FlyBase Gene Report: Dmel\CstF64

General Information

Symbol

Dmel\CstF64

Species

D. melanogaster

Name

Cleavage stimulation factor 64 kD subunit

Annotation Symbol

CG7697

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027841

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Snapshot

Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. [Date last reviewed: 2018-09-27]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

CstF-64

Key Links

Genomic Location

Cytogenetic map

91B8-91B8

Sequence location

3R:18,659,618..18,661,126 [+]

Recombination map

3-64

RefSeq locus

NT_033777 REGION:18659618..18661126

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables mRNA binding

inferred from sequence or structural similarity

(Lasko, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000566843

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of autophagy

inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198, FLYBASE:Tsc1; FB:FBgn0026317

(Tang et al., 2018)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in pre-mRNA cleavage required for polyadenylation

inferred from biological aspect of ancestor with PANTHER:PTN000566843

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of mRNA cleavage stimulating factor complex

inferred from direct assay

(Sullivan et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of mRNA cleavage and polyadenylation specificity factor complex

inferred from biological aspect of ancestor with PANTHER:PTN000566843

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

HISTONE PRE-MRNA CLEAVAGE COMPLEX

POLYADENYLATION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

HISTONE PRE-MRNA CLEAVAGE COMPLEX -: Histone cleavage complex includes endonucleases and polyadenylation factors involved in processing of histone pre-mRNA. (Adapted from FBrf0223323 and PMID:23071092).
POLYADENYLATION FACTORS -: Polyadenylation factors associate with snRNPs, cleavage complexes and other factors to mediate the 3' end processing of pre-mRNA. (Adapted from FBrf0223323).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CstF64 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.53

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CstF64-RA

FBtr0083660

NM_058105

1446

419

Additional Transcript Data and Comments

Reported size (kB)

1.5 (northern blot)

(Hatton et al., 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CstF64-PA

FBpp0083075

46.2

419

5.50

NP_477453

AAF55577

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

419 (aa); 64 (kD observed)

(Hatton et al., 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CstF64 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CstF-64_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Hatton et al., 2000)

Additional Descriptive Data

CstF-64 transcripts are detected throughout development with the highest levels in early embryos and adult females.

(Hatton et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of mRNA cleavage stimulating factor complex

inferred from direct assay

(Sullivan et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CstF64 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CstF64

View exonic expression by tissue for Dmel\CstF64

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027841

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027841

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7697-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7697

Flygut - An atlas of the Drosophila adult midgut

FBgn0027841

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CstF64

Transgenic constructs containing regulatory region of CstF64

Deletions and Duplications ( 1 )

Disrupted in

Df(3R)Exel6180

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

CstF64^GD9942

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

CstF64^GD9942

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

CstF64^GD9942

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CstF64^GD9942

viable, with Scer\GAL4^tin.CΔ4

CstF64^GD9942

Other Phenotypes

Allele

neuroanatomy defective | larval stage

CstF64^GD9942

some die during pupal stage, with Scer\GAL4^pnr-MD237

CstF64^GD9942

starvation stress response defective | larval stage | somatic clone, with Scer\GAL4^Act.PU

CstF64^GD9942

Phenotype manifest in

Allele

autophagosome | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

CstF64^GD9942

embryonic/larval fat body | larval stage | somatic clone | conditional, with Scer\GAL4^Act.PU

CstF64^GD9942

ganglion mother cell | larval stage

CstF64^GD9942

larval neuroblast | larval stage

CstF64^GD9942

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CSTF2

10 of 15

Yes

Hsap\CSTF2T

10 of 15

Yes

Hsap\HNRNPM

1 of 15

Hsap\MYEF2

1 of 15

Hsap\RAVER1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cstf2

11 of 15

Yes

Mmus\Cstf2t

9 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\Cstf2t

7 of 13

Yes

Rnor\Cstf2

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\cstf2

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (16)

Drer\cstf2

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\cpf-2

10 of 15

Yes

Cele\R06C1.4

4 of 15

Yes

Cele\rbm-3.2

4 of 15

Yes

Cele\rbm-3.1

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\CSTF64

6 of 9

Yes

Atha\AT5G11412

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\RNA15

8 of 15

Yes

Scer\PTI1

2 of 15

Yes

Scer\NOP6

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Scer\SNP1

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC644.16

8 of 12

Yes

Spom\ctf1

5 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190C0V )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20525

Drosophila persimilis

Dper\GL24357

Drosophila willistoni

Dwil\GK14167

Drosophila virilis

Dvir\GJ10336

Drosophila mojavensis

Dmoj\GI23336

Drosophila grimshawi

Dgri\GH18352

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505RT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018405

Glossina morsitans

Tsetse fly

Gmor\GMOY002081

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13656

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09602

Mayetiola destructor

Hessian fly

Mdes\Mdes002661

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013869

Anopheles darlingi

American malaria mosquito

Adar\ADAC010368

Anopheles gambiae

Malaria mosquito

Agam\AGAP010918

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012662

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05PQ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006476

