• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\kirre

General Information
Symbol	Dmel\kirre	Species	D. melanogaster
Name	kin of irre	Annotation symbol	CG3653
Feature type	protein_coding_gene	FlyBase ID	FBgn0028369
Gene Model Status	Current	Stock availability	41 publicly available
Also Known As	Duf, Duf/Kirre
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	3C3-3C7	Sequence location	X:2,634,417..3,028,565 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kin of irre is referred to in FlyBase by the symbol Dmel\kirre (CG3653, FBgn0028369). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding; protein binding. There is experimental evidence that it is involved in the biological process: myoblast fusion; nephrocyte filtration; homophilic cell adhesion; larval visceral muscle development; heterophilic cell-cell adhesion; regulation of striated muscle tissue development; garland nephrocyte differentiation; nephrocyte diaphragm assembly; compound eye morphogenesis. 84 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; eye; myoblast; inter-ommatidial precursor cell; interommatidial bristle; optic lobe; embryonic/larval garland cell; inter-ommatidial cell; ommatidium; wing hair. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: CD80-like, immunoglobulin C2-set; Immunoglobulin I-set; Immunoglobulin V-set; Immunoglobulin subtype; Immunoglobulin-like domain; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, adult heart, larval trachea. Gene sequence location is X:2634417..3028565.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3C3-3C7
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3C7-3C7     (Taylor, 2000.7.3)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\kirre for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kirre-RA FBtr0070560  NM_166958   3426   956 kirre-RB FBtr0070559  NM_080320   5433   956 kirre-RC FBtr0309498  NM_001258576   4031   956 kirre-RD FBtr0309499  NM_001258577   4055   956 kirre-RE FBtr0309500  NM_001258578   4366   956 kirre-RF FBtr0309501  NM_001258579   6275   956 kirre-RG FBtr0332492  NM_001272267   4953   956
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein kirre-PA   FBpp0070535   101.1   956   8.25     NP_726844   AAF45847 kirre-PB   FBpp0070534   101.1   956   8.25     NP_525059   AAN09598 kirre-PC   FBpp0301278   101.1   956   8.25     NP_001245505   AFH07219 kirre-PD   FBpp0301279   101.1   956   8.25     NP_001245506   AFH07220 kirre-PE   FBpp0301280   101.1   956   8.25     NP_001245507   AFH07221 kirre-PF   FBpp0301281   101.1   956   8.25     NP_001245508   AFH07222 kirre-PG   FBpp0304768   101.1   956   8.25     NP_001259196   AGB95042
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) CD80-like, immunoglobulin C2-set (IPR013162) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141333   AA141456   AA141593   AA141655   AA141714   AA141885   AA142289   AE014298 AAF45847   AE014298 AAN09598   AF196553 AAF86308   AE014298 AFH07219   AE014298 AFH07220   AE014298 AFH07221   AE014298 AFH07222   AE014298 AGB95042   AI062288   AI386899   AI530816   AI533463   AI533599   AI533610   AI542377   AI542378   AJ289882 CAB96574   AL035436 CAB36503   AY060372   AY118686 AAM50546   BF489526   BF490300   BF500129   BG637093   BG639495   BG639680   BG640623   BI142092   BI165760   BI367893   BI368978   BI566503   BI569579   BI569730   BI571671   BI571679   BI573695   BI588633   BI589043   BI590333   BI604852   BI638345   BI638603   BI639929   BP549972   BP549973   BT011061   BT024949   BT083408   CO153583   CO153587   CO154719   CO177549   CO178669   CO178934   CO179410   CO179470   CO179610   CO180997   CO185385   CO187484   CO190469   CO196399   CO261862   CO262083   CO262294   CO262308   CO262541   CO263378   CO265804   CO266528   CO267012   CO267484   CO268279   CO268775   CO268945   CO269679   CO269723   CO269956   CO270891   CO271243   CO271944   CO272166   CO272320   CO272871   CO273402   CO274786   CO275886   CO276122   CO277297   CO278056   CO278471   CO278634   CO279733   CO280947   CO281268   CO281433   CO281528   CO281955   CO281956   CO282712   CO284001   CO284589   CO284981   CO285421   CO286248   CO286446   CO286890   CO287862   CO288445   CO291601   CO291625   CO292457   CO293028   CO294915   CO295160   CO295477   