Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.50
3.053, 1.119 (longest cDNA)
753, 372 (aa); 200, 95 (kD observed)
Homodimer (PubMed:10480937). Interacts with Cam; interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937). Interacts with N/Notch; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414). Interacts with Pka-R2 (PubMed:10480936, PubMed:10480937). Binds to F-actin; interaction is independent of myristoylation, but is inhibited by Akap200 phosphorylation and Cam binding (PubMed:10480937). Isoform B: Does not bind to Pka-R2 (PubMed:10480936).
Myristoylated; myristoylation promotes accumulation at the cell periphery.
Phosphorylated; phosphorylation prevents binding to F-actin and Cam.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Akap200 using the Feature Mapper tool.
Comment: reported as head epidermis primordium
GBrowse - Visual display of RNA-Seq signalsView Dmel\Akap200 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Akap200 mutant ovaries have enlarged, thin ring canals and binucleate nurse cells are seen.
Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background.
Area matching Drosophila EST AA803082. Forms 2166bp EST contig with AA941565, AA820668, AA978815 and AA697381.
Area matching Drosophila ESTs AI114059 and AA941565.