FlyBase Gene Report: Dmel\Dp1

General Information

Symbol

Dmel\Dp1

Species

D. melanogaster

Name

Dodeca-satellite-binding protein 1

Annotation Symbol

CG5170

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027835

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Snapshot

Dodeca-satellite-binding protein 1 (Dp1) encodes a single-stranded nucleic acid binding protein that belongs to the vigilin protein family. It binds to target mRNAs and enhances their translation. [Date last reviewed: 2018-09-27]

Other Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

DDP1, Vigilin

Key Links

Genomic Location

Cytogenetic map

55C8-55C8

Sequence location

2R:18,412,027..18,421,124 [+]

Recombination map

2-85

RefSeq locus

NT_033778 REGION:18412027..18421124

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables mRNA 3'-UTR binding

inferred from direct assay

(Nelson et al., 2007)

enables satellite DNA binding

inferred from direct assay

(Cortes and Azorin, 2000)

enables single-stranded DNA binding

inferred from direct assay

(Cortes and Azorin, 2000, Cortes et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables mRNA binding

inferred from biological aspect of ancestor with PANTHER:PTN001318954

(assigned by GO_Central )

(Gaudet et al., 2011)

enables single-stranded DNA binding

traceable author statement

(Birchler et al., 2004)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in chromosome condensation

inferred from mutant phenotype

(Huertas et al., 2004)

involved_in chromosome segregation

inferred from mutant phenotype

(Huertas et al., 2004)

involved_in heterochromatin assembly

inferred from direct assay

(Wang et al., 2005)

involved_in positive regulation of translation

inferred from direct assay

(Nelson et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in heterochromatin

inferred from direct assay

(Cortes et al., 1999)

located_in nucleus

inferred from direct assay

(Cortes et al., 1999)

located_in polytene chromosome chromocenter

inferred from direct assay

(Cortes et al., 1999)

part_of ribonucleoprotein complex

inferred from direct assay

(Nelson et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN001318954

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001318954

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of polysome

inferred from biological aspect of ancestor with PANTHER:PTN001318954

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dp1-RA

FBtr0086682

NM_206164

5377

1301

Dp1-RB

FBtr0086683

NM_206163

5762

1301

Dp1-RD

FBtr0086679

NM_166280

5680

1301

Dp1-RE

FBtr0086681

NM_166281

5453

1301

Dp1-RF

FBtr0086680

NM_166282

5608

1301

Dp1-RG

FBtr0340329

NM_079057

5456

1301

Dp1-RH

FBtr0345226

NM_001299644

5811

1301

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Dp1-PA

FBpp0089201

144.3

1301

6.11

NP_995886

AAS64809

Dp1-PB

FBpp0089202

144.3

1301

6.11

NP_995885

AAS64810

Dp1-PD

FBpp0085860

144.3

1301

6.11

NP_725785

AAM68449

Dp1-PE

FBpp0085862

144.3

1301

6.11

NP_725786

AAM68450

Dp1-PF

FBpp0085861

144.3

1301

6.11

NP_725787

AAM68451

Dp1-PG

FBpp0309290

144.3

1301

6.11

NP_523781

AAF57691

Dp1-PH

FBpp0311418

144.3

1301

6.11

NP_001286573

AHN56368

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1301 aa isoforms: Dp1-PA, Dp1-PB, Dp1-PD, Dp1-PE, Dp1-PF, Dp1-PG, Dp1-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dp1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic epipharynx

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval muscle system

(Fisher et al., 2012)

adult stage

adult mushroom body | restricted

(Kobayashi et al., 2006)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

somatic cell

• polytene chromosome chromocenter

(Cortes et al., 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Dp1 protein binds dodeca-satellite DNA sequences with high affinity. Dp1 localizes to the heterochromatic chromocenter. It also localizes to euchromatic sites on all chromosomes, colocalizing with Su(var)205 protein.

