FB2020_01, released Feb 12, 2020

Gene: Dmel\Hey

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General Information
Symbol
Dmel\Hey
Species
D. melanogaster
Name
Hairy/E(spl)-related with YRPW motif
Annotation Symbol
CG11194
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027788
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
Hairy/E(spl)-related with YRPW motif (Hey) encodes a transcription factor involved in neuron fate determination. Hey expression is regulated by Notch signalling in the embryonic and larval central nervous system. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

Hesr-1

Key Links
Genomic Location
Cytogenetic map
44A2-44A2
Sequence location
2R:7,995,438..7,998,278 [-]
Recombination map

2-58

RefSeq locus
NT_033778 REGION:7995438..7998278
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the HEY family. (Q7KM13)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein dimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
Transcriptional repressor which acts as a downstream effector of Notch signaling.
(UniProt, Q7KM13)
Summary (Interactive Fly)

bHLH-Orange protein family - expressed in a subset of newly born neurons that receive Notch signalling - promotes one of two alternative fates adopted by sibling neurons

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Hey or the JBrowse view of Dmel\Hey for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hey-RA
FBtr0088869
NM_078933
1687
425
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hey-PA
FBpp0087945
46.8
425
7.61
NP_523657
AAF59152
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hey using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
DNA binding
inferred from sequence or structural similarity with UniProtKB:Q9QUS4
(assigned by UniProt )
(UniProt Curators, 2002-)
DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000105427
(assigned by GO_Central )
(Gaudet et al., 2011)
protein dimerization activity
inferred from electronic annotation with InterPro:IPR011598
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000105427
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
neuron fate determination
inferred from mutant phenotype
(Monastirioti et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
anterior/posterior pattern specification
inferred from biological aspect of ancestor with PANTHER:PTN000105428
(assigned by GO_Central )
(Gaudet et al., 2011)
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000105428
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000105427
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of neurogenesis
inferred from biological aspect of ancestor with PANTHER:PTN000105428
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Monastirioti et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000105427
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:Q9QUS4
(assigned by UniProt )
(UniProt Curators, 2002-)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
somatic cell | subset of embryonic mesothoracic segment
(Ulvklo et al., 2012)
somatic cell | subset of embryonic metathoracic segment
(Ulvklo et al., 2012)
embryonic stage 12
presumptive embryonic/larval central nervous system
(Monastirioti et al., 2010)
presumptive embryonic/larval peripheral nervous system
(Monastirioti et al., 2010)
embryonic stage 11
ganglion mother cell
(Monastirioti et al., 2010)
RP2sib neuron

Comment: not in RP2 motor neuron

(Monastirioti et al., 2010)
MP1 neuron
(Monastirioti et al., 2010)
embryonic stage 15
neuron
(Monastirioti et al., 2010)
embryonic stage 10
neuroblast MP2
(Monastirioti et al., 2010)
U neuron
(Monastirioti et al., 2010)
embryonic stage 12 -- 13
vMP2 neuron

Comment: not in dMP2 neuron

(Monastirioti et al., 2010)
embryonic stage 11 -- 13
pCC neuron

Comment: not in aCC neuron

(Monastirioti et al., 2010)
third instar larval stage
embryonic/larval central nervous system
(Monastirioti et al., 2010)
embryonic/larval optic lobe
(Monastirioti et al., 2010)
glial cell of larval inner optic anlage
(Monastirioti et al., 2010)
glial cell of larval outer optic anlage
(Monastirioti et al., 2010)
pharate adult stage P8
ganglion mother cell of mushroom body
(Monastirioti et al., 2010)
Additional Descriptive Data

In embryonic meso- and metathoracic segments Hey-protein is expressed in early postmitotic A-cells of the neuroblast NB5-6-lineage.

(Ulvklo et al., 2012)

Hey-positive neurons are newly differentiated secondary neurons, located near the surface of the CNS adjacent to a neuroblast/ganglion mother cell cluster. They are positive for elav but not for ase, indicating that Hey is not expressed by GMCs but by their progeny. Positively-marked neuroblast clones generated one day before fixation were found that expressed Hey, indicating expression in very recently differentiated cells.

(Monastirioti et al., 2010)

For asymetric GMC divisions where daughter cells have unequal levels of N signaling, Hey-positive cells were the high-N 'A' sibling (vMP2 neuron, pCC neuron, RP2sib neuron).

(Monastirioti et al., 2010)

In embryos and larvae, expression of Hey occurs during periods of neurogenesis, but does not persist after. Two exceptions to this are in the mushroom body, where Hey is present during pupation, and in some of the glia of the inner and outer larval optic anlage.

(Monastirioti et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Monastirioti et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hey in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hey
Transgenic constructs containing regulatory region of Hey
Deletions and Duplications ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HEY2
9 of 15
Yes
Yes
 
Hsap\HEYL
8 of 15
No
Yes
Hsap\HEY1
7 of 15
No
Yes
Hsap\HELT
2 of 15
No
No
Hsap\BHLHE40
1 of 15
No
No
Hsap\BHLHE41
1 of 15
No
No
 
