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Gene Dmel\GluRIID

General Information
Symbol	Dmel\GluRIID	Species	D. melanogaster
Name	Glutamate receptor IID	Annotation symbol	CG18039
Feature type	protein_coding_gene	FlyBase ID	FBgn0028422
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	brec, KaiRIA
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92F4-92F4	Sequence location	3R:16,474,317..16,478,172 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Glutamate receptor IID is referred to in FlyBase by the symbol Dmel\GluRIID (CG18039, FBgn0028422). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ionotropic glutamate receptor activity; kainate selective glutamate receptor activity. There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; rhythmic excitation. 12 alleles are reported. The phenotypes of these alleles are annotated with: NMJ bouton; neuromuscular junction; embryonic/larval neuromuscular junction. It has one annotated transcript and one annotated polypeptide. Protein features are: Extracellular ligand-binding receptor; Glutamate receptor, L-glutamate/glycine-binding; Ionotropic glutamate receptor; NMDA receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult heart, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1631710_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of KaiRIA. Gene sequence location is 3R:16474317..16478172.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms regulation of neuromuscular synaptic transmission postsynaptic membrane
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92F4-92F4   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References 92E-92E     (Featherstone, 2002.3.5) 90C-90D     (Voelkner, 1999.9.15)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\GluRIID for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) GluRIID-RA FBtr0083938  NM_143725   3080   902
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein GluRIID-PA   FBpp0083346   101.7   902   4.61     NP_651982   AAG22164
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Glutamate receptor, L-glutamate/glycine-binding (IPR019594)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAG22164   AJ251888 CAB64941   AJ251889 CAB64942   AY768536 AAV54100   AY768537 AAV54101   AY768538   AY768539   BI227629   BI362589   BT021942   CO303751   CO311363   CZ479255
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9TVI0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 15   somatic muscle primordium   (Qin et al., 2005) embryonic stage 12 -- 17   cardioblast   (Qin et al., 2005) embryonic stage 16 -- larval stage   embryonic/larval somatic muscle   (Qin et al., 2005)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- larval stage   somatic muscle   • neuromuscular junction (Qin et al., 2005) larval stage   somatic muscle   • postsynaptic density (Qin et al., 2005) embryonic/larval neuromuscular junction   (Banovic et al., 2010) Comment:postsynaptically localized western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Qin et al., 2005)
Additional Descriptive Data
	GluRIID is expressed in the postsynaptic part of the neuromuscular junction. (Banovic et al., 2010)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
ionotropic glutamate receptor complex inferred from physical interaction with GluRIIB, GluRIIC, GluRIIA, GluRIIE (Qin et al., 2005) neuromuscular junction inferred from direct assay (Qin et al., 2005) postsynaptic membrane inferred from direct assay (Qin et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult heart, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    6.225 Larval Midgut    9.9 Larval Hindgut    71.9 Larval Malpighian Tubules    4.6 Larval Fat Body    3.5 Larval Salivary Gland    3.4 Larval Trachea    12.025 Larval Carcass    301.75 Adult Head    22.3 Adult Eye    8 Adult Brain    7.1 Adult Thoracic-Abdominal Ganglion    6.8 Adult Crop    158.9 Adult Midgut    13.1 Adult Hindgut    40.2 Adult Malpighian Tubules    10.1 Adult Fat Body    13.2 Adult Salivary Gland    5.6 Adult Heart    209.225 Adult VirginFemale Spermatheca    17.2 Adult InseminatedFemale Spermatheca    15.5 Adult Ovary    4.9 Adult Testis    8.6 Adult Male Accessory Gland    50.2 Adult Carcass    39 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    22.3   NA  Eye    8   NA  Brain    7.1   6.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.8   NA  Crop    158.9   9.9  Midgut    no informative data   71.9  Hindgut    40.2   4.6  Malpighian Tubules    no informative data   3.5  Fat Body    no informative data   3.4  Salivary Gland    5.6   NA  Heart    209.225   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    17.