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Gene Dmel\Drep-2

General Information
Symbol	Dmel\Drep-2	Species	D. melanogaster
Name	DNA fragmentation factor-related protein 2	Annotation symbol	CG1975
Feature type	protein_coding_gene	FlyBase ID	FBgn0028408
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	Rep2
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	45C4-45C5	Sequence location	2R:5,179,362..5,189,715 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene DNA fragmentation factor-related protein 2 is referred to in FlyBase by the symbol Dmel\Drep-2 (CG1975, FBgn0028408). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: neurogenesis. 16 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Caspase-activated nuclease CIDE-N. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1628189_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Drep-2. Gene sequence location is 2R:5179362..5189715.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN29394 HFA07528
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 45C4-45C5   Limits computationally determined from genome sequence between P{lacW}Pknk11209 and P{lacW}wunk09507&P{lacW}l(2)k12402k12402
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Drep-2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone GM07741 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Drep-2-RA FBtr0088597  NM_136634   5228   482 Drep-2-RB FBtr0112930  NM_001103768   4809   549 Drep-2-RC FBtr0304798     2766   482
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Drep-2-PA   FBpp0087678   51.9   482   5.10     NP_610478   AAF58954 Drep-2-PB   FBpp0111843   57.8   549   5.27     NP_001097238   ABV53736 Drep-2-PC   FBpp0293338   51.9   482   5.10
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Caspase-activated nuclease CIDE-N (IPR003508)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201570   AA202547   AA202864   AA390646   AA392448   AA440523   AA441346   AA539699   AA540237   AA540303   AA540504   AA696470   AA816245   AA978589   AA978912   AA979311   AA979434   AE013599 AAF58954   AE013599 ABV53736   AF149795 AAF03218   AI518298   AI519141   AI519447   AI519448   AQ073459   AW941294   AW943111   AX094038   AX094044   AY060400 AAL25439   AY060935 AAL28483   BG638720   BH615064   BI162734   BI162735   BI167021   BI168050   BI170752   BI215928   BI229686   BI237052   BI243240   BI355826   BI356283   BI368472   BI371338   BI375322   BI614704   BT126211   CK604506   CK604507   CK605065   CK605066   CL868547   CO177551   CO279225   CO333055   CZ469671   CZ469672   CZ471465   CZ477557   CZ477558   CZ480430   CZ480690   CZ482430   CZ485846   CZ485847   CZ487467   EC052332   EC053804   EC067900   EC088777   EC210138   EV593351   EV594804   EV598392
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95S67 Q9U787 Q7K304 A8DY77
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028408    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028408 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028408 expression level Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5345) embryo 02-04hr  (5859) embryo 04-06hr  (1315) embryo 06-08hr  (1227) embryo 08-10hr  (1519) embryo 10-12hr  (1192) embryo 12-14hr  (1033) embryo 14-16hr  (1706) embryo 16-18hr  (1503) embryo 18-20hr  (1005) embryo 20-22hr  (2352) embryo 22-24hr  (2082) larva L1  (735) larva L2  (311) larva L3 12hr old  106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6  (110) larva L3 puffstage 7-9  (136) white prepupae new  (143) white prepupae 12hr  (352) white prepupae 24hr  (432) pupae 2d postWPP  (802) pupae 3d postWPP  (1521) pupae 4d postWPP  (384) adult male 01day  (164) adult male 05day  (146) adult male 30day  (143) adult female 01day  (2106) adult female 05day  (3558) adult female 30day  (3350) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5345) embryo 02-04hr  (5859) embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr  (1519) embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr  (1706) embryo 16-18hr  1503 embryo 18-20hr    1005 embryo 20-22hr  (2352) embryo 22-24hr  (2082) larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP  (1521) pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day  (2106) adult female 05day  (3558) adult female 30day  (3350) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028408 expression level Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5345) embryo 02-04hr  (5859) embryo 04-06hr  (1315) embryo 06-08hr  (1227) embryo 08-10hr  (1519) embryo 10-12hr  (1192) embryo 12-14hr  (1033) embryo 14-16hr  (1706) embryo 16-18hr  (1503) embryo 18-20hr  (1005) embryo 20-22hr  (2352) embryo 22-24hr  (2082) larva L1  (735) larva L2  (311) larva L3 12hr old  106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6  110 larva L3 puffstage 7-9  136 white prepupae new  143 white prepupae 12hr  (352) white prepupae 24hr  (432) pupae 2d postWPP  (802) pupae 3d postWPP  (1521) pupae 4d postWPP  (384) adult male 01day  (164) adult male 05day  (146) adult male 30day  143 adult female 01day  (2106) adult female 05day  (3558) adult female 30day  (3350) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5345) embryo 02-04hr  (5859) embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr  1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr  1706 embryo 16-18hr  1503 embryo 18-20hr    1005 embryo 20-22hr  2352 embryo 22-24hr  2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP  1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day  2106 adult female 05day  (3558) adult female 30day  (3350) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5345 embryo 02-04hr    