Hsap\HES1
1 of 15
No
No
Hsap\HES2
1 of 15
No
No
Hsap\HES4
1 of 15
No
No
 
Hsap\HES6
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hey1
9 of 15
Yes
Yes
Mmus\Hey2
8 of 15
No
Yes
Mmus\Heyl
8 of 15
No
Yes
Mmus\Helt
2 of 15
No
No
Mmus\Bhlhe40
1 of 15
No
No
Mmus\Bhlhe41
1 of 15
No
No
Mmus\Hes1
1 of 15
No
No
Mmus\Hes2
1 of 15
No
No
Mmus\Hes6
1 of 15
No
No
Mmus\Hes7
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Hey2
8 of 13
Yes
Yes
Rnor\Heyl
7 of 13
No
Yes
Rnor\Helt
2 of 13
No
No
Rnor\Hey1
2 of 13
No
Yes
Rnor\Bhlhe40
1 of 13
No
No
Rnor\Bhlhe41
1 of 13
No
No
Rnor\Hes1
1 of 13
No
No
Rnor\Hes2
1 of 13
No
No
Rnor\Hes6
1 of 13
No
No
Rnor\Hes7
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\hey1
7 of 12
Yes
Yes
Xtro\hey2
4 of 12
No
Yes
Xtro\bhlhe40
1 of 12
No
Yes
Xtro\bhlhe41
1 of 12
No
Yes
Xtro\hes1
1 of 12
No
No
Xtro\hes2
1 of 12
No
No
Xtro\hes4
1 of 12
No
No
Xtro\hes6.1
1 of 12
No
No
Xtro\hes7.1
1 of 12
No
No
Xtro\hes7.2
1 of 12
No
Yes
Danio rerio (Zebrafish) (17)
Drer\hey1
9 of 15
Yes
Yes
Drer\hey2
9 of 15
Yes
Yes
Drer\heyl
7 of 15
No
Yes
Drer\helt
2 of 15
No
No
Drer\bhlhe40
1 of 15
No
No
Drer\bhlhe41
1 of 15
No
No
Drer\her1
1 of 15
No
No
Drer\her5
1 of 15
No
No
Drer\her6
1 of 15
No
No
Drer\her8.2
1 of 15
No
No
Drer\her8a
1 of 15
No
No
Drer\her9
1 of 15
No
No
Drer\her11
1 of 15
No
No
Drer\her13
1 of 15
No
No
Drer\hes2.1
1 of 15
No
No
Drer\hes2.2
1 of 15
No
No
Drer\hes6
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\lin-22
2 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PHO4
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BMZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Hey
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006692
Drosophila simulans
Dsim\GD10200
Drosophila sechellia
Dsec\GM20733
Drosophila erecta
Dere\GG10686
Drosophila yakuba
Dyak\GE23399
Drosophila ananassae
Dana\GF11221
Drosophila pseudoobscura pseudoobscura
Dpse\GA10830
Drosophila persimilis
Dper\GL10603
Drosophila willistoni
Dwil\GK21562
Drosophila virilis
Dvir\GJ20236
Drosophila mojavensis
Dmoj\GI19174
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BCD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022748
Glossina morsitans
Tsetse fly
Gmor\GMOY003951
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03824
Mayetiola destructor
Hessian fly
Mdes\Mdes001705
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001428
Anopheles darlingi
American malaria mosquito
Adar\ADAC002255
Anopheles gambiae
Malaria mosquito
Agam\AGAP007450
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017595
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GEL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013539
Danaus plexippus
Monarch butterfly
Dple\DPOGS210592-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003084
Apis florea
Little honeybee
Aflo\2161482372
Apis mellifera
Western honey bee
Amel\GB51105
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25701
Bombus terrestris
Buff-tailed bumblebee
Bter\15213886
Linepithema humile
Argentine ant
Lhum\LH15050
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0025a6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG024975
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09192
Tribolium castaneum
Red flour beetle
Tcas\TC001593
Pediculus humanus
Human body louse
Phum\PHUM454530
Rhodnius prolixus
Kissing bug
Rpro\RPRC009163
Cimex lectularius
Bed bug
Clec\CLEC011631
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010001
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12292
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HWL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012977
Strigamia maritima
European centipede
Smar\SMAR011929
Ixodes scapularis
Black-legged tick
Isca\ISCW011251
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75137.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75136.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73331.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g03010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g03020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347250
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0SVH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hey
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006427
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (12)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
cwo
3 of 10
dpn
2 of 10
E(spl)m3-HLH
2 of 10
E(spl)m7-HLH
2 of 10
E(spl)m8-HLH
2 of 10
E(spl)mβ-HLH
2 of 10
E(spl)mδ-HLH
2 of 10
E(spl)mγ-HLH
2 of 10
h
2 of 10
Sidpn
2 of 10
E(spl)m5-HLH
1 of 10
Hesr
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HEY2; hes related family bHLH transcription factor with YRPW motif 2
    9 of 15
    604674
         
        HEYL; hes related family bHLH transcription factor with YRPW motif like
        8 of 15
        609034
            HEY1; hes related family bHLH transcription factor with YRPW motif 1
            7 of 15
            602953
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                esyN Network Diagram
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2R
                Recombination map

                2-58

                Cytogenetic map
                44A2-44A2
                Sequence location
                2R:7,995,438..7,998,278 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                44A2-44A2
                Limits computationally determined from genome sequence between P{lacW}CSN4k08018&P{lacW}l(2)k08504k08504 and P{lacW}Vps28k16503
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                44A2-44A3
                (Kokubo, 1999.5.14)
                Experimentally Determined Recombination Data
                Location

                2-58

                (FlyBase, 2016)

                2-57.2

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (11)
                Genomic Clones (12)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (6)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequences
                BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Monastirioti et al., 2010)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments
                  Other Comments

                  RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

                  (Boutros et al., 2004)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 30 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Synonyms and Secondary IDs (15)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
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