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4.9   NA  Testis    8.6   NA  Male Accessory Gland    50.2   301.75  Carcass    39 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    2 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    1 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    7 embryo 12-14hr    16 embryo 14-16hr    14 embryo 16-18hr    11 embryo 18-20hr    5 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    4 larva L2    5 larva L3 12hr old    7 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    6 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    0 pupae 2d postWPP    1 pupae 3d postWPP    5 pupae 4d postWPP    1 adult male 01day    2 adult male 05day    1 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    0 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028422 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18039-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | recessive GluRIID1 GluRIID2 lethal | partially | recessive GluRIIDP1 lethal | recessive GluRIIDe01443 GluRIIDP2 GluRIIDP5 viable, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW GluRIIDGD3089 viable, with Scer\GAL4pnr-MD237 GluRIIDGD3089 Other Phenotypes Allele neurophysiology defective GluRIIDP2 neurophysiology defective | recessive GluRIID1 GluRIID2 GluRIIDP5 paralytic GluRIIDe01443 paralytic | recessive GluRIID1 GluRIID2 Phenotype manifest in Allele central nervous system & motor neuron GluRIID2 embryonic/larval neuromuscular junction GluRIID1 GluRIID2 GluRIIDP5 neuromuscular junction GluRIIDP2 GluRIIDe01443 NMJ bouton GluRIIDP5
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of GluRIID Class Mutagen Stocks Known lesion GluRIIDe01443 loss of function allele piggyBac transposase 2 Yes GluRIID1 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes GluRIID2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes GluRIIDP1 hypomorphic allele - genetic evidence Delta2-3 0 Yes GluRIIDP2 hypomorphic allele - genetic evidence Delta2-3 0 Yes GluRIIDP5 hypomorphic allele - genetic evidence Delta2-3 0 Yes GluRIIDunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of GluRIID Class Mutagen Stocks Known lesion GluRIIDGD3089 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GluRIIDJF02035 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GluRIIDc.Scer\UAS in vitro construct - regulatory fusion 0 Yes GluRIIDg.Scer\UAS in vitro construct - regulatory fusion 0 Yes GluRIIDNIG.18039R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC488 (Christensen et al., 2008.4.15) Df(3R)E3 (Featherstone et al., 2005, Featherstone et al., 2005) Df(3R)GluRIID&IIEE3 (Qin et al., 2005) Df(3R)H-B79 (Qin et al., 2005)
Not disrupted in	Df(3R)e01443 (Featherstone et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions I{}GluRIIDP5 NA PBac{RB}GluRIIDe01443 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neuromuscular synaptic transmission inferred from mutant phenotype (Featherstone et al., 2005) rhythmic excitation inferred from mutant phenotype (Featherstone et al., 2005)
Cellular Component
CV term Evidence References
ionotropic glutamate receptor complex inferred from physical interaction with GluRIIB, GluRIIC, GluRIIA, GluRIIE (Qin et al., 2005) neuromuscular junction inferred from direct assay (Qin et al., 2005) postsynaptic membrane inferred from direct assay (Qin et al., 2005)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
extracellular-glutamate-gated ion channel activity inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR001508, InterPro:IPR019594 (FlyBase Curators et al., 2004-) ionotropic glutamate receptor activity inferred by curator from GO:0008328 (Qin et al., 2005) inferred from electronic annotation with InterPro:IPR001320, InterPro:IPR019594 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Volkner et al., 1999) kainate selective glutamate receptor activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000)
Biological Process
CV term Evidence References
ion transport inferred from electronic annotation with InterPro:IPR001508 (FlyBase Curators et al., 2004-) regulation of neuromuscular synaptic transmission inferred by curator from GO:0031594|GO:0008328 (Qin et al., 2005)
Cellular Component
CV term Evidence References
ionotropic glutamate receptor complex inferred from sequence or structural similarity (Volkner et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions GluRIID allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69079 DroID - A comprehensive database of gene and protein interactions. • FBgn0028422 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44483
Orthologs
OrthoDB Orthologs (70) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GJ07K Dipteran inclusive ortholog search EOG6X6CHF Insect inclusive ortholog search EOG6280WJ Arthropod inclusive ortholog search EOG644J18 Metazoa inclusive ortholog search EOG6B61ZS
Orthologs in Drosophila Species (EOG6GJ07K)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\GluRIID     Drosophila simulans   Dsim\GD20046     Drosophila sechellia   Dsec\GM23173     Drosophila erecta   Dere\GG15269     Drosophila yakuba   Dyak\GE25051     Drosophila ananassae   Dana\GF18325     Drosophila pseudoobscura pseudoobscura   Dpse\GA14772     Drosophila persimilis   Dper\GL27140     Drosophila willistoni   Dwil\GK22709     Drosophila virilis   Dvir\GJ24288     Drosophila mojavensis   Dmoj\GI22168     Drosophila grimshawi   Dgri\GH16102
Orthologs in non-Drosophila Dipterans (EOG6X6CHF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002511 Y Anopheles gambiae Malaria mosquito  Agam\AGAP000798 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002797 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006668 Y
Orthologs in non-Dipteran Insects (EOG6280WJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB49275 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002756 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18020 Y Atta cephalotes Leafcutter ant  Acep\ACEP25403 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19234 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18140 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22072 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25133 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25135 Y Solenopsis invicta Red fire ant  Sinv\SINV18747 Y Solenopsis invicta Red fire ant  Sinv\SINV18709 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011486 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011527 Y Pediculus humanus Human body louse  Phum\PHUM518040 Y Tribolium castaneum Red flour beetle  Tcas\TC011401 Y
Orthologs in non-Insect Arthropods (EOG644J18)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_327119 Y
Orthologs in non-Arthropod Metazoa (EOG6B61ZS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\glr-5 Y Caenorhabditis elegans Nematode  Cele\glr-3 Y Caenorhabditis elegans Nematode  Cele\glr-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015492gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014664gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028455gn Y Danio rerio Zebrafish  Drer\ENSDARG00000077715 Y Danio rerio Zebrafish  Drer\ENSDARG00000040627 Y Danio rerio Zebrafish  Drer\ENSDARG00000074515 Y Danio rerio Zebrafish  Drer\si:ch211-264f5.8 Y Danio rerio Zebrafish  Drer\grik5 Y Danio rerio Zebrafish  Drer\ENSDARG00000091173 Y Danio rerio Zebrafish  Drer\grik4 Y Danio rerio Zebrafish  Drer\grik1a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000013277 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014704 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031503 Y Xenopus tropicalis Western clawed frog  Xtro\grik1 Y Xenopus tropicalis Western clawed frog  Xtro\grik4 Y Gallus gallus Domestic chicken  Ggal\GRIK1 Y Gallus gallus Domestic chicken  Ggal\GRIK4 Y Gallus gallus Domestic chicken  Ggal\GRIK3 Y Gallus gallus Domestic chicken  Ggal\GRIK2 Y Mus musculus House mouse  Mmus\Grik2 Y Mus musculus House mouse  Mmus\Grik3 Y Mus musculus House mouse  Mmus\Grik5 Y Mus musculus House mouse  Mmus\Grik1 Y Mus musculus House mouse  Mmus\Grik4 Y Rattus norvegicus Norway rat  Rnor\Grik3 Y Rattus norvegicus Norway rat  Rnor\Grik4 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000000368 Y Rattus norvegicus Norway rat  Rnor\Grik5 Y Rattus norvegicus Norway rat  Rnor\Grik1 Y Homo sapiens Human  Hsap\GRIK1 Y Homo sapiens Human  Hsap\GRIK2 Y Homo sapiens Human  Hsap\GRIK4 Y Homo sapiens Human  Hsap\GRIK3 Y Homo sapiens Human  Hsap\GRIK5 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\GRIK1     Hsap\GRIK2     Hsap\GRIK4     Hsap\GRIK3     Hsap\GRIK5
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	26010 y1 v1; P{TRiP.JF02035}attP2 17952 w1118; PBac{RB}GluRIIDe01443/TM6B, Tb1
Harvard	- PBac{RB}GluRIIDe01443
VDRC	v40929 w1118; P{GD3089}v40929
Genomic Clones ( 2 )
	BACR13J19 BACR26M03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE24732
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE47190
Other clones	EK224307 EK242701
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028422 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44483
Antibody Information
	polyclonal (Qin et al., 2005)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GluRIID KaiRIA (FlyBase, 2009-) Source for identity of: KaiRIA CG18039 (Featherstone et al., 2005)
Source for database merge of	Source for merge of: KaiRIA brec (Featherstone, 2004.10.16) Source for merge of: KaiRIA CG18039 (Bayraktaroglu, 2000.8.7)
Additional comments	FlyBase curator comment: 'GluRIID' renamed 'KaiRIA' for the following reasons: i) The first published research papers to characterize this gene refer to it as 'GluRIID' (FBrf0184094, FBrf0184095). ii) 'GluRIID' is much prefered over 'KaiRIA' in the published literature. iii) 'KaiRIA' appears to stem from an EDRC abstract (FBrf0111008), and this is not a valid source upon which to name a gene in FlyBase. iv) 'GluRIID' matches the nomenclature of the GluR genes. (FlyBase, 2009-)
Other Comments
	Identification: In a screen for mutants with defective synaptic development. (Featherstone et al., 2005) KaiRIA is essential at the Drosophila neuromuscular junction and is the first glutamate receptor subunit known to function within the CNS. (Featherstone et al., 2005) Mutants are completely paralysed and die as embryos. Mutant neuromuscular junctions are devoid of glutamate receptors. (Featherstone et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143725 RefSeq (Proteins) • NP_651982 DDBJ / EMBL / GenBank • AAG22164 AAV54100 AAV54101 AJ251888 AJ251889 AY768536 AY768537 AY768538 AY768539 BI227629 CAB64941 CAB64942 CZ479255 Entrez Gene - A searchable database of RefSeq genes. • 44483 UniProtKB/TrEMBL • Q9TVI0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ionotropic glutamate receptor (IPR001320) NMDA receptor (IPR001508) Extracellular ligand-binding receptor (IPR001828) Glutamate receptor, L-glutamate/glycine-binding (IPR019594)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69079 DroID - A comprehensive database of gene and protein interactions. • FBgn0028422 DRSC - Results from RNAi screens. • FBgn0028422 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028422 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18039-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028422 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44483 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44483 modMine - Data generated by the modENCODE project. • FBgn0028422
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	brec (Featherstone, 2004.10.16, Featherstone, 2002.3.5, Featherstone et al., 2001, Rohrbough and Broadie, 2010) CG18039 (Perkins et al., 1.15.2009, Benton et al., 2009, Croset et al., 2010, Tsubouchi et al., 2012) CT13538 (Littleton and Ganetzky, 2000) DGluRIID (Owald et al., 2010) DKaiR-IA (Volkner et al., 1999) DmelGluRIID (Croset et al., 2010) GluRIA (Littleton and Ganetzky, 2000) GluR-IID (Qin et al., 2005) GluRIID (Qin et al., 2005, Featherstone, 2004.10.16, Banovic et al., 2010, Chen et al., 2005, Rohrbough et al., 2007, Weyhersmüller et al., 2011, Lee et al., 2009, Schmid et al., 2006, Besse et al., 2007, Benton et al., 2009, Schmid et al., 2008, Karr et al., 2009, Fouquet et al., 2009, Chai et al., 2008, Hallermann et al., 2010, Bachmann et al., 2010, Liu et al., 2011, Croset et al., 2010, Jordán-Álvarez et al., 2012, ) gluRIID (Kim et al., 2012) Kai-RIA   KaiRIA (Tsubouchi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Christensen et al., 2008.4.15)
Name Synonym	bad reception (Featherstone et al., 2001) Glutamate receptor IID   KaiRIA
Secondary FlyBase IDs
	FBgn0038817 FBgn0061176 FBgn0082321
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Stock list  ( 1 )
Recent research papers ( 4 )
	Jordán-Álvarez et al., 2012, J. Cell Sci. 125(15): 3621--3629 Presynaptic PI3K activity triggers the formation of glutamate receptors at neuromuscular terminals of Drosophila. [FBrf0219610] Kim et al., 2012, Genes Dev. 26(9): 974--987 Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. [FBrf0218161] Liu et al., 2011, Science 334(6062): 1565--1569 RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. [FBrf0216992] Weyhersmüller et al., 2011, J. Neurosci. 31(16): 6041--6052 Rapid Active Zone Remodeling during Synaptic Plasticity. [FBrf0213525] Show all research papers ...