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Gene Dmel\l(1)G0255

General Information
Symbol	Dmel\l(1)G0255	Species	D. melanogaster
Name	lethal (1) G0255	Annotation symbol	CG4094
Feature type	protein_coding_gene	FlyBase ID	FBgn0028336
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	6C5-6C5	Sequence location	X:6,572,499..6,575,887 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (1) G0255 is referred to in FlyBase by the symbol Dmel\l(1)G0255 (CG4094, FBgn0028336). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: fumarate hydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process: tricarboxylic acid cycle. 7 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Fumarase C, C-terminal; Fumarase/histidase, N-terminal; Fumarate hydratase, class II; Fumarate lyase; Fumarate lyase, N-terminal; Fumarate lyase, conserved site; L-Aspartase-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult midgut, larval fat body, larval salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1635025_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of l(1)G0255. Gene sequence location is X:6572499..6575887.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 6C5-6C5   Limits computationally determined from genome sequence between P{EP}Ctr1AEP1364&P{EP}EP1445 and P{EP}C3GEP1613
Experimentally Determined Cytological Location
Cytogenetic map Notes References 6C1-6C7   (determined by in situ hybridisation) 6C4--8 (determined by in situ hybridisation)   (Peter et al., 2002) 6C1-6C7   (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 6C4-6C8   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(1)G0255 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Evidence indicates that 3' UTR overlaps 5' UTR of downstream gene; extends to coordinate AE003438:141885 (based upon 3' extent of LD46083)
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(1)G0255-RA FBtr0070953  NM_132111   1707   495 l(1)G0255-RB FBtr0070954  NM_167081   1699   467
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(1)G0255-PA   FBpp0070914   53.6   495   8.67     NP_572339   AAF46186 l(1)G0255-PB   FBpp0070915   50.5   467   7.62     NP_727108   AAN09177
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fumarate lyase (IPR000362) Fumarate hydratase, class II (IPR005677) L-Aspartase-like (IPR008948) Fumarase C, C-terminal (IPR018951) Fumarase/histidase, N-terminal (IPR024083) Fumarate lyase, conserved site (IPR020557) Fumarate lyase, N-terminal (IPR022761) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME04094
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202562   AA695872   AA696703   AA801512   AA941118   AE014298 AAF46186   AE014298 AAN09177   AI061763   AI063557   AI064497   AI107027   AI107331   AI108590   AI109647   AI113975   AI134163   AI135984   AI294330   AI297531   AI389722   AI404223   AI404751   AI544059   AI546275   AJ426727   AJ426728   AW943819   AY089559 AAL90297   AY231683   BF501759   BG634406   BI165676   BI167248   BI170024   BI234648   BI239716   BI352371   BI352971   BI357475   BI358414   BI363193   BI363672   BI372458   BI484507   BI487116   BI564966   BI567728   BI567813   BI568524   BI576270   BI576351   BI577318   BI579190   BI581237   BI581707   BI583129   BI583353   BI583424   BI583583   BI584173   BI584752   BI586327   BI586744   BI589018   BI589046   BI589175   BI592337   BI605657   BI606598   BI607011   BI608154   BI611548   BI612199   BI613100   BI613144   BI614828   BI615932   BI621328   BI625602   BI625848   BI627176   BI627353   BI629624   BI631143   BI631468   BI631564   BI635846   BI636897   BI638632   BP547528   BP548512   BP558338   BT099624   BT126329   BZ665517   CK131197   CK604530   CO153310   CO298481   CO305262   CO316599   CO318469   CO319378   EC051497   EC051984   EC053506   EC056089   EC065635   EC204354   EC226208   EC238505   EC238821   EC251025   EC262681   EL875553   EL875554   EL880401   EV575872   EV577351   EV580237   EV597776   GH748322   GH748883   GH748941   GH749129   GH750180   GH750267   GH750977   GH754598   GH755867   GH757116   GH757692   GH770504   GH771543   GH771659   GH772784   GH776638   GH777431   GH779086   GH781136   GH781972   GH782615   GH782673   GH785634   GH786192   GH787440   GH789501   GH790027   GH790203   GH790207   GH792481   GH794353   GH795595   GH795964   GH798038   GH798145   GH798154   GH799418   GH800074   GH801401   GH801821   GH802071   GH803001   GH803845   GH804476   GH805307   GH805627   GH805635   GH806659   GH810239   GH813010   GH815875   GH820831   GH825100   GH827541   GH828107   GH829150   GH829551   GH830958   GH832602   GH833097   GH834998   GH836900   GH838462   GH839451   GH842332   GH843688   GH843825   GH844313   GH844451   GH844538   GH844726   GH845519   GH845799   GH846307   GH846322   GH847199   GH848092   GH849288   GH849560   GH850133   GH850775   GH850877   GH851615   GH853169   GH853189   GH853346   GH854692   GH856100   GH856106   GH858565   GH861608   GH864645   GH864803   GH864976   GH867051   GH869004   GH869411   GH870332   GH870703   GH871716   GH872945   