q9VKV1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   central brain anlage in statu nascendi   (Fisher et al., 2012) clypeo-labral anlage in statu nascendi   (Fisher et al., 2012) antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   clypeo-labral primordium   (Fisher et al., 2012) fat body/gonad primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval/adult midgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, larval trachea, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut    1449.5 Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body    4512.3 Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head    1119.2 Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut    2749.8 Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body    1454.4 Adult Salivary Gland    71.6 Adult Heart    1171.15 Adult VirginFemale Spermatheca    2119.4 Adult InseminatedFemale Spermatheca    1631.4 Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass    1079.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut  (1449.5) Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body  (4512.3) Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head  (1119.2) Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion  (579.1) Adult Crop    72.2 Adult Midgut  (2749.8) Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body  (1454.4) Adult Salivary Gland    71.6 Adult Heart  (1171.15) Adult VirginFemale Spermatheca  (2119.4) Adult InseminatedFemale Spermatheca  (1631.4) Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass  (1079.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut  (1449.5) Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body  (4512.3) Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head  (1119.2) Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut  (2749.8) Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body  (1454.4) Adult Salivary Gland    71.6 Adult Heart  (1171.15) Adult VirginFemale Spermatheca  (2119.4) Adult InseminatedFemale Spermatheca  (1631.4) Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass  (1079.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut    1449.5 Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body    4512.3 Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head    1119.2 Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut    2749.8 Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body    1454.4 Adult Salivary Gland    71.6 Adult Heart    1171.15 Adult VirginFemale Spermatheca    2119.4 Adult InseminatedFemale Spermatheca    1631.4 Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass    1079.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut    1449.5 Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body    4512.3 Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head    1119.2 Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut    2749.8 Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body    1454.4 Adult Salivary Gland    71.6 Adult Heart    1171.15 Adult VirginFemale Spermatheca    2119.4 Adult InseminatedFemale Spermatheca    1631.4 Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass    1079.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut  (1449.5) Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body  (4512.3) Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head  (1119.2) Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion  579.1 Adult Crop    72.2 Adult Midgut  (2749.8) Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body  (1454.4) Adult Salivary Gland    71.6 Adult Heart  (1171.15) Adult VirginFemale Spermatheca  (2119.4) Adult InseminatedFemale Spermatheca  (1631.4) Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass  (1079.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut  1449.5 Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body  (4512.3) Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head  1119.2 Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut  (2749.8) Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body  1454.4 Adult Salivary Gland    71.6 Adult Heart  1171.15 Adult VirginFemale Spermatheca  (2119.4) Adult InseminatedFemale Spermatheca  1631.4 Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass  1079.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    177.8 Larval Midgut    1449.5 Larval Hindgut    54.3 Larval Malpighian Tubules    234.1 Larval Fat Body    4512.3 Larval Salivary Gland    43.9 Larval Trachea    154.525 Larval Carcass    146.3 Adult Head    1119.2 Adult Eye    399.35 Adult Brain    447.6 Adult Thoracic-Abdominal Ganglion    579.1 Adult Crop    72.2 Adult Midgut    2749.8 Adult Hindgut    126.6 Adult Malpighian Tubules    22.6 Adult Fat Body    1454.4 Adult Salivary Gland    71.6 Adult Heart    1171.15 Adult VirginFemale Spermatheca    2119.4 Adult InseminatedFemale Spermatheca    1631.4 Adult Ovary    83.5 Adult Testis    101.7 Adult Male Accessory Gland    79.1 Adult Carcass    1079.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1119.2   NA  Eye    399.35   NA  Brain    447.6   177.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    579.1   NA  Crop    72.2   1449.5  Midgut    2749.8   54.3  Hindgut    126.6   234.1  Malpighian Tubules    no informative data   4512.3  Fat Body    1454.4   43.9  Salivary Gland    71.6   NA  Heart    1171.15   154.525  Trachea    NA   NA  VirginFemale Spermatheca    2119.4   NA  InseminatedFemale Spermatheca    1631.4   NA  Ovary    83.5   NA  Testis    101.7   NA  Male Accessory Gland    79.1   146.3  Carcass    1079.