FlyBase Gene Report: Dmel\Decay

General Information

Symbol

Dmel\Decay

Species

D. melanogaster

Name

Death executioner caspase related to Apopain/Yama

Annotation Symbol

CG14902

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028381

Gene Model Status

Current

Stock Availability

5 publicly available

Enzyme Name (EC)

Cathepsin B (3.4.22.1)

Actinidain (3.4.22.14)

Cathepsin L (3.4.22.15)

Cathepsin H (3.4.22.16)

Cathepsin S (3.4.22.27)

Picornain 3C (3.4.22.28)

Legumain (3.4.22.34)

Cathepsin K (3.4.22.38)

Bleomycin hydrolase (3.4.22.40)

Cathepsin F (3.4.22.41)

Clostripain (3.4.22.8)

Gene Snapshot

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

caspase-3, Caspase 3, Casp3, Cas3, CC3

Key Links

Genomic Location

Cytogenetic map

89B18-89B18

Sequence location

3R:16,499,058..16,501,050 [-]

Recombination map

3-58

RefSeq locus

NT_033777 REGION:16499058..16501050

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

cysteine-type endopeptidase activity

inferred from direct assay

(Dorstyn et al., 1999)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

cysteine-type endopeptidase activity

inferred from sequence or structural similarity with FLYBASE:Dcp-1; FB:FBgn0010501

(Dorstyn et al., 1999)

cysteine-type endopeptidase activity involved in apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

cysteine-type endopeptidase activity involved in execution phase of apoptosis

inferred from biological aspect of ancestor with PANTHER:PTN000048300

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

apoptotic process

inferred from mutant phenotype

(Dorstyn et al., 1999)

NOT larval midgut histolysis

inferred from mutant phenotype

(Denton et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

apoptotic process

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

programmed cell death

traceable author statement

(Richardson and Kumar, 2002)

proteolysis

inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR011600, InterPro:IPR016129

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Dorstyn et al., 1999)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000047947

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

CASPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Hydrolysis of proteins with broad specificity for peptide bonds (3.4.22.1)

Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L) (3.4.22.1)

In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides (3.4.22.1)

Specificity close to that of papain (3.4.22.14)

Specificity close to that of papain (3.4.22.15)

As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity (3.4.22.15)

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase (3.4.22.16)

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound (3.4.22.27)

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein (3.4.22.28)

In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly (3.4.22.28)

Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds (3.4.22.34)

Broad proteolytic activity (3.4.22.38)

With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg (3.4.22.38)

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity (3.4.22.40)

The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred (3.4.22.40)

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L (3.4.22.41)

Preferential cleavage: Arg-|-Xaa, including Arg-|-Pro bond, but not Lys-|-Xaa (3.4.22.8)

Predictions / Assertions

Hydrolysis of proteins with broad specificity for peptide bonds (3.4.22.1)

Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L) (3.4.22.1)

In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides (3.4.22.1)

Specificity close to that of papain (3.4.22.14)

Specificity close to that of papain (3.4.22.15)

As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity (3.4.22.15)

Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-|-Xaa bonds) as well as an endopeptidase (3.4.22.16)

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound (3.4.22.27)

Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein (3.4.22.28)

In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly (3.4.22.28)

Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds (3.4.22.34)

Broad proteolytic activity (3.4.22.38)

With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg (3.4.22.38)

Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity (3.4.22.40)

The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred (3.4.22.40)

The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L (3.4.22.41)

Preferential cleavage: Arg-|-Xaa, including Arg-|-Pro bond, but not Lys-|-Xaa (3.4.22.8)

Summaries

Gene Group (FlyBase)

CASPASES -: Caspases are a family of cysteine proteases that are particularly well known for their role in apoptosis. Caspases are translated as inactive zymogen precursor proteins. Initiator caspases have a large prodomain, and are cleaved to yield active enzyme in response to proapoptotic stimuli. Initiator caspases cleave and active effector (or executioner) caspases which cleave the substrates leading to programmed cell death. Caspases belong to MEROPS family C14. (Adapted from FBrf0215539).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Decay for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Decay-RA

FBtr0083304

NM_058114

1111

308

Additional Transcript Data and Comments

Reported size (kB)

1.1 (northern blot)

(Dorstyn et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Decay-PA

FBpp0082755

34.9

308

6.38

NP_477462

AAF55329

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

308 (aa)

(Dorstyn et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Decay using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Decay_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

eye disc

(Dorstyn et al., 1999)

embryonic stage 13 -- 16

embryonic midgut chamber

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

oocyte

(Dorstyn et al., 1999)

egg chamber

(Dorstyn et al., 1999)

nurse cell

(Dorstyn et al., 1999)

embryonic stage 13 -- 17

embryonic/larval midgut

(Dorstyn et al., 1999)

third instar larval stage

embryonic/larval brain

(Dorstyn et al., 1999)

embryonic/larval salivary gland

(Dorstyn et al., 1999)

embryonic/larval midgut

(Dorstyn et al., 1999)

embryonic stage 1 -- 7

organism | ubiquitous

(Dorstyn et al., 1999)

embryonic stage -- adult stage

(Dorstyn et al., 1999)

Additional Descriptive Data

Decay transcripts are expressed at low levels throughout embryogenesis. In early stages the transcript is ubiquitously distributed. At later stages, it is prominant in the gut. In third instar larvae, high levels of Decay transcripts are observed in salivary glands and midgut. Low levels are present throughout eye imaginal discs and brain lobes. Decay transcripts are present throughout oogenesis with elevated levels in stage 10 nurse cells. Transcripts disappear from stage 12 nurse cells that have initiated apoptosis and are present at high levels in the oocyte. No up-regulation of Decay expression is observed in ecdysone-treated salivary glands.

(Dorstyn et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage

male genital disc

(Benitez et al., 2010)

female genital disc

(Benitez et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Decay protein expression was assayed in prepupal genital discs as a measure of caspase activation. In both sexes, expression appears as fine, bright spots in all cells, as well as a few large spots which are nuclei of apoptotic cells. In males, active caspases are more abundant and present in a higher density in the en domain, but does not coincide with the expression of hid or rpr.

(Benitez et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Dorstyn et al., 1999)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Decay in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Decay

View exonic expression by tissue for Dmel\Decay

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028381

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028381

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14902-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14902

Flygut - An atlas of the Drosophila adult midgut

FBgn0028381

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Decay

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Decay

Transgenic constructs containing regulatory region of Decay

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)Exel6269

(Ryder, 2004.4.26)

Df(3R)Exel8163

(Ryder, 2004.4.26)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^ap-md544

Decay^HMC06141

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Decay^GD8484

viable, with Scer\GAL4^Mef2.PR

Decay^GD8484

viable, with Scer\GAL4^pnr-MD237

Decay^GD8484

viable, with Scer\GAL4^tin.CΔ4

Decay^GD8484

Sterility

Allele

fertile

male semi-sterile

Decay^d07129

Other Phenotypes

Allele

size defective | adult stage, with Scer\GAL4^C10

visible, with Scer\GAL4^pnr-MD237

Decay^GD8484

visible | adult stage, with Scer\GAL4^ap-md544

visible | adult stage, with Scer\GAL4^C10

Phenotype manifest in

Allele

ejaculatory duct

Decay^d07129

male accessory gland

Decay^d07129

seminal vesicle

Decay^d07129

trichogen cell, with Scer\GAL4^pnr-MD237

Decay^GD8484

wing, with Scer\GAL4^ap-md544

wing, with Scer\GAL4^C10

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (22)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CASP3

5 of 15

Yes

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

Yes

Hsap\CARD16

2 of 15

Yes

Hsap\CARD17

2 of 15

Yes

Hsap\CARD18

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\PYCARD

1 of 15

Yes

Hsap\PYDC1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Casp3

4 of 15

Yes

Mmus\Casp6

4 of 15

Yes

Mmus\Casp7

4 of 15

Yes

Mmus\Casp2

3 of 15

Mmus\Casp8

3 of 15

Mmus\Casp9

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

Yes

Mmus\Pea15a

1 of 15

Yes

Mmus\Pycard

1 of 15

Yes

Rattus norvegicus (Norway rat) (14)

Rnor\Casp3

4 of 13

Yes

Rnor\Casp2

3 of 13

Rnor\Casp6

3 of 13

Yes

Rnor\Casp7

3 of 13

Rnor\Casp8

3 of 13

Rnor\LOC103689977

3 of 13

Yes

Rnor\Casp1

2 of 13

Rnor\Casp4

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Rnor\Pycard

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (11)

Xtro\casp3

5 of 12

Yes

Xtro\casp7

4 of 12

Xtro\LOC733553

4 of 12

Yes

Xtro\casp2

3 of 12

Xtro\casp6

3 of 12

Yes

Xtro\casp1

2 of 12

Xtro\casp10

2 of 12

Xtro\LOC100486222

2 of 12

Yes

Xtro\casp9

1 of 12

Xtro\LOC100486968

1 of 12

Yes

Xtro\pea15

1 of 12

Yes

Danio rerio (Zebrafish) (25)