5859 embryo 04-06hr    1315 embryo 06-08hr    1227 embryo 08-10hr    1519 embryo 10-12hr    1192 embryo 12-14hr    1033 embryo 14-16hr    1706 embryo 16-18hr    1503 embryo 18-20hr    1005 embryo 20-22hr    2352 embryo 22-24hr    2082 larva L1    735 larva L2    311 larva L3 12hr old    106 larva L3 puffstage 1-2    57 larva L3 puffstage 3-6    110 larva L3 puffstage 7-9    136 white prepupae new    143 white prepupae 12hr    352 white prepupae 24hr    432 pupae 2d postWPP    802 pupae 3d postWPP    1521 pupae 4d postWPP    384 adult male 01day    164 adult male 05day    146 adult male 30day    143 adult female 01day    2106 adult female 05day    3558 adult female 30day    3350 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028408    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028408 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028408 expression level Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028408 expression level Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    102.8 Larval Midgut    4.3 Larval Hindgut    5.3 Larval Malpighian Tubules    1.9 Larval Fat Body    1.3 Larval Salivary Gland    5.4 Larval Trachea    2.775 Larval Carcass    3.525 Adult Head    13.6 Adult Eye    8.7 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    99.5 Adult Crop    2.9 Adult Midgut    2.5 Adult Hindgut    3.3 Adult Malpighian Tubules    3.5 Adult Fat Body    7.2 Adult Salivary Gland    7.7 Adult Heart    1.15 Adult VirginFemale Spermatheca    4.9 Adult InseminatedFemale Spermatheca    4.9 Adult Ovary    30.1 Adult Testis    0.8 Adult Male Accessory Gland    2.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    13.6   NA  Eye    8.7   NA  Brain    177.4   102.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    99.5   NA  Crop    2.9   4.3  Midgut    2.5   5.3  Hindgut    3.3   1.9  Malpighian Tubules    3.5   1.3  Fat Body    7.2   5.4  Salivary Gland    7.7   NA  Heart    1.15   2.775  Trachea    NA   NA  VirginFemale Spermatheca    4.9   NA  InseminatedFemale Spermatheca    4.9   NA  Ovary    30.1   NA  Testis    0.8   NA  Male Accessory Gland    2.8   3.525  Carcass    3.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1975-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Drep-2GD9693 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Drep-2GD9693 viable Drep-2EY12060 Sterility Allele fertile Drep-2EY12060 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Drep-2GD9693 visible, with Scer\GAL4pnr-MD237 Drep-2GD9693 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Drep-2GD9693 ganglion mother cell | larval stage, with Scer\GAL41407 Drep-2GD9693 mesothoracic tergum, with Scer\GAL4pnr-MD237 Drep-2GD9693
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of Drep-2 Class Mutagen Stocks Known lesion Drep-25-HA-2820 1 -- Drep-25-HA-3117 1 -- Drep-2c00500 1 -- Drep-2c05007 piggyBac transposase 1 -- Drep-2d00223 P-element activity 1 -- Drep-2d11111 P-element activity 1 -- Drep-2DG08311 1 -- Drep-2e02653 piggyBac transposase 1 -- Drep-2e02920 piggyBac transposase 1 -- Drep-2EY12060 P-element activity 1 -- Drep-2f03304 piggyBac transposase 1 -- Drep-2f04882 piggyBac transposase 1 -- Drep-2KG02396 P-element activity 1 -- Drep-2e04659 piggyBac transposase 0 -- Drep-2EP2284 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Drep-2 Class Mutagen Stocks Known lesion Drep-2GD9693 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Drep-2EP2284 NA P{EPgy2}Drep-2EY12060 NA P{GSV1}EP-M89EP-M89 NA P{XP}Drep-2d00223 NA P{XP}Drep-2d11111 NA miscellaneous insertions P{RS5}Drep-25-HA-2820 NA P{RS5}Drep-25-HA-3117 NA P{SUPor-P}Drep-2KG02396 NA P{wHy}Drep-2DG08311 NA PBac{PB}Drep-2c00500 NA PBac{PB}Drep-2c05007 NA PBac{RB}Drep-2e02653 NA PBac{RB}Drep-2e02920 NA PBac{RB}Drep-2e04659 NA PBac{WH}Drep-2f03304 NA PBac{WH}Drep-2f04882 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apoptotic process inferred from electronic annotation with InterPro:IPR003508 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR003508 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Drep-2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61791 DroID - A comprehensive database of gene and protein interactions. • FBgn0028408 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35955
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11819 Dere\GG23432 Dgri\GH20347 Dmoj\GI20016 Dper\GL17583 Dpse\GA15166 Dsec\GM21115 Dsim\GD10649 Dvir\GJ21264 Dwil\GK19508 Dyak\GE19270
Curated drosophilid orthologs	Dpse\GA15166
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006265-PA Aedes aegypti (mosquito) AGAP005254-PA Anopheles gambiae (mosquito) XP_394755.3 Apis mellifera (honey bee) XP_001948509.1 Acyrthosiphon pisum (pea aphid) BGIBMGA002832-PA Bombyx mori (silk worm) CPIJ010258 Culex pipens (mosquito) 304804 Daphnia pulex (daphnia) ISCW017650-PA Ixodes scapularis (deer tick) PHUM002495-PA Pediculus humanus (human body louse) XP_974468.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH16118 FBgn0236622 FBgn0221506 FBgn0208397 FBgn0182416 FBgn0175996 JGI_V11_304804 FBgn0075191 FBgn0155186 FBgn0142752 FBgn0127811 FBgn0115579 FBgn0088859 CPIJ010258 BGIBMGA002832 ACYPI009707 GB15679 AGAP005254 AAEL006265 PB21764 PHUM579440 GLEAN_11893
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	21654 y1 w67c23; P{wHy}Drep-2DG08311
Harvard	- P{XP}Drep-2d00223 - P{XP}Drep-2d11111 - PBac{PB}Drep-2c00500 - PBac{PB}Drep-2c05007 - PBac{RB}Drep-2e02653 - PBac{RB}Drep-2e02920 - PBac{WH}Drep-2f03304 - PBac{WH}Drep-2f04882
Kyoto	125690 w1118; P{RS5}Drep-25-HA-2820 125802 w1118; P{RS5}Drep-25-HA-3117
VDRC	v20771 w1118; P{GD9693}v20771
	More stocks available...