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male    116 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    548 digestive system, 4-day adult    430 digestive system, 20-day adult    306 fat body, larvae L3 wandering    218 fat body, white prepupae    912 fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  (37) central nervous system, pupae P8    19 head, virgin 1-day female  (44) head, virgin 4-day female  (35) head, virgin 20-day female  (72) head, mated 1-day female  (31) head, mated 4-day female  (40) head, mated 20-day female  (54) head, mated 1-day male  (43) head, mated 4-day male  (64) head, mated 20-day male  (116) salivary gland, larvae L3 wandering    11 salivary gland, white prepupae  (65) digestive system, larvae L3 wandering  (73) digestive system, 1-day adult  (548) digestive system, 4-day adult  (430) digestive system, 20-day adult  (306) fat body, larvae L3 wandering  (218) fat body, white prepupae  (912) fat body, pupae P8  (90) carcass, larvae L3 wandering  (47) carcass, 1-day adult  (49) carcass, 4-day adult  (41) carcass, 20-day adult  (52) ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male  (116) salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult  (548) digestive system, 4-day adult  (430) digestive system, 20-day adult  (306) fat body, larvae L3 wandering  (218) fat body, white prepupae  (912) fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male    116 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    548 digestive system, 4-day adult    430 digestive system, 20-day adult    306 fat body, larvae L3 wandering    218 fat body, white prepupae    912 fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male    116 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    548 digestive system, 4-day adult    430 digestive system, 20-day adult    306 fat body, larvae L3 wandering    218 fat body, white prepupae    912 fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (36) central nervous system, larvae L3  (37) central nervous system, pupae P8    19 head, virgin 1-day female  (44) head, virgin 4-day female  (35) head, virgin 20-day female  (72) head, mated 1-day female  31 head, mated 4-day female  (40) head, mated 20-day female  (54) head, mated 1-day male  (43) head, mated 4-day male  (64) head, mated 20-day male  (116) salivary gland, larvae L3 wandering    11 salivary gland, white prepupae  (65) digestive system, larvae L3 wandering  (73) digestive system, 1-day adult  (548) digestive system, 4-day adult  (430) digestive system, 20-day adult  (306) fat body, larvae L3 wandering  (218) fat body, white prepupae  (912) fat body, pupae P8  (90) carcass, larvae L3 wandering  (47) carcass, 1-day adult  (49) carcass, 4-day adult  (41) carcass, 20-day adult  (52) ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male  116 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult  (548) digestive system, 4-day adult  (430) digestive system, 20-day adult  (306) fat body, larvae L3 wandering  (218) fat body, white prepupae  (912) fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    36 central nervous system, larvae L3    37 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    35 head, virgin 20-day female    72 head, mated 1-day female    31 head, mated 4-day female    40 head, mated 20-day female    54 head, mated 1-day male    43 head, mated 4-day male    64 head, mated 20-day male    116 salivary gland, larvae L3 wandering    11 salivary gland, white prepupae    65 digestive system, larvae L3 wandering    73 digestive system, 1-day adult    548 digestive system, 4-day adult    430 digestive system, 20-day adult    306 fat body, larvae L3 wandering    218 fat body, white prepupae    912 fat body, pupae P8    90 carcass, larvae L3 wandering    47 carcass, 1-day adult    49 carcass, 4-day adult    41 carcass, 20-day adult    52 ovary, virgin 4-day female    7 ovary, mated 4-day female    6 testis, mated 4-day male    17 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr    107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2    115 larva L3 12hr old    122 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    101 white prepupae new    112 white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    127 adult male 05day    119 adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr  (57) embryo 04-06hr  (107) embryo 06-08hr  (98) embryo 08-10hr  (82) embryo 10-12hr  (41) embryo 12-14hr  (38) embryo 14-16hr    25 embryo 16-18hr  (28) embryo 18-20hr  (27) embryo 20-22hr  (38) embryo 22-24hr  (42) larva L1  (46) larva L2  (115) larva L3 12hr old  (122) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (129) larva L3 puffstage 7-9  (101) white prepupae new  (112) white prepupae 12hr  (51) white prepupae 24hr  (63) pupae 2d postWPP  (73) pupae 3d postWPP  (27) pupae 4d postWPP    17 adult male 01day  (127) adult male 05day  (119) adult male 30day  (78) adult female 01day  (86) adult female 05day  (91) adult female 30day  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr  107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2  (115) larva L3 12hr old  (122) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (129) larva L3 puffstage 7-9  101 white prepupae new  (112) white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day  (127) adult male 05day  (119) adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr    107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2    115 larva L3 12hr old    122 