FB2025_04 , released October 2, 2025
Gene: Dmel\Nup107
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General Information
Symbol
Dmel\Nup107
Species
D. melanogaster
Name
Nucleoporin 107kD
Annotation Symbol
CG6743
Feature Type
protein_coding_gene
FlyBase ID
FBgn0027868
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Plays a role in nuclear pore complex (NPC) assembly and maintenance (PubMed:20547758). Required for nuclear import of Mad (PubMed:20547758). Mediates the association between the nuclear pore complex and a subset of active chromatin regions adjacent to lamin-associated domains (PubMed:31784359). Plays a role in double strand break repair by relocalizing the heterochromatic double strand breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope (PubMed:27402967). Regulates female gonad development and oogenesis (PubMed:26485283). (UniProt, Q9V466)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Nup170, BcDNA:LD18761 , Nup

Key Links
Genomic Location
Cytogenetic map
32A5-32A5
Sequence location
Recombination map
2-43
RefSeq locus
NT_033779 REGION:10733293..10736071
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Gozalo et al., 2020)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables structural constituent of nuclear pore
inferred from electronic annotation with InterPro:IPR007252
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P57740
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000313483
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in double-strand break repair via homologous recombination
inferred from mutant phenotype
(Ryu et al., 2015)
involved_in eggshell formation
inferred from mutant phenotype
(Weinberg-Shukron et al., 2015)
involved_in female gonad development
inferred from mutant phenotype
(Weinberg-Shukron et al., 2015)
involved_in male meiosis cytokinesis
inferred from mutant phenotype
(Hayashi et al., 2016)
involved_in meiosis I cytokinesis
inferred from mutant phenotype
(Hayashi et al., 2016)
involved_in positive regulation of protein localization to nucleus
inferred from mutant phenotype
(Hayashi et al., 2016)
involved_in protein import into nucleus
inferred from mutant phenotype
(Chen and Xu, 2010)
involved_in regulation of nucleocytoplasmic transport
inferred from mutant phenotype
(Wu et al., 2019)
involved_in spermatocyte division
inferred from mutant phenotype
(Hayashi et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in mRNA export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000313483
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P57740
(Gene Ontology Curators, 2002-)
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
inferred from biological aspect of ancestor with PANTHER:PTN000313483
(GO Reference Genome Project, 2011-)
involved_in protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000313483
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in nuclear envelope
inferred from direct assay
(Katsani et al., 2008)
located_in nuclear periphery
inferred from direct assay
(Gozalo et al., 2020)
part_of nuclear pore
inferred from direct assay
(Gozalo et al., 2020)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of nuclear pore outer ring
inferred from biological aspect of ancestor with PANTHER:PTN000313483
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P57740
(Gene Ontology Curators, 2002-)
part_of nuclear pore
inferred from electronic annotation with InterPro:IPR007252
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the nucleoporin Nup84/Nup107 family. (Q9V466)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
NUCLEAR PORE COMPLEX -
The Nuclear Pore Complex (NPC) is a large protein complex embedded in the nuclear membrane that facilitates nucleocytoplasmic traffic. The NPC is composed of approximately 30 different proteins: the nucleoporins. The NPC displays 8-fold symmetry and each nucleoporin is present in multiple copies. From the central ring that forms the pore, filaments protrude into the cytoplasm (cytoplasmic filaments) and the nucleoplasm (nuclear basket). Many nucleoporins contain FG repeats which are thought to act as a diffusion barrier and docking sight for transport receptors (karyopherins). Export and import is controlled by the interaction of the karyopherins with localization and export sequences. (Adapted from FBrf0220062 and PMID:21495847).
Protein Function (UniProtKB)
Plays a role in nuclear pore complex (NPC) assembly and maintenance (PubMed:20547758). Required for nuclear import of Mad (PubMed:20547758). Mediates the association between the nuclear pore complex and a subset of active chromatin regions adjacent to lamin-associated domains (PubMed:31784359). Plays a role in double strand break repair by relocalizing the heterochromatic double strand breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope (PubMed:27402967). Regulates female gonad development and oogenesis (PubMed:26485283).
(UniProt, Q9V466)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Nup107 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V466)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Nup107-RA
FBtr0080121
NM_135602
2715
845
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Nup107-PA
FBpp0079710
97.4
845
5.79
Q9V466
NP_609446
AAF53002
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Part of the nuclear pore complex (NPC).