GH875564   GH875571   GH876041   GH877114   GH879612   GH880332   GH881886   GH883235   GH886032   GH886236   GH888068   GH888196   GH889034   GH889262   GH889572   GH892247   GH892280   GH894174   GH894405   GH894553   GH895229   GH895776   GH896050   GH899334   GH901868   GH902231   GH902992   GH903893   GH905636   GH907683   GH908712   GH910370   GH913818   GH913977   GH915419   GH915805   GH916945   GH917015   GH917404   GH918338   GH921546   GH922725   GH923559   GH923586   GH923670   GH924520   GH925138   GH925782   GH926500   GH926505   GH927846   GH929837   GH931929   GH933281   GH933483   GH933635   GH934704   GH935553   GH935975   GH936304   GH936781   GH938453   GH939266   GH939396   GH939741   GH939747   GH939999   GH940077   GH940351   GH940481   GH940543   GH940671
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IRQ5 Q9W3X6 Q8SXM1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | intense & ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) Comment:rapidly degraded pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) labral sensory complex primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) labral sensory complex   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mitochondrion inferred from direct assay (Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult midgut, larval fat body, larval salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut    1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass    1157.175 Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut    1169.6 Adult Malpighian Tubules    1396.7 Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart    1105.25 Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass    1388.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  539.175 Larval Midgut  (651.3) Larval Hindgut  (1065.1) Larval Malpighian Tubules  522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea  (788.275) Larval Carcass  (1157.175) Adult Head  (639.9) Adult Eye  500.375 Adult Brain  (743.4) Adult Thoracic-Abdominal Ganglion  (734.7) Adult Crop  (655.2) Adult Midgut    413.6 Adult Hindgut  (1169.6) Adult Malpighian Tubules  (1396.7) Adult Fat Body  (956.3) Adult Salivary Gland  (750.6) Adult Heart  (1105.25) Adult VirginFemale Spermatheca  (790.5) Adult InseminatedFemale Spermatheca  (741) Adult Ovary  (608.5) Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass  (1388.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut  1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass  (1157.175) Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut  (1169.6) Adult Malpighian Tubules  (1396.7) Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart  (1105.25) Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass  (1388.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut    1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass    1157.175 Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut    1169.6 Adult Malpighian Tubules    1396.7 Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart    1105.25 Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass    1388.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut    1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass    1157.175 Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut    1169.6 Adult Malpighian Tubules    1396.7 Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart    1105.25 Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass    1388.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  539.175 Larval Midgut  651.3 Larval Hindgut  (1065.1) Larval Malpighian Tubules  522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea  788.275 Larval Carcass  (1157.175) Adult Head  639.9 Adult Eye  500.375 Adult Brain  743.4 Adult Thoracic-Abdominal Ganglion  734.7 Adult Crop  655.2 Adult Midgut    413.6 Adult Hindgut  (1169.6) Adult Malpighian Tubules  (1396.7) Adult Fat Body  (956.3) Adult Salivary Gland  750.6 Adult Heart  (1105.25) Adult VirginFemale Spermatheca  790.5 Adult InseminatedFemale Spermatheca  741 Adult Ovary  608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass  (1388.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut  1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass  1157.175 Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut  1169.6 Adult Malpighian Tubules  1396.7 Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart  1105.25 Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass  1388.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    539.175 Larval Midgut    651.3 Larval Hindgut    1065.1 Larval Malpighian Tubules    522.3 Larval Fat Body    424.3 Larval Salivary Gland    446.8 Larval Trachea    788.275 Larval Carcass    1157.175 Adult Head    639.9 Adult Eye    500.375 Adult Brain    743.4 Adult Thoracic-Abdominal Ganglion    734.7 Adult Crop    655.2 Adult Midgut    413.6 Adult Hindgut    1169.6 Adult Malpighian Tubules    1396.7 Adult Fat Body    956.3 Adult Salivary Gland    750.6 Adult Heart    1105.25 Adult VirginFemale Spermatheca    790.5 Adult InseminatedFemale Spermatheca    741 Adult Ovary    608.5 Adult Testis    49 Adult Male Accessory Gland    343.7 Adult Carcass    1388.