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Gene Dmel\Kr-h1

General Information
Symbol	Dmel\Kr-h1	Species	D. melanogaster
Name	Kruppel homolog 1	Annotation symbol	CG18783
Feature type	protein_coding_gene	FlyBase ID	FBgn0028420
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	Kr-h, CG9167, Pow, l(2)10642
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26B5-26B5	Sequence location	2L:6,081,808..6,096,498 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Kruppel homolog 1 is referred to in FlyBase by the symbol Dmel\Kr-h1 (CG18783, FBgn0028420). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: negative regulation of compound eye photoreceptor development; metamorphosis; response to ecdysone. 29 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; spiracle; adult segment; multicellular structure; thoracic segment; integumentary specialisation; imaginal precursor; external compound sense organ; adult. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631481_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Kr-h1. Gene sequence location is 2L:6081808..6096498.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Kr-h1[MI08215]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26B5-26B5   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26B7-26B9   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 26B-26C     (Pecasse, 1998.4.16) 26B8-26B9   (determined by in situ hybridisation)   (Spradling et al., 1999) 26B8-26B9     (BDGP Project Members, 1994-1999) 26A-26B   (determined by in situ hybridisation)   (Schuh et al., 1986)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Kr-h1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Kr-h1-RA FBtr0079194  NM_058119   5268   791 Kr-h1-RB FBtr0079195  NM_058118   4163   845 Kr-h1-RC FBtr0290297  NM_001144324   3564   873
Additional Transcript Data & Comments
Reported size (kB)	4.5, 3.8, 3.2 (northern blot) (Pecasse et al., 2000) 3.8 (longest cDNA) (Schuh et al., 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Kr-h1-PA   FBpp0078825   85.6   791   8.00     NP_477467   AAG22417 Kr-h1-PB   FBpp0078826   91.5   845   8.44     NP_477466   AAF52343 Kr-h1-PC   FBpp0288736   95.4   873   8.78     NP_001137796   ACL83002
Additional Polypeptide Data & Comments
Reported size (kDa)	845, 791 (aa) (Pecasse et al., 2000)
Comments	The eight zinc finger domains of Kr-h1 protein are preceded by a glutamine-rich domain and followed by a serine-threonine rich domain, both of which are characteristic of transcription factors. (Pecasse et al., 2000, Pecasse et al., 2000)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536612   AA951662   AE014134 AAF52343   AE014134 AAG22417   AC004268   AC004639   AC004758   AE014134 ACL83002   AJ005440 CAA06543   AJ005441 CAA06544   AQ073287   AQ254845   AW943129   AY051816 AAK93240   BG638138   BH610062   BI170217   BI170251   BI216131   BI216143   BI228996   BI230003   BI370634   BI372678   BI579407   BZ665704   CK132094   CO188670   CO192965   CO265379   CO267070   CO271280   CO282011   CO282893   CO292582   CO303449   CO304431   CO304762   CO305448   CO305550   CO318312   CO325596   CO325687   CO328007   CO331186   CO331925   CO333961   CO338967   CO339378   CZ471345   CZ477186   CZ477203   EC063638   EC067012   EC070970   EC073500   EC074954   EC075181   EC076704   EC077078   EC077162   EC078237   EC079221   EC082356   EC084251   EC085063   EC089015   EC195315   EC209976   EC214697   EC216788   EC221808   EC240361   EC245271   EC247930   EC249267   EC258862   EC258921   EC259916   EV585932   EV592142   EV595320   EV598259   G00625   GH918758   M14940 AAA28660
UniProtKB/Swiss-Prot	P08155
UniProtKB/TrEMBL	B7Z023
