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Gene Dmel\chm

General Information
Symbol	Dmel\chm	Species	D. melanogaster
Name	chameau	Annotation symbol	CG5229
Feature type	protein_coding_gene	FlyBase ID	FBgn0028387
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	HAT1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27F3-27F4	Sequence location	2L:7,412,453..7,422,389 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene chameau is referred to in FlyBase by the symbol Dmel\chm (CG5229, FBgn0028387). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: H4 histone acetyltransferase activity; transcription factor binding; transcription coactivator activity. There is experimental evidence that it is involved in the biological process: gene silencing; positive regulation of transcription from RNA polymerase II promoter; dendrite morphogenesis; neuron development; wing disc dorsal/ventral pattern formation. 20 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Acyl-CoA N-acyltransferase; MOZ/SAS-like protein; Zinc finger, C2HC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631863_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of chm. Gene sequence location is 2L:7412453..7422389.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Reis et al., 2010, PLoS Genet. 6(11): e1001206 Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Sequence features BKN25497 HFA03341 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter H4 histone acetyltransferase activity transcription factor binding
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27F3-27F4   Limits computationally determined from genome sequence between P{PZ}wg02657 and P{EP}EP787EP787
Experimentally Determined Cytological Location
Cytogenetic map Notes References 28A-28A     (Grienenberger et al., 2002) 28A-28A   (determined by in situ hybridisation)   (Graba, 1999.9.27)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\chm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) chm-RA FBtr0079443  NM_135273   2919   811 chm-RB FBtr0308610     2386   703
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein chm-PA   FBpp0079071   89.6   811   9.76     NP_609117   AAF52513 chm-PB   FBpp0300834   77.1   703   9.80
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2HC-type (IPR002515) MOZ/SAS-like protein (IPR002717) Acyl-CoA N-acyltransferase (IPR016181)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390506   AA539095   AE014134 AAF52513   AF218777 AAF44628   AI403635   AW941688   BH011483   BI367228   BT010080 AAQ22549   BT125057   CA803291   CO281355   CO287401   CO290031   CO295655   CO298940   CO299684   CO312002   CO317594   CO317666   CO320798   CO335398   CO339520   CZ472465   CZ474758   CZ474759   CZ477581   CZ477936   CZ479852   CZ480829   EC080111   EC081705   EC085188   EC089561   EC089588   EC199454   EC202425   EC230746   EC238663   EC250606   EC253001   GH757027   GH758699   GH760188   GH777627   GH781719   GH787709   GH793100   GH801219   GH802803   GH805648   GH813615   GH818286   GH821478   GH828938   GH829521   GH837718   GH839027   GH839999   GH841519   GH850420   GH863775   GH876803   GH878856   GH880552   GH890703   GH891926   GH893164   GH898004   GH907672   GH917740   GH922302   GH923275   GH925949   GH935422   GH935570   GH937005   GH940331
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7YTZ9 Q9NHW0 Q9VM15
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028387    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028387 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028387 expression level Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2196) embryo 02-04hr  (1457) embryo 04-06hr  (1900) embryo 06-08hr  (1729) embryo 08-10hr  (1374) embryo 10-12hr  (894) embryo 12-14hr  (771) embryo 14-16hr  (345) embryo 16-18hr  (319) embryo 18-20hr  (244) embryo 20-22hr  (289) embryo 22-24hr  (312) larva L1  (228) larva L2  (209) larva L3 12hr old  (154) larva L3 puffstage 1-2  (208) larva L3 puffstage 3-6  (425) larva L3 puffstage 7-9  (614) white prepupae new  (712) white prepupae 12hr  (660) white prepupae 24hr  (732) pupae 2d postWPP  (474) pupae 3d postWPP  (220) pupae 4d postWPP  (158) adult male 01day  (218) adult male 05day  (270) adult male 30day  (218) adult female 01day  (473) adult female 05day  (1331) adult female 30day  (1387) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2196) embryo 02-04hr  1457 embryo 04-06hr  (1900) embryo 06-08hr  (1729) embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028387 expression level Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2196) embryo 02-04hr  (1457) embryo 04-06hr  (1900) embryo 06-08hr  (1729) embryo 08-10hr  (1374) embryo 10-12hr  (894) embryo 12-14hr  (771) embryo 14-16hr  (345) embryo 16-18hr  (319) embryo 18-20hr  (244) embryo 20-22hr  (289) embryo 22-24hr  (312) larva L1  (228) larva L2  (209) larva L3 12hr old  (154) larva L3 puffstage 1-2  (208) larva L3 puffstage 3-6  (425) larva L3 puffstage 7-9  (614) white prepupae new  (712) white prepupae 12hr  (660) white prepupae 24hr  (732) pupae 2d postWPP  (474) pupae 3d postWPP  (220) pupae 4d postWPP  (158) adult male 01day  (218) adult male 05day  (270) adult male 30day  (218) adult female 01day  (473) adult female 05day  (1331) adult female 30day  (1387) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2196 embryo 02-04hr  1457 embryo 04-06hr  1900 embryo 06-08hr  1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2196 embryo 02-04hr    1457 embryo 04-06hr    1900 embryo 06-08hr    1729 embryo 08-10hr    1374 embryo 10-12hr    894 embryo 12-14hr    771 embryo 14-16hr    345 embryo 16-18hr    319 embryo 18-20hr    244 embryo 20-22hr    289 embryo 22-24hr    312 larva L1    228 larva L2    209 larva L3 12hr old    154 larva L3 puffstage 1-2    208 larva L3 puffstage 3-6    425 larva L3 puffstage 7-9    614 white prepupae new    712 white prepupae 12hr    660 white prepupae 24hr    732 pupae 2d postWPP    474 pupae 3d postWPP    220 pupae 4d postWPP    158 adult male 01day    218 adult male 05day    270 adult male 30day    218 adult female 01day    473 adult female 05day    1331 adult female 30day    1387 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028387    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028387 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028387 expression level Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028387 expression level Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    90.5 Larval Midgut    26.9 Larval Hindgut no informative data Larval Malpighian Tubules    32.2 Larval Fat Body no informative data Larval Salivary Gland    34.3 Larval Trachea    44.075 Larval Carcass    27.15 Adult Head    30.3 Adult Eye    29.1 Adult Brain    76.5 Adult Thoracic-Abdominal Ganglion    51.7 Adult Crop    44 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules    28 Adult Fat Body    23.3 Adult Salivary Gland    44.3 Adult Heart    19.125 Adult VirginFemale Spermatheca    32.3 Adult InseminatedFemale Spermatheca    40.5 Adult Ovary    137.2 Adult Testis    44.2 Adult Male Accessory Gland no informative data Adult Carcass    39.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30.3   NA  Eye    29.1   NA  Brain    76.5   90.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    51.7   NA  Crop    44   26.9  Midgut    no informative data   no informative data  Hindgut    no informative data   32.2  Malpighian Tubules    28   no informative data  Fat Body    23.3   34.3  Salivary Gland    44.3   NA  Heart    19.125   44.075  Trachea    NA   NA  VirginFemale Spermatheca    32.3   NA  InseminatedFemale Spermatheca    40.5   NA  Ovary    137.2   NA  Testis    44.2   NA  Male Accessory Gland    no informative data   27.15  Carcass    39.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028387 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5229-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage | recessive chm14 chm221 viable, with Scer\GAL4pnr-MD237 chmGD1235 Other Phenotypes Allele suppressor of variegation | dominant, with Dp(1;f)γ238 chm14 suppressor of variegation | dominant, with In(1)wm4h chm14 suppressor of variegation | dominant, with P{UAS-lacZ.Abd-B.5F24}25,2a chm14 wild-type chmhs.PG Phenotype manifest in Allele adult thorax | pharate adult stage chm14