(Cortes et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in heterochromatin

inferred from direct assay

(Cortes et al., 1999)

located_in nucleus

inferred from direct assay

(Cortes et al., 1999)

located_in polytene chromosome chromocenter

inferred from direct assay

(Cortes et al., 1999)

part_of ribonucleoprotein complex

inferred from direct assay

(Nelson et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dp1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dp1

View exonic expression by tissue for Dmel\Dp1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027835

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027835

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5170-RC

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5170

Flygut - An atlas of the Drosophila adult midgut

FBgn0027835

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Dp1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dp1

Transgenic constructs containing regulatory region of Dp1

Deletions and Duplications ( 1 )

Disrupted in

Df(2R)PC4

(Huertas et al., 2004)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage | non-rescuable maternal effect | recessive

Dp1^15.1

lethal | recessive

Dp1^15.1

partially lethal (with Df(2R)PC4)

partially lethal (with Df(2R)PC4), with Scer\GAL4^- :

Dp1^EP2249

partially lethal (with Dp1^15.1)

Dp1^SH2987

partially lethal (with Dp1^SH2987)

Dp1^15.1

partially lethal | recessive

Dp1^SH2987

partially lethal - majority die | recessive

Dp1¹⁸⁵

viable, with Scer\GAL4^- :

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dp1^GD4204

viable, with Scer\GAL4^Mef2.PR

Dp1^GD4204

viable, with Scer\GAL4^pnr-MD237

Dp1^GD4204

viable, with Scer\GAL4^tin.CΔ4

Dp1^GD4204

viable (with Df(2R)PC4), with Scer\GAL4^- :

Dp1^EP2422

viable (with Dp1^15.1)

Dp1^EP2249

viable (with Dp1^15.1), with Scer\GAL4^- :

Dp1^EP2249

viable (with Dp1^EP2249)

Dp1^15.1

viable (with Dp1^EP2249), with Scer\GAL4^- :

Dp1^15.1

Sterility

Allele

female sterile | recessive

Dp1^15.1

female sterile | recessive, with Scer\GAL4^- :

Dp1^EP2249

Other Phenotypes

Allele

decreased cell number, with Scer\GAL4^NP7397

Dp1^NIG.5170R

non-suppressor of variegation, with In(1)w^m4, Scer\GAL4^- :

non-suppressor of variegation, with P{hsp26-pt-T}39C-4

Dp1^15.1

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

Dp1^15.1

non-suppressor of variegation, with P{hsp26-pt-T}39C-12, Scer\GAL4^- :

Dp1^EP2422

non-suppressor of variegation, with P{hsp26-pt-T}39C-27

Dp1^15.1

non-suppressor of variegation, with P{hsp26-pt-T}118E-5, Scer\GAL4^- :

Dp1^EP2422

non-suppressor of variegation, with P{hsp26-pt-T}118E-12

Dp1^15.1

non-suppressor of variegation, with P{hsp26-pt-T}118E-25-5, Scer\GAL4^- :

Dp1^EP2422

suppressor of variegation | dominant, with In(1)w^m4

Dp1^15.1

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-12

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-41

Dp1^15.1

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-41, Scer\GAL4^- :

Dp1^EP2249

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-42, Scer\GAL4^- :

Dp1^EP2249

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-5

Dp1^15.1

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-19

Dp1^15.1

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5

suppressor of variegation | dominant, with P{hsp26-pt-T}118E-25-5, Scer\GAL4^- :

Dp1^EP2249

suppressor of variegation | dominant | partially, with P{hsp26-pt-T}39C-41

Dp1^SH2987

suppressor of variegation | dominant | partially, with P{hsp26-pt-T}39C-72

Dp1^15.1

suppressor of variegation | dominant | partially, with P{hsp26-pt-T}Abcd1^39C-34

Dp1^15.1

Phenotype manifest in

Allele

egg | maternal effect

Dp1^15.1

egg chamber

Dp1^15.1

male accessory gland secondary cell, with Scer\GAL4^NP7397

Dp1^NIG.5170R

mitotic anaphase | embryonic stage | maternal effect

Dp1^15.1

mitotic telophase | embryonic stage | maternal effect

Dp1^15.1

nucleus | embryonic stage | maternal effect

Dp1^15.1

ovariole

Dp1^15.1

ovary

Dp1^15.1

ovary, with Scer\GAL4^- :

