• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\cyp33

General Information
Symbol	Dmel\cyp33	Species	D. melanogaster
Name	cyclophilin-33	Annotation symbol	CG4886
Feature type	protein_coding_gene	FlyBase ID	FBgn0028382
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	54C3-54C3	Sequence location	2R:13,432,727..13,433,905 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cyclophilin-33 is referred to in FlyBase by the symbol Dmel\cyp33 (CG4886, FBgn0028382). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: phagocytosis, engulfment. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain; Cyclophilin-type peptidyl-prolyl cis-trans isomerase E; Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site; Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623009_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cyp33. Gene sequence location is 2R:13432727..13433905.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 54C3-54C3   Limits computationally determined from genome sequence between P{lacW}l(2)k07433k07433 and P{EP}MESR4EP988
Experimentally Determined Cytological Location
Cytogenetic map Notes References 54C-54C   (determined by in situ hybridisation)   (Anderson et al., 2002) 54C-54C     (Anderson, 1999.9.3)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cyp33 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cyp33-RA FBtr0086945  NM_079049   986   300
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cyp33-PA   FBpp0086101   33.3   300   5.93     NP_523773   AAF57839
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Nucleotide-binding, alpha-beta plait (IPR012677) Cyclophilin-type peptidyl-prolyl cis-trans isomerase E (IPR016304) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57839   AF182826 AAF01031   AI518843   AW943273   AY061421 AAL28969   AY231912   AY232025   BI371257   BI633379   BI637303   BI640913   BI641490   CO308877   CO336278   EC249624   EC262316   EV587645   EV595435
UniProtKB/Swiss-Prot	Q9V3G3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.1 Larval Midgut    89.4 Larval Hindgut    126.3 Larval Malpighian Tubules    400.8 Larval Fat Body    123.1 Larval Salivary Gland    183.3 Larval Trachea    147.05 Larval Carcass    117.7 Adult Head    95.6 Adult Eye    78.3 Adult Brain    141.8 Adult Thoracic-Abdominal Ganglion    132.7 Adult Crop    116.6 Adult Midgut    101 Adult Hindgut    115 Adult Malpighian Tubules    166.2 Adult Fat Body    97.9 Adult Salivary Gland    127.7 Adult Heart    65.2 Adult VirginFemale Spermatheca    82 Adult InseminatedFemale Spermatheca    78.1 Adult Ovary    208.6 Adult Testis    49.5 Adult Male Accessory Gland    137.8 Adult Carcass    58.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    95.6   NA  Eye    78.3   NA  Brain    141.8   288.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    132.7   NA  Crop    116.6   89.4  Midgut    101   126.3  Hindgut    115   400.8  Malpighian Tubules    166.2   123.1  Fat Body    97.9   183.3  Salivary Gland    127.7   NA  Heart    65.2   147.05  Trachea    NA   NA  VirginFemale Spermatheca    82   NA  InseminatedFemale Spermatheca    78.1   NA  Ovary    208.6   NA  Testis    49.5   NA  Male Accessory Gland    137.8   117.7  Carcass    58.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    21 central nervous system, larvae L3    22 central nervous system, pupae P8    14 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    5 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    11 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    9 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    3 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    18 ovary, mated 4-day female    12 testis, mated 4-day male    18 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (27) embryo 02-04hr  (32) embryo 04-06hr  (64) embryo 06-08hr  (45) embryo 08-10hr  (31) embryo 10-12hr  (27) embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  27 embryo 02-04hr  32 embryo 04-06hr  (64) embryo 06-08hr  (45) embryo 08-10hr  31 embryo 10-12hr  27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    27 embryo 02-04hr    32 embryo 04-06hr    64 embryo 06-08hr    45 embryo 08-10hr    31 embryo 10-12hr    27 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    9 embryo 18-20hr    6 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    15 larva L2    14 larva L3 12hr old    11 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    21 white prepupae new    18 white prepupae 12hr    19 white prepupae 24hr    25 pupae 2d postWPP    16 pupae 3d postWPP    8 pupae 4d postWPP    7 adult male 01day    9 adult male 05day    11 adult male 30day    10 adult female 01day    17 adult female 05day    24 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4  (29) embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1  (32) wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21  (30) wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5  (27) mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  (28) ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4  29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1  32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21  30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5  27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2  (33) tumorous blood cells mbn2  28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    29 embryonic 1182-4H    20 embryonic GM2    14 embryonic Kc167    18 embryonic S1    24 embryonic S3    22 leg disc CME L1    32 wing disc CME-W2    22 wing disc ML-DmD8    15 wing disc ML-DmD9    20 wing disc