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    639.9   NA  Eye    500.375   NA  Brain    743.4   539.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    734.7   NA  Crop    655.2   651.3  Midgut    413.6   1065.1  Hindgut    1169.6   522.3  Malpighian Tubules    1396.7   424.3  Fat Body    956.3   446.8  Salivary Gland    750.6   NA  Heart    1105.25   788.275  Trachea    NA   NA  VirginFemale Spermatheca    790.5   NA  InseminatedFemale Spermatheca    741   NA  Ovary    608.5   NA  Testis    49   NA  Male Accessory Gland    343.7   1157.175  Carcass    1388.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female    125 head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male    115 head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult    214 carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (58) central nervous system, larvae L3  (52) central nervous system, pupae P8  (42) head, virgin 1-day female  (125) head, virgin 4-day female  (63) head, virgin 20-day female  (72) head, mated 1-day female  (84) head, mated 4-day female  (50) head, mated 20-day female  (63) head, mated 1-day male  (115) head, mated 4-day male  (76) head, mated 20-day male  (89) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (31) digestive system, 1-day adult  (68) digestive system, 4-day adult  (56) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (50) fat body, white prepupae  (42) fat body, pupae P8  (65) carcass, larvae L3 wandering  (55) carcass, 1-day adult  (214) carcass, 4-day adult  (99) carcass, 20-day adult  (80) ovary, virgin 4-day female  (94) ovary, mated 4-day female  (92) testis, mated 4-day male    17 accessory gland, mated 4-day male  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female  (125) head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male  (115) head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult  (214) carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female    125 head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male    115 head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult    214 carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female    125 head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male    115 head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult    214 carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (58) central nervous system, larvae L3  (52) central nervous system, pupae P8  (42) head, virgin 1-day female  (125) head, virgin 4-day female  (63) head, virgin 20-day female  (72) head, mated 1-day female  (84) head, mated 4-day female  (50) head, mated 20-day female  (63) head, mated 1-day male  (115) head, mated 4-day male  (76) head, mated 20-day male  (89) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  31 digestive system, 1-day adult  (68) digestive system, 4-day adult  (56) digestive system, 20-day adult  (58) fat body, larvae L3 wandering  (50) fat body, white prepupae  (42) fat body, pupae P8  (65) carcass, larvae L3 wandering  (55) carcass, 1-day adult  (214) carcass, 4-day adult  (99) carcass, 20-day adult  (80) ovary, virgin 4-day female  (94) ovary, mated 4-day female  (92) testis, mated 4-day male    17 accessory gland, mated 4-day male  (39) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female  125 head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male  115 head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult  (214) carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    58 central nervous system, larvae L3    52 central nervous system, pupae P8    42 head, virgin 1-day female    125 head, virgin 4-day female    63 head, virgin 20-day female    72 head, mated 1-day female    84 head, mated 4-day female    50 head, mated 20-day female    63 head, mated 1-day male    115 head, mated 4-day male    76 head, mated 20-day male    89 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    31 digestive system, 1-day adult    68 digestive system, 4-day adult    56 digestive system, 20-day adult    58 fat body, larvae L3 wandering    50 fat body, white prepupae    42 fat body, pupae P8    65 carcass, larvae L3 wandering    55 carcass, 1-day adult    214 carcass, 4-day adult    99 carcass, 20-day adult    80 ovary, virgin 4-day female    94 ovary, mated 4-day female    92 testis, mated 4-day male    17 accessory gland, mated 4-day male    39 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 and 18-24 hour embryonic stages, at stages throughout the larval period, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    153 embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr    127 embryo 12-14hr    67 embryo 14-16hr    120 embryo 16-18hr    116 embryo 18-20hr    139 embryo 20-22hr    158 embryo 22-24hr    136 larva L1    278 larva L2    282 larva L3 12hr old    318 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr    118 pupae 2d postWPP    123 