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Gene Dmel\MTA1-like

General Information
Symbol	Dmel\MTA1-like	Species	D. melanogaster
Name	MTA1-like	Annotation symbol	CG2244
Feature type	protein_coding_gene	FlyBase ID	FBgn0027951
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dMTA1-like
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83B7-83B7	Sequence location	3R:1,464,377..1,474,459 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene MTA1-like is referred to in FlyBase by the symbol Dmel\MTA1-like (CG2244, FBgn0027951). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; zinc ion binding. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 12 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Bromo adjacent homology (BAH) domain; ELM2 domain; Homeodomain-like; Myb, DNA-binding; SANT domain, DNA binding; SANT, eukarya; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding; Zinc finger, GATA-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Gene sequence location is 3R:1464377..1474459.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN31241 HFA12382 BKN45588 BKN28061
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B7-83B7   Limits computationally determined from genome sequence between P{lacW}Atus1938 and P{lacW}casj1C2
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MTA1-like for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 DGC clone LD15632 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MTA1-like-RA FBtr0078733  NM_169086   4166   880 MTA1-like-RB FBtr0078734  NM_141309   4058   844 MTA1-like-RC FBtr0290206  NM_001144539   4976   853
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MTA1-like-PA   FBpp0078382   96.6   880   9.80     NP_730976   AAF51980 MTA1-like-PB   FBpp0078383   92.8   844   9.85     NP_649566   AAF51981 MTA1-like-PC   FBpp0288645   93.7   853   9.82     NP_001138011   ACL83470
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, GATA-type (IPR000679) ELM2 domain (IPR000949) SANT domain, DNA binding (IPR001005) Bromo adjacent homology (BAH) domain (IPR001025) Zinc finger, C2H2 (IPR007087) Homeodomain-like (IPR009057) Zinc finger, C2H2-like (IPR015880) Myb, DNA-binding (IPR014778) SANT, eukarya (IPR017884) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201265   AA201691   AA202682   AA246573   AA247024   AA264592   AA264914   AA391581   AA391764   AA391805   AA438544   AA439107   AA440759   AA539458   AA539494   AA567780   AA694724   AA696460   AA816412   AA820636   AA941221   AA949267   AA951824   AE014297 AAF51980   AE014297 AAF51981   AE014297 ACL83470   AF170345 AAD55388   AF171805   AI402331   AI517197   AI532371   AW942369   AW942705   AY058628 AAL13857   AY061204 AAL28752   AY075389   BF501444   BG637812   BG638045   BG638669   BI168700   BI235535   BI239356   BI353374   BI356928   BI357750   BI358343   BI361649   BI361650   BI362360   BI363279   BI363948   BI364883   BI365504   BI368928   BI370014   BI481991   BI482499   BI621776   BI635371   BI637980   BT003590 AAO39593   BT015176 AAT94405   CK661041   CL844354   CO178457   CO179224   CO185880   CO188817   CO188831   CO272425   CO272724   CO272897   CO276553   CO277875   CO283278   CO285117   CO287211   CO289491   CO289544   CO289951   CO293754   CO294107   CO295709   CO296072   CO297660   CO304770   CO306728   CO307509   CO314289   CO321249   CO323473   CO329968   CO330179   CO333510   CO338473   CZ471877   CZ476580   EC058244   EC058748   EC061225   EC061234   EC063859   EC068671   EC068825   EC069786   EC069849   EC070251   EC072389   EC079366   EC080102   EC082948   EC085803   EC086777   EC088753   EC089211   EC090289   EC194703   EC197571   EC198590   EC204085   EC206533   EC216729   EC220729   EC222885   EC223630   EC229134   EC229803   EC233971   EC236196   EC238075   EC239446   EC241165   EC242231   EC249060   EC263502   ES695077   EV586056   EV589542   GH945341   GH950865   GH952629   GH955874   GH959701   GH962445   GH963653   GH967830   GH972461   GH976316   GH976495   GH981514   GH983741