(UniProt, Q9V466)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nup107 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.86

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nuclear envelope
inferred from direct assay
(Katsani et al., 2008)
located_in nuclear periphery
inferred from direct assay
(Gozalo et al., 2020)
part_of nuclear pore
inferred from direct assay
(Gozalo et al., 2020)
Expression Deduced from Reporters
Reporter: P{mRFP-Nup107.K}
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
follicle cell
(Groen et al., 2015)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nup107 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Nup107
Transgenic constructs containing regulatory region of Nup107
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel8026
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\NUP107
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Nup107
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Nup107
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\nup107
7 of 13
Yes
Yes
Xtro\prr13
6 of 13
No
Yes
Xtro\ciao1
5 of 13
No
No
Xtro\nek4
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\nup107
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\npp-5
4 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001685
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT3G14120
9 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\NUP84
11 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\nup107
11 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Nup107. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
NUP107; nucleoporin 107
model of  ovarian dysgenesis 6
IEA
(FlyBase, 2019-)
model of  nephrotic syndrome type 11
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 2 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NUP107; nucleoporin 107
14 of 14
607617
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Subunit Structure (UniProtKB)
Part of the nuclear pore complex (NPC).
(UniProt, Q9V466 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-43
Cytogenetic map
32A5-32A5
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
32A5-32A5
Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

2-43

(FlyBase, 2016)

2-36.5

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (12)
Genomic Clones (14)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (130)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Gozalo et al., 2020, Katsani et al., 2008)
Commercially Available Antibodies
 
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
    Other Comments
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (10)
    Reported As
    Symbol Synonym
    BcDNA:LD18761
    (Giot et al., 2003, Zinke et al., 2002)
    CG6743
    (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Müller et al., 2010, Keleman et al., 2009.8.5, Katsani et al., 2008, Sabri et al., 2007, Dimova et al., 2003)
    Nup
    (Lucas et al., 2018, Lucas et al., 2013)
    Nup 107
    (Clark and Aquadro, 2010)
    Nup107
    (Klumpe et al., 2025, Merigliano et al., 2025, Doronin et al., 2024, Ryu et al., 2024, Yamamoto-Hino et al., 2024, di Pietro et al., 2023, Emond-Fraser et al., 2023, McQuarrie et al., 2023, Sarkar et al., 2023, Bose et al., 2022, Falo-Sanjuan and Bray, 2022, National Institute of Genetics Fly Stocks, 2022-, Richards et al., 2022, Shore et al., 2022, Capelson, 2021.7.27, Jacquemyn et al., 2021, Layalle et al., 2021, Garrido et al., 2020, Gozalo et al., 2020, Levi et al., 2020, Mehta et al., 2020, Warecki et al., 2020, Hampoelz et al., 2019, Ren et al., 2019, Wu et al., 2019, Chou et al., 2018, Hirai et al., 2018, Steyaert et al., 2018, Yuva-Aydemir et al., 2018, Amaral et al., 2017, Caridi et al., 2017, Montembault et al., 2017, Boeynaems et al., 2016, Frey et al., 2016, Sarov et al., 2016, Freibaum et al., 2015, Groen et al., 2015, Karg et al., 2015, Ryu et al., 2015, Weinberg-Shukron et al., 2015, Katsani et al., 2014, Pascual-Garcia et al., 2014, Finan et al., 2011, Friedman et al., 2011, Kallappagoudar et al., 2010, Müller et al., 2010, Neumann et al., 2010, Leatherbarrow and Halfon, 2009, Karess, 2007.6.29, Presgraves and Stephan, 2007)
    Nup170
    (Okuda et al., 2022, Vardanyan et al., 2008)
    dmNup107
    (Senger et al., 2011)
    nup107
    (Munafò et al., 2021, Ryu et al., 2015, Chen and Xu, 2010, Katsani et al., 2008)
    Name Synonyms
    Nucleoporin 107
    Nucleoporin 107kD
    Nup107
    Nup170
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 80 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      References (111)