CO295533   CO296503   CO298433   CO299908   CO300458   CO300848   CO301034   CO302803   CO303448   CO304688   CO304728   CO306158   CO308750   CO309979   CO311288   CO312884   CO314047   CO315467   CO315692   CO316193   CO316223   CO316395   CO319487   CO320331   CO321061   CO321607   CO321636   CO325830   CO325971   CO325983   CO326143   CO326309   CO327053   CO328882   CO329578   CO331136   CO331743   CO331749   CO332242   CO332680   CO332704   CO332727   CO333054   CO336331   CO338252   CO338595   CO339030   CO339033   CO339323   CO339425   CO339724   CO339761   CO340147   CO340571   CO340901   CO341146   CO341425   CO341491   CO341811   CO342049   CO342388   CO343721   CO344057   CO344644   CO345052   CZ488393   CZ488394   EC059058   EC059082   EC060404   EC067886   EC070459   EC081914   EC084098   EC198424   EC216679   EC219681   EC229644   EC231808   EC241870   EC249823   EC256184   EC258186   EC259284   EC260432   EL884696   EL884697   ES690835   EV589701   GH950502   GH978893   GH980335
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W4T9 O97174 Q9N9Y9 Q8MSN7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435224 X:2,989,630..2,990,462 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000435712 X:2,986,949..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000435821 X:2,992,679..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436065 X:2,987,786..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436172 X:2,979,215..2,979,970 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436191 X:2,986,256..2,990,462 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436320 X:2,993,171..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436428 X:2,991,269..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436597 X:2,988,871..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19) regulatory region FBsf0000436829 X:2,984,332..2,994,224 evidence=Reporter construct (in vivo) (Guruharsha et al., 2009, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 6 -- 8   mesoderm | restricted   (Ruiz-Gomez et al., 2000) Comment:invaginating mesoderm embryonic stage 11   visceral muscle primordium   (Strunkelnberg et al., 2001, Ruiz-Gomez et al., 2000) dorsal pharyngeal muscle anlage   (Ruiz-Gomez et al., 2000) embryonic stage 11 -- 12   somatic muscle primordium   (Ruiz-Gomez et al., 2000) embryonic stage 11 -- 16   embryonic garland cell   (Ruiz-Gomez et al., 2000) embryonic stage 12 -- 14   muscle founder cell   (Strunkelnberg et al., 2001) embryonic stage 12 -- 15   dorsal pharyngeal muscle primordium   (Ruiz-Gomez et al., 2000) embryonic stage 15 -- 17   presumptive embryonic/larval central nervous system | restricted   (Ruiz-Gomez et al., 2000) embryonic stage 16   embryonic head | posterior & ventral   (Strunkelnberg et al., 2001)
Additional Descriptive Data
	kirre transcript is expressed in all somatic muscle precursors. By the end of embryonic stage 12, kirre expression is downregulated in the adult muscle precursor cells. (Ruiz-Gomez et al., 2000) kirre expression begins at embryonic stage 11, in the visceral muscle pregenitors. During stages 12-13, kirre transcript is expressed in segmentally repeated clusters, in the muscle founder cells. During stages 13-14 expression continues in outgrowing muscle founder cells, and in muscle precursors. Expression can be last detected at embryonic stage 16, in a ventral U-shaped pattern at the posterior end of the head region. (Strunkelnberg et al., 2001)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   inter-ommatidial cell   (Hoehne et al., 2005) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
