FlyBase Gene Report: Dmel\Hey

General Information

Symbol

Dmel\Hey

Species

D. melanogaster

Name

Hairy/E(spl)-related with YRPW motif

Annotation Symbol

CG11194

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027788

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Hairy/E(spl)-related with YRPW motif (Hey) encodes a transcription factor involved in neuron fate determination. Hey expression is regulated by Notch signalling in the embryonic and larval central nervous system. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Hesr-1

Key Links

Genomic Location

Cytogenetic map

44A2-44A2

Sequence location

2R:7,995,438..7,998,278 [-]

Recombination map

2-58

RefSeq locus

NT_033778 REGION:7995438..7998278

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables DNA binding

inferred from sequence or structural similarity with UniProtKB:Q9QUS4

(assigned by UniProt )

(UniProt Curators, 2002-)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004213585

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein dimerization activity

inferred from electronic annotation with InterPro:IPR011598

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004213585

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in neuron fate determination

inferred from mutant phenotype

(Monastirioti et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in anterior/posterior pattern specification

inferred from biological aspect of ancestor with PANTHER:PTN000105428

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of neurogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000105428

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004213585

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Monastirioti et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q9QUS4

(assigned by UniProt )

(UniProt Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN004213585

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the HEY family. (Q7KM13)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -: Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).

Protein Function (UniProtKB)

Transcriptional repressor which acts as a downstream effector of Notch signaling.

(UniProt, Q7KM13)

Summary (Interactive Fly)

bHLH-Orange protein family - expressed in a subset of newly born neurons that receive Notch signalling - promotes one of two alternative fates adopted by sibling neurons

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hey for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hey-RA

FBtr0088869

NM_078933

1687

425

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Hey-PA

FBpp0087945

46.8

425

7.61

NP_523657

AAF59152

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KM13

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hey using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hey_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 10 -- 12

presumptive embryonic/larval central nervous system

• nucleus

(Monastirioti et al., 2010)

presumptive embryonic/larval peripheral nervous system

• nucleus

(Monastirioti et al., 2010)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10

neuroblast MP2

(Monastirioti et al., 2010)

U neuron

(Monastirioti et al., 2010)

embryonic stage 11

ganglion mother cell

(Monastirioti et al., 2010)

RP2sib neuron

Comment: not in RP2 motor neuron

(Monastirioti et al., 2010)

MP1 neuron

(Monastirioti et al., 2010)

embryonic stage 11 -- 13

pCC neuron

Comment: not in aCC neuron

(Monastirioti et al., 2010)

embryonic stage 12

presumptive embryonic/larval central nervous system

(Monastirioti et al., 2010)

presumptive embryonic/larval peripheral nervous system

(Monastirioti et al., 2010)

embryonic stage 12 -- 13

vMP2 neuron

Comment: not in dMP2 neuron

(Monastirioti et al., 2010)

embryonic stage 13 -- 16

somatic cell | subset of embryonic mesothoracic segment

(Ulvklo et al., 2012)

somatic cell | subset of embryonic metathoracic segment

(Ulvklo et al., 2012)

embryonic stage 15

neuron

(Monastirioti et al., 2010)

third instar larval stage

embryonic/larval central nervous system

(Monastirioti et al., 2010)

embryonic/larval optic lobe

(Monastirioti et al., 2010)

glial cell of larval inner optic anlage

(Monastirioti et al., 2010)

glial cell of larval outer optic anlage

(Monastirioti et al., 2010)

pharate adult stage P8

ganglion mother cell of mushroom body

(Monastirioti et al., 2010)

Additional Descriptive Data

In embryonic meso- and metathoracic segments Hey-protein is expressed in early postmitotic A-cells of the neuroblast NB5-6-lineage.

(Ulvklo et al., 2012)

Hey-positive neurons are newly differentiated secondary neurons, located near the surface of the CNS adjacent to a neuroblast/ganglion mother cell cluster. They are positive for elav but not for ase, indicating that Hey is not expressed by GMCs but by their progeny. Positively-marked neuroblast clones generated one day before fixation were found that expressed Hey, indicating expression in very recently differentiated cells.

