FlyBase Gene Report: Dmel\GluRIID

General Information

Symbol

Dmel\GluRIID

Species

D. melanogaster

Name

Glutamate receptor IID

Annotation Symbol

CG18039

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028422

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Glutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

brec, KaiRIA

Key Links

Genomic Location

Cytogenetic map

92F4-92F4

Sequence location

3R:20,648,595..20,652,450 [-]

Recombination map

3-69

RefSeq locus

NT_033777 REGION:20648595..20652450

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables glutamate-gated calcium ion channel activity

inferred from direct assay

(Han et al., 2015)

enables ionotropic glutamate receptor activity

inferred from mutant phenotype

(Featherstone et al., 2005)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

enables ionotropic glutamate receptor activity

inferred by curator from GO:0008328

(Qin et al., 2005)

enables kainate selective glutamate receptor activity

inferred from sequence or structural similarity

(Littleton and Ganetzky, 2000)

enables ligand-gated ion channel activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in calcium ion transport

inferred from direct assay

(Han et al., 2015)

involved_in neuromuscular synaptic transmission

inferred from expression pattern

(Qin et al., 2005)

inferred from mutant phenotype

(Featherstone et al., 2005)

involved_in rhythmic excitation

inferred from mutant phenotype

(Featherstone et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in synaptic transmission, glutamatergic

inferred by curator from GO:0007274,GO:0008328

(Qin et al., 2005)

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from mutant phenotype

(Qin et al., 2005)

located_in muscle cell postsynaptic specialization

inferred from direct assay

(Qin et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Glutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

NON-NMDA IONOTROPIC GLUTAMATE RECEPTORS - GLURII NEUROMUSCULAR JUNCTION-SUBTYPE -: In Drosophila, neuromuscular junction type A and type B glutamate receptors are heterotetramers assembled from either GluRIIA or GluRIIB plus other GluRII subunits. In response to the neurotransmitter, glutamate, they conduct Ca2⁺. (Adapted from FBrf0228432).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\GluRIID for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

GluRIID-RA

FBtr0083938

NM_143725

3080

902

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

GluRIID-PA

FBpp0083346

101.7

902

4.61

NP_651982

AAG22164

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9TVI0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluRIID using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GluRIID_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 15

somatic muscle primordium

(Qin et al., 2005)

embryonic stage 12 -- 17

cardioblast

(Qin et al., 2005)

embryonic stage 16 -- larval stage

embryonic/larval somatic muscle

(Qin et al., 2005)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- larval stage

somatic muscle

• neuromuscular junction

(Qin et al., 2005)

larval stage

somatic muscle

• postsynaptic density

(Qin et al., 2005)

embryonic/larval neuromuscular junction

Comment: postsynaptically localized

(Banovic et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

(Qin et al., 2005)

Additional Descriptive Data

GluRIID is expressed in the postsynaptic part of the neuromuscular junction.

(Banovic et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of ionotropic glutamate receptor complex

inferred from mutant phenotype

(Qin et al., 2005)

located_in muscle cell postsynaptic specialization

inferred from direct assay

(Qin et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\GluRIID in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\GluRIID

View exonic expression by tissue for Dmel\GluRIID

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028422

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG18039-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18039

Flygut - An atlas of the Drosophila adult midgut

FBgn0028422

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of GluRIID

Transgenic constructs containing regulatory region of GluRIID

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)BSC488

(Christensen et al., 2008.4.15)

Df(3R)E3

(Featherstone et al., 2005)

Df(3R)GluRIID&IIE^E3

(Qin et al., 2005)

Df(3R)H-B79

(Qin et al., 2005)

Gene not disrupted in

Df(3R)e01443

(Featherstone et al., 2005)

Gene partially disrupted in

Df(3R)GluRIID^attP

(Rao and Deng, 2019.10.23)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die during embryonic stage | recessive

partially lethal | recessive

GluRIID^P1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

GluRIID^GD3089

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

GluRIID^GD3089

viable, with Scer\GAL4^pnr-MD237

GluRIID^GD3089

viable, with Scer\GAL4^tin.CΔ4

GluRIID^GD3089

Other Phenotypes

Allele

abnormal neuroanatomy, with Scer\GAL4^G14

GluRIID^JF02035

abnormal neurophysiology

GluRIID^P2

abnormal neurophysiology | recessive

paralytic

GluRIID^e01443

paralytic | recessive

some die during embryonic stage | recessive

Phenotype manifest in

Allele

central nervous system & motor neuron

GluRIID²

embryonic/larval neuromuscular junction

neuromuscular junction

NMJ bouton

GluRIID^P5

terminal bouton, with Scer\GAL4^G14

GluRIID^JF02035

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GRIK3

8 of 15

Yes

7 of 15

7 of 15

6 of 15

5 of 15

3 of 15

3 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\ENPP2

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Grik1

7 of 15

Yes

Mmus\Grik2

7 of 15

Yes

Mmus\Grik3

7 of 15

Yes

6 of 15

6 of 15

3 of 15

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Rattus norvegicus (Norway rat) (17)