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | mid -- embryonic stage | late   organism   (Pecasse et al., 2000) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) midline primordium   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage ventral midline neuroblast   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Schuh et al., 1986, Pecasse et al., 2000) embryonic stage -- adult stage     (Pecasse et al., 2000) embryonic stage 5 -- 8   organism   (Schuh et al., 1986) embryonic stage 17     (Pecasse et al., 2000) Comment:reference states 0-24 hr AEL first instar larval stage     (Pecasse et al., 2000) second instar larval stage     (Pecasse et al., 2000) third instar larval stage     (Pecasse et al., 2000) prepupal stage P1 -- P4     (Pecasse et al., 2000) Comment:reference states <=6-8 hr APF prepupal stage P4(i)     (Pecasse et al., 2000) Comment:reference states 6-8 hr APF adult stage     (Pecasse et al., 2000)
Additional Descriptive Data
	The largest Kr-h1 transcript is detected in embryos. (Schuh et al., 1986) The 3.8 kb Kr-h1 transcript is present at low levels in 0-4 hr embryos and at high levels in mid-embryogenesis. Levels subsequently decline. (Pecasse et al., 2000) Low levels of the 4.5 kb Kr-h1 transcripts are present in mid-embryogenesis and also in first instar larvae. Expression levels become significant starting at second larval instar and continue through 6-8 hours after pupariation. The transcript is also present in adult flies. (Pecasse et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    273.65 Larval Midgut    116.3 Larval Hindgut    124.3 Larval Malpighian Tubules    136.5 Larval Fat Body    121.3 Larval Salivary Gland    258.5 Larval Trachea    144.45 Larval Carcass    127.3 Adult Head    151.2 Adult Eye    167.525 Adult Brain    204.2 Adult Thoracic-Abdominal Ganglion    168.5 Adult Crop    265.3 Adult Midgut    128.8 Adult Hindgut    243.5 Adult Malpighian Tubules    335.8 Adult Fat Body    359.1 Adult Salivary Gland    411.7 Adult Heart    209.175 Adult VirginFemale Spermatheca    313.5 Adult InseminatedFemale Spermatheca    347.5 Adult Ovary    25.8 Adult Testis    20.6 Adult Male Accessory Gland    103.2 Adult Carcass    208.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    151.2   NA  Eye    167.525   NA  Brain    204.2   273.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    168.5   NA  Crop    265.3   116.3  Midgut    128.8   124.3  Hindgut    243.5   136.5  Malpighian Tubules    335.8   121.3  Fat Body    359.1   258.5  Salivary Gland    411.7   NA  Heart    209.175   144.45  Trachea    NA   NA  VirginFemale Spermatheca    313.5   NA  InseminatedFemale Spermatheca    347.5   NA  Ovary    25.8   NA  Testis    20.6   NA  Male Accessory Gland    103.2   127.3  Carcass    208.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (60) central nervous system, pupae P8    0 head, virgin 1-day female  (29) head, virgin 4-day female  (28) head, virgin 20-day female  (28) head, mated 1-day female  (32) head, mated 4-day female  (32) head, mated 20-day female  (32) head, mated 1-day male  (36) head, mated 4-day male  (42) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  (27) digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult  (29) digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering  (30) carcass, 1-day adult  26 carcass, 4-day adult  (33) carcass, 20-day adult  (30) ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (41) central nervous system, larvae L3  (60) central nervous system, pupae P8    0 head, virgin 1-day female  29 head, virgin 4-day female  28 head, virgin 20-day female  28 head, mated 1-day female  32 head, mated 4-day female  32 head, mated 20-day female  32 head, mated 1-day male  (36) head, mated 4-day male  (42) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae  27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult  29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering  30 carcass, 1-day adult  26 carcass, 4-day adult  (33) carcass, 20-day adult  30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    41 central nervous system, larvae L3    60 central nervous system, pupae P8    0 head, virgin 1-day female    29 head, virgin 4-day female    28 head, virgin 20-day female    28 head, mated 1-day female    32 head, mated 4-day female    32 head, mated 20-day female    32 head, mated 1-day male    36 head, mated 4-day male    42 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    14 digestive system, 1-day adult    16 digestive system, 4-day adult    29 digestive system, 20-day adult    22 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    1 carcass, larvae L3 wandering    30 carcass, 1-day adult    26 carcass, 4-day adult    33 carcass, 20-day adult    30 ovary, virgin 4-day female    2 ovary, mated 4-day female    2 testis, mated 4-day male    2 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr  (63) embryo 12-14hr  (77) embryo 14-16hr  (39) embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr  (63) embryo 12-14hr  (77) embryo 14-16hr  (39) embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    7 embryo 08-10hr    12 embryo 10-12hr    63 embryo 12-14hr    77 embryo 14-16hr    39 embryo 16-18hr    12 embryo 18-20hr    11 embryo 20-22hr    12 embryo 22-24hr    11 larva L1    7 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    21 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    14 adult male 01day    13 adult male 05day    18 adult male 30day    17 adult female 01day    12 adult female 05day    7 adult female 30day    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    25 Schneider line 2 Sg4    4 embryonic 1182-4H    9 embryonic GM2    17 embryonic Kc167    16 embryonic S1    14 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    10 wing disc ML-DmD8    0 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    7 wing disc ML-DmD32    4 haltere disc ML-DmD17-c3    16 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    1 ovary OSC    3 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult  (29) Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult  29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    9 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    12 Zinc 4.5 mM 48 hrs, 4-day adult    29 Ethanol 2.5% 3 hrs, larvae L3    12 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    8 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    14 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD32311 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028420 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18783-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Kr-h1 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4en-e16E Kr-h1EP2289 lethal, with Scer\GAL4sca-4512 Kr-h1EP2289 Kr-h1GS-A029 lethal (with Kr-h11) Kr-h17.1 lethal (with Kr-h17.1) Kr-h11 Kr-h1k12409b lethal (with Kr-h1k12409b) Kr-h17.1 lethal | embryonic stage | recessive Kr-h17id Kr-h1k04411 lethal | larval stage | partially | recessive Kr-h1k04411 lethal | larval stage | recessive Kr-h17.1 Kr-h1k05905 lethal | prepupal stage (with Kr-h17.1) Kr-h17id Kr-h1k05905 lethal | prepupal stage (with Kr-h17id) Kr-h17.1 Kr-h1k05905 lethal | prepupal stage (with Kr-h1k04411) Kr-h1k05905 lethal | prepupal stage (with Kr-h1k05905) Kr-h17.1 Kr-h17id Kr-h1k04411 lethal | prepupal stage | recessive Kr-h1k04411 lethal | recessive Kr-h11 Kr-h17.1 Kr-h105208 Kr-h110642 Kr-h1k04411 Kr-h1k05905 Kr-h1k05917 Kr-h1k06134 Kr-h1k12409a Kr-h1k12409b Kr-h1k16802 partially lethal - majority die | dominant Kr-h1k05905 viable Kr-h105208rev Other Phenotypes Allele developmental rate defective | recessive Kr-h17.1 non-enhancer of variegation, with In(1)wm4h Kr-h105208 non-suppressor of variegation, with In(1)wm4h Kr-h105208 visible, with Scer\GAL4ey.PH Kr-h1EP2289 visible, with Scer\GAL4hs.2sev Kr-h1EP2289 visible, with Scer\GAL4sca-537.4 Kr-h1EP2289 Phenotype manifest in Allele adult abdomen & microchaeta, with Scer\GAL4sca-537.4 Kr-h1EP2289 anterior pupal spiracle Kr-h1k04411 anterior pupal spiracle (with Kr-h17.1) Kr-h1k04411 anterior pupal spiracle (with Kr-h1k04411) Kr-h17.1 dorsocentral bristle, with Scer\GAL4sca-537.4 Kr-h1EP2289 embryonic/larval anterior spiracle Kr-h1k04411 embryonic/larval anterior spiracle (with Kr-h17.1) Kr-h17id Kr-h1k04411 embryonic/larval anterior spiracle (with Kr-h17id) Kr-h17.1 Kr-h1k04411 embryonic/larval anterior spiracle (with Kr-h1k04411) Kr-h17.1 Kr-h17id embryonic/larval mouth | embryonic stage Kr-h11 eye, with Scer\GAL4ey.PH Kr-h1EP2289 eye, with Scer\GAL4hs.2sev Kr-h1EP2289 eye | pharate adult stage Kr-h1k05905 imaginal disc Kr-h1k04411 Kr-h1k05905 intersegmental nerve, with Scer\GAL4elav-C155 Kr-h1EP2289 larval head Kr-h11 longitudinal connective Kr-h1GS-A029 photoreceptor, with Scer\GAL4oc.1.6 Kr-h1Scer\UAS.cFa pigment cell | ectopic Kr-h11 scutellar bristle, with Scer\GAL4sca-537.4 Kr-h1EP2289 segment Kr-h11 ventral nerve cord commissure, with Scer\GAL4sca-4512 Kr-h1EP2289 Kr-h1GS-A029
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of Kr-h1 Class Mutagen Stocks Known lesion Kr-h1k04411 P-element activity 2 Yes Kr-h1KG00354 P-element activity 2 -- Kr-h1NP1247 2 -- Kr-h110642 P-element activity 1 Yes Kr-h1CB-0109-3 1 -- Kr-h1CB-5786-3 1 -- Kr-h1CB-6247-3 1 -- Kr-h1d00043 P-element activity 1 -- Kr-h1d08561 1 -- Kr-h1d10264 P-element activity 1 -- Kr-h1d10301 P-element activity 1 -- Kr-h1k05905 P-element activity 1 Yes Kr-h1k06134 P-element activity 1 Yes Kr-h1k16802 P-element activity 1 Yes Kr-h1KG09713 P-element activity 1 -- Kr-h105208 P-element activity 0 Yes Kr-h105208rev Delta2-3 0 Yes Kr-h11 P-element activity 0 Yes Kr-h17.1 P-element activity 0 Yes Kr-h17id 0 Yes Kr-h1EP2289 P-element activity 0 Yes Kr-h1GS-A029 P-element activity 0 Yes Kr-h1k05917 P-element activity 0 -- Kr-h1k12409a P-element activity 0 -- Kr-h1k12409b P-element activity 0 -- Kr-h1MI08215 0 -- Kr-h1NP4249 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Kr-h1 Class Mutagen Stocks Known lesion Kr-h1KK112003 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Kr-h1GD4367 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Kr-h1Scer\UAS.cFa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)cl-h3 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)E110 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)GpdhA (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)BSC239 (Christensen and Cook, 2006.12.5) Df(2L)Exel8017 (Ryder, 2004.4.26) Df(2L)Kr-h17.1 (Pecasse et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4367} NA P{KK112003} NA P{UAS-Kr-h1.F} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Kr-h1k04411 No P{lacW}Kr-h1k05905 No P{lacW}Kr-h1k05917 No P{lacW}Kr-h1k06134 No P{lacW}Kr-h1k12409a No P{lacW}Kr-h1k12409b No P{lacW}Kr-h1k16802 No P{lacW}l(2)SH1627SH1627 No P{PZ}Kr-h105208 No P{PZ}Kr-h110642 No insertion of mobile activating element P{EP}Kr-h1EP2289 NA P{EP}Kr-h1GS-A029 NA P{GSV1}GSd113GSd113 NA P{GSV1}GSd204GSd204 NA P{GSV1}GSd246a NA P{XP}Kr-h1d00043 NA P{XP}Kr-h1d08561 NA P{XP}Kr-h1d10264 NA P{XP}Kr-h1d10301 NA miscellaneous insertions Mi{MIC}Kr-h1MI08215 NA P{lacW-Δ7id}Kr-h17id NA P{RS3}Kr-h1CB-0109-3 NA P{RS3}Kr-h1CB-5786-3 NA P{RS3}Kr-h1CB-6247-3 NA P{Sgs.g71ΔI}Kr-h11 NA P{SUPor-P}Kr-h1KG00354 NA P{SUPor-P}Kr-h1KG09713 NA insertion of enhancer trap binary system P{GawB}Kr-h1NP1247 No P{GawB}Kr-h1NP4249 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
metamorphosis inferred from mutant phenotype (Pecasse et al., 2000) negative regulation of compound eye photoreceptor development inferred from mutant phenotype (Fichelson et al., 2012) response to ecdysone inferred from mutant phenotype (Pecasse et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity non-traceable author statement (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
metamorphosis non-traceable author statement (Swiss-Prot Project Members, 1988.8.1) regulation of transcription, DNA-dependent non-traceable author statement (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1988.