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q6AWS2 Q95RR0 Q95TP6 Q9U6X3 Q9VNF6 Q9VNF7 B7Z0T5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0027951    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0027951 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0027951 expression level Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5558) embryo 02-04hr  (7485) embryo 04-06hr  (6669) embryo 06-08hr  (6656) embryo 08-10hr  (5776) embryo 10-12hr  (4615) embryo 12-14hr  (3584) embryo 14-16hr  (3632) embryo 16-18hr  (2345) embryo 18-20hr  (1397) embryo 20-22hr  (1577) embryo 22-24hr  (1508) larva L1  (1127) larva L2  (1023) larva L3 12hr old  (832) larva L3 puffstage 1-2  (905) larva L3 puffstage 3-6  (1549) larva L3 puffstage 7-9  (1645) white prepupae new  (1898) white prepupae 12hr  (1944) white prepupae 24hr  (2640) pupae 2d postWPP  (2202) pupae 3d postWPP  (925) pupae 4d postWPP  (737) adult male 01day  (895) adult male 05day  (912) adult male 30day  (1026) adult female 01day  (2264) adult female 05day  (3271) adult female 30day  (3284) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5558) embryo 02-04hr  (7485) embryo 04-06hr  (6669) embryo 06-08hr  (6656) embryo 08-10hr  (5776) embryo 10-12hr  (4615) embryo 12-14hr  (3584) embryo 14-16hr  (3632) embryo 16-18hr  (2345) embryo 18-20hr    1397 embryo 20-22hr  (1577) embryo 22-24hr  1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6  (1549) larva L3 puffstage 7-9  (1645) white prepupae new  (1898) white prepupae 12hr  (1944) white prepupae 24hr  (2640) pupae 2d postWPP  (2202) pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day  (2264) adult female 05day  (3271) adult female 30day  (3284) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0027951 expression level Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5558) embryo 02-04hr  (7485) embryo 04-06hr  (6669) embryo 06-08hr  (6656) embryo 08-10hr  (5776) embryo 10-12hr  (4615) embryo 12-14hr  (3584) embryo 14-16hr  (3632) embryo 16-18hr  (2345) embryo 18-20hr  (1397) embryo 20-22hr  (1577) embryo 22-24hr  (1508) larva L1  (1127) larva L2  (1023) larva L3 12hr old  (832) larva L3 puffstage 1-2  (905) larva L3 puffstage 3-6  (1549) larva L3 puffstage 7-9  (1645) white prepupae new  (1898) white prepupae 12hr  (1944) white prepupae 24hr  (2640) pupae 2d postWPP  (2202) pupae 3d postWPP  (925) pupae 4d postWPP  (737) adult male 01day  (895) adult male 05day  (912) adult male 30day  (1026) adult female 01day  (2264) adult female 05day  (3271) adult female 30day  (3284) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5558) embryo 02-04hr  (7485) embryo 04-06hr  (6669) embryo 06-08hr  (6656) embryo 08-10hr  (5776) embryo 10-12hr  (4615) embryo 12-14hr  (3584) embryo 14-16hr  (3632) embryo 16-18hr  2345 embryo 18-20hr    1397 embryo 20-22hr  1577 embryo 22-24hr  1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6  1549 larva L3 puffstage 7-9  1645 white prepupae new  1898 white prepupae 12hr  1944 white prepupae 24hr  (2640) pupae 2d postWPP  2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day  2264 adult female 05day  (3271) adult female 30day  (3284) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5558 embryo 02-04hr    7485 embryo 04-06hr    6669 embryo 06-08hr    6656 embryo 08-10hr    5776 embryo 10-12hr    4615 embryo 12-14hr    3584 embryo 14-16hr    3632 embryo 16-18hr    2345 embryo 18-20hr    1397 embryo 20-22hr    1577 embryo 22-24hr    1508 larva L1    1127 larva L2    1023 larva L3 12hr old    832 larva L3 puffstage 1-2    905 larva L3 puffstage 3-6    1549 larva L3 puffstage 7-9    1645 white prepupae new    1898 white prepupae 12hr    1944 white prepupae 24hr    2640 pupae 2d postWPP    2202 pupae 3d postWPP    925 pupae 4d postWPP    737 adult male 01day    895 adult male 05day    912 adult male 30day    1026 adult female 01day    2264 adult female 05day    3271 adult female 30day    3284 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0027951    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0027951 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027951 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31545-RA;CG2244-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable MTA1-likeEY10750 viable, with Scer\GAL4pnr-MD237 MTA1-likeGD9759 Sterility Allele fertile MTA1-likeEY10750 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 MTA1-likeGD9759 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 MTA1-likeGD9759