adherens junction inferred from direct assay (Menon et al., 2005) cell surface inferred from direct assay (Menon et al., 2005) nephrocyte diaphragm inferred from direct assay (Weavers et al., 2009, Zhuang et al., 2009) plasma membrane inferred from direct assay (Weavers et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain, adult heart, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    8 head, virgin 1-day female    2 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    3 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    8 embryo 12-14hr    8 embryo 14-16hr    6 embryo 16-18hr    4 embryo 18-20hr    4 embryo 20-22hr    4 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    2 white prepupae 12hr    3 white prepupae 24hr    6 pupae 2d postWPP    7 pupae 3d postWPP    3 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    1 adult female 01day    2 adult female 05day    4 adult female 30day    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    6 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    1 embryonic S3    12 leg disc CME L1    3 wing disc CME-W2    0 wing disc ML-DmD8    25 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    11 wing disc ML-DmD21    7 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    13 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3653-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU kirreGD99 kirreGD2595 kirreGD14476 viable kirree03862 viable, with Scer\GAL4pnr-MD237 kirreGD99 kirreGD2595 kirreGD14476 Sterility Allele fertile kirree03862 male fertile, with Scer\GAL4C855a kirreGD2595 Other Phenotypes Allele visible, with Scer\GAL4hs.2sev kirreScer\UAS.cRa Phenotype manifest in Allele embryonic/larval garland cell kirreunspecified embryonic/larval garland cell, with Scer\GAL4sns.GCN kirreGD2595 kirreGD14476 embryonic/larval garland cell | third instar larval stage kirresps-1 embryonic/larval garland cell | third instar larval stage, with Scer\GAL4pros.PMG kirreScer\UAS.cRa eye, with Scer\GAL4GMR.PF kirredsRNA.Scer\UAS eye, with Scer\GAL4hs.2sev kirreScer\UAS.cRa interommatidial bristle, with Scer\GAL4GMR.PF kirredsRNA.Scer\UAS inter-ommatidial cell, with Scer\GAL4GMR.PF kirredsRNA.Scer\UAS inter-ommatidial precursor cell, with Scer\GAL4GMR.PF kirredsRNA.Scer\UAS myoblast, with Df(1)w67k30, Scer\GAL4Dll-md23 kirreScer\UAS.cRa myoblast, with Df(1)w67k30, Scer\GAL4wg.PM kirreScer\UAS.cRa nucleus | supernumerary | third instar larval stage kirresps-1 nucleus | supernumerary | third instar larval stage, with Scer\GAL4pros.PMG kirreScer\UAS.cRa ommatidium, with Scer\GAL4GMR.PF kirredsRNA.Scer\UAS optic lobe, with Scer\GAL4MZ1369 kirreScer\UAS.cRa wing hair, with Scer\GAL4wg-IS650 kirreKK107679 wing margin, with Scer\GAL4wg-IS650 kirreKK107679
Classical Alleles ( 56 )
For All Classical Alleles Show
Allele of kirre Class Mutagen Stocks Known lesion kirree03862 piggyBac transposase 2 -- kirreCB-0012-3 1 -- kirred05817 1 -- kirred06125 1 -- kirred06226 1 -- kirred08289 1 -- kirred08606 1 -- kirree00634 1 -- kirree02337 1 -- kirree03324 1 -- kirree03629 1 -- kirree03883 1 -- kirree04348 1 -- kirree04391 1 -- kirreEY04872 1 -- kirreEY14585 1 -- kirref01401 1 -- kirref01511 1 -- kirref02316 1 -- kirref03717 1 -- kirref05766 piggyBac transposase 1 -- kirref05848 1 -- kirref06069 1 -- kirref06137 1 -- kirref07355 1 -- kirref07362 1 -- kirreG1566 P-element activity 1 -- kirreG876 1 -- kirreKG05552 1 -- kirreMB00990 1 -- kirreMI00678 1 -- kirreMI07148 1 -- kirreNP2044 1 -- kirreNP2273 1 -- kirreNP6008 1 -- kirreNP7195 1 -- kirree01634 0 -- kirree03302 0 -- kirree04336 0 -- kirree04339 0 -- kirree04352 0 -- kirref01407 0 -- kirref02273 0 -- kirref03230 0 -- kirref04418 0 -- kirref04425 0 -- kirref06075 0 -- kirref07973 0 -- kirreGG01300 0 -- kirreGG01653 0 -- kirreGG01678 0 -- kirreGG01742 0 -- kirreGG01796 0 -- kirreMI05438 0 -- kirresps-1 0 Yes kirreunspecified 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of kirre Class Mutagen Stocks Known lesion kirreGD99 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes kirreGD14476 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kirreGD2595 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kirreAct5C.C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kirreAct5C.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kirredsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes kirreKK107679 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kirreMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kirrePADVI.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes kirrePDZ.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes kirreScer\UAS.C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kirreScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes kirreScer\UAS.N.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kirreScer\UAS.T:Ivir\HA1 0 Yes kirreT637A.S680A.T810A.T814A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes kirreT810A.T814A.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes kirreΔ103-553.Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔ103-553.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔ2-611.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔ586-959.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔ610-959.Act5C.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔ610-959.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔCT1.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔCT2.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔCT3.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔCT5.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔN.Scer\UAS.T:TM-Sema-1a,Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes kirreΔN.Scer\UAS.T:TM-shg,Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)N-8 (Ruiz-Gomez et al., 2000) Df(1)vt (Ruiz-Gomez et al., 2000) Df(1)w67k30 (Ruiz-Gomez et al., 2000, Chen et al., 2003, Massarwa et al., 2007, Bulchand et al., 2010)
Duplicated in	Dp(1;3)wvco (Ruiz-Gomez et al., 2000)
Not disrupted in	Df(1)N-81k1 (Ruiz-Gomez et al., 2000) Df(1)rst2 (Ruiz-Gomez et al., 2000) Df(1)w258-42 (Ruiz-Gomez et al., 2000)
Not duplicated in	T(1;4)wm258-18 (Ruiz-Gomez et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD99} NA P{GD2595} NA P{GD14476} NA P{KK107679} NA P{UAS-kirre.2phos.flag} NA P{UAS-kirre.4phos.flag} NA P{UAS-kirre.flag(TM)CT} NA P{UAS-kirre.flagC} NA P{UAS-kirre.flagCT} NA P{UAS-kirre.flagN} NA P{UAS-kirre.IR} NA P{UAS-kirre.NT(TM)flag} NA P{UAS-kirre.NTflag} NA P{UAS-kirre.PADVI.flag} NA P{UAS-kirre.PDZ.flag} NA P{UAS-kirre.R} NA P{UAS-kirre.TM.DE-Cadh.flag} NA P{UAS-kirre.TM.Sema-1a.flag} NA P{UAS-kirre.ΔCT1.flag} NA P{UAS-kirre.ΔCT2.flag} NA P{UAS-kirre.ΔCT3.flag} NA P{UAS-kirre.ΔCT5.flag} NA characterization construct P{kirre-GAL4.R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}kirreMI00678 NA Mi{MIC}kirreMI05438 NA Mi{MIC}kirreMI07148 NA P{RS3}kirreCB-0012-3 NA P{SUPor-P}kirreKG05552 NA PBac{RB}e03862 NA PBac{RB}kirree00634 NA PBac{RB}kirree01634 NA PBac{RB}kirree02337 NA PBac{RB}kirree03302 NA PBac{RB}kirree03324 NA PBac{RB}kirree03629 NA PBac{RB}kirree03883 NA PBac{RB}kirree04336 NA PBac{RB}kirree04339 NA PBac{RB}kirree04348 NA PBac{RB}kirree04352 NA PBac{RB}kirree04391 NA PBac{WH}kirref01401 NA PBac{WH}kirref01407 NA PBac{WH}kirref01511 NA PBac{WH}kirref02273 NA PBac{WH}kirref02316 NA PBac{WH}kirref03230 NA PBac{WH}kirref03717 NA PBac{WH}kirref04418 NA PBac{WH}kirref04425 NA PBac{WH}kirref05766 NA PBac{WH}kirref05848 NA PBac{WH}kirref06069 NA PBac{WH}kirref06075 NA PBac{WH}kirref06137 NA PBac{WH}kirref07355 NA PBac{WH}kirref07362 NA PBac{WH}kirref07973 NA insertion of mobile activating element P{EP}kirreG876 NA P{EP}kirreG1566 NA P{EPgy2}kirreEY04872 NA P{EPgy2}kirreEY14585 NA P{GSV1}EP-489EP-489 NA P{Mae-UAS.6.11}kirreGG01300 NA P{Mae-UAS.6.11}kirreGG01653 NA P{Mae-UAS.6.11}kirreGG01678 NA P{Mae-UAS.6.11}kirreGG01742 NA P{Mae-UAS.6.11}kirreGG01796 NA P{XP}kirred05817 NA P{XP}kirred06125 NA P{XP}kirred06226 NA P{XP}kirred08289 NA P{XP}kirred08606 NA insertion of enhancer trap binary system Mi{ET1}kirreMB00990 No P{GawB}kirreNP2044 No P{GawB}kirreNP2273 No P{GawB}kirreNP6008 No P{GawB}kirreNP7195 No insertion of enhancer trap P{PZ}rP298 No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from physical interaction with pyd (Weavers et al., 2009) protein binding inferred from physical interaction with rols (Chen and Olson, 2001)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Bao et al., 2010) garland nephrocyte differentiation inferred from mutant phenotype (Zhuang et al., 2009) heterophilic cell-cell adhesion inferred from mutant phenotype (Menon et al., 2005) homophilic cell adhesion inferred from genetic interaction with sns (Zhuang et al., 2009) inferred from mutant phenotype (Menon et al., 2005) larval visceral muscle development inferred from mutant phenotype (Klapper et al., 2002) myoblast fusion inferred from mutant phenotype (Ruiz-Gomez et al., 2000, Menon et al., 2005, Bulchand et al., 2010) nephrocyte diaphragm assembly inferred from mutant phenotype (Weavers et al., 2009, Zhuang et al., 2009) nephrocyte filtration inferred from mutant phenotype (Weavers et al., 2009) regulation of striated muscle tissue development inferred from genetic interaction with rst AND inferred from mutant phenotype (Strunkelnberg et al., 2001)
Cellular Component
CV term Evidence References
adherens junction inferred from direct assay (Menon et al., 2005) cell surface inferred from direct assay (Menon et al., 2005) nephrocyte diaphragm inferred from direct assay (Weavers et al., 2009, Zhuang et al., 2009) plasma membrane inferred from direct assay (Weavers et al., 2009)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
myoblast fusion non-traceable author statement (Taylor, 2000.7.3) traceable author statement (Cooper, 2001, Dworak and Sink, 2002)
Cellular Component
CV term Evidence References
plasma membrane non-traceable author statement (Struenkelnberg, 1999.10.20)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions kirre allele Gene References unspecified rst (Strunkelnberg et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57822 DroID - A comprehensive database of gene and protein interactions. • FBgn0028369 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31292
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BZNN1 Dipteran inclusive ortholog search EOG6DV5VD Insect inclusive ortholog search EOG6N8Q0V Arthropod inclusive ortholog search EOG6GTHV0 Metazoa inclusive ortholog search EOG62G59J
Orthologs in Drosophila Species (EOG6BZNN1)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\kirre     Drosophila simulans   Dsim\GD16630 Y   Drosophila sechellia   Dsec\GM19263 Y   Drosophila erecta   Dere\GG18645 Y   Drosophila yakuba   Dyak\GE16293 Y   Drosophila ananassae   Dana\GF19598 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17590 Y   Drosophila persimilis   Dper\GL19949 Y   Drosophila willistoni   Dwil\GK25537     Drosophila virilis   Dvir\kirre     Drosophila grimshawi   Dgri\GH12487 Y
Orthologs in non-Drosophila Dipterans (EOG6DV5VD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002754 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002732 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000217 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000218 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006789 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009311 Y
Orthologs in non-Dipteran Insects (EOG6N8Q0V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49778 Y Apis mellifera Western honey bee  Amel\GB40327 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007772 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10957 Y Atta cephalotes Leafcutter ant  Acep\ACEP20092 Y Atta cephalotes Leafcutter ant  Acep\ACEP20091 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13507 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19775 Y Linepithema humile Argentine ant  Lhum\LH23703 Y Linepithema humile Argentine ant  Lhum\LH23702 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB26029 Y Solenopsis invicta Red fire ant  Sinv\SINV13955 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI28711 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013289 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013290 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013310 Y Pediculus humanus Human body louse  Phum\PHUM111230 Y Tribolium castaneum Red flour beetle  Tcas\TC002914 Y
Orthologs in non-Insect Arthropods (EOG6GTHV0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\nad5 Y Ixodes scapularis Deer tick  Isca\ISCW023039 Y
Orthologs in non-Arthropod Metazoa (EOG62G59J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K02E10.8 Y Danio rerio Zebrafish  Drer\kirrelb Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16630 Drosophila sechellia Dsec\GM19263 Drosophila erecta Dere\GG18645 Drosophila yakuba Dyak\GE16293 Drosophila ananassae Dana\GF19598 Drosophila pseudoobscura pseudoobscura Dpse\GA17590 Drosophila persimilis Dper\GL19949 Drosophila grimshawi Dgri\GH12487
Stocks & Reagents
Stocks Listed in FlyBase ( 41 )
Harvard	- PBac{RB}e03862 - P{XP}kirred05817 - P{XP}kirred06125 - P{XP}kirred06226 - P{XP}kirred08289 - P{XP}kirred08606 - PBac{RB}kirree00634 - PBac{RB}kirree02337 - PBac{RB}kirree03324 - PBac{RB}kirree03629 - PBac{RB}kirree03883
VDRC	v6696 w1118; P{GD99}v6696
	More stocks available...
