caspase-3, Caspase 3, Casp3, Cas3, CC3
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Decay using the Feature Mapper tool.
Decay transcripts are expressed at low levels throughout embryogenesis. In early stages the transcript is ubiquitously distributed. At later stages, it is prominant in the gut. In third instar larvae, high levels of Decay transcripts are observed in salivary glands and midgut. Low levels are present throughout eye imaginal discs and brain lobes. Decay transcripts are present throughout oogenesis with elevated levels in stage 10 nurse cells. Transcripts disappear from stage 12 nurse cells that have initiated apoptosis and are present at high levels in the oocyte. No up-regulation of Decay expression is observed in ecdysone-treated salivary glands.
Decay protein expression was assayed in prepupal genital discs as a measure of caspase activation. In both sexes, expression appears as fine, bright spots in all cells, as well as a few large spots which are nuclei of apoptotic cells. In males, active caspases are more abundant and present in a higher density in the en domain, but does not coincide with the expression of hid or rpr.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Decay in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Decay decay
Capitalized initial letter of gene symbol and name to be consistent with similarly named 'death genes' and to follow FlyBase nomenclature rules.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
decay is required for the normal pattern of programmed cell death in embryogenesis.