duf, dumbfounded, Duf/Kirre, Dumbfounded/Kirre
IG superfamily - required for myoblast aggregation and fusion - Roughest, Hibris, Kin of Irre and Sticks and Stones are required for long range spacing of the Drosophila wing disc sensory sensilla
Please see the GBrowse view of Dmel\kirre or the JBrowse view of Dmel\kirre for information on other features
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Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.41
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kirre using the Feature Mapper tool.
kirre expression begins at embryonic stage 11, in the visceral muscle pregenitors. During stages 12-13, kirre transcript is expressed in segmentally repeated clusters, in the muscle founder cells. During stages 13-14 expression continues in outgrowing muscle founder cells, and in muscle precursors. Expression can be last detected at embryonic stage 16, in a ventral U-shaped pattern at the posterior end of the head region.
Comment: 18-22 hr APF
kirre protein expression is specific to muscle founder cells.
kirre protein is observed primarily in interommatidial cells.
kirre protein is localized to regions of cell-cell contact in mononucleate embryonic garland cells and binucleate embryonic/larval garland cells; distribution is also observed in in intracellular and cell surface puncta. sns protein is partially colocalized with kirre protein. kirre protein is expressed in garland cells at all larval stages; immuno-EM reveals kirre protein to be localized to the nephrocyte diaphragm of larval garland cells in third instar larvae.
GBrowse - Visual display of RNA-Seq signals
View Dmel\kirre in GBrowse 21-1.5
1-1.5
1-2.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: EG:163A10.1 CG3653
Source for merge of: kirre EG:163A10.1
Source for merge of kirre EG:163A10.1 was sequence comparison ( date:000721 ).
The putative transmembrane region of the kirre protein functions as a membrane anchor.
The extracellular region of the kirre protein is required for its localization to adherens junctions.
The extracellular region of the kirre protein is sufficient for homophilic cell interaction in trans.
The membrane-anchored extracellular region of of the kirre protein is sufficient to initiate the first round of myoblast fusion (development of the precursor) although fusion beyond this stage requires both the membrane-anchored extracellular region and the intracellular region to be present as a single entity.
kirre is required for the formation of syncytia within the visceral musculature of the midgut.
kirre is required for myoblast aggregation and fusion.
Named kirre because it shows very high homology to irreC-rst.