Genomic Clones ( 4 )
	BACR01A14 BACR03D13 BACR30B01 BACR34O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 199 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT15038 IP15852 LD21513 LD23922
Other clones	RT02552
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25571 AT26635 GH01442 GH17272 RE05714 RE53763 RE55048 RH01677 RH01869 RH03938 RH06941 RH06949 RH30020 RH30716 RH36065 RH70341 SD04322 SD05284 SD05488 SD05505 SD08671 SD08672 SD11749 SD14952 SD16092 SD20610 SD20937 SD22651
Other clones	9459 17883 29231 161045 214217.4 214217.52 214281.45 214309.58 280548 280694 CK01.41B.F3 CK01.76A.H6 CK01.99C.C8 CK01.100C.E11 CK01.101C.H9 CK01.106B.C3 CK01.129A.B2 CK01358 CK01771 CK01836 CK02256 CK02584 CK02684 CK02693 Dmel_neb_013175_0436_2813 EC13319 EK004047 EK008922 EK030002 EK048304 EK053803 EK057316 EK058008 EK059327 EK059463 EK060011 EK062229 EK062839 EK064209 EK067002 EK068527 EK080910 EK084344 EK084963 EK085018 EK085723 EK088356 EK090809 EK092643 EK093145 EK095528 EK095703 EK097007 EK100937 EK102527 EK105244 EK106046 EK106728 EK108612 EK110833 EK115509 EK119043 EK119732 EK123744 EK128624 EK130137 EK130640 EK135752 EK143704 EK146664 EK148339 EK150444 EK155537 EK156329 EK157147 EK157360 EK159162 EK159163 EK161027 EK165013 EK166349 EK167802 EK168941 EK173007 EK176904 EK178232 EK179526 EK179933 EK184927 EK186020 EK186058 EK197806 EK197836 EK200229 EK201531 EK207953 EK208757 EK209943 EK210625 EK213836 EK220109 EK224049 EK230464 EK234764 EK241457 EK245728 EK245947 EK250406 EK259242 EK261553 EK262215 EK263921 EK264004 EK264826 EK278350 EK284052 EK290234 EK291606 EK293141 EK298525 EK301608 EK301618 EK302908 EK304220 EK304318 EK304353 EK305549 EN02401 EN02405 EN04650 EN12324 EN16322 EN17143 EP00644 EP00647 EP01622 EP01948 EP02618 EP03007 EP03024 EP03318 EP03630 EP05631 EP09350 EP10112 EP10919 EP11538 EP11939 EP12425 EP12539 EP13216 EP13712 EP14817 EP17909 EP18609 EP19647 EP21212 EP22363 FGM104E09 IP15952 RC0-DA0003-130700-022-A05 RH09239 RP004172305 RP004242183 RP004255421 SD01540
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31292
Antibody Information
	polyclonal (Bao et al., 2010)
Other Information
Discoverer
Etymology
	Named kirre because it shows very high homology to irreC-rst. (Struenkelnberg, 1999.9.15)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: EG:163A10.1 CG3653 (Gabrielian, 1999.11)
Source for database merge of	Source for merge of: kirre EG:163A10.1 (FlyBase, 1996-)
Additional comments	Source for merge of kirre EG:163A10.1 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	The putative transmembrane region of the kirre protein functions as a membrane anchor. (Menon et al., 2005) The extracellular region of the kirre protein is sufficient for homophilic cell interaction in trans. (Menon et al., 2005) The extracellular region of the kirre protein is required for its localization to adherens junctions. (Menon et al., 2005) The membrane-anchored extracellular region of of the kirre protein is sufficient to initiate the first round of myoblast fusion (development of the precursor) although fusion beyond this stage requires both the membrane-anchored extracellular region and the intracellular region to be present as a single entity. (Menon et al., 2005) Full length kirre protein is able to translocate rols protein from the cytoplasm to adherens junctions in polarized non-mesodermal cells. Translocation occurs only where kirre protein is engaged in homophilic or kirre-sns-directed heterophilic cell adhesion. (Menon et al., 2005) kirre is required for the formation of syncytia within the visceral musculature of the midgut. (Klapper et al., 2002) rst and kirre act redundantly during muscle development as myoblast attractants. (Strunkelnberg et al., 2001) kirre is required for myoblast aggregation and fusion. (Ruiz-Gomez et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080320 NM_166958 NM_001258576 NM_001258577 