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of chm Class Mutagen Stocks Known lesion chmBG02254 P-element activity 1 -- chmd01826 P-element activity 1 -- chmd05849 P-element activity 1 -- chmd11149 P-element activity 1 -- chme00024 piggyBac transposase 1 -- chme02040 piggyBac transposase 1 -- chme03060 piggyBac transposase 1 -- chm14 P-element activity 0 Yes chm221 P-element activity 0 Yes chmEP2-1069 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of chm Class Mutagen Stocks Known lesion chmGD1235 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chmHMS00487 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chmJF02348 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chmKK104537 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes chmG680.hs in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes chmG680E.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes chmhs.PG in vitro construct - regulatory fusion 0 Yes chmhs.T:Scer\GAL4 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes chmScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes chmScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7031 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1235} NA P{KK104537} NA P{TRiP.HMS00487} NA P{TRiP.JF02348} NA P{UAS-chm.M} NA P{UAS-chm.Myc.G680E} NA P{UAS-chm.Myc} NA heat-shock construct P{hs-chm.G680} NA P{hs-chm.G} NA P{hs-chm.T:GAL4} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG5261EP816 NA P{EP}chmEP2-1069 NA P{EP}EP380 NA P{EP}EP787EP787 NA P{EP}EP2369 NA P{EP}EP2467 NA P{EP}l(2)k10113EP1221 NA P{XP}chmd01826 NA P{XP}chmd05849 NA P{XP}chmd11149 NA miscellaneous insertions P{GT1}BG02510BG02510 NA P{GT1}chmBG02254 NA P{UASp-YFP.Rab8.Q67L}05 NA PBac{RB}chme00024 NA PBac{RB}chme02040 NA PBac{RB}chme03060 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
H4 histone acetyltransferase activity inferred from direct assay (Miotto et al., 2006) transcription coactivator activity inferred from direct assay (Miotto et al., 2006) transcription factor binding inferred from physical interaction with Jra (Miotto et al., 2006) inferred from physical interaction with kay (Miotto et al., 2006)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) gene silencing inferred from genetic interaction with Pc (Grienenberger et al., 2002) neuron development inferred from mutant phenotype (Parrish et al., 2006) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Miotto et al., 2006) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Miotto et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
histone acetyltransferase activity inferred from sequence or structural similarity (Grienenberger, 1999.12.23) inferred from sequence or structural similarity with EMBL:AF074606 (FlyBase, 1992-) non-traceable author statement (Grienenberger et al., 2000) traceable author statement (McNairn and Gilbert, 2003) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR002515 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR002515 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
gene silencing traceable author statement (Carrozza et al., 2003) negative regulation of transcription, DNA-dependent traceable author statement (McNairn and Gilbert, 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions chm allele Gene References chm14 ph-p (Grienenberger et al., 2002) unspecified hep (Miotto et al., 2006) kay (Miotto et al., 2006) puc (Miotto et al., 2006) Rpd3 (Miotto et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68722 DroID - A comprehensive database of gene and protein interactions. • FBgn0028387 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43928
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15859 Dere\GG10479 Dgri\GH13734 Dmoj\GI23751 Dper\GL25815 Dpse\GA18752 Dsec\GM16444 Dsim\GD23471 Dvir\GJ20948 Dwil\GK24305 Dyak\GE14543
Curated drosophilid orthologs	Dpse\GA18752
