Hesr-1
bHLH-Orange protein family - expressed in a subset of newly born neurons that receive Notch signalling - promotes one of two alternative fates adopted by sibling neurons
Please see the JBrowse view of Dmel\Hey for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hey using the Feature Mapper tool.
Comment: not in RP2 motor neuron
Comment: not in aCC neuron
Comment: not in dMP2 neuron
In embryonic meso- and metathoracic segments Hey-protein is expressed in early postmitotic A-cells of the neuroblast NB5-6-lineage.
Hey-positive neurons are newly differentiated secondary neurons, located near the surface of the CNS adjacent to a neuroblast/ganglion mother cell cluster. They are positive for elav but not for ase, indicating that Hey is not expressed by GMCs but by their progeny. Positively-marked neuroblast clones generated one day before fixation were found that expressed Hey, indicating expression in very recently differentiated cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Hey in GBrowse 22-58
2-57.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.