Drer\casp3a

7 of 15

Yes

Drer\casp3b

7 of 15

Yes

Drer\casp6a

5 of 15

Yes

Drer\casp6b.1

5 of 15

Yes

Drer\casp21

5 of 15

Drer\casp6b.2

4 of 15

Yes

4 of 15

3 of 15

3 of 15

3 of 15

Yes

Drer\casp17

3 of 15

Yes

Drer\caspxa

3 of 15

Yes

Drer\LOC798445

3 of 15

Yes

Drer\casp8

2 of 15

Yes

Drer\casp10

2 of 15

Drer\casp20

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Yes

Drer\pea15

1 of 15

Yes

Drer\si:ch211-195h23.3

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\ced-3

8 of 15

Yes

Cele\csp-1

4 of 15

Yes

Cele\csp-2

3 of 15

Yes

Cele\csp-3

2 of 15

Yes

Cele\ZK795.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BQN )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13340

Drosophila persimilis

Dper\GL27295

Drosophila willistoni

Dwil\GK11868

Drosophila virilis

Dvir\GJ22849

Drosophila mojavensis

Dmoj\GI10391

Drosophila grimshawi

Dgri\GH17516

Drosophila grimshawi

Dgri\GH20516

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507RY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015414

Glossina morsitans

Tsetse fly

Gmor\GMOY001829

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08588

Anopheles gambiae

Malaria mosquito

Agam\CASPS3

Anopheles gambiae

Malaria mosquito

Agam\CASPS4

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07O6 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003516

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05YD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN2b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1b2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_023703gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-CspeN2a

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_001472gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007259gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe6L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe9L1b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe8L2b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cspe3/7L

Ciona intestinalis

Vase tunicate

Cint\LOC100185724

Ciona intestinalis

Vase tunicate

Cint\LOC100175572

Ciona intestinalis

Vase tunicate

Cint\LOC100177955

Ciona intestinalis

Vase tunicate

Cint\LOC100185209

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024334

Ciona intestinalis

Vase tunicate

Cint\LOC494382

Ciona intestinalis

Vase tunicate

Cint\LOC100178691

Ciona intestinalis

Vase tunicate

Cint\LOC100183628

Gallus gallus

Domestic chicken

Ggal\CASP3

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008346

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008240

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008305

Gallus gallus

Domestic chicken

Ggal\CASP6

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008355

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001366

Gallus gallus

Domestic chicken

Ggal\CASP2

Gallus gallus

Domestic chicken

Ggal\CASP7

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

6 of 10

6 of 10

3 of 10

3 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

5 of 15

4 of 15

4 of 15

3 of 15

3 of 15

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Decay

suppressible

Atg7

(Shinoda et al., 2019)

Decay

suppressible

Atg9

(Shinoda et al., 2019)

Decay

suppressible

Atg13

(Shinoda et al., 2019)

Decay

suppressible

Atg18a

(Shinoda et al., 2019)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Der-1

suppressible

Decay

(Liang et al., 2014)

Drice|Diap1

suppressible

Damm|Dcp-1|Decay

(Leulier et al., 2006)

hid

suppressible

Decay

(Leulier et al., 2006)

hid

suppressible

Dronc|Decay

(Leulier et al., 2006)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0028381

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42008

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-58

Cytogenetic map

89B18-89B18

Sequence location

3R:16,499,058..16,501,050 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89B18-89B18

Limits computationally determined from genome sequence between P{lacW}CSN5^L4032 and P{EP}MESK4^EP1015

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

89C6-89D4

(Dorstyn et al., 1999)

Determined by hybridisation to P1 clones (details unspecified).

(Dorstyn et al., 1999)

Experimentally Determined Recombination Data

Location

3-58

(FlyBase, 2016)

3-58.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

81439

y¹ v¹; P{TKO.GS04672}attP40

65879

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06141}attP2

VDRC

v100168

P{KK105137}VIE-260B

v43028

w¹¹¹⁸; P{GD8484}v43028

v43029

w¹¹¹⁸; P{GD8484}v43029

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT03047

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028381

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028381

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42008

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Decay decay

(Steller et al., 2014.7.9)

Source for database merge of

Additional comments

Capitalized initial letter of gene symbol and name to be consistent with similarly named 'death genes' and to follow FlyBase nomenclature rules.

(Steller et al., 2014.7.9)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

decay is required for the normal pattern of programmed cell death in embryogenesis.

(Quinn et al., 1999)

Ectopic expression of decay results in ectopic apoptotic death.

