FB2019_06, released Dec 19, 2019

Gene: Dmel\jdp

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General Information
Symbol
Dmel\jdp
Species
D. melanogaster
Name
jdp
Annotation Symbol
CG2239
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027654
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Also Known As
dJDP
Key Links
Genomic Location
Cytogenetic map
99F7-99F7
Sequence location
3R:30,517,059..30,527,037 [-]
Recombination map
3-100
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
chaperone binding; unfolded protein binding
Summaries
Gene Group (FlyBase)
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES -
The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\jdp or the JBrowse view of Dmel\jdp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
jdp-RA
FBtr0085681
NM_143550
1960
195
jdp-RB
FBtr0085682
NM_170501
1921
182
jdp-RC
FBtr0085683
NM_170502
663
170
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
jdp-PA
FBpp0085043
21.7
195
7.55
NP_651807
AAF57063
jdp-PB
FBpp0085044
20.1
182
7.04
NP_733380
AAN14240
jdp-PC
FBpp0085045
19.4
170
6.91
NP_733381
AAN14241
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jdp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (4 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
chaperone binding
inferred from sequence or structural similarity with UniProtKB:P08622
(FlyBase Curators, 2008--)
unfolded protein binding
inferred from sequence or structural similarity with UniProtKB:P08622
(FlyBase Curators, 2008--)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
chaperone cofactor-dependent protein refolding
inferred from sequence or structural similarity with UniProtKB:P08622
(FlyBase Curators, 2008--)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytosol
inferred from sequence or structural similarity with UniProtKB:P08622
(FlyBase Curators, 2008--)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic/larval corpus allatum
(Fisher et al., 2012)
Additional Descriptive Data
Isoform-specific expression patterns are observed. Sex-specific expression of alternative transcripts observed.
(Telonis-Scott et al., 2009)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\jdp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of jdp
Transgenic constructs containing regulatory region of jdp
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DNAJC12
12 of 15
Yes
Yes
Hsap\DNAJC17
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dnajc12
12 of 15
Yes
Yes
Mmus\Dnajc17
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Dnajc12
9 of 13
Yes
Yes
Rnor\Dnajc4
1 of 13
No
No
Rnor\Dnajc17
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\dnajc12
4 of 12
Yes
Yes
Xtro\dnajc4
1 of 12
No
No
Xtro\dnajc17
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\dnajc12
13 of 15
Yes
Yes
Drer\dnajc4
1 of 15
No
No
Drer\dnajc30b
1 of 15
No
No
Drer\LOC100333185
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\K07F5.16
11 of 15
Yes
Yes
Cele\dnj-4
1 of 15
No
No
Cele\dnj-16
1 of 15
No
Yes
Cele\dnj-22
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G21080
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CAJ1
2 of 15
Yes
Yes
Scer\DJP1
2 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190GM4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\jdp
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009548
Drosophila simulans
Dsim\GD16969
Drosophila sechellia
Dsec\GM16265
Drosophila sechellia
Dsec\GM12145
Drosophila erecta
Dere\GG11926
Drosophila yakuba
Dyak\GE23376
Drosophila ananassae
Dana\GF23324
Drosophila pseudoobscura pseudoobscura
Dpse\GA15317
Drosophila persimilis
Dper\GL14039
Drosophila willistoni
Dwil\GK13121
Drosophila virilis
Dvir\GJ22754
Drosophila mojavensis
Dmoj\GI22753
Drosophila grimshawi
Dgri\GH17424
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CUM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015049
Glossina morsitans
Tsetse fly
Gmor\GMOY000552
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00114
Mayetiola destructor
Hessian fly
Mdes\Mdes000567
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007034
Anopheles darlingi
American malaria mosquito
Adar\ADAC003812
Anopheles gambiae
Malaria mosquito
Agam\AGAP000970
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017130
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0E56 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010387
Danaus plexippus
Monarch butterfly
Dple\DPOGS214054-PA
Apis florea
Little honeybee
Aflo\2278767524
Apis mellifera
Western honey bee
Amel\LOC408863
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24914
Bombus terrestris
Buff-tailed bumblebee
Bter\15206080
Linepithema humile
Argentine ant
Lhum\LH21680
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002921
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010083
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05467
Tribolium castaneum
Red flour beetle
Tcas\TC011165
Pediculus humanus
Human body louse
Phum\PHUM362620
Rhodnius prolixus
Kissing bug
Rpro\RPRC004186
Cimex lectularius
Bed bug
Clec\CLEC008107
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002505
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04205
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0E3Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015102
Ixodes scapularis
Black-legged tick
Isca\ISCW002129
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74510.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02030
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231138
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0UTL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011486
Gallus gallus
Domestic chicken
Ggal\DNAJC12
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG17187
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DNAJC12; DnaJ heat shock protein family (Hsp40) member C12
    12 of 15
    606060
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Interactions Browser
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-100
      Cytogenetic map
      99F7-99F7
      Sequence location
      3R:30,517,059..30,527,037 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      99F7-99F7
      Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location
      3-100
      (FlyBase, 2016)
      3-98.4
      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (9)
      Genomic Clones (25)
      cDNA Clones (87)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      polyclonal
      (Ye et al., 2004)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for identity of: jdp CG2239
      (Ye, 1999.11)
      Source for database merge of
      Additional comments
      Other Comments
      Identification: as a 25kD peptide that is phosphorylated in dissociated brain cells.
      (Inoue et al., 2000)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 56 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (5)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (47)