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of MTA1-like Class Mutagen Stocks Known lesion MTA1-liked09140 P-element activity 2 -- MTA1-liked00901 P-element activity 1 -- MTA1-likeDP00445 1 -- MTA1-likeEY10750 P-element activity 1 -- MTA1-likeMI01790 1 -- MTA1-likeCPTI000256 piggyBac transposase 0 Yes MTA1-likeCPTI001990 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MTA1-like Class Mutagen Stocks Known lesion MTA1-likeGD9759 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MTA1-likeHMS01084 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MTA1-likeHMS01251 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MTA1-likeHMS01299 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MTA1-likeKK108061 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9759} NA P{KK108061} NA P{TRiP.HMS01084} NA P{TRiP.HMS01251} NA P{TRiP.HMS01299} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}MTA1-likeEY10750 NA P{Mae-UAS.6.11}MTA1-likeDP00445 NA P{XP}MTA1-liked00901 NA P{XP}MTA1-liked09140 NA miscellaneous insertions Mi{MIC}MTA1-likeMI01790 NA PBac{602.P.SVS-1}MTA1-likeCPTI000256 NA PBac{681.P.FSVS-1}MTA1-likeCPTI001990 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
histone deacetylase complex inferred from direct assay (Barlow et al., 2001)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR000679 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR000679 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR000679, InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR000679 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MTA1-like allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65899 DroID - A comprehensive database of gene and protein interactions. • FBgn0027951 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40693
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17406 Dere\GG10908 Dgri\GH19193 Dmoj\GI24226 Dper\GL23145 Dpse\GA27157 Dsec\GM10605 Dsim\GD19594 Dvir\GJ10798 Dwil\GK10851 Dyak\GE24151
Curated drosophilid orthologs	Dsec\MTA1-like (Dworkin and Jones, 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008611-PA Aedes aegypti (mosquito) AGAP004341-PA Anopheles gambiae (mosquito) XP_396763.3 Apis mellifera (honey bee) XP_001945975.1 Acyrthosiphon pisum (pea aphid) 217047 Branchiostoma floridae (lancelet) XP_001896367.1 Brugia malayi (roundworm nematode) BGIBMGA004821-PA Bombyx mori (silk worm) ENSBTAP00000015748 Bos taurus (bovine) CBP34161 Caenorhabditis briggsae (nematode) CE21211 Caenorhabditis elegans (worm) ENSCAFP00000009773 Canis familiaris (dog) ENSCINP00000013282 Ciona intestinalis (sea squirt) JA04683 Caenorhabditis japonica (nematode) CPIJ005379 Culex pipens (mosquito) ENSCPOP00000014361 Cavia porcellus (guinea pig) ENSCSAVP00000000306 Ciona savignyi (sedentary tunicate) 46320 Daphnia pulex (daphnia) ENSDARP00000071648 Danio rerio (zebra fish) ENSECAP00000007626 Equus caballus (horse) ENSGACP00000003650 Gymnopilus aculeatus (mushroom) ENSGALP00000004425 Gallus gallus (chicken) 187398 Hypsipyla robusta (cedar shoot borer) ENSP00000333633 Homo sapiens (human) ISCW003309-PA Ixodes scapularis (deer tick) 180212 Lottia gigantea (owl limpet) ENSMODP00000000450 Monodelphis domestica (gray opossum) ENSMMUP00000022782 Macaca mulatta (rhesus monkey) ENSMUSP00000068931 Mus musculus (house mouse) 107943 Nematostella vectensis (starlet anemone) XP_001602629.1 Nasonia vitripennis (wasp) ENSOANP00000007272 Ornithorynchus anatinus (platypus) ENSORLP00000014788 Oryzias latipes (japanese killifish) PHUM004212-PA Pediculus humanus (human body louse) ENSPPYP00000007052 Pongo pygmaeus (orangutan) ENSPTRP00000011606 Pan troglodytes (chimpanzee) ENSRNOP00000043558 Rattus norvegicus (norway rat) Smp_049730.2 Schistosoma mansoni (trematode parasite) XP_001194554.1 Strongylocentrotus purpuratus (purple sea urchin) 33395 Trichoplax adhaerens (metazoa) XP_975498.