(Quinn et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42008

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028381

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028381

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Decay_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14902

Flygut - An atlas of the Drosophila adult midgut

FBgn0028381

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42008

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003841

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG14902

modMine - A data warehouse for the modENCODE project

FBgn0028381

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0028381

DRSC - Results frm RNAi screens

FBgn0028381

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028381

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG14902-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028381

FlyMine - An integrated database for Drosophila genomics

FBgn0028381

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

42008

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

CAS3

(Christiansen et al., 2013)

CC-3

(Wu et al., 2015)

CC3

(Khan et al., 2017, Monserrate and Baker Brachmann, 2007)

CG14902

(Hosono et al., 2015, Walls et al., 2013, Keleman et al., 2009.8.5, Perkins et al., 2009, Irving et al., 2001)

Cas3

(Fan et al., 2010, Yavari et al., 2010, Dichtel-Danjoy et al., 2009, Terriente-Félix and de Celis, 2009, Wang et al., 2008, Vrailas and Moses, 2006)

Casp3

(Ngo et al., 2020, Kwon et al., 2015, Mukherjee et al., 2012, Vincent et al., 2011, Bosch et al., 2010, Ghiglione et al., 2008, Herranz et al., 2006, Chotard et al., 2005)

Caspae-3

(Liang et al., 2020)

Caspase-3

(Zhang et al., 2018, Simon and Guerrero, 2015, Galindo et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Herz et al., 2006, Swan et al., 2005)

DECAY

(Sentürk et al., 2020, Fan and Bergmann, 2010, Quinn et al., 1999)

Drosophila executioner caspase related to Apopain/Yama

(Dorstyn et al., 1999)

cas3

(Sakurai et al., 2014)

caspase 3

(Bardet et al., 2008, Marenda et al., 2006)

caspase-3

(Srivastav et al., 2018, Ly et al., 2013, Fan et al., 2010, Baena-Lopez and Garcia-Bellido, 2006, Adachi-Yamada et al., 2005, Dorstyn et al., 2004)

decay

(Shinoda et al., 2019, Everman and Morgan, 2018, Mao et al., 2016, Liang et al., 2014, Li et al., 2013, Felix et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Khammari et al., 2011, Lee et al., 2011, Xu et al., 2009, Hou et al., 2008, Hueber et al., 2007, Primrose et al., 2007, Kondo et al., 2006, Leulier et al., 2006, Doumanis et al., 2001)

Name Synonyms

Caspase 3

(Muñoz-Nava et al., 2020, Kwon et al., 2015, Rojas-Ríos et al., 2012, Dichtel-Danjoy et al., 2009, Bazigou et al., 2007, Janody and Treisman, 2006, Roignant et al., 2006, Vrailas and Moses, 2006, Vrailas et al., 2006)

Caspase-3

(Wu et al., 2015, Christiansen et al., 2013, Shlevkov and Morata, 2012, Vaccari et al., 2010, Yavari et al., 2010, Shen et al., 2008, Wang et al., 2008, Zhu et al., 2008, Zhu et al., 2008, Wang et al., 2007, Thompson and Cohen, 2006, Vrailas and Moses, 2006, Wehr et al., 2006, Wells et al., 2006)

Caspase3

(Zimmermann et al., 2015)

Cleaved Caspase 3

(Clark et al., 2006)

Death executioner caspase related to Apopain/Yama

(Steller et al., 2014.7.9, Felix et al., 2012)

Decay

(Kuranaga, 2011, Vaccari et al., 2010, Dichtel-Danjoy et al., 2009, Zhu et al., 2008)

caspase 3

(Podratz et al., 2017, Pérez-Garijo et al., 2013, Babcock et al., 2009, Monserrate and Baker Brachmann, 2007, Silva, 2006)

caspase-3

(Yang et al., 2020, Zhang et al., 2015, Stickel and Su, 2014, Suissa et al., 2011, Yan et al., 2011, Ahamed et al., 2010, Bossuyt et al., 2009, Babcock et al., 2008, Mehrotra et al., 2008, Shen et al., 2008, Manjon et al., 2007, Tanaka-Matakatsu et al., 2007, Akdemir et al., 2006, Cela and Llimargas, 2006, Gilboa and Lehmann, 2006, Mills et al., 2006, Scuderi et al., 2006, Thompson and Cohen, 2006, Bruckner et al., 2004)

caspase-3 protein

(Moberg and Hariharan, 2003)

death executioner caspase related to Apopain/Yama

(Dorstyn et al., 1999)

decay

(Denton et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (166)

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