pupae 3d postWPP    312 pupae 4d postWPP    442 adult male 01day    313 adult male 05day    246 adult male 30day    164 adult female 01day    366 adult female 05day    171 adult female 30day    171 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (153) embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr  (41) embryo 10-12hr  (127) embryo 12-14hr  (67) embryo 14-16hr  (120) embryo 16-18hr  (116) embryo 18-20hr  (139) embryo 20-22hr  (158) embryo 22-24hr  (136) larva L1  (278) larva L2  (282) larva L3 12hr old  (318) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  (110) larva L3 puffstage 7-9  (79) white prepupae new  (83) white prepupae 12hr  (95) white prepupae 24hr  (118) pupae 2d postWPP  (123) pupae 3d postWPP  (312) pupae 4d postWPP  (442) adult male 01day  (313) adult male 05day  (246) adult male 30day  (164) adult female 01day  (366) adult female 05day  (171) adult female 30day  (171) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (153) embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr  (127) embryo 12-14hr    67 embryo 14-16hr  (120) embryo 16-18hr  (116) embryo 18-20hr  (139) embryo 20-22hr  (158) embryo 22-24hr  (136) larva L1  (278) larva L2  (282) larva L3 12hr old  (318) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  (110) larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr  (118) pupae 2d postWPP  (123) pupae 3d postWPP  (312) pupae 4d postWPP  (442) adult male 01day  (313) adult male 05day  (246) adult male 30day  (164) adult female 01day  (366) adult female 05day  (171) adult female 30day  (171) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    153 embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr    127 embryo 12-14hr    67 embryo 14-16hr    120 embryo 16-18hr    116 embryo 18-20hr    139 embryo 20-22hr    158 embryo 22-24hr    136 larva L1    278 larva L2    282 larva L3 12hr old    318 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr    118 pupae 2d postWPP    123 pupae 3d postWPP    312 pupae 4d postWPP    442 adult male 01day    313 adult male 05day    246 adult male 30day    164 adult female 01day    366 adult female 05day    171 adult female 30day    171 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    153 embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr    127 embryo 12-14hr    67 embryo 14-16hr    120 embryo 16-18hr    116 embryo 18-20hr    139 embryo 20-22hr    158 embryo 22-24hr    136 larva L1    278 larva L2    282 larva L3 12hr old    318 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr    118 pupae 2d postWPP    123 pupae 3d postWPP    312 pupae 4d postWPP    442 adult male 01day    313 adult male 05day    246 adult male 30day    164 adult female 01day    366 adult female 05day    171 adult female 30day    171 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (153) embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr  (41) embryo 10-12hr  (127) embryo 12-14hr  (67) embryo 14-16hr  (120) embryo 16-18hr  (116) embryo 18-20hr  (139) embryo 20-22hr  (158) embryo 22-24hr  (136) larva L1  (278) larva L2  (282) larva L3 12hr old  (318) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  (110) larva L3 puffstage 7-9  (79) white prepupae new  (83) white prepupae 12hr  (95) white prepupae 24hr  (118) pupae 2d postWPP  (123) pupae 3d postWPP  (312) pupae 4d postWPP  (442) adult male 01day  (313) adult male 05day  (246) adult male 30day  (164) adult female 01day  (366) adult female 05day  (171) adult female 30day  (171) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (153) embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr  127 embryo 12-14hr    67 embryo 14-16hr  120 embryo 16-18hr  116 embryo 18-20hr  139 embryo 20-22hr  (158) embryo 22-24hr  136 larva L1  (278) larva L2  (282) larva L3 12hr old  (318) larva L3 puffstage 1-2  (144) larva L3 puffstage 3-6  110 larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr  118 pupae 2d postWPP  123 pupae 3d postWPP  (312) pupae 4d postWPP  (442) adult male 01day  (313) adult male 05day  (246) adult male 30day  (164) adult female 01day  (366) adult female 05day  (171) adult female 30day  (171) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    153 embryo 02-04hr    14 embryo 04-06hr    8 embryo 06-08hr    25 embryo 08-10hr    41 embryo 10-12hr    127 embryo 12-14hr    67 embryo 14-16hr    120 embryo 16-18hr    116 embryo 18-20hr    139 embryo 20-22hr    158 embryo 22-24hr    136 larva L1    278 larva L2    282 larva L3 12hr old    318 larva L3 puffstage 1-2    144 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    79 white prepupae new    83 white prepupae 12hr    95 white prepupae 24hr    118 pupae 2d postWPP    123 pupae 3d postWPP    312 pupae 4d postWPP    442 adult male 01day    313 adult male 05day    246 adult male 30day    164 adult female 01day    366 adult female 05day    171 adult female 30day    171 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    191 embryonic 1182-4H    120 embryonic GM2    68 embryonic Kc167    67 embryonic S1    116 embryonic S3    71 leg disc CME L1    