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022474 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032391 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038916 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12099 NV14853 LH12011 ISCW003309 FBgn0241285 FBgn0212862 FBgn0198069 FBgn0191087 FBgn0165551 JGI_V11_46320 FBgn0248528 FBgn0160735 FBgn0146949 FBgn0126660 FBgn0103212 FBgn0094424 CPIJ005379 BGIBMGA004821 ACYPI001458 GB15896 AGAP004341 AAEL008611 PHUM171690 GLEAN_08832
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	34249 y1 w*; Mi{MIC}MTA1-likeMI01790 33745 y1 sc* v1; P{TRiP.HMS01084}attP2 34624 y1 sc* v1; P{TRiP.HMS01299}attP2 20209 y1 w67c23; P{EPgy2}MTA1-likeEY10750 19306 w1118; P{XP}MTA1-liked09140/TM6B, Tb1 22052 y1 w67c23; P{Mae-UAS.6.11}MTA1-likeDP00445 34905 y1 sc* v1; P{TRiP.HMS01251}attP2/TM3, Sb1
Harvard	- P{XP}MTA1-liked00901 - P{XP}MTA1-liked09140
VDRC	v20855 w1118; P{GD9759}v20855 v20857 w1118; P{GD9759}v20857/TM3
Genomic Clones ( 1 )
	BACR03P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 137 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD04853 LD15632 LD24461 LD32549 SD15071
Other clones	AF171805
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16781 GH21396 GH27854 GM01408 GM07723 GM23353 HL01758 LD01465 LD03076 LD04289 LD05654 LD06127 LD08251 LD08535 LD10601 LD10705 LD11693 LD12342 LD17591 LD17649 LD25241 LD28094 LD32562 LP20127 RE09545 RE31390 RE35828 RE43226 RE44304 RE45087 RE45962 RE45963 RE46901 RE48059 RE48942 RE50075 RE50842 RE54988 RE56376 RE64629 RE65195 RH53179 SD03865 SD16704 SD20210
Other clones	9171 16196 19069 19281 30204 43486 54122 60051 63844 74756 74855 80298 123179 144898 149156 157264 162574 191820 192226 281509 281785 571443 CK01.11C.F2 CK01.13A.D4 CK01.13A.D6 CK01.13C.B6 CK01.22B.C3 CK01.34A.G11 CK01.51D.H4 CK01.52A.A12 CK01.64D.G1 CK01.71C.E4 CK01.75A.C3 CK01.90D.E8 CK01.91B.F3 CK01.92D.E12 CK01.147B.F6 CK01.147D.F3 Dmel_dig_000813_0643_0367 Dmel_neb_011410_0356_3517 EK014047 EK042062 EK042136 EK056738 EK058810 EK065225 EK071152 EK071306 EK072650 EK107109 EK108143 EK108741 EK121322 EK127327 EK162747 EK168248 EK170308 EK190547 EK204507 EK206019 EK211401 EK212628 EK235637 EK246158 EK252054 EK254723 EK290561 EK294252 EK294654 EK307135 EN16862 LD13573 RC0-DL0001-140700-122-A06 RP004089278 RP004141382 RP004167944 RP004205916 RP004230491 RP004231377 RP004318102 RP004322266 RP004397366 RP004462826 RP004513134 RP004525368 RP004553999
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0027951 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40693
Antibody Information
	polyclonal (Reddy et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: metastasis-associated-1-like-protein CG2244 (Zheng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141309 NM_169086 NM_001144539 RefSeq (Proteins) • NP_649566 NP_730976 NP_001138011 DDBJ / EMBL / GenBank • AA201691 AA440759 AA820636 AA951824 AAD55388 AAF51980 AAF51981 AAL13857 AAL28752 AAO39593 AAT94405 ACL83470 AF170345 AW942369 AW942705 AY058628 AY061204 AY075389 BG637812 BT003590 BT015176 CL844354 CZ471877 CZ476580 Entrez Gene - A searchable database of RefSeq genes. • 40693 UniProtKB/TrEMBL • B7Z0T5 Q6AWS2 Q9U6X3 Q9VNF6 Q9VNF7 Q95RR0 Q95TP6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, GATA-type (IPR000679) ELM2 domain (IPR000949) SANT domain, DNA binding (IPR001005) Bromo adjacent homology (BAH) domain (IPR001025) Zinc finger, C2H2 (IPR007087) Homeodomain-like (IPR009057) Zinc finger, C2H2-like (IPR015880) Myb, DNA-binding (IPR014778) SANT, eukarya (IPR017884) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65899 DroID - A comprehensive database of gene and protein interactions. • FBgn0027951 DRSC - Results from RNAi screens. • FBgn0027951 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0027951 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31545-RA;CG2244-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0027951 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40693 InParanoid A subset of ortholog calls from InParanoid. • AAEL008611-PA Aedes aegypti (mosquito) AGAP004341-PA Anopheles gambiae (mosquito) XP_396763.3 Apis mellifera (honey bee) XP_001945975.1 Acyrthosiphon pisum (pea aphid) 217047 Branchiostoma floridae (lancelet) XP_001896367.1 Brugia malayi (roundworm nematode) BGIBMGA004821-PA Bombyx mori (silk worm) ENSBTAP00000015748 Bos taurus (bovine) CBP34161 Caenorhabditis briggsae (nematode) CE21211 Caenorhabditis elegans (worm) ENSCAFP00000009773 Canis familiaris (dog) ENSCINP00000013282 Ciona intestinalis (sea squirt) JA04683 Caenorhabditis japonica (nematode) CPIJ005379 Culex pipens (mosquito) ENSCPOP00000014361 Cavia porcellus (guinea pig) ENSCSAVP00000000306 Ciona savignyi (sedentary tunicate) 46320 Daphnia pulex (daphnia) ENSDARP00000071648 Danio rerio (zebra fish) ENSECAP00000007626 Equus caballus (horse) ENSGACP00000003650 Gymnopilus aculeatus (mushroom) ENSGALP00000004425 Gallus gallus (chicken) 187398 Hypsipyla robusta (cedar shoot borer) ENSP00000333633 Homo sapiens (human) ISCW003309-PA Ixodes scapularis (deer tick) 180212 Lottia gigantea (owl limpet) ENSMODP00000000450 Monodelphis domestica (gray opossum) ENSMMUP00000022782 Macaca mulatta (rhesus monkey) ENSMUSP00000068931 Mus musculus (house mouse) 107943 Nematostella vectensis (starlet anemone) XP_001602629.1 Nasonia vitripennis (wasp) ENSOANP00000007272 Ornithorynchus anatinus (platypus) ENSORLP00000014788 Oryzias latipes (japanese killifish) PHUM004212-PA Pediculus humanus (human body louse) ENSPPYP00000007052 Pongo pygmaeus (orangutan) ENSPTRP00000011606 Pan troglodytes (chimpanzee) ENSRNOP00000043558 Rattus norvegicus (norway rat) Smp_049730.2 Schistosoma mansoni (trematode parasite) XP_001194554.1 Strongylocentrotus purpuratus (purple sea urchin) 33395 Trichoplax adhaerens (metazoa) XP_975498.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022474 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032391 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000038916 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40693 modMine - Data generated by the modENCODE project. • FBgn0027951 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12099 NV14853 LH12011 ISCW003309 FBgn0241285 FBgn0212862 FBgn0198069 FBgn0191087 FBgn0165551 JGI_V11_46320 FBgn0248528 FBgn0160735 FBgn0146949 FBgn0126660 FBgn0103212 FBgn0094424 CPIJ005379 BGIBMGA004821 ACYPI001458 GB15896 AGAP004341 AAEL008611 PHUM171690 GLEAN_08832
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG2244 (Mount, 2001.8.14, Kirienko and Fay, 2010, Reddy et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dMTA (Eberharter and Becker, 2004) dMTA-1 (Taylor-Harding et al., 2004) dMTA1-like (Ballestar et al., 2001, Taylor-Harding et al., 2004) MTA1-like (Stroschein-Stevenson et al., 2006, Bajpe et al., 2008, Stielow et al., 2008, Reddy et al., 2010, Wasbrough et al., 2010) MTA-like (Marhold et al., 2004) p120 (Barlow et al., 2001)
Name Synonym	metastasis-associated-1-like-protein   MTA1-like   MTA-like (Ashburner, 2004.6.30)
Secondary FlyBase IDs
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 )
Recent research papers ( 2 )
	Kirienko and Fay, 2010, EMBO J. 29(4): 727--739 SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. [FBrf0210031] Reddy et al., 2010, Mol. Cell. Biol. 30(21): 5234--5244 Drosophila Transcription Factor Tramtrack69 Binds MEP1 To Recruit the Chromatin Remodeler NuRD. [FBrf0212010] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...