NM_001258578 NM_001258579 NM_001272267 RefSeq (Proteins) • NP_525059 NP_726844 NP_001245505 NP_001245506 NP_001245507 NP_001245508 NP_001259196 DDBJ / EMBL / GenBank • AAF45847 AAF86308 AAM50546 AAN09598 AF196553 AFH07219 AFH07220 AFH07221 AFH07222 AGB95042 AJ289882 AL035436 AY118686 BF500129 CAB36503 CAB96574 CZ488393 CZ488394 Entrez Gene - A searchable database of RefSeq genes. • 31292 UniProtKB/TrEMBL • O97174 Q8MSN7 Q9N9Y9 Q9W4T9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Immunoglobulin V-set (IPR013106) CD80-like, immunoglobulin C2-set (IPR013162) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57822 DroID - A comprehensive database of gene and protein interactions. • FBgn0028369 DRSC - Results from RNAi screens. • FBgn0028369 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028369 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3653-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028369 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31292 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dumbfounded1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31292 modMine - Data generated by the modENCODE project. • FBgn0028369
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	CG3653 (Molnar et al., 2006, Keleman et al., 2009.8.5, Cammarato et al., 2011) CT12279 (Hynes and Zhao, 2000) Duf (Chen and Olson, 2005, Bullard et al., 2004, Fernandes and Keshishian, 2005, Fernandes and Keshishian, 2005, Taylor, 2003, Gonzalez-Gaitan, 2003, Freeman, 2003, Dworak et al., 2002, Baylies and Michelson, 2001, Anonymous, 2000, Jones, 2000, Fernandes et al., 2006, IV et al., 2007, Bernard et al., 2006, Fernandes and Krishan, 2007, Griemert et al., 2007, Schäfer et al., 2007, Chen et al., 2007, Maqbool et al., 2006, Dottermusch-Heidel et al., 2012, Schäfer et al., 2008, Dottermusch et al., 2008, Rudolf et al., 2012, Wei et al., 2007, Carrasco-Rando and Ruiz-Gómez, 2008, Berger et al., 2008, Gildor et al., 2009, Sens et al., 2010, Duan et al., 2012) duf (Schnorrer and Dickson, 2004, Soler et al., 2004, Schroter et al., 2004, Dutta et al., 2004, Chen and Olson, 2004, Chen et al., 2003, Shah et al., 2005, Englund et al., 2003, Guruharsha et al., 2004, Lee et al., 2003, Chen and Olson, 2001, Menon and Chia, 2001, Lee et al., 2003, Stute et al., 2003, Taylor, 2002, Kozopas and Nusse, 2002, San Martin et al., 2001, Cooper, 2001, Artero et al., 2001, Chakravarti et al., 2001, Ruiz-Gomez et al., 2001, Taylor, 2000, Ruiz-Gomez et al., 2000, Frasch and Leptin, 2000, Taylor, 2000.7.3, Dutta et al., 2005, Nguyen and Frasch, 2006, Menon et al., 2005, Estrada et al., 2006, Shah et al., 2011, Benchabane et al., 2011, Zhuang et al., 2008, Badrinath, 2008, Kesper et al., 2007, Dutta et al., 2010, Rotkopf et al., 2011, Susic-Jung et al., 2012, Massarwa et al., 2007, Nguyen et al., 2007, Weavers et al., 2009, Weavers et al., 2009, Guruharsha et al., 2009, Helmstadter et al., 2012, Hossain et al., 2005, Bulchand et al., 2010) DUF (Donaldson, 2003, Chen and Olson, 2002) Duf/Kirre (Galletta et al., 2004, Schäfer et al., 2007) DUF/KIRRE (Galletta et al., 2003) duf/kirre (Guruharsha et al., 2009) EG:163A10.1   kirre (Levis, 2007.5.10, Molnar et al., 2006, Dietzl et al., 2007, Kesper et al., 2007, Takemura and Adachi-Yamada, 2011, Sugie et al., 2010, Weavers et al., 2009, Krejcí et al., 2009, Shelton et al., 2009, Demakov et al., 2004, Zhuang et al., 2009, Guruharsha et al., 2009, Helmstadter et al., 2012, Bao et al., 2010, Strunkelnberg et al., 2003) Kirre (Vishnu et al., 2006, Griemert et al., 2007, Linneweber and Fischbach, 2007, Schäfer et al., 2008, Dottermusch et al., 2008, Höhne et al., 2011, Haralalka et al., 2011, Hoehne et al., 2005, Bulchand et al., 2010) RH09239 (Kvon et al., 2011)