Rnor\Grik2

6 of 13

Yes

Rnor\Grik3

6 of 13

Yes

Rnor\Grik4

6 of 13

Yes

Rnor\Grik5

6 of 13

Yes

Rnor\Grik1

5 of 13

Rnor\Grid2

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Rnor\Grin3b

2 of 13

Yes

Rnor\Gria1

1 of 13

Rnor\Gria2

1 of 13

Rnor\Grid1

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (15)

Xtro\grik1

5 of 12

Yes

Xtro\grid1

3 of 12

Yes

Xtro\grid2

3 of 12

Yes

Xtro\grik4

3 of 12

Xtro\grik5-like.1

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Xtro\grik5

1 of 12

Yes

Danio rerio (Zebrafish) (32)

Drer\grik1a

7 of 15

Yes

Drer\grik1b

7 of 15

Yes

6 of 15

6 of 15

5 of 15

4 of 15

3 of 15

Yes

Drer\grid1b

3 of 15

Yes

Drer\grid2

3 of 15

Yes

Drer\LOC100331381

3 of 15

Drer\si:ch211-251b21.1

3 of 15

Yes

Drer\si:dkey-183j2.10

3 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Drer\grin3ba

2 of 15

Yes

Drer\LOC100149482

2 of 15

Drer\gria4a

1 of 15

Drer\grin3bb

1 of 15

Yes

Drer\LOC100537813

1 of 15

Drer\LOC110438919

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\glr-5

7 of 15

Yes

Cele\glr-3

5 of 15

Cele\glr-4

4 of 15

Cele\glr-6

4 of 15

Yes

Cele\glr-8

3 of 15

Yes

Cele\C08B6.5

1 of 15

Cele\F59E12.8

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T25E4.2

1 of 15

Yes

Cele\W02A2.5

1 of 15

Cele\ZK867.2

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (20)

Atha\GLR3.4

6 of 9

Yes

Atha\GLR3.5

6 of 9

Yes

Atha\GLR3.6

6 of 9

Yes

Atha\GLR5

6 of 9

Yes

Atha\GLR2

5 of 9

Yes

Atha\GLR3.3

5 of 9

Atha\GLUR2

5 of 9

Atha\ATGLR1.2

4 of 9

Yes

Atha\GLR1.1

4 of 9

Yes

Atha\GLR1.3

4 of 9

Yes

Atha\GLR1.4

4 of 9

Yes

Atha\GLR2.4

4 of 9

Yes

Atha\GLR2.1

3 of 9

Yes

Atha\GLR2.2

3 of 9

Yes

Atha\GLR2.3

3 of 9

Yes

Atha\GLR2.5

3 of 9

Yes

Atha\GLR2.6

3 of 9

Yes

Atha\GLR2.7

3 of 9

Yes

Atha\GLR2.8

3 of 9

Yes

Atha\GLR2.9

3 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919021S )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14772

Drosophila persimilis

Dper\GL27140

Drosophila virilis

Dvir\GJ24288

Drosophila mojavensis

Dmoj\GI22168

Drosophila grimshawi

Dgri\GH16102

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501J4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17022583

Musca domestica

House fly

Mdoa\17020327

Musca domestica

House fly

Mdoa\17006141

Musca domestica

House fly

Mdoa\17020326

Glossina morsitans

Tsetse fly

Gmor\GMOY001514

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07883

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_05203

Mayetiola destructor

Hessian fly

Mdes\Mdes014274

Mayetiola destructor

Hessian fly

Mdes\Mdes006774

Aedes aegypti

Yellow fever mosquito

Aaeg\GNBPB4

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002511

Anopheles darlingi

American malaria mosquito

Adar\ADAC003393

Anopheles gambiae

Malaria mosquito

Agam\GLURIIc

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006668

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01QX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009564

Bombyx mori

Silkmoth

Bmor\BGIBMGA009597

Bombyx mori

Silkmoth

Bmor\BGIBMGA011486

Bombyx mori

Silkmoth

Bmor\BGIBMGA011528

Danaus plexippus

Monarch butterfly

Dple\DPOGS213730-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS209173-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS215109-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS213732-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015522