Genomic Clones ( 1 )
	BACR15P11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM07741 LD32009
Other clones	FI14507
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM32510 LD01018 LD01978 LD03208 LD04642 LD09646 LD11318 LD16244 LD16695 LD17996 LD19655 LD19755 LD20212 LD33113 LD33995 LD37771 LD38582 LD39050 LD39051 RE07290 RE08585 RE12324 RE22705 RE27521 RE33207 RE40818 RE42386 RE54447 RE58211 RE63102 RH44154
Other clones	19910 145399 280778 Dmel_neb_010502_0698_1167 Dmel_neb_012282_0636_3272 Dmel_neb_015036_0844_2475 EC052332 EC053804 EK053805 EK133829 EK305550 LD33802 RE01967 UT01243 UT01653
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35955
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rep2 anon-WO0118547.162 anon-WO0118547.168 (FlyBase, 1996-)
Additional comments	Source for merge of Rep2 anon-WO0118547.162 anon-WO0118547.168 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AA441346. This EST forms a 1677bp contig with ESTs AA390646 and AA696470. (Davies, 2001.3.15) Area matching Drosophila EST AA390646. This EST forms a 1705bp contig with ESTs AA440523 and AA696470. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136634 NM_001103768 RefSeq (Proteins) • NP_610478 NP_001097238 DDBJ / EMBL / GenBank • AA390646 AA441346 AA696470 AA978589 AAF03218 AAF58954 AAL25439 AAL28483 ABV53736 AF149795 AQ073459 AW941294 AW943111 AX094038 AX094044 AY060400 AY060935 BH615064 CL868547 CZ469671 CZ469672 CZ471465 CZ477557 CZ477558 CZ480430 CZ480690 CZ482430 CZ485846 CZ485847 CZ487467 Entrez Gene - A searchable database of RefSeq genes. • 35955 UniProtKB/TrEMBL • A8DY77 Q7K304 Q9U787 Q95S67
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Caspase-activated nuclease CIDE-N (IPR003508)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61791 DroID - A comprehensive database of gene and protein interactions. • FBgn0028408 DRSC - Results from RNAi screens. • FBgn0028408 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1975-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35955 InParanoid A subset of ortholog calls from InParanoid. • AAEL006265-PA Aedes aegypti (mosquito) AGAP005254-PA Anopheles gambiae (mosquito) XP_394755.3 Apis mellifera (honey bee) XP_001948509.1 Acyrthosiphon pisum (pea aphid) BGIBMGA002832-PA Bombyx mori (silk worm) CPIJ010258 Culex pipens (mosquito) 304804 Daphnia pulex (daphnia) ISCW017650-PA Ixodes scapularis (deer tick) PHUM002495-PA Pediculus humanus (human body louse) XP_974468.2 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35955 modMine - Data generated by the modENCODE project. • FBgn0028408 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH16118 FBgn0236622 FBgn0221506 FBgn0208397 FBgn0182416 FBgn0175996 JGI_V11_304804 FBgn0075191 FBgn0155186 FBgn0142752 FBgn0127811 FBgn0115579 FBgn0088859 CPIJ010258 BGIBMGA002832 ACYPI009707 GB15679 AGAP005254 AAEL006265 PB21764 PHUM579440 GLEAN_11893
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	anon-WO0118547.162   anon-WO0118547.168   CG1975 (Molnar et al., 2006) drep2 (Inohara, 1999.5.10) Drep2   Drep-2   DREP-2 (Inohara and Nunez, 1999) Rep2 (FlyBase Curators, 2008, Molnar et al., 2006)
Name Synonym	DNA fragmentation factor-related protein 2   Rep2
Secondary FlyBase IDs
	FBgn0062196 FBgn0062202
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Patent  ( 1 ) Computer file  ( 3 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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