Dp1^EP2249

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HDLBP

15 of 15

Yes

Hsap\BICC1

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hdlbp

14 of 15

Yes

Mmus\Gm382

8 of 15

Yes

Mmus\4921511C20Rik

2 of 15

Yes

Mmus\Bicc1

1 of 15

Rattus norvegicus (Norway rat) (5)

Rnor\Hdlbp

13 of 13

Yes

Rnor\RGD1563104

8 of 13

Yes

Rnor\RGD1561230

7 of 13

Yes

Rnor\RGD1562485

3 of 13

Yes

Rnor\Bicc1

1 of 13

Xenopus tropicalis (Western clawed frog) (2)

Xtro\hdlbp

9 of 12

Yes

Xtro\bicc1

1 of 12

Danio rerio (Zebrafish) (5)

Drer\hdlbpa

13 of 15

Yes

Drer\hdlbpb

9 of 15

Yes

Drer\bicc2

2 of 15

Drer\bicc1a

1 of 15

Drer\bicc1b

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\vgln-1

13 of 15

Yes

Cele\bcc-1

2 of 15

Cele\C06G4.1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (5)

Atha\AT3G11860

1 of 9

Yes

Atha\AT3G11890

1 of 9

Yes

Atha\AT3G48800

1 of 9

Yes

Atha\AT5G23680

1 of 9

Yes

Atha\AT5G46190

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\SCP160

13 of 15

Yes

Scer\YLL032C

2 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\vgl1

10 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919011H )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18708

Drosophila persimilis

Dper\GL17775

Drosophila willistoni

Dwil\GK22993

Drosophila virilis

Dvir\GJ19895

Drosophila mojavensis

Dmoj\GI20125

Drosophila grimshawi

Dgri\GH21672

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500M4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17027480

Glossina morsitans

Tsetse fly

Gmor\GMOY008511

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02239

Mayetiola destructor

Hessian fly

Mdes\Mdes005481

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001421

Anopheles darlingi

American malaria mosquito

Adar\ADAC007023

Anopheles gambiae

Malaria mosquito

Agam\AGAP005467

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014531

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00H3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Danaus plexippus

Monarch butterfly

Dple\DPOGS206108-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005038

Apis florea

Little honeybee

Aflo\2209622292

Apis mellifera

Western honey bee

Amel\LOC412111

Apis mellifera

Western honey bee

Amel\GB53060

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17314

Bombus terrestris

Buff-tailed bumblebee

Bter\15210341

Linepithema humile

Argentine ant

Lhum\LH13011

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002a4b

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12984

Tribolium castaneum

Red flour beetle

Tcas\TC012484

Pediculus humanus

Human body louse

Phum\PHUM004660

Rhodnius prolixus

Kissing bug

Rpro\RPRC009632

Cimex lectularius

Bed bug

Clec\CLEC002993

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008258

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI083931

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04448

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00G3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008445

Ixodes scapularis

Black-legged tick

Isca\ISCW008601

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62860.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g00850

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_234231

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00NZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hdlbp

Ciona intestinalis

Vase tunicate

Cint\LOC100176627

Gallus gallus

Domestic chicken

Ggal\HDLBP

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

3 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Dp1^NIG.5170R

model of prostate cancer

CEA

(Ito et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HDLBP; high density lipoprotein binding protein

15 of 15

142695

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dp1 - CG6701

experimental knowledge based

(Guruharsha et al., 2011)

Dp1 - Dsor1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Dp1 - Gale

experimental knowledge based

(Guruharsha et al., 2011)

Dp1 - Map205

experimental knowledge based

(Guruharsha et al., 2011)

Dp1 - Nfs1

experimental knowledge based

(Guruharsha et al., 2011)

Dp1 - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Dp1 - Rheb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Dp1 - S6k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Dp1 - Su(var)205

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Piacentini et al., 2009)

Dp1 - eIF2β

experimental knowledge based

(Guruharsha et al., 2011)

Dp1 - ft

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Dp1 - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Dp1 - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

RNA-protein

Physical Interaction

Assay

References

Dp1 - Hsp83

nucleic acid uv cross-linking assay, autoradiography

(Nelson et al., 2007)

Dp1 - grk

pull down, peptide massfingerprinting

(McDermott et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pbl

suppressible

Dp1

(Gregory et al., 2007)

RacGAP84C

enhanceable

Dp1

(Raymond et al., 2004)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62793

DroID - A comprehensive database of gene and protein interactions.

FBgn0027835

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37116

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-85

Cytogenetic map

55C8-55C8

Sequence location

2R:18,412,027..18,421,124 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

55C8-55C8

Limits computationally determined from genome sequence between P{PZ}sbb⁰⁴⁵²⁵&P{EP}EP1081^EP1081 and P{lacW}l(2)08770^k04808

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-85

(FlyBase, 2016)

2-89.8

(Comeron et al., 2012)

(Horn et al., 2003)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Bloomington

12855

w¹¹¹⁸; P{GT1}Dp1^BG02288 imd^BG02288

32872

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00659}attP2

56344

y¹ w^*; Mi{MIC}Dp1^MI11574 imd^MI11574/SM6a

Kyoto

201484

y¹ w^67c23; P{GSV6}Dp1^GS9049/SM1

VDRC

v106047

P{KK100749}VIE-260B

v37583

w¹¹¹⁸; P{GD4204}v37583

v318850

PBac{fTRG01340.sfGFP-TVPTBF}VK00033

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (274)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027835

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027835

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37116

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Na et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Dp1 BcDNA:LD21677

(FlyBase, 1996-)

Source for merge of: Dp1 anon-WO0118547.516 anon-WO0172774.168

(FlyBase, 1996-)

Source for merge of: Dp1 BcDNA:LD21383

(FlyBase, 1996-)

Additional comments

Dp1 complements a Scer\SCP160 deletion in yeast, a multi KH domain protein that is involved in control of cell ploidy.

(Cortes et al., 1999)

Source for merge of Dp1 BcDNA:LD21677 was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Source for merge of Dp1 anon-WO0118547.516 anon-WO0172774.168 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for merge of Dp1 BcDNA:LD21383 was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Other Comments

Dp1 encodes a single stranded DNA-binding protein that binds the unstructured dodeca-satellite C-strand in pericentric heterochromatin with high affinity and specificity.

(Cortes et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 78 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37116

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027835

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027835

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5170

Flygut - An atlas of the Drosophila adult midgut

FBgn0027835

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37116

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012484

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5170

modMine - A data warehouse for the modENCODE project

FBgn0027835

Linkouts

BioGRID - A database of protein and genetic interactions.

62793

DroID - A comprehensive database of gene and protein interactions.

FBgn0027835

DRSC - Results frm RNAi screens

FBgn0027835

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027835

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5170-RC

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027835

FlyMine - An integrated database for Drosophila genomics

FBgn0027835

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37116

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BcDNA:LD21383

BcDNA:LD21677

CG5170

(Kolkhof et al., 2017, Çiçek et al., 2016, Na et al., 2016, Brooks et al., 2015, Horan et al., 2015, Hoffmann et al., 2013, Christis and Munro, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Przewloka et al., 2007, Whitfield, 2000.6.22)

DDP1

(Batlle et al., 2011, Piacentini et al., 2009, Nelson et al., 2007, Przewloka et al., 2007, Wang et al., 2005, Cortes et al., 2003, Goolsby and Shapiro, 2003, Li et al., 2002, Cortes and Azorin, 2000, Cortes et al., 1999)

DP1

(Kohzaki, 2018)

anon-WO0118547.516

anon-WO0172774.168

ddp1

(Piacentini et al., 2009, Kavi et al., 2005, Birchler et al., 2004, Huertas et al., 2004)

Name Synonyms

Dodeca satellite binding protein 1

(Begun et al., 2007)

Dodeca-satellite-binding protein 1

(Hoffmann et al., 2013, Cammarato et al., 2011, Baig et al., 2010, Raymond et al., 2004, Cortes et al., 1999)

Drosophila dodeca-satellite-binding protein 1

(Cortes et al., 1999)

Vigilin

(Batlle et al., 2011, Goolsby and Shapiro, 2003)

dodeca-satellite protein 1

(Nelson et al., 2007)

dodeca-satellite-binding protein 1

(Wang et al., 2005)

Secondary FlyBase IDs

FBgn0027520
FBgn0027530
FBgn0046433
FBgn0061926

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections