FlyBase Gene Report: Dmel\Nxt1

Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).

(UniProt, Q9V3H8)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Nxt1 or the JBrowse view of Dmel\Nxt1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nxt1-RA

FBtr0072241

NM_137989

527

133

Nxt1-RB

FBtr0343270

NM_001299854

540

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Nxt1-PA

FBpp0072150

15.2

133

5.87

NP_611833

AAF47066

Nxt1-PB

FBpp0309935

5.4

8.21

NP_001286783

AHN56578

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Forms a complex with RanGAP, Nup358/RanBP2 and sbr/Nxf1.

(UniProt, Q9V3H8)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nxt1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Nxt1_1

Linkouts

Gene Ontology (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

protein binding

inferred from physical interaction with UniProtKB:Q9U1H9

(assigned by UniProt )

(Zhao et al., 2019)

inferred from physical interaction with UniProtKB:Q9VV73

(assigned by UniProt )

(Zhao et al., 2019)

inferred from physical interaction with UniProtKB:Q9VV73,UniProtKB:Q9W2H9

(assigned by UniProt )

(Fabry et al., 2019, Zhao et al., 2019)

inferred from physical interaction with UniProtKB:Q9VKM1,UniProtKB:Q9VV73,UniProtKB:Q9W2H9

(assigned by UniProt )

(Batki et al., 2019, Murano et al., 2019)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

defense response to Gram-negative bacterium

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

negative regulation of innate immune response

inferred from high throughput mutant phenotype

(Cronin et al., 2009)

poly(A)+ mRNA export from nucleus

inferred from mutant phenotype

(Herold et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

nucleocytoplasmic transport

inferred from biological aspect of ancestor with PANTHER:PTN000289031

(assigned by GO_Central )

(Gaudet et al., 2011)

protein import into nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000289032

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

cytoplasm

inferred from direct assay

(Herold et al., 2001)

nuclear envelope

inferred from direct assay

(Herold et al., 2001)

nuclear transcriptional repressor complex

inferred from direct assay

(assigned by UniProt )

(Fabry et al., 2019, Zhao et al., 2019)

nucleoplasm

inferred from direct assay

(Herold et al., 2001)

nucleus

inferred from direct assay

(assigned by UniProt )

(Batki et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nuclear pore central transport channel

inferred from biological aspect of ancestor with PANTHER:PTN000289031

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium