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Gene Dmel\msb1l

General Information
Symbol	Dmel\msb1l	Species	D. melanogaster
Name	msb1l	Annotation symbol	CG10364
Feature type	protein_coding_gene	FlyBase ID	FBgn0027949
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37F2-37F2	Sequence location	2L:19,577,707..19,579,131 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene msb1l is referred to in FlyBase by the symbol Dmel\msb1l (CG10364, FBgn0027949). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631344_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of msb1l. Gene sequence location is 2L:19577707..19579131.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA03572 BKN23775
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37F2-37F2   Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\msb1l for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) msb1l-RA FBtr0081258  NM_136147   1360   381
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein msb1l-PA   FBpp0080799   42.5   381   5.54     NP_609991   AAF53832
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390920   AA392671   AA440490   AA538599   AA950422   AA951525   AE014134 AAF53832   AF178442 AAF01024   AI062261   AI455829   AI456091   AI456612   AI511645   AI518096   AI519490   AW943115   AY051807 AAK93231   BF505940   BG633684   BG636408   BI170190   BI215093   BI241556   BI361668   BI361980   BI365196   BI366939   BI368538   BI370506   BI633028   BI635370   BI637539   BI640244   BT001884 AAN71658   CK131780   CL868446   CO186878   CO261805   CO262122   CO263126   CO263593   CO291225   CO302278   CO305845   EC068973   EC070719   EC081941   EC082092   EC212317   EC219651   EC222798   EC223004   EC231303   EC237945   EC242474   EC246246   FE862820   FE862872   FE862930   FE862978   FE863024   FE863065   FE863117
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGA0 Q9U6R8 Q9VIT3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027949    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027949 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027949 expression level Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr    15395 embryo 04-06hr    25411 embryo 06-08hr    18279 embryo 08-10hr    10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8326) embryo 02-04hr  (15395) embryo 04-06hr  (25411) embryo 06-08hr  (18279) embryo 08-10hr  (10316) embryo 10-12hr  (3824) embryo 12-14hr  (2346) embryo 14-16hr  (2437) embryo 16-18hr  (1824) embryo 18-20hr  (962) embryo 20-22hr  (3059) embryo 22-24hr  (2819) larva L1  107 larva L2  (185) larva L3 12hr old  (240) larva L3 puffstage 1-2  (801) larva L3 puffstage 3-6  (1176) larva L3 puffstage 7-9  (1359) white prepupae new  (1194) white prepupae 12hr  (2268) white prepupae 24hr  (2055) pupae 2d postWPP  (899) pupae 3d postWPP  (587) pupae 4d postWPP  (618) adult male 01day  (797) adult male 05day  (1341) adult male 30day  (1367) adult female 01day  (1455) adult female 05day  (3126) adult female 30day  (3293) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8326) embryo 02-04hr  (15395) embryo 04-06hr  (25411) embryo 06-08hr  (18279) embryo 08-10hr  (10316) embryo 10-12hr  (3824) embryo 12-14hr  (2346) embryo 14-16hr  (2437) embryo 16-18hr  (1824) embryo 18-20hr    962 embryo 20-22hr  (3059) embryo 22-24hr  (2819) larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr  (2268) white prepupae 24hr  (2055) pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day  1455 adult female 05day  (3126) adult female 30day  (3293) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr  (15395) embryo 04-06hr  (25411) embryo 06-08hr  (18279) embryo 08-10hr  10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr    15395 embryo 04-06hr    25411 embryo 06-08hr    18279 embryo 08-10hr    10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027949 expression level Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr    15395 embryo 04-06hr    25411 embryo 06-08hr    18279 embryo 08-10hr    10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8326) embryo 02-04hr  (15395) embryo 04-06hr  (25411) embryo 06-08hr  (18279) embryo 08-10hr  (10316) embryo 10-12hr  (3824) embryo 12-14hr  (2346) embryo 14-16hr  (2437) embryo 16-18hr  (1824) embryo 18-20hr  (962) embryo 20-22hr  (3059) embryo 22-24hr  (2819) larva L1  107 larva L2  (185) larva L3 12hr old  (240) larva L3 puffstage 1-2  (801) larva L3 puffstage 3-6  (1176) larva L3 puffstage 7-9  (1359) white prepupae new  (1194) white prepupae 12hr  (2268) white prepupae 24hr  (2055) pupae 2d postWPP  (899) pupae 3d postWPP  (587) pupae 4d postWPP  (618) adult male 01day  (797) adult male 05day  (1341) adult male 30day  (1367) adult female 01day  (1455) adult female 05day  (3126) adult female 30day  (3293) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8326) embryo 02-04hr  (15395) embryo 04-06hr  (25411) embryo 06-08hr  (18279) embryo 08-10hr  (10316) embryo 10-12hr  (3824) embryo 12-14hr  2346 embryo 14-16hr  2437 embryo 16-18hr  1824 embryo 18-20hr    962 embryo 20-22hr  (3059) embryo 22-24hr  (2819) larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr  2268 white prepupae 24hr  2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day  1455 adult female 05day  (3126) adult female 30day  (3293) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr  15395 embryo 04-06hr  (25411) embryo 06-08hr  18279 embryo 08-10hr  10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8326 embryo 02-04hr    15395 embryo 04-06hr    25411 embryo 06-08hr    18279 embryo 08-10hr    10316 embryo 10-12hr    3824 embryo 12-14hr    2346 embryo 14-16hr    2437 embryo 16-18hr    1824 embryo 18-20hr    962 embryo 20-22hr    3059 embryo 22-24hr    2819 larva L1    107 larva L2    185 larva L3 12hr old    240 larva L3 puffstage 1-2    801 larva L3 puffstage 3-6    1176 larva L3 puffstage 7-9    1359 white prepupae new    1194 white prepupae 12hr    2268 white prepupae 24hr    2055 pupae 2d postWPP    899 pupae 3d postWPP    587 pupae 4d postWPP    618 adult male 01day    797 adult male 05day    1341 adult male 30day    1367 adult female 01day    1455 adult female 05day    3126 adult female 30day    3293 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027949    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027949 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0027949 expression level Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (654.85) Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary  (696.4) Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0027949 expression level Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary  696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    654.85 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    8.3 Larval Fat Body    98 Larval Salivary Gland no informative data Larval Trachea    77.45 Larval Carcass no informative data Adult Head    2.5 Adult Eye    1.925 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    1.1 Adult Crop    4.9 Adult Midgut no informative data Adult Hindgut    4.4 Adult Malpighian Tubules    4.4 Adult Fat Body    4.9 Adult Salivary Gland    5.5 Adult Heart    1.225 Adult VirginFemale Spermatheca    2.4 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    696.4 Adult Testis    424.1 Adult Male Accessory Gland    0.9 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.5   NA  Eye    1.925   NA  Brain    3.3   654.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.1   NA  Crop    4.9   no informative data  Midgut    no informative data   no informative data  Hindgut    4.4   8.3  Malpighian Tubules    4.4   98  Fat Body    4.9   no informative data  Salivary Gland    5.5   NA  Heart    1.225   77.45  Trachea    NA   NA  VirginFemale Spermatheca    2.4   NA  InseminatedFemale Spermatheca    2.6   NA  Ovary    696.4   NA  Testis    424.1   NA  Male Accessory Gland    0.9   no informative data  Carcass    7.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027949 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10364-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for msb1l Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable msb1lEY10753 viable, with Scer\GAL4pnr-MD237 msb1lGD6957 Sterility Allele fertile msb1lEY10753 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 msb1lGD6957 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 msb1lGD6957
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of msb1l Class Mutagen Stocks Known lesion msb1lEY10753 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of msb1l Class Mutagen Stocks Known lesion msb1lGD17084 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes msb1lGD6957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6044 (Ryder, 2004.4.26) Df(2L)Exel8041 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6957} NA P{GD17084} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}msb1lEY10753 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a biological process, cellular component or molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions msb1l allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61230 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027949 DroID - A comprehensive database of gene and protein interactions. • FBgn0027949 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35254
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14252 Dere\GG21201 Dgri\GH13428 Dmoj\GI13947 Dper\GL25555 Dpse\GA10275 Dsec\GM17372 Dsim\GD24228 Dvir\GJ18232 Dwil\GK14920 Dyak\GE13275
Curated drosophilid orthologs	Dpse\GA10275
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001922-PA Aedes aegypti (mosquito) AGAP005363-PA Anopheles gambiae (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230961 FBgn0216925 FBgn0205394 FBgn0195577 FBgn0172282 FBgn0070333 FBgn0163139 FBgn0136701 FBgn0120904 FBgn0113381 FBgn0091279 CPIJ012115 CPIJ009918 AGAP005363 AAEL001922
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	20632 y1 w67c23; P{EPgy2}msb1lEY10753
VDRC	v16035 w1118; P{GD6957}v16035 v48314 w1118; P{GD17084}v48314/TM3
Genomic Clones ( 1 )
	BACR30H01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32040 SD14117
Other clones	DPiM_LD32040
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08273 GH01408 LD11755 LD11927 LD13290 LD18166 LD30190 LD35540 LD35932 LD36689 LD37514 LD39103 LD43121 LP12783 RE11568 RE21309 RE38655 RE45985 RE46427 RE50435 RE52583 RE54526 RE57148 SD16701 SD19580 SD23055 SD26983
Other clones	52833 55638 59843 69940 146839 CK01.28B.C10 CK01.99D.H11 CK01.104B.D12 CK01.106C.G1 EK024243 EK076732 EK079748 EK084432 EK087546 EK089025 EK183815 EK249541 GM06980 RM06634 RM06834 RM06934 RM07034 RM07134 RM07234 RM07334
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027949 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35254
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136147 RefSeq (Proteins) • NP_609991 DDBJ / EMBL / GenBank • AA951525 AAF01024 AAF53832 AAK93231 AAN71658 AF178442 AW943115 AY051807 BG636408 BT001884 CL868446 Entrez Gene - A searchable database of RefSeq genes. • 35254 UniProtKB/TrEMBL • Q8IGA0 Q9U6R8 Q9VIT3
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 61230 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0027949 DroID - A comprehensive database of gene and protein interactions. • FBgn0027949 DRSC - Results from RNAi screens. • FBgn0027949 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027949 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10364-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027949 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35254 InParanoid A subset of ortholog calls from InParanoid. • AAEL001922-PA Aedes aegypti (mosquito) AGAP005363-PA Anopheles gambiae (mosquito) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35254 modMine - Data generated by the modENCODE project. • FBgn0027949 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230961 FBgn0216925 FBgn0205394 FBgn0195577 FBgn0172282 FBgn0070333 FBgn0163139 FBgn0136701 FBgn0120904 FBgn0113381 FBgn0091279 CPIJ012115 CPIJ009918 AGAP005363 AAEL001922
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG10364 (Asha et al., 2003, ) msb1l (Mensch et al., 2008, Magalhaes et al., 2007) msh1l (Asha et al., 2003)
Name Synonym	msb1l
Secondary FlyBase IDs
References ( 12 )
Research paper	Mensch et al., 2008, BMC Dev. Biol. 8: 78 Identifying candidate genes affecting developmental time in Drosophila melanogaster: pervasive pleiotropy and gene-by-environment interaction. [FBrf0205813] Magalhaes et al., 2007, BMC Neurosci. 8: 59 Transcriptional control in embryonic Drosophila midline guidance assessed through a whole genome approach. [FBrf0201584] Asha et al., 2003, Genetics 163(1): 203--215 Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]