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010729-PA Aedes aegypti (mosquito) AGAP009676-PA Anopheles gambiae (mosquito) XP_392324.3 Apis mellifera (honey bee) 220603 Branchiostoma floridae (lancelet) 280514 Branchiostoma floridae (lancelet) BGIBMGA010518-PA Bombyx mori (silk worm) ENSBTAP00000024887 Bos taurus (bovine) ENSCAFP00000024954 Canis familiaris (dog) ENSCINP00000006517 Ciona intestinalis (sea squirt) CPIJ006118 Culex pipens (mosquito) ENSCPOP00000001650 Cavia porcellus (guinea pig) ENSCSAVP00000005035 Ciona savignyi (sedentary tunicate) 228212 Capitella spl (polychaete worm) ENSDARP00000021648 Danio rerio (zebra fish) ENSECAP00000008441 Equus caballus (horse) ENSGACP00000013042 Gymnopilus aculeatus (mushroom) ENSGALP00000016147 Gallus gallus (chicken) 76642 Hypsipyla robusta (cedar shoot borer) ENSP00000259021 Homo sapiens (human) ISCW013774-PA Ixodes scapularis (deer tick) 135618 Lottia gigantea (owl limpet) 33338 Monocosta brevicollis (choanoflagellate) ENSMODP00000015208 Monodelphis domestica (gray opossum) ENSMUSP00000090441 Mus musculus (house mouse) 21019 Nematostella vectensis (starlet anemone) XP_001602789.1 Nasonia vitripennis (wasp) ENSORLP00000005128 Oryzias latipes (japanese killifish) PHUM011229-PA Pediculus humanus (human body louse) ENSPPYP00000010014 Pongo pygmaeus (orangutan) ENSPTRP00000015934 Pan troglodytes (chimpanzee) ENSRNOP00000036991 Rattus norvegicus (norway rat) XP_970403.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015833 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042338 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047415 Xenopus tropicalis (frog) YALI0A03861g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12146 PB12144 NV11357 LH23545 ISCW013774 FBgn0232143 FBgn0226265 FBgn0208084 FBgn0194851 FBgn0171359 JGI_V11_96197 JGI_V11_96198 FBgn0078752 FBgn0163399 FBgn0146476 FBgn0121210 FBgn0102787 FBgn0092882 CPIJ006118 BGIBMGA010518 ACYPI001454 GB13407 AGAP009676 AAEL010729 PHUM590320 GLEAN_11945
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	12666 w1118; P{GT1}chmBG02254 27027 y1 v1; P{TRiP.JF02348}attP2 32484 y1 sc* v1; P{TRiP.HMS00487}attP2
Harvard	- P{XP}chmd01826 - P{XP}chmd05849 - P{XP}chmd11149 - PBac{RB}chme00024 - PBac{RB}chme02040 - PBac{RB}chme03060
VDRC	v105542 P{KK104537}VIE-260B v5684 w1118; P{GD1235}v5684
Genomic Clones ( 2 )
	BACR01E19 BACR30I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD08703
Other clones	MIP19344
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH23117 LD18807 RE52942
Other clones	42536 50311 103983 164224 164239 164690 183127 CK01.13B.D2 CK01.93C.E7 CK01.93C.H7 EC253001 EK065750 EK072920 EK156936 EK174144 EK176328 EK211301 EK227632 EK268560 EK268732 EK288235 EN10248 EP02153 ESG011b.E7_H03 RP003018160 RP003130801 RP003137545 RP003185272 RP003206419 RP003225015 RP003239645 RP003264508 RP003273949 RP003309300 RP003316820 RP003327336 RP003335470 RP003342656 RP003343054 RP003346773 RP003350716 RP003382182 RP003386393 RP003426219 RP003444772 RP003490953 RP003503898 RP003517937 RP003527818 RP003532431 RP003537487 RP003543882 RP003566617 RP003566669 RP003591575 RP003612242 RP003651940 RP003662838 RP003663786 RP003671157 RP003680121
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028387 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43928
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: HAT CG5229 (FlyBase, 1996-)
Source for database merge of	Source for merge of: chm HAT (Grienenberger et al., 2002)
Additional comments	Source for identity of HAT CG5229 was sequence comparison (date:000327). (FlyBase, 1996-)
Other Comments
	chm and Rpd3 act as antagonistic cofactors of Jra and kay proteins to modulate JNK-dependent transcription during thorax metamorphosis and JNK-induced apoptosis. chm enhances JNK signaling during thorax closure during metamorphosis and acts positively in the JNK-dependent apoptotic pathway. (Miotto et al., 2006) dsRNA has been made from templates generated with primers directed against this gene. RNAi of chm causes an increase in the number of class I da neurons. RNAi also causes alterations in the number of MD neurons and defects in dendrite morphogenesis. (Parrish et al., 2006) chm is required for the maintenance of Hox gene silencing by Pc group proteins. (Grienenberger et al., 2002) chm may have a role in chromatin mediated gene silencing. (Graba et al., 1999) Mutations in chm result in late pupal lethality. Pharate adults have ectopic macrochaetae on the scutellum and on the thorax, and occasionally a large cleft separates the two hemithoraces. (Graba et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135273 RefSeq (Proteins) • NP_609117 DDBJ / EMBL / GenBank • AA390506 AAF44628 AAF52513 AAQ22549 AF218777 AW941688 BH011483 BT010080 CZ472465 CZ474758 CZ474759 CZ477581 CZ477936 CZ479852 CZ480829 Entrez Gene - A searchable database of RefSeq genes. • 43928 UniProtKB/TrEMBL • Q7YTZ9 Q9NHW0 Q9VM15