Name Synonym	dumbfounded (Lee et al., 2003, Dworak and Sink, 2002, Lee et al., 2003, Chakravarti et al., 2001, Taylor, 2000, Ruiz-Gomez et al., 2000, Taylor, 2000.7.3, Nguyen and Frasch, 2006, Menon et al., 2005, Estrada et al., 2006, Zhuang et al., 2008, Dutta et al., 2010, Takemura and Adachi-Yamada, 2011, Nguyen et al., 2007, Duan et al., 2007, Estrada et al., 2007, Weavers et al., 2009, Guruharsha et al., 2009, Massarwa et al., 2007, Maqbool et al., 2006) Dumbfounded (Donaldson, 2003, Chen and Olson, 2002, Jones, 2000, Bernard et al., 2006, Fernandes and Krishan, 2007, Griemert et al., 2007, Schäfer et al., 2007, Massarwa et al., 2007, Chen et al., 2007, Badrinath, 2008, Schejter et al., 2007, Kesper et al., 2007, Wei et al., 2007, Atreya and Fernandes, 2008, Gildor et al., 2009, Bulchand et al., 2010) Dumbfounded/Kirre (Schäfer et al., 2007, Bazigou et al., 2007) kin of irre (Struenkelnberg, 1999.10.20, Cammarato et al., 2011) Kin-of-irre (Hoehne et al., 2005) Kin of irre (Bao et al., 2010) kin-of-irreC (Strunkelnberg et al., 2001) Kin of IrreC (Griemert et al., 2007) kin of irreC (Takemura and Adachi-Yamada, 2011) Kin of irregular-chiasm-C (Bulchand et al., 2010) Kirre (Chen et al., 2007) kirre (Jensen et al., 2007, Andreyenkov et al., 2010)
Secondary FlyBase IDs
	FBgn0028745
References ( 150 )
Generate a list of	All references relating to this gene ( 150 )
List References by type	Research paper  ( 71 ) Supplementary material  ( 7 ) Review  ( 19 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 31 ) FlyBase analysis  ( 3 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 3 )
Recent research papers ( 15 )
	Kaipa et al., 2013, J. Cell Sci. 126(1): 360--372 Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts. [FBrf0221091] Dottermusch-Heidel et al., 2012, Dev. Biol. 368(1): 18--27 The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. [FBrf0218661] Duan et al., 2012, J. Cell Biol. 199(1): 169--185 Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. [FBrf0219579] Gildor et al., 2012, Development 139(21): 4040--4050 Bidirectional Notch activation represses fusion competence in swarming adult Drosophila myoblasts. [FBrf0219658] Helmstadter et al., 2012, PLoS ONE 7(7): e40300 Functional Study of Mammalian Neph Proteins in Drosophila melanogaster. [FBrf0218912] Rudolf et al., 2012, Europ. J. Cell Biol. 91(3): 192--203 The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion. [FBrf0217503] Susic-Jung et al., 2012, Dev. Biol. 370(1): 86--97 Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. [FBrf0219326] Haralalka et al., 2011, Development 138(8): 1551--1562 Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila. [FBrf0213340] Höhne et al., 2011, Mol. Cell. Biol. 31(16): 3241--3251 The BAR Domain Protein PICK1 Regulates Cell Recognition and Morphogenesis by Interacting with Neph Proteins. [FBrf0214537] Kvon et al., 2011, Russ. J. Genet. 47(6): 674--681 Chromatin decompaction in the interbands of Drosophila polytene chromosomes does not correlate with high transcription level. [FBrf0218797] Kvon et al., 2011, Genetika, Moscow 47(6): 765--773 [Chromatin decompaction in the interbands of Drosophila polytene chromosomes does not correlate with high transcription level]. [FBrf0214812] Machado et al., 2011, PLoS ONE 6(8): e22536 rst Transcriptional Activity Influences kirre mRNA Concentration in the Drosophila Pupal Retina during the Final Steps of Ommatidial Patterning. [FBrf0214740] Rotkopf et al., 2011, Development 138(13): 2729--2739 The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. [FBrf0213892] Shah et al., 2011, Mech. Dev. 128(3-4): 222--233 Cardiac remodeling in Drosophila arises from changes in actin gene expression and from a contribution of lymph gland-like cells to the heart musculature. [FBrf0213326] Takemura and Adachi-Yamada, 2011, Dev. Biol. 357(2): 336--346 Cell death and selective adhesion reorganize the dorsoventral boundary for zigzag patterning of Drosophila wing margin hairs. [FBrf0214791] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...