Danaus plexippus

Monarch butterfly

Dple\DPOGS210993-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL025026

Apis florea

Little honeybee

Aflo\2403486324

Apis mellifera

Western honey bee

Amel\GB44830

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13208

Bombus terrestris

Buff-tailed bumblebee

Bter\15206541

Linepithema humile

Argentine ant

Lhum\LH14379

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001e76

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016573

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04443

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_00127

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01419

Tribolium castaneum

Red flour beetle

Tcas\TC004378

Pediculus humanus

Human body louse

Phum\PHUM441150

Rhodnius prolixus

Kissing bug

Rpro\RPRC006841

Cimex lectularius

Bed bug

Clec\CLEC002296

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000681

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009079

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06211

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0D4M )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013164

Ixodes scapularis

Black-legged tick

Isca\ISCW015573

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57261.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g06760

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_299933

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0A7G )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cstf2

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000017649

Gallus gallus

Domestic chicken

Ggal\CSTF2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

trv

2 of 10

B52

1 of 10

CG10466

1 of 10

LS2

1 of 10

rump

1 of 10

SF2

1 of 10

U2af50

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CSTF2; cleavage stimulation factor subunit 2

10 of 15

300907

CSTF2T; cleavage stimulation factor subunit 2 tau variant

10 of 15

611968

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CstF64 - Clp

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Cpsf100

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Cpsf160

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Cpsf5

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Cpsf6

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Cpsf73

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - CstF50

anti bait coimmunoprecipitation, peptide massfingerprinting, western blot

(Sabath et al., 2013)

CstF64 - FLASH

anti bait coimmunoprecipitation, peptide massfingerprinting, western blot

(Sabath et al., 2013)

CstF64 - Fip1

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Sym

anti bait coimmunoprecipitation, western blot, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - Wdr33

anti bait coimmunoprecipitation, peptide massfingerprinting

(Sabath et al., 2013)

CstF64 - su(f)

anti bait coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Sabath et al., 2013, Hatton et al., 2000)

RNA-protein

Physical Interaction

Assay

References

CstF64 - His3

affinity technology, western blot, Identification by mass spectrometry, pull down, anti tag western blot

(Skrajna et al., 2018, Skrajna et al., 2017)

CstF64 - snRNA:U7

pull down, peptide massfingerprinting

(Sabath et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg1

suppressible

CstF64

(Tang et al., 2018)

Tsc1|gig

suppressible

CstF64

(Tang et al., 2018)

tut

enhanceable

CstF64

(Shan et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67247

DroID - A comprehensive database of gene and protein interactions.

FBgn0027841

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42239

MIST (protein-protein) - An integrated Molecular Interaction Database

CstF-64

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mRNA surveillance pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-64

Cytogenetic map

91B8-91B8

Sequence location

3R:18,659,618..18,661,126 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

91B8-91B8

Limits computationally determined from genome sequence between P{PZ}sprd⁰⁵²⁸⁴ and P{PZ}cdi⁰⁷⁰¹³&P{lacW}nos^j3B6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-64

(FlyBase, 2016)

3-63.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Bloomington

31812

w¹¹¹⁸; P{EP}CstF64^G16431

65987

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06278}attP2

76367

y^* w^*; M{UAS-CstF64.A}ZH-51D/CyO; tut⁴/TM6B, Tb¹

VDRC

v21045

w¹¹¹⁸; P{GD9942}v21045/CyO

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE27227

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027841

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH27275

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027841

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42239

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Skrajna et al., 2018, Sabath et al., 2013)

monoclonal

(Na et al., 2016)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CstF64 CstF-64

(Sabath et al., 2013)

Source for database merge of

Additional comments

PCR analysis suggests that "CstF-64" maps to 91D1 before the distal end of Df(3R)Cha5 but after the distal end of Df(3R)Cha^M5. The only gene known in this interval is "l(3)91Cd" but as the mutants for "l(3)91Cd" are no longer extant it is not possible to test whether these are the same gene.

(Hatton et al., 2000)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42239

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027841

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027841

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CstF-64_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7697

Flygut - An atlas of the Drosophila adult midgut

FBgn0027841

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42239

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004378

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7697

modMine - A data warehouse for the modENCODE project

FBgn0027841

Linkouts

BioGRID - A database of protein and genetic interactions.

67247

DroID - A comprehensive database of gene and protein interactions.

FBgn0027841

DRSC - Results frm RNAi screens

FBgn0027841

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0027841

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG7697-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027841

FlyMine - An integrated database for Drosophila genomics

FBgn0027841

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42239

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

mRNA surveillance pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

CstF-64

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG7697

(Çiçek et al., 2016, Na et al., 2016, Hosono et al., 2015, Shanshan and Laixin, 2015, Perkins et al., 2009, Mount and Salz, 2000, O'Hare, 2000.8.2)

CStF 64

(Lasko, 2000)

CstF 64

(Wagner et al., 2007)

CstF-64

(Brewer-Jensen et al., 2016, Na et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Guo et al., 2011, Ding et al., 2010, Kong et al., 2010, Salisbury et al., 2006)

CstF64

(Skrajna et al., 2018, Tang et al., 2018, Moschall et al., 2017, Shan et al., 2017, Skrajna et al., 2017, Tatomer et al., 2014, Sabath et al., 2013, Ezzeddine et al., 2011, Sullivan et al., 2009, Wagner et al., 2007, Gawande et al., 2006)

dCstF64

(Soller and White, 2003)

Name Synonyms

Cleavage stimulation factor 64 kD subunit

Cleavage stimulation factor 64 kilodalton subunit

cleavage stimulation factor

(Soller and White, 2003)

Secondary FlyBase IDs

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Study focus (0)

Experimental Role

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References (55)

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