155 wing disc CME-W2    86 wing disc ML-DmD8    107 wing disc ML-DmD9    173 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    207 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    146 eye-antennal disc ML-DmD11    169 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    138 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (103) Schneider line 2 Sg4  (191) embryonic 1182-4H  (120) embryonic GM2  (68) embryonic Kc167  (67) embryonic S1  (116) embryonic S3  (71) leg disc CME L1  (155) wing disc CME-W2  (86) wing disc ML-DmD8  (107) wing disc ML-DmD9  (173) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (207) wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (146) eye-antennal disc ML-DmD11  (169) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (138) CNS ML-DmBG1-c1  (71) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (37) ovary fGS/OSS  (72) ovary OSC  (64) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  103 Schneider line 2 Sg4  (191) embryonic 1182-4H  (120) embryonic GM2    68 embryonic Kc167    67 embryonic S1  (116) embryonic S3    71 leg disc CME L1  (155) wing disc CME-W2    86 wing disc ML-DmD8  107 wing disc ML-DmD9  (173) wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (207) wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (146) eye-antennal disc ML-DmD11  (169) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (138) CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    191 embryonic 1182-4H    120 embryonic GM2    68 embryonic Kc167    67 embryonic S1    116 embryonic S3    71 leg disc CME L1    155 wing disc CME-W2    86 wing disc ML-DmD8    107 wing disc ML-DmD9    173 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    207 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    146 eye-antennal disc ML-DmD11    169 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    138 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    191 embryonic 1182-4H    120 embryonic GM2    68 embryonic Kc167    67 embryonic S1    116 embryonic S3    71 leg disc CME L1    155 wing disc CME-W2    86 wing disc ML-DmD8    107 wing disc ML-DmD9    173 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    207 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    146 eye-antennal disc ML-DmD11    169 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    138 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (103) Schneider line 2 Sg4  (191) embryonic 1182-4H  (120) embryonic GM2  (68) embryonic Kc167  (67) embryonic S1  (116) embryonic S3  (71) leg disc CME L1  (155) wing disc CME-W2  (86) wing disc ML-DmD8  (107) wing disc ML-DmD9  (173) wing disc ML-DmD16-c3  (100) wing disc ML-DmD21  (207) wing disc ML-DmD32  (138) haltere disc ML-DmD17-c3  (146) eye-antennal disc ML-DmD11  (169) antennal disc ML-DmD20-c5  (127) mixed discs ML-DmD4-c1  (138) CNS ML-DmBG1-c1  (71) CNS ML-DmBG2-c2  (50) tumorous blood cells mbn2  (37) ovary fGS/OSS  (72) ovary OSC  (64) ovary OSS  (34) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  103 Schneider line 2 Sg4  (191) embryonic 1182-4H  120 embryonic GM2    68 embryonic Kc167    67 embryonic S1  116 embryonic S3    71 leg disc CME L1  (155) wing disc CME-W2    86 wing disc ML-DmD8  107 wing disc ML-DmD9  (173) wing disc ML-DmD16-c3    100 wing disc ML-DmD21  (207) wing disc ML-DmD32  138 haltere disc ML-DmD17-c3  (146) eye-antennal disc ML-DmD11  (169) antennal disc ML-DmD20-c5  127 mixed discs ML-DmD4-c1  138 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    103 Schneider line 2 Sg4    191 embryonic 1182-4H    120 embryonic GM2    68 embryonic Kc167    67 embryonic S1    116 embryonic S3    71 leg disc CME L1    155 wing disc CME-W2    86 wing disc ML-DmD8    107 wing disc ML-DmD9    173 wing disc ML-DmD16-c3    100 wing disc ML-DmD21    207 wing disc ML-DmD32    138 haltere disc ML-DmD17-c3    146 eye-antennal disc ML-DmD11    169 antennal disc ML-DmD20-c5    127 mixed discs ML-DmD4-c1    138 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    50 tumorous blood cells mbn2    37 ovary fGS/OSS    72 ovary OSC    64 ovary OSS    34 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    174 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3    137 Ethanol 5% 3 hrs, larvae L3    134 Ethanol 10% 3 hrs, larvae L3    153 Caffeine 1.5 mg/ml 4 hrs, larvae L3    119 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    101 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    134 Rotenone 8 μg 12 hrs, larvae L3    197 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (45) heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3  (174) Cadmium 50 mM 12 hrs, larvae L3  (60) Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult  (85) Copper 0.5 mM 12 hrs, larvae L3  (94) Copper 15 mM 48 hrs, 4-day adult  (28) Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult  (37) Ethanol 2.5% 3 hrs, larvae L3  (137) Ethanol 5% 3 hrs, larvae L3  (134) Ethanol 10% 3 hrs, larvae L3  (153) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (119) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (86) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (101) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (134) Rotenone 8 μg 12 hrs, larvae L3  (197) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3  (174) Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3  (137) Ethanol 5% 3 hrs, larvae L3  (134) Ethanol 10% 3 hrs, larvae L3  (153) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (119) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult  101 Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (134) Rotenone 8 μg 12 hrs, larvae L3  (197) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    174 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3    137 Ethanol 5% 3 hrs, larvae L3    134 Ethanol 10% 3 hrs, larvae L3    153 Caffeine 1.5 mg/ml 4 hrs, larvae L3    119 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    101 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    134 Rotenone 8 μg 12 hrs, larvae L3    197 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    174 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3    137 Ethanol 5% 3 hrs, larvae L3    134 Ethanol 10% 3 hrs, larvae L3    153 Caffeine 1.5 mg/ml 4 hrs, larvae L3    119 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    101 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    134 Rotenone 8 μg 12 hrs, larvae L3    197 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (59) cold shock, 4-day adult  (45) heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3  (174) Cadmium 50 mM 12 hrs, larvae L3  (60) Cadmium 50 mM 48 hrs, 4-day adult  (131) Cadmium 100 mM 48 hrs, 4-day adult  (85) Copper 0.5 mM 12 hrs, larvae L3  (94) Copper 15 mM 48 hrs, 4-day adult  28 Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult  (37) Ethanol 2.5% 3 hrs, larvae L3  (137) Ethanol 5% 3 hrs, larvae L3  (134) Ethanol 10% 3 hrs, larvae L3  (153) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (119) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (86) Caffeine 25 mg/ml 48 hrs, 4-day adult  (55) Paraquat 5 mM 48 hrs, 4-day adult  (101) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (134) Rotenone 8 μg 12 hrs, larvae L3  (197) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult  (150) Cadmium 50 mM 6 hrs, larvae L3  (174) Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult  131 Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3  137 Ethanol 5% 3 hrs, larvae L3  134 Ethanol 10% 3 hrs, larvae L3  (153) Caffeine 1.5 mg/ml 4 hrs, larvae L3  119 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult  101 Paraquat 10 mM 48 hrs, 4-day adult  141 Rotenone 2 μg 12 hrs, larvae L3  134 Rotenone 8 μg 12 hrs, larvae L3  (197) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    59 cold shock, 4-day adult    45 heat shock, 4-day adult    150 Cadmium 50 mM 6 hrs, larvae L3    174 Cadmium 50 mM 12 hrs, larvae L3    60 Cadmium 50 mM 48 hrs, 4-day adult    131 Cadmium 100 mM 48 hrs, 4-day adult    85 Copper 0.5 mM 12 hrs, larvae L3    94 Copper 15 mM 48 hrs, 4-day adult    28 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    37 Ethanol 2.5% 3 hrs, larvae L3    137 Ethanol 5% 3 hrs, larvae L3    134 Ethanol 10% 3 hrs, larvae L3    153 Caffeine 1.5 mg/ml 4 hrs, larvae L3    119 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    86 Caffeine 25 mg/ml 48 hrs, 4-day adult    55 Paraquat 5 mM 48 hrs, 4-day adult    101 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    134 Rotenone 8 μg 12 hrs, larvae L3    197 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • FI05334 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028336 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4094-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage l(1)G0255G0290 lethal | larval stage l(1)G0255G0255 l(1)G0255G0290 lethal | recessive l(1)G0255G0255 l(1)G0255G0290 viable, with Scer\GAL4pnr-MD237 l(1)G0255GD11215 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 l(1)G0255GD11215 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 l(1)G0255GD11215
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of l(1)G0255 Class Mutagen Stocks Known lesion l(1)G0255EY00709 P-element activity 2 -- l(1)G0255G0290 P-element activity 2 -- l(1)G0255EY11019 1 -- l(1)G0255G0255 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(1)G0255 Class Mutagen Stocks Known lesion l(1)G0255GD11215 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes l(1)G0255KK108008 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(1)G0255GD17821 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11215} NA P{GD17821} NA P{KK108008} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}l(1)G0255EY00709 NA P{EPgy2}l(1)G0255EY11019 NA insertion of enhancer trap P{lacW}l(1)G0254G0254 No P{lacW}l(1)G0255G0255 No P{lacW}l(1)G0255G0290 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
mitochondrion inferred from direct assay (Alonso et al., 2005)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
fumarate hydratase activity inferred from sequence or structural similarity with NCBI:NP_498642 (FlyBase Genome Annotators, 2002-2003) inferred from sequence or structural similarity with UniProtKB:P07954 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
fumarate metabolic process inferred from electronic annotation with InterPro:IPR005677 (FlyBase Curators et al., 2004-) tricarboxylic acid cycle inferred from sequence or structural similarity with UniProtKB:P07954 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
cytoplasm inferred from sequence or structural similarity with UniProtKB:P07954 (Sardiello et al., 2003.6.11) mitochondrion inferred from sequence or structural similarity with mouse Fh1 (FlyBase Genome Annotators, 2002-2003) inferred from sequence or structural similarity with UniProtKB:P07954 (Sardiello et al., 2003.6.11) tricarboxylic acid cycle enzyme complex inferred from electronic annotation with InterPro:IPR005677 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(1)G0255 - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - Mdh2 experimental knowledge based (Guruharsha et al., 2011) l(1)G0255 - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - SmD3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(1)G0255 - kdn experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(1)G0255 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58091 DroID - A comprehensive database of gene and protein interactions. • FBgn0028336 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31605
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66DMNH Dipteran inclusive ortholog search EOG61ZFK7 Insect inclusive ortholog search EOG6HQCDN Arthropod inclusive ortholog search EOG6PVMF1 Metazoa inclusive ortholog search EOG6F554J
Orthologs in Drosophila Species (EOG66DMNH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(1)G0255     Drosophila sechellia   Dsec\GM12511     Drosophila erecta   Dere\GG19604 Y   Drosophila yakuba   Dyak\GE16764 Y   Drosophila ananassae   Dana\GF21422 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22866     Drosophila willistoni   Dwil\GK15449     Drosophila virilis   Dvir\GJ16987     Drosophila mojavensis   Dmoj\GI21814     Drosophila grimshawi   Dgri\GH24716
Orthologs in non-Drosophila Dipterans (EOG61ZFK7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008167 Y Anopheles gambiae Malaria mosquito  Agam\AGAP001884 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008384 Y
Orthologs in non-Dipteran Insects (EOG6HQCDN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51042 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000426 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\fumC Y Atta cephalotes Leafcutter ant  Acep\fumC Y Camponotus floridanus Florida carpenter ant  Cflo\fumC Y Harpegnathos saltator Jerdons jumping ant  Hsal\fumC Y Linepithema humile Argentine ant  Lhum\LH16775 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17681 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17685 Y Solenopsis invicta Red fire ant  Sinv\SINV13725 Y Solenopsis invicta Red fire ant  Sinv\SINV17632 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007258 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008214 Y Pediculus humanus Human body louse  Phum\PHUM229900 Y Tribolium castaneum Red flour beetle  Tcas\TC013056 Y
Orthologs in non-Insect Arthropods (EOG6PVMF1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rpl2 Y Ixodes scapularis Deer tick  Isca\ISCW020593 Y
Orthologs in non-Arthropod Metazoa (EOG6F554J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\fum-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026226gn Y Danio rerio Zebrafish  Drer\fh Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032112 Y Gallus gallus Domestic chicken  Ggal\FH Y Mus musculus House mouse  Mmus\Fh Y Rattus norvegicus Norway rat  Rnor\Fh1 Y Homo sapiens Human  Hsap\FH Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\FH
AAA Orthologs (3) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG19604 Drosophila yakuba Dyak\GE16764 Drosophila ananassae Dana\GF21422
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	10282 w67c23 P{lacW}l(1)G0255G0290/FM7c 11961 w67c23 P{lacW}l(1)G0255G0255/FM7c 20654 y1 w67c23 P{EPgy2}l(1)G0255EY11019 15037 y1 w67c23 P{EPgy2}l(1)G0255EY00709/FM7c
Kyoto	111751 w67c23 P{lacW}l(1)G0255G0290 P{neoFRT}19A/FM7c; P{ey-FLP.N}5 111957 y1 w* P{EPgy2}l(1)G0255EY00709 P{neoFRT}19A/FM7c; P{ey-FLP.N}5
VDRC	v105680 P{KK108008}VIE-260B v34796 w1118; P{GD11215}v34796 v34797 w1118; P{GD11215}v34797
Genomic Clones ( 1 )
	BACR11K20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 286 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD46083 LP02262
Other clones	FI05334 yak-em_CG4094
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17304 AT30611 GH03430 GH04137 GH04944 GH06312 GH07781 GH08890 GH10549 GH11543 GH13947 GH14669 GH20962 GH23854 GH24575 GM04692 GM08208 GM19002 GM21521 HL06501 LD02703 LD25084 LD34869 LD47809 LP07672 LP11850 RE05616 RE07586 RE11360 RE30386 RE36285 RE43977 RE45175 RE47949 RE48587 RE59423 RE67622 RE70627 RE70980 RE73179 RH09986 RH12331 RH17879 RH18603 RH19244 RH21591 RH21944 RH22034 RH22233 RH23154 RH24023 RH26253 RH26840 RH30679 RH30719 RH31526 RH32796 RH32893 RH38287 RH38505 RH40093 RH40611 RH42174 RH42234 RH44308 RH45839 RH52652 RH58522 RH60560 RH61047 RH61158 RH62570 RH66061 RH66345 RH68412 RH68640 RH71501 RH73196 RH73987 SD17362 SD18741 SD20975 UT01258
Other clones	120642 126039 161453 167205 167453.1 273996 522274 Dmel_dig_003707_0639_1895 Dmel_dig_008479_0658_1886 Dmel_dig_019587_0582_3360 Dmel_neb_015786_0891_2864 EC051497 EC051984 EC053506 EC056089 EK173116 EK247812 EK265353 EK272249 EK277840 EN01720 FGH117H08 FGH128E11 FGM314D06 IP05548 IP10233 RP003006020 RP003008833 RP003014230 RP003014402 RP003015263 RP003015904 RP003026489 RP003031313 RP003034782 RP003042587 RP003048773 RP003051477 RP003052989 RP003059716 RP003063153 RP003063925 RP003064862 RP003068805 RP003075684 RP003086708 RP003086766 RP003094478 RP003097455 RP003101403 RP003101635 RP003103864 RP003117274 RP003124796 RP003135077 RP003139534 RP003140871 RP003167295 RP003168898 RP003189102 RP003191630 RP003192719 RP003203124 RP003206360 RP003209450 RP003209813 RP003211766 RP003217607 RP003227280 RP003230307 RP003236181 RP003236904 RP003237254 RP003240485 RP003250856 RP003252223 RP003252866 RP003253265 RP003253581 RP003258107 RP003260308 RP003261084 RP003265176 RP003266063 RP003271404 RP003280789 RP003286758 RP003287523 RP003292980 RP003297744 RP003307284 RP003309051 RP003318760 RP003322351 RP003325869 RP003328248 RP003333133 RP003333572 RP003333647 RP003335116 RP003335798 RP003340980 RP003342304 RP003342587 RP003346569 RP003350408 RP003351919 RP003352671 RP003374097 RP003375677 RP003381201 RP003390926 RP003391346 RP003401081 RP003403325 RP003408578 RP003409499 RP003417709 RP003418720 RP003423286 RP003424860 RP003439766 RP003443957 RP003447905 RP003460418 RP003465437 RP003474315 RP003476152 RP003476391 RP003480478 RP003483502 RP003484414 RP003484814 RP003485266 RP003498151 RP003498940 RP003502256 RP003505976 RP003507173 RP003507955 RP003508444 RP003511401 RP003516810 RP003532392 RP003539348 RP003541175 RP003541337 RP003543948 RP003546865 RP003553029 RP003555052 RP003558129 RP003558325 RP003559140 RP003560594 RP003568680 RP003577932 RP003580544 RP003585093 RP003588698 RP003595848 RP003597976 RP003598530 RP003599230 RP003600665 RP003601534 RP003601821 RP003605101 RP003605209 RP003606229 RP003608556 RP003608993 RP003614470 RP003618724 RP003619755 RP003619970 RP003620605 RP003622494 RP003626002 RP003627729 RP003629807 RP003630494 RP003637999 RP003639320 RP003640752 RP003641984 RP003647254 RP003648467 RP003655337 RP003656805 RP003657914 RP003663026 RP003663072 RP003663475 RP003663871 RP003664447 RP003667643 RP003676104 RP003676726
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028336 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31605
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(1)G0255 l(1)G0290 CG4094 (Peter et al., 2002)
Additional comments	"l(1)G0255" may correspond to "Fum" based on map position and relevant GO annotations. (Gelbart, 2009.2.13) "l(1)G0254" may affect "CG4094". (Peter et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132111 NM_167081 RefSeq (Proteins) • NP_572339 NP_727108 DDBJ / EMBL / GenBank • AAF46186 AAL90297 AAN09177 AI544059 AJ426727 AJ426728 AW943819 AY089559 BZ665517 Entrez Gene - A searchable database of RefSeq genes. • 31605 UniProtKB/TrEMBL • Q8IRQ5 Q8SXM1 Q9W3X6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fumarate lyase (IPR000362) Fumarate hydratase, class II (IPR005677) L-Aspartase-like (IPR008948) Fumarase C, C-terminal (IPR018951) Fumarase/histidase, N-terminal (IPR024083) Fumarate lyase, conserved site (IPR020557) Fumarate lyase, N-terminal (IPR022761) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME04094 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI05334
Linkouts
	BioGRID - A database of protein and genetic interactions • 58091 DroID - A comprehensive database of gene and protein interactions. • FBgn0028336 DRSC - Results from RNAi screens. • FBgn0028336 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028336 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4094-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028336 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31605 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31605 modMine - Data generated by the modENCODE project. • FBgn0028336
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4094 (Inlow and Restifo, 2004, de Morais Guedes et al., 2003, Lindsay et al., 2008, Keleman et al., 2009.8.5, Cammarato et al., 2011) CG 4094 (Alonso et al., 2005) FBgn0029889 (Raychaudhuri et al., 2003) l(1)G0255 (Dorus et al., 2006, Zhou et al., 2008, Gelbart, 2009.2.13, Alonso et al., 2005) l(1)G0290 (Schaefer et al., 1999.6.15, )
Name Synonym	l(1)G0255 (Zhou et al., 2008) lethal (1) G0255 (Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0027231 FBgn0029889
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 3 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...