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Kr-h1 - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG2691 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG31694 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG3548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG3995 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG4858 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - CG9797 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Dbp45A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Dpy-30L1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Ect4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Gnf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Hlc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Nop56 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - OstStt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Pgam5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RFeSP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RfC38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RpL37a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Srp54 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - TFAM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Tap42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - U2af38 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - bocksbeutel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - dream anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - gish anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - pit anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - pont anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - prod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - pzg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - row anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Kr-h1 - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Kr-h1 allele Gene References Kr-h105208 w (Benevolenskaya et al., 2000) Kr-h110642 Kr (Abrell et al., 2000) w (Benevolenskaya et al., 2000) Kr-h1EP2289 pnr (Pena-Rangel et al., 2002) unspecified w (Benevolenskaya and Birchler, 1998, Benevolenskaya, 1998.3.10)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60025 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028420 DroID - A comprehensive database of gene and protein interactions. • FBgn0028420 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33861
Orthologs
OrthoDB Orthologs (3) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61G3R4 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG61G3R4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Kr-h1     Drosophila simulans   Dsim\GD23386     Drosophila sechellia   Dsec\GM18602
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23387 Drosophila sechellia Dsec\GM18603 Drosophila erecta Dere\GG10387 Drosophila yakuba Dyak\GE13637 Drosophila ananassae Dana\GF14504 Drosophila pseudoobscura pseudoobscura Dpse\GA15080 Drosophila persimilis Dper\GL19065 Drosophila willistoni Dwil\GK14726 Drosophila virilis Dvir\GJ15822 Drosophila mojavensis Dmoj\GI17314 Drosophila grimshawi Dgri\GH10804
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	12380 cn1 P{PZ}Kr-h110642/CyO; ry506 10381 y1 w67c23; P{lacW}Kr-h1k04411/CyO 15207 y1; P{SUPor-P}Kr-h1KG09713; ry506
Harvard	- P{XP}Kr-h1d00043 - P{XP}Kr-h1d08561 - P{XP}Kr-h1d10264 - P{XP}Kr-h1d10301
Kyoto	123037 w1118; P{RS3}Kr-h1CB-0109-3 123817 w1118; P{RS3}Kr-h1CB-5786-3 123998 w1118; P{RS3}Kr-h1CB-6247-3 102310 y1 w67c23 ; P{lacW}Kr-h1k04411 / CyO
VDRC	v107935 P{KK112003}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR10M11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 42 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD32311
Other clones	DPiM_LD32311
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD17232 LD17382 LP13349 RE11606 RE11644 RE23056 RE23073 RE26678 RE27918 RE57338 RE59711 RE73434
Other clones	31826 Dmel_dig_008719_0655_3404 Dmel_neb_008782_0673_1694 Dmel_neb_009389_0879_1567 Dmel_neb_011084_0691_3381 EC34914 EK041432 EK102746 EK142521 EK148624 EK159326 EK161721 EK196906 EK197164 EK200515 EK241458 EK244663 EK246060 EK248653 EK248929 EK271525 EK298803 EK302032 EK308457 EP00440 EP01833 EP08420 RP003277337
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028420 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33861
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Kr-h1 CG18783 (FlyBase, 1996-) Source for merge of: Kr-h1 Pow (Spradling et al., 1999)
Additional comments	Source for merge of Kr-h1 CG18783 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	Kr-h1 acts as a modulator of the expression of many ecdysone regulated genes during metamorphosis. (Beck et al., 2004) A 4.5kb transcript of Kr-h1 is indispensable for normal progression of metamorphosis. (Pecasse et al., 2000) Identified as a dosage sensitive modifier of w allele expression. (Benevolenskaya and Birchler, 1998) A dosage sensitive regulator of w gene expression. (Benevolenskaya, 1998.3.10) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058118 NM_058119 NM_001144324 RefSeq (Proteins) • NP_477466 NP_477467 NP_001137796 DDBJ / EMBL / GenBank • AA951662 AAA28660 AAF52343 AAG22417 AAK93240 AC004268 AC004639 AC004758 ACL83002 AJ005440 AJ005441 AQ073287 AQ254845 AW943129 AY051816 BH610062 BZ665704 CAA06543 CAA06544 CZ471345 CZ477186 CZ477203 G00625 M14940 Entrez Gene - A searchable database of RefSeq genes. • 33861 UniProtKB/Swiss-Prot • P08155 UniProtKB/TrEMBL • B7Z023
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD32311
Linkouts
	BioGRID - A database of protein and genetic interactions • 60025 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028420 DroID - A comprehensive database of gene and protein interactions. • FBgn0028420 DRSC - Results from RNAi screens. • FBgn0028420 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028420 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18783-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028420 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33861 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/kruppelhomolog.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33861 modMine - Data generated by the modENCODE project. • FBgn0028420
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	44/11 (Roch et al., 1998) CG9167 (Brody et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Whitfield, 2000.7.14, Boehm, 2000.5.30, ) CG18783 (Keleman et al., 2009.8.5) Kr-h (Mueller et al., 2005, Beck et al., 2005, Beck et al., 2004, Thummel and Chory, 2002, Boehm, 2000.5.30, Benevolenskaya et al., 2000, Pecasse et al., 2000, Pecasse, 1998.4.16, Pecasse, 1998.4.16, ) Kr h (Schuh et al., 1986) Kr-h1 (Jordan et al., 2005, Christensen and Cook, 2006.12.5, Hoopfer et al., 2008, Shi et al., 2007, Minakuchi et al., 2008, Fichelson et al., 2012, Liebl et al., 2006, Lawniczak and Begun, 2004, McClure and Schubiger, 2008, Minidorff et al., 2007, Grimberg et al., 2011, Minidorff et al., 2007, Abdou et al., 2011, Peng et al., 2007, Ruedi and Hughes, 2009, Liebl and Featherstone, 2005, Beckstead et al., 2005, Abruzzi et al., 2011) Kr-H1 (Liu et al., 2009) l(2)05208   l(2)10642 (Abrell et al., 2000, Liebl, 1999, ) P381 (Liebl, 1999) Pow (Benevolenskaya, 1998.3.10, Benevolenskaya and Birchler, 1998, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) unnamed (Benevolenskaya and Birchler, 1998)
Name Synonym	Krueppel-homolog alpha-isoform (Abdelilah-Seyfried et al., 2000) Kruppel homolog 1 (Minakuchi et al., 2008, Fichelson et al., 2012, Ruedi and Hughes, 2009) Kruppel-homolog 1 (Shi et al., 2007) Kruppel-homolog-1 (McClure and Schubiger, 2008) kruppel homolog 1 (Beckstead et al., 2005) Krupple homolog 1 (Jordan et al., 2005) Passion of white (Benevolenskaya, 1998.3.10, Benevolenskaya and Birchler, 1998, )
Secondary FlyBase IDs
	FBgn0001326 FBgn0010668 FBgn0024313 FBgn0042122
References ( 69 )
Generate a list of	All references relating to this gene ( 69 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898 Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313] Abdou et al., 2011, Insect Biochem. Mol. Biol. 41(12): 938--945 Drosophila Met and Gce are partially redundant in transducing juvenile hormone action. [FBrf0216586] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Grimberg et al., 2011, Mol. Cell. Biol. 31(4): 897--909 Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome. [FBrf0212906] Huang et al., 2011, Development 138(11): 2283--2291 DPP-mediated TGF{beta} signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. [FBrf0213687] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...