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    101 white prepupae new    112 white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    127 adult male 05day    119 adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr    107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2    115 larva L3 12hr old    122 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    101 white prepupae new    112 white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    127 adult male 05day    119 adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr  (57) embryo 04-06hr  (107) embryo 06-08hr  (98) embryo 08-10hr  (82) embryo 10-12hr  (41) embryo 12-14hr  (38) embryo 14-16hr    25 embryo 16-18hr  28 embryo 18-20hr  27 embryo 20-22hr  (38) embryo 22-24hr  (42) larva L1  (46) larva L2  (115) larva L3 12hr old  (122) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (129) larva L3 puffstage 7-9  (101) white prepupae new  (112) white prepupae 12hr  (51) white prepupae 24hr  (63) pupae 2d postWPP  (73) pupae 3d postWPP  27 pupae 4d postWPP    17 adult male 01day  (127) adult male 05day  (119) adult male 30day  (78) adult female 01day  (86) adult female 05day  (91) adult female 30day  (91) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr  107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2  115 larva L3 12hr old  122 larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  129 larva L3 puffstage 7-9  101 white prepupae new  112 white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day  127 adult male 05day  119 adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    57 embryo 04-06hr    107 embryo 06-08hr    98 embryo 08-10hr    82 embryo 10-12hr    41 embryo 12-14hr    38 embryo 14-16hr    25 embryo 16-18hr    28 embryo 18-20hr    27 embryo 20-22hr    38 embryo 22-24hr    42 larva L1    46 larva L2    115 larva L3 12hr old    122 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    129 larva L3 puffstage 7-9    101 white prepupae new    112 white prepupae 12hr    51 white prepupae 24hr    63 pupae 2d postWPP    73 pupae 3d postWPP    27 pupae 4d postWPP    17 adult male 01day    127 adult male 05day    119 adult male 30day    78 adult female 01day    86 adult female 05day    91 adult female 30day    91 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS    116 ovary OSC    59 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1  (99) embryonic S3  (39) leg disc CME L1    7 wing disc CME-W2  (58) wing disc ML-DmD8  (60) wing disc ML-DmD9    14 wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (37) wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  (28) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2    6 ovary fGS/OSS  (116) ovary OSC  (59) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS  (116) ovary OSC    59 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS    116 ovary OSC    59 ovary OSS    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS    116 ovary OSC    59 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1  (99) embryonic S3  (39) leg disc CME L1    7 wing disc CME-W2  (58) wing disc ML-DmD8  (60) wing disc ML-DmD9    14 wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (37) wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11  (44) antennal disc ML-DmD20-c5  (137) mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1  28 CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2    6 ovary fGS/OSS  (116) ovary OSC  (59) ovary OSS  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5  137 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS  116 ovary OSC    59 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    17 Schneider line 2 Sg4    4 embryonic 1182-4H    2 embryonic GM2    11 embryonic Kc167    10 embryonic S1    99 embryonic S3    39 leg disc CME L1    7 wing disc CME-W2    58 wing disc ML-DmD8    60 wing disc ML-DmD9    14 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    37 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    44 antennal disc ML-DmD20-c5    137 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    28 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    6 ovary fGS/OSS    116 ovary OSC    59 ovary OSS    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    124 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    120 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (45) heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  (76) Cadmium 50 mM 12 hrs, larvae L3  (85) Cadmium 50 mM 48 hrs, 4-day adult  (66) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (38) Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3  (38) Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3  (100) Ethanol 10% 3 hrs, larvae L3  (57) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (124) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (28) Paraquat 10 mM 48 hrs, 4-day adult  (28) Rotenone 2 μg 12 hrs, larvae L3  (120) Rotenone 8 μg 12 hrs, larvae L3  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (124) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3  (120) Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    124 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    120 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    124 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    120 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (43) cold shock, 4-day adult  (45) heat shock, 4-day adult  (45) Cadmium 50 mM 6 hrs, larvae L3  (76) Cadmium 50 mM 12 hrs, larvae L3  (85) Cadmium 50 mM 48 hrs, 4-day adult  (66) Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3  (38) Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3  (38) Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3  (100) Ethanol 10% 3 hrs, larvae L3  (57) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (124) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  28 Paraquat 10 mM 48 hrs, 4-day adult  28 Rotenone 2 μg 12 hrs, larvae L3  (120) Rotenone 8 μg 12 hrs, larvae L3  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3  124 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3  120 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    43 cold shock, 4-day adult    45 heat shock, 4-day adult    45 Cadmium 50 mM 6 hrs, larvae L3    76 Cadmium 50 mM 12 hrs, larvae L3    85 Cadmium 50 mM 48 hrs, 4-day adult    66 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    14 Ethanol 5% 3 hrs, larvae L3    100 Ethanol 10% 3 hrs, larvae L3    57 Caffeine 1.5 mg/ml 4 hrs, larvae L3    124 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    28 Paraquat 10 mM 48 hrs, 4-day adult    28 Rotenone 2 μg 12 hrs, larvae L3    120 Rotenone 8 μg 12 hrs, larvae L3    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH02419 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027611 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6206-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for LM408 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 LM408GD4948 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of LM408 Class Mutagen Stocks Known lesion LM408d05564 P-element activity 1 -- LM408e01592 piggyBac transposase 1 -- LM408MI04187 1 -- LM408MI08174 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of LM408 Class Mutagen Stocks Known lesion LM408GD4948 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes LM408KK102185 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7048 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}LM408MI04187 NA Mi{MIC}LM408MI08174 NA PBac{RB}LM408e01592 NA insertion of mobile activating element P{XP}LM408d05564 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
alpha-mannosidase activity inferred from direct assay (Nemčovičová et al., 2012)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular region inferred from direct assay (Karlsson et al., 2004)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
alpha-mannosidase activity inferred from sequence or structural similarity with UniProtKB:O09159 (FlyBase, 1992-) carbohydrate binding inferred from electronic annotation with InterPro:IPR011013 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR015341 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mannose metabolic process inferred from electronic annotation with InterPro:IPR011682 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
lysosome inferred from sequence or structural similarity with UniProtKB:O09159 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
LM408 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) LM408 - CG2469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) LM408 - CG7997 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) LM408 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) LM408 - me31B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) LM408 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions LM408 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60518 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027611 DroID - A comprehensive database of gene and protein interactions. • FBgn0027611 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34437
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RBR3Z Dipteran inclusive ortholog search EOG6TQMJ1 Insect inclusive ortholog search EOG6W3RH1 Arthropod inclusive ortholog search EOG6XD260 Metazoa inclusive ortholog search EOG6TJ7KT
Orthologs in Drosophila Species (EOG6RBR3Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\LM408     Drosophila simulans   Dsim\GD23708 Y   Drosophila sechellia   Dsec\GM18459     Drosophila erecta   Dere\GG23643     Drosophila yakuba   Dyak\GE18464     Drosophila ananassae   Dana\GF15795 Y   Drosophila persimilis   Dper\GL19134     Drosophila willistoni   Dwil\GK14884     Drosophila virilis   Dvir\GJ13861     Drosophila mojavensis   Dmoj\GI20521     Drosophila grimshawi   Dgri\GH13617
Orthologs in non-Drosophila Dipterans (EOG6TQMJ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005752   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005763   Anopheles gambiae Malaria mosquito  Agam\AGAP008584   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802255   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802254
Orthologs in non-Dipteran Insects (EOG6W3RH1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44223 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011999 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21614 Y Atta cephalotes Leafcutter ant  Acep\ACEP16189 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20204 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13198 Y Linepithema humile Argentine ant  Lhum\LH17851 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25066 Y Solenopsis invicta Red fire ant  Sinv\SINV25543 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003815 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000918 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011378 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001728 Y Pediculus humanus Human body louse  Phum\PHUM407580 Y Pediculus humanus Human body louse  Phum\PHUM446310 Y Tribolium castaneum Red flour beetle  Tcas\TC006453 Y Tribolium castaneum Red flour beetle  Tcas\TC006455 Y Tribolium castaneum Red flour beetle  Tcas\TC002467 Y Tribolium castaneum Red flour beetle  Tcas\TC002465 Y Tribolium castaneum Red flour beetle  Tcas\TC002466 Y Tribolium castaneum Red flour beetle  Tcas\TC006456 Y Tribolium castaneum Red flour beetle  Tcas\TC006454 Y Tribolium castaneum Red flour beetle  Tcas\TC002464 Y
Orthologs in non-Insect Arthropods (EOG6XD260)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_207420 Y Daphnia pulex Water flea  Dpux\JGI_V11_324591 Y Daphnia pulex Water flea  Dpux\Ilkap Y Daphnia pulex Water flea  Dpux\RPB2 Y Daphnia pulex Water flea  Dpux\JGI_V11_315529 Y Daphnia pulex Water flea  Dpux\JGI_V11_337859 Y Ixodes scapularis Deer tick  Isca\ISCW017358 Y Ixodes scapularis Deer tick  Isca\ISCW012835 Y
Orthologs in non-Arthropod Metazoa (EOG6TJ7KT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\aman-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006585gn Y Danio rerio Zebrafish  Drer\zgc:110815 Y Xenopus tropicalis Western clawed frog  Xtro\man2b1 Y Mus musculus House mouse  Mmus\Man2b1 Y Rattus norvegicus Norway rat  Rnor\Man2b1 Y Homo sapiens Human  Hsap\MAN2B1 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\MAN2B1
AAA Orthologs (2) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23708 Drosophila ananassae Dana\GF15795
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	37404 y1 w*; Mi{MIC}LM408MI04187
Harvard	- P{XP}LM408d05564 - PBac{RB}LM408e01592
VDRC	v108218 P{KK102185}VIE-260B v49352 w1118; P{GD4948}v49352 v49351 w1118; P{GD4948}v49351/CyO
Genomic Clones ( 2 )
	BACR34C10 BACR48K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 91 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02419
Other clones	DPiM_GH02419
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03567 GH03449 GH03792 GH05046 GH05646 GH06207 GH06448 GH12303 GH14258 GH18578 GH23724 GH23819 GH24717 GH27276 GM06378 LD05467 LD05944 LD15618 LD18482 LD18516 LD19968 LD27260 LD36536 LD42449 LP01351 LP01415 LP06056 LP15376 LP24003 RE10477 RE12994 RE16564 RE18480 RE35544 RE47881 RE54844 RE62883 RE65839 RE67214 RE68179 RH42615 RH63924 RH69778 RH72365 SD12631 SD17053 SD17206
Other clones	45173 83382 101424 108719 148610 175552 CK01.1B.C6 CK01.59C.H12 CK01.113B.D3 CK01.121B.A10 CK01.124B.H2 CK02239 EC30892 EC36320 EC256277 EK006343 EK048164 EK092503 EK092833 EK094561 EK160859 EK243512 EK275201 EK280142 EK283406 EP18924 LP04457 RP003315454 RP004097490 RP004211167 RP004228899 RP004238124 RP004239867 RP004249260 RP004249818 RP004299026 RP004315454 RP004426445 RP004442731 RP004461193 RP004463858 RP004520290
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027611 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34437
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: LM408 CG6206 (Nemčovičová et al., 2012)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135564 NM_164929 RefSeq (Proteins) • NP_609408 NP_723591 DDBJ / EMBL / GenBank • AAD38576 AAF52958 AAN10754 AF145601 AI063010 AI401859 CZ474613 CZ479407 CZ479408 Entrez Gene - A searchable database of RefSeq genes. • 34437 UniProtKB/TrEMBL • Q8IPB7 Q9VKV1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Glycoside hydrolase family 38, N-terminal domain (IPR000602) Galactose mutarotase-like domain (IPR011013) Glycosyl hydrolase family 38, C-terminal (IPR011682) Glycoside hydrolase/deacetylase, beta/alpha-barrel (IPR011330) Glycoside hydrolase, family 38, central domain (IPR015341) Glycoside hydrolase 38/57, N-terminal domain (IPR027291) Glycosyl hydrolase, family 13, all-beta (IPR013780) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH02419
Linkouts
	BioGRID - A database of protein and genetic interactions • 60518 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027611 DroID - A comprehensive database of gene and protein interactions. • FBgn0027611 DRSC - Results from RNAi screens. • FBgn0027611 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027611 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6206-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027611 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34437 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34437 modMine - Data generated by the modENCODE project. • FBgn0027611
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BcDNA:GH02419 (Inlow and Restifo, 2004, Giot et al., 2003, ) CG6206 (Izutsu et al., 2012, Nemčovičová et al., 2012, Wittkopp et al., 2008, Wittkopp et al., 2004, Keleman et al., 2009.8.5, Wittkopp et al., 2008, Kuntz et al., 2008, Sieber and Thummel, 2009, Cammarato et al., 2011) dLM (Kuntz et al., 2008, Poláková et al., 2011) dLM408 (Nemčovičová et al., 2012) LM408
Name Synonym	class II lysosomal α-mannosidase (Nemčovičová et al., 2012) lysosomal mannosidase (Kuntz et al., 2008) lysosomal α-mannosidase (Nemčovičová et al., 2012, Poláková et al., 2011) Lysosomal α-mannosidase
Secondary FlyBase IDs
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Nemčovičová et al., 2012, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(8): 965--970 Expression, purification and preliminary crystallographic analysis of Drosophila melanogaster lysosomal alpha-mannosidase. [FBrf0219086] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Poláková et al., 2011, Eur. J. Med. Chem. 46(3): 944--952 α-d-Mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II. [FBrf0213098] Show all research papers ...