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2HC-type (IPR002515) MOZ/SAS-like protein (IPR002717) Acyl-CoA N-acyltransferase (IPR016181)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68722 DroID - A comprehensive database of gene and protein interactions. • FBgn0028387 DRSC - Results from RNAi screens. • FBgn0028387 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028387 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5229-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028387 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43928 InParanoid A subset of ortholog calls from InParanoid. • AAEL010729-PA Aedes aegypti (mosquito) AGAP009676-PA Anopheles gambiae (mosquito) XP_392324.3 Apis mellifera (honey bee) 220603 Branchiostoma floridae (lancelet) 280514 Branchiostoma floridae (lancelet) BGIBMGA010518-PA Bombyx mori (silk worm) ENSBTAP00000024887 Bos taurus (bovine) ENSCAFP00000024954 Canis familiaris (dog) ENSCINP00000006517 Ciona intestinalis (sea squirt) CPIJ006118 Culex pipens (mosquito) ENSCPOP00000001650 Cavia porcellus (guinea pig) ENSCSAVP00000005035 Ciona savignyi (sedentary tunicate) 228212 Capitella spl (polychaete worm) ENSDARP00000021648 Danio rerio (zebra fish) ENSECAP00000008441 Equus caballus (horse) ENSGACP00000013042 Gymnopilus aculeatus (mushroom) ENSGALP00000016147 Gallus gallus (chicken) 76642 Hypsipyla robusta (cedar shoot borer) ENSP00000259021 Homo sapiens (human) ISCW013774-PA Ixodes scapularis (deer tick) 135618 Lottia gigantea (owl limpet) 33338 Monocosta brevicollis (choanoflagellate) ENSMODP00000015208 Monodelphis domestica (gray opossum) ENSMUSP00000090441 Mus musculus (house mouse) 21019 Nematostella vectensis (starlet anemone) XP_001602789.1 Nasonia vitripennis (wasp) ENSORLP00000005128 Oryzias latipes (japanese killifish) PHUM011229-PA Pediculus humanus (human body louse) ENSPPYP00000010014 Pongo pygmaeus (orangutan) ENSPTRP00000015934 Pan troglodytes (chimpanzee) ENSRNOP00000036991 Rattus norvegicus (norway rat) XP_970403.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015833 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000042338 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047415 Xenopus tropicalis (frog) YALI0A03861g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/chameau1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43928 modMine - Data generated by the modENCODE project. • FBgn0028387 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12146 PB12144 NV11357 LH23545 ISCW013774 FBgn0232143 FBgn0226265 FBgn0208084 FBgn0194851 FBgn0171359 JGI_V11_96197 JGI_V11_96198 FBgn0078752 FBgn0163399 FBgn0146476 FBgn0121210 FBgn0102787 FBgn0092882 CPIJ006118 BGIBMGA010518 ACYPI001454 GB13407 AGAP009676 AAEL010729 PHUM590320 GLEAN_11945
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG5229 (Sanjuan and Marin, 2001, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) chm (Turner et al., 2008, Levine and Begun, 2008, Zhang et al., 2007, Reis et al., 2010) Chm (Parrish et al., 2006) dmHAG404 (Pandey et al., 2002) HAT (Andersen et al., 2010) HAT1 (Aggarwal and Calvi, 2004, Aggarwal and Calvi, 2004, Aggarwal and Calvi, 2003, Scharf et al., 2009)
Name Synonym	chameau (Graba et al., 1999, Levine and Begun, 2007, Sambandan et al., 2006, Bejarano et al., 2008)
Secondary FlyBase IDs
	FBgn0031911
References ( 45 )
Generate a list of	All references relating to this gene ( 45 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Andersen et al., 2010, Mol. Cell. Biol. 30(19): 4744--4755 Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. [FBrf0211794] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...