(Monastirioti et al., 2010)

For asymetric GMC divisions where daughter cells have unequal levels of N signaling, Hey-positive cells were the high-N 'A' sibling (vMP2 neuron, pCC neuron, RP2sib neuron).

(Monastirioti et al., 2010)

In embryos and larvae, expression of Hey occurs during periods of neurogenesis, but does not persist after. Two exceptions to this are in the mushroom body, where Hey is present during pupation, and in some of the glia of the inner and outer larval optic anlage.

(Monastirioti et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Monastirioti et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hey in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hey

View exonic expression by tissue for Dmel\Hey

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027788

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027788

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11194-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0027788

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hey

Transgenic constructs containing regulatory region of Hey

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)ED1735

(Monastirioti et al., 2010)

Df(2R)Exel6055

(Monastirioti et al., 2010, Ryder, 2004.4.26)

Gene not disrupted in

Df(2R)Optix^ΔC

(Li et al., 2013)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Bx-MS1096

Hey^{UAS.ORF.GW.Tag:HA}

lethal | cold sensitive, with Scer\GAL4^Bx-MS1096

Hey^{UAS.ORF.GW.Tag:HA}

lethal - all die before end of second instar larval stage (with Df(2R)ED1735)

Hey^f06656

lethal - all die before end of second instar larval stage (with Df(2R)Exel6055)

Hey^f06656

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^ftz.ng

Hey^UAS.cMa

majority die during first instar larval stage (with Df(2R)ED1735)

Hey^f06656

majority die during first instar larval stage (with Df(2R)Exel6055)

Hey^f06656

some die during embryonic stage (with Df(2R)ED1735)

Hey^f06656

some die during embryonic stage (with Df(2R)Exel6055)

Hey^f06656

visible, with Scer\GAL4^Bx-MS1096

Hey^KK101381

Phenotype manifest in

Allele

dMP2 neuron, with Scer\GAL4^ftz.ng

Hey^UAS.cMa

RP2 motor neuron, with Scer\GAL4^ftz.ng

Hey^UAS.cMa

RP2sib neuron, with Scer\GAL4^ftz.ng

Hey^UAS.cMa

vMP2 neuron, with Scer\GAL4^ftz.ng

Hey^UAS.cMa

wing, with Scer\GAL4^Bx-MS1096

Hey^KK101381

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HEY2

9 of 15

Yes

Hsap\HEY1

7 of 15

Yes

Hsap\HEYL

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hey2

9 of 15

Yes

Mmus\Hey1

8 of 15

Yes

Mmus\Heyl

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (11)

Rnor\Hey2

8 of 13

Yes

Rnor\Heyl

6 of 13

Yes

Rnor\Hey1

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\hey1

9 of 12

Yes

Xtro\hey2

5 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (18)

Drer\hey1

9 of 15

Yes

Drer\hey2

9 of 15

Yes

Drer\heyl

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\lin-22

3 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G40200

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PHO4

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BMZ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA10830

Drosophila persimilis

Dper\GL10603

Drosophila willistoni

Dwil\GK21562

Drosophila virilis

Dvir\GJ20236

Drosophila mojavensis

Dmoj\GI19174

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BCD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022748

Glossina morsitans

Tsetse fly

Gmor\GMOY003951

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03824

Mayetiola destructor

Hessian fly

Mdes\Mdes001705

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001428

Anopheles darlingi

American malaria mosquito

Adar\ADAC002255

Anopheles gambiae

Malaria mosquito

Agam\AGAP007450

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ017595

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0GEL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013539

Danaus plexippus

Monarch butterfly

Dple\DPOGS210592-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003084

Apis florea

Little honeybee

Aflo\2161482372

Apis mellifera

Western honey bee

Amel\GB51105

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP25701

Bombus terrestris

Buff-tailed bumblebee

Bter\15213886

Linepithema humile

Argentine ant

Lhum\LH15050

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0025a6

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG024975

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09192

Tribolium castaneum

Red flour beetle

Tcas\TC001593

Pediculus humanus

Human body louse

Phum\PHUM454530

Rhodnius prolixus

Kissing bug

Rpro\RPRC009163

Cimex lectularius

Bed bug

Clec\CLEC011631

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI010001

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12292

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HWL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR012977

Strigamia maritima

European centipede

Smar\SMAR011929

Ixodes scapularis

Black-legged tick

Isca\ISCW011251

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75137.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75136.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73331.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g03010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g03020

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_347250

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0SVH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hey

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000006427

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (12)

Gene Symbol

Score

Source

Alignment

cwo

2 of 10

dpn

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

9 of 15

604674

7 of 15

602953

7 of 15

609034

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hey - E(spl)mγ-HLH

two hybrid array

(Shokri et al., 2019)

Hey - Eip78C

two hybrid array

(Shokri et al., 2019)

Hey - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Hey - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Hey - dgrn

pull down, autoradiography

(Barry et al., 2011)

Hey - foxo

two hybrid array

(Shokri et al., 2019)

Hey - zen

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61625

DroID - A comprehensive database of gene and protein interactions.

FBgn0027788

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35764

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-58

Cytogenetic map

44A2-44A2

Sequence location

2R:7,995,438..7,998,278 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

44A2-44A2

Limits computationally determined from genome sequence between P{lacW}CSN4^k08018&P{lacW}l(2)k08504^k08504 and P{lacW}Vps28^k16503

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

44A2-44A3

(Kokubo, 1999.5.14)

Experimentally Determined Recombination Data

Location

2-58

(FlyBase, 2016)

2-57.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

64826

w¹¹¹⁸; PBac{Hey-GFP.FPTB}VK00033

31898

y¹ v¹; P{TRiP.JF02186}attP2

41650

y¹ v¹; P{TRiP.GL01232}attP2

18997

w¹¹¹⁸; PBac{WH}Hey^f06656/CyO

36153

y¹ w^*; Mi{MIC}Hey^MI02860/SM6a

79948

y¹ sc^* v¹ sev²¹; P{TOE.GS02242}attP40

FlyORF

F003419

M{UAS-Hey.ORF-CC}ZH-21F

F000566

M{UAS-Hey.ORF.3xHA.GW}ZH-86Fb

VDRC

v103570

P{KK101381}VIE-260B

v30562

w¹¹¹⁸; P{GD4355}v30562

v342334

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02118}attP40/CyO-GFP

v342364

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02216}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT01017

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027788

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

HL05458

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027788

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35764

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Monastirioti et al., 2010)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 30 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35764

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KM13

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027788

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027788

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hey_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0027788

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

35764

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG11194

modMine - A data warehouse for the modENCODE project

FBgn0027788

Linkouts

BioGRID - A database of protein and genetic interactions.

61625

DroID - A comprehensive database of gene and protein interactions.

FBgn0027788

DRSC - Results frm RNAi screens

FBgn0027788

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027788

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG11194-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027788

FlyMine - An integrated database for Drosophila genomics

FBgn0027788

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35764

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG11194

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Schlatter and Maier, 2005, Whitfield, 2000.5.17)

HEY

(Blatti et al., 2015)

Hesr-1

(Kokubo, 1999.5.14)

Hey

(Flint Brodsly et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Liu and Jin, 2017, Transgenic RNAi Project members, 2017-, Schertel et al., 2015, Harbison et al., 2013, Kux et al., 2013, Zhan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kelsom and Lu, 2012, Ulvklo et al., 2012, Barry et al., 2011, Monastirioti et al., 2010, Nedelsky et al., 2010, Lu et al., 2008, Schlatter and Maier, 2005)

bHLHe44

(Stevens et al., 2008)

d-hey

(Lai, 2002)

dHey

(Leimeister et al., 1999)

hesr-1

(Kokubo et al., 1999)

hey

(San-Juán and Baonza, 2011, Kozhina et al., 2007)

Name Synonyms

Hairy and enhancer of split related protein

Hairy/E(spl)

(Kozhina et al., 2007)

Hairy/E(spl) related with YRPW motif

(Zhan et al., 2013)

Hairy/E(spl)-related

(Zhan et al., 2013)

Hairy/E(spl)-related with YRPW motif

(Harbison et al., 2013, Carpenter et al., 2009, Leimeister et al., 1999)

hairy and enhancer of split related-1

(Kokubo et al., 1999)

Secondary FlyBase IDs

FBgn0027789

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (66)

The following external sites may use different assemblies or annotations than FlyBase.

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