ML-DmD16-c3    17 wing disc ML-DmD21    30 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    24 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    21 CNS ML-DmBG1-c1    16 CNS ML-DmBG2-c2    33 tumorous blood cells mbn2    28 ovary fGS/OSS    15 ovary OSC    9 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    5 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    8 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    12 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD35248 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028382 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4886-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for cyp33 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of cyp33 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cyp33 Class Mutagen Stocks Known lesion cyp33GL00451 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cyp33KK107578 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cyp33GD11457 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cyp33NIG.4886R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cyp33RRM in vitro construct 0 Yes cyp33T:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11457} NA P{KK107578} NA P{NIG.4886R} NA P{TRiP.GL00451} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) peptidyl-prolyl cis-trans isomerase activity inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR016304, InterPro:IPR020892 (FlyBase Curators et al., 2004-) non-traceable author statement (Anderson, 1999.9.3, Swiss-Prot Project Members, 2000.10.1) RNA binding inferred from electronic annotation with InterPro:IPR016304 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) protein folding inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR016304, InterPro:IPR020892 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cyp33 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62673 DroID - A comprehensive database of gene and protein interactions. • FBgn0028382 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36984
Orthologs
OrthoDB Orthologs (116) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG605SM6 Dipteran inclusive ortholog search EOG6T78C2 Insect inclusive ortholog search EOG66WX56 Arthropod inclusive ortholog search EOG6C8685 Metazoa inclusive ortholog search EOG651SJN
Orthologs in Drosophila Species (EOG605SM6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cyp33     Drosophila simulans   Dsim\GD11288 Y   Drosophila sechellia   Dsec\GM21798 Y   Drosophila erecta   Dere\GG21795 Y   Drosophila yakuba   Dyak\GE11871 Y   Drosophila ananassae   Dana\GF11346 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18502 Y   Drosophila persimilis   Dper\GL11464 Y   Drosophila willistoni   Dwil\GK21899 Y   Drosophila virilis   Dvir\GJ20579 Y   Drosophila mojavensis   Dmoj\GI20843 Y   Drosophila grimshawi   Dgri\GH20760 Y
Orthologs in non-Drosophila Dipterans (EOG6T78C2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013948   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007273   Anopheles gambiae Malaria mosquito  Agam\AGAP009810   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008841
Orthologs in non-Dipteran Insects (EOG66WX56)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409427   Apis mellifera Western honey bee  Amel\GB52855   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037318   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10853   Atta cephalotes Leafcutter ant  Acep\ACEP13460   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20210   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19516   Linepithema humile Argentine ant  Lhum\LH19772   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23024   Solenopsis invicta Red fire ant  Sinv\SINV14451   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010179   Bombyx mori Silkmoth  Bmor\BGIBMGA003414   Bombyx mori Silkmoth  Bmor\BGIBMGA003415   Pediculus humanus Human body louse  Phum\PHUM293600   Tribolium castaneum Red flour beetle  Tcas\TC002359
Orthologs in non-Insect Arthropods (EOG6C8685)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307711   Ixodes scapularis Deer tick  Isca\ISCW002449
Orthologs in non-Arthropod Metazoa (EOG651SJN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cyn-9 Y Caenorhabditis elegans Nematode  Cele\cyn-11 Y Caenorhabditis elegans Nematode  Cele\cyn-1 Y Caenorhabditis elegans Nematode  Cele\cyn-2 Y Caenorhabditis elegans Nematode  Cele\cyn-13 Y Caenorhabditis elegans Nematode  Cele\cyn-3 Y Caenorhabditis elegans Nematode  Cele\cyn-7 Y Caenorhabditis elegans Nematode  Cele\cyn-8 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003109gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002789gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028896gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015311gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015986gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000637gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002790gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022735gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008305gn Y Danio rerio Zebrafish  Drer\ppial Y Danio rerio Zebrafish  Drer\ppif Y Danio rerio Zebrafish  Drer\ppil6 Y Danio rerio Zebrafish  Drer\zgc:123307 Y Danio rerio Zebrafish  Drer\ppig Y Danio rerio Zebrafish  Drer\nktr Y Danio rerio Zebrafish  Drer\ppih Y Danio rerio Zebrafish  Drer\ppia Y Danio rerio Zebrafish  Drer\ppie Y Danio rerio Zebrafish  Drer\ENSDARG00000087128 Y Xenopus tropicalis Western clawed frog  Xtro\ppie Y Xenopus tropicalis Western clawed frog  Xtro\ppia Y Xenopus tropicalis Western clawed frog  Xtro\ppil6 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025399 Y Xenopus tropicalis Western clawed frog  Xtro\nktr Y Xenopus tropicalis Western clawed frog  Xtro\ppih Y Xenopus tropicalis Western clawed frog  Xtro\ppid Y Gallus gallus Domestic chicken  Ggal\PPIH Y Gallus gallus Domestic chicken  Ggal\PPIL6 Y Gallus gallus Domestic chicken  Ggal\PPIF Y Gallus gallus Domestic chicken  Ggal\PPIE Y Gallus gallus Domestic chicken  Ggal\PPID Y Gallus gallus Domestic chicken  Ggal\NKTR Y Gallus gallus Domestic chicken  Ggal\PPIG Y Mus musculus House mouse  Mmus\Ppil6 Y Mus musculus House mouse  Mmus\Ppif Y Mus musculus House mouse  Mmus\Gm9234 Y Mus musculus House mouse  Mmus\Ppia Y Mus musculus House mouse  Mmus\Nktr Y Mus musculus House mouse  Mmus\Ppig Y Mus musculus House mouse  Mmus\Gm5160 Y Mus musculus House mouse  Mmus\ENSMUSG00000091052 Y Mus musculus House mouse  Mmus\Ppia Y Mus musculus House mouse  Mmus\Ppie Y Mus musculus House mouse  Mmus\Ppid Y Mus musculus House mouse  Mmus\Ppih Y Rattus norvegicus Norway rat  Rnor\Ppia Y Rattus norvegicus Norway rat  Rnor\Ppig Y Rattus norvegicus Norway rat  Rnor\Ppie Y Rattus norvegicus Norway rat  Rnor\Ppia Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030050 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000036609 Y Rattus norvegicus Norway rat  Rnor\Ppif Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023821 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008489 Y Rattus norvegicus Norway rat  Rnor\Ppid Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023461 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027085 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024916 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039269 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000002712 Y Rattus norvegicus Norway rat  Rnor\Ppil6 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031045 Y Homo sapiens Human  Hsap\PPID Y Homo sapiens Human  Hsap\ENSG00000185250 Y Homo sapiens Human  Hsap\ENSG00000255963 Y Homo sapiens Human  Hsap\ENSG00000255854 Y Homo sapiens Human  Hsap\ENSG00000198161 Y Homo sapiens Human  Hsap\NKTR Y Homo sapiens Human  Hsap\PPIE Y Homo sapiens Human  Hsap\PPIAL4D Y Homo sapiens Human  Hsap\PPIH Y Homo sapiens Human  Hsap\PPIA Y Homo sapiens Human  Hsap\PPIF Y Homo sapiens Human  Hsap\PPIAL4G Y Homo sapiens Human  Hsap\PPIG Y
Human Orthologs (13)
Gene OMIM HGNC Hsap\PPID     Hsap\ENSG00000185250     Hsap\ENSG00000255963     Hsap\ENSG00000255854     Hsap\ENSG00000198161     Hsap\NKTR     Hsap\PPIE     Hsap\PPIAL4D     Hsap\PPIH     Hsap\PPIA     Hsap\PPIF     Hsap\PPIAL4G     Hsap\PPIG
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11288 Drosophila sechellia Dsec\GM21798 Drosophila erecta Dere\GG21795 Drosophila yakuba Dyak\GE11871 Drosophila ananassae Dana\GF11346 Drosophila pseudoobscura pseudoobscura Dpse\GA18502 Drosophila persimilis Dper\GL11464 Drosophila willistoni Dwil\GK21899 Drosophila virilis Dvir\GJ20579 Drosophila mojavensis Dmoj\GI20843 Drosophila grimshawi Dgri\GH20760
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	35611 y1 sc* v1; P{TRiP.GL00451}attP2/TM3, Sb1
VDRC	v108734 P{KK107578}VIE-260B
Genomic Clones ( 1 )
	BACR21A09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35248
Other clones	yak-ad_Cyp1 yak-em_Cyp1
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE58115 SD19273 SD23943 SD24841 SD27451
Other clones	156666 557689 Dmel_neb_013728_0193_3413 Dmel_neb_014598_0581_0756 EK259552 EN12213
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028382 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36984
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The CG7768 gene may be derived from the cyp33 gene by retroposition. (Betran et al., 2002)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079049 RefSeq (Proteins) • NP_523773 DDBJ / EMBL / GenBank • AAF01031 AAF57839 AAL28969 AF182826 AI518843 AW943273 AY061421 Entrez Gene - A searchable database of RefSeq genes. • 36984 UniProtKB/Swiss-Prot • Q9V3G3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Nucleotide-binding, alpha-beta plait (IPR012677) Cyclophilin-type peptidyl-prolyl cis-trans isomerase E (IPR016304) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD35248
Linkouts
	BioGRID - A database of protein and genetic interactions • 62673 DroID - A comprehensive database of gene and protein interactions. • FBgn0028382 DRSC - Results from RNAi screens. • FBgn0028382 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028382 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4886-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028382 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36984 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36984 modMine - Data generated by the modENCODE project. • FBgn0028382
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4886 (Nybakken et al., 2005, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2011.7.19) Cyp33 (Betran et al., 2002, Liu and Lehmann, 2008, Hom et al., 2010) cyp33 (Stroschein-Stevenson et al., 2006, Nybakken et al., 2005, Herold et al., 2009, Japanese National Institute of Genetics, 2012.5.21) CYP33 (Chauhan et al., 2012) Dcyp33 (Anderson et al., 2002)
Name Synonym	cyclophilin-33
Secondary FlyBase IDs
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Chauhan et al., 2012, Development 139(11): 1997--2008 Histone Recognition and Nuclear Receptor Co-Activator Functions of Drosophila Cara Mitad, a Homolog of the N-Terminal Portion of Mammalian MLL2 and MLL3. [FBrf0218263] Show all research papers ...