Heliconius melpomene

Postman butterfly

Hmel\HMEL017170

Heliconius melpomene

Postman butterfly

Hmel\HMEL013710

Heliconius melpomene

Postman butterfly

Hmel\HMEL004580

Apis florea

Little honeybee

Aflo\3156287700

Apis florea

Little honeybee

Aflo\4590677124

Apis florea

Little honeybee

Aflo\2147533299

Apis florea

Little honeybee

Aflo\3780165908

Apis florea

Little honeybee

Aflo\3022081892

Apis mellifera

Western honey bee

Amel\GB49268

Apis mellifera

Western honey bee

Amel\GB53122

Apis mellifera

Western honey bee

Amel\GB53118

Apis mellifera

Western honey bee

Amel\GB49273

Apis mellifera

Western honey bee

Amel\GB49275

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24960

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21318

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24114

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24961

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24105

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21738

Bombus terrestris

Buff-tailed bumblebee

Bter\15215897

Bombus terrestris

Buff-tailed bumblebee

Bter\15205451

Bombus terrestris

Buff-tailed bumblebee

Bter\15205452

Bombus terrestris

Buff-tailed bumblebee

Bter\15215888

Bombus terrestris

Buff-tailed bumblebee

Bter\15205453

Linepithema humile

Argentine ant

Lhum\LH24045

Linepithema humile

Argentine ant

Lhum\LH20394

Linepithema humile

Argentine ant

Lhum\LH24044

Linepithema humile

Argentine ant

Lhum\LH15649

Linepithema humile

Argentine ant

Lhum\LH15650

Linepithema humile

Argentine ant

Lhum\LH15651

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0022bc

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002bd4

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0022bf

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002bcc

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0022bd

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010011

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG018970

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG010019

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07381

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12929

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07839

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07382

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12931

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08566

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10387

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08568

Tribolium castaneum

Red flour beetle

Tcas\TC033173

Tribolium castaneum

Red flour beetle

Tcas\TC032202

Tribolium castaneum

Red flour beetle

Tcas\TC012818

Tribolium castaneum

Red flour beetle

Tcas\TC032415

Tribolium castaneum

Red flour beetle

Tcas\TC003560

Tribolium castaneum

Red flour beetle

Tcas\TC032203

Tribolium castaneum

Red flour beetle

Tcas\TC031399

Pediculus humanus

Human body louse

Phum\PHUM253980

Pediculus humanus

Human body louse

Phum\PHUM518040

Pediculus humanus

Human body louse

Phum\PHUM570680

Pediculus humanus

Human body louse

Phum\PHUM518050

Pediculus humanus

Human body louse

Phum\PHUM536820

Rhodnius prolixus

Kissing bug

Rpro\RPRC000199

Rhodnius prolixus

Kissing bug

Rpro\RPRC000021

Rhodnius prolixus

Kissing bug

Rpro\RPRC010182

Rhodnius prolixus

Kissing bug

Rpro\RPRC000154

Rhodnius prolixus

Kissing bug

Rpro\RPRC002040

Rhodnius prolixus

Kissing bug

Rpro\RPRC010372

Cimex lectularius

Bed bug

Clec\CLEC006915

Cimex lectularius

Bed bug

Clec\CLEC001553

Cimex lectularius

Bed bug

Clec\CLEC006914

Cimex lectularius

Bed bug

Clec\CLEC006916

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006027

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008906

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI071399

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004687

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI060830

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006975

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_19052

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05107

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_19051

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_18949

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0764 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR000906

Strigamia maritima

European centipede

Smar\SMAR013852

Strigamia maritima

European centipede

Smar\SMAR000902

Strigamia maritima

European centipede

Smar\SMAR006430

Ixodes scapularis

Black-legged tick

Isca\ISCW008266

Ixodes scapularis

Black-legged tick

Isca\ISCW001842

Ixodes scapularis

Black-legged tick

Isca\ISCW023274

Ixodes scapularis

Black-legged tick

Isca\ISCW012402

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59945.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75325.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57371.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM83024.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81343.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM81344.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73260.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75323.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur06g03760

Tetranychus urticae

Two-spotted spider mite

Turt\tetur12g00180

Tetranychus urticae

Two-spotted spider mite

Turt\tetur09g02270

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g05440

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g06860

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g01930

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_55220

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_327119

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_55388

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_309661

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02LN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glur6_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Glur6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Grik3

Ciona intestinalis

Vase tunicate

Cint\LOC100175916

Gallus gallus

Domestic chicken

Ggal\GRIK1

Gallus gallus

Domestic chicken

Ggal\GRIK4

Gallus gallus

Domestic chicken

Ggal\GRIK3

Gallus gallus

Domestic chicken

Ggal\GRIK2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (43)

Gene Symbol

Score

Source

Alignment

7 of 10

7 of 10

6 of 10

6 of 10

6 of 10

6 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIK3; glutamate ionotropic receptor kainate type subunit 3

8 of 15

138243

GRIK1; glutamate ionotropic receptor kainate type subunit 1

7 of 15

138245

GRIK2; glutamate ionotropic receptor kainate type subunit 2

7 of 15

138244

MENTAL RETARDATION, AUTOSOMAL RECESSIVE 6; MRT6

autosomal recessive non-syndromic intellectual disability

GRIK4; glutamate ionotropic receptor kainate type subunit 4

6 of 15

600282

GRIK5; glutamate ionotropic receptor kainate type subunit 5

5 of 15

600283

GRID1; glutamate ionotropic receptor delta type subunit 1

3 of 15

610659

GRID2; glutamate ionotropic receptor delta type subunit 2

3 of 15

602368

SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 18; SCAR18

autosomal recessive spinocerebellar ataxia 18

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

GluRIID - cora

two hybrid

(Chen et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Eaat1

suppressible

GluRIID

(Peng et al., 2019)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69079

DroID - A comprehensive database of gene and protein interactions.

FBgn0028422

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44483

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-69

Cytogenetic map

92F4-92F4

Sequence location

3R:20,648,595..20,652,450 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

92F4-92F4

Limits computationally determined from genome sequence between P{PZ}l(3)10585¹⁰⁵⁸⁵ and P{EP}Synd^EP409

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

92E-92E

(Featherstone, 2002.3.5)

90C-90D

(Voelkner, 1999.9.15)

Experimentally Determined Recombination Data

Location

3-69

(FlyBase, 2016)

3-72.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

26010

y¹ v¹; P{TRiP.JF02035}attP2

82928

y¹ v¹; P{TKO.GS05167}attP40

17952

w¹¹¹⁸; PBac{RB}GluRIID^e01443/TM6B, Tb¹

84638

w^*; TI{2A-GAL4}GluRIID^2A-GAL4/TM3, Sb¹

84396

w^*; TI{2A-lexA::p65}GluRIID^2A-lexA/TM3, Sb¹

84509

w^*; Df(3R)GluRIID^attP TI{TI}GluRIID^attP/TM3, Sb¹

VDRC

v330057

P{VSH330057}attP40

v40929

w¹¹¹⁸; P{GD3089}v40929

v341982

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01321}attP40/CyO-GFP

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE24732

Other clones

FI23915

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028422

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE47190

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028422

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44483

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kamimura et al., 2019, Qin et al., 2005)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: KaiRIA CG18039

(Featherstone et al., 2005)

Source for identity of: GluRIID KaiRIA

(FlyBase, 2009-)

Source for database merge of

Source for merge of: KaiRIA CG18039

(Bayraktaroglu, 2000.8.7)

Source for merge of: KaiRIA brec

(Featherstone, 2004.10.16)

Additional comments

FlyBase curator comment: 'GluRIID' renamed 'KaiRIA' for the following reasons: i) The first published research papers to characterize this gene refer to it as 'GluRIID' (FBrf0184094, FBrf0184095). ii) 'GluRIID' is much prefered over 'KaiRIA' in the published literature. iii) 'KaiRIA' appears to stem from an EDRC abstract (FBrf0111008), and this is not a valid source upon which to name a gene in FlyBase. iv) 'GluRIID' matches the nomenclature of the GluR genes.

(FlyBase, 2009-)

Other Comments

Identification: In a screen for mutants with defective synaptic development.

(Featherstone et al., 2005)

KaiRIA is essential at the Drosophila neuromuscular junction and is the first glutamate receptor subunit known to function within the CNS.

(Featherstone et al., 2005)

Mutants are completely paralysed and die as embryos. Mutant neuromuscular junctions are devoid of glutamate receptors.

(Featherstone et al., 2001)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44483

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9TVI0

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028422

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

GluRIID_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18039

Flygut - An atlas of the Drosophila adult midgut

FBgn0028422

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44483

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG18039

modMine - A data warehouse for the modENCODE project

FBgn0028422

Linkouts

BioGRID - A database of protein and genetic interactions.

69079

DroID - A comprehensive database of gene and protein interactions.

FBgn0028422

DRSC - Results frm RNAi screens

FBgn0028422

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028422

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG18039-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028422

FlyMine - An integrated database for Drosophila genomics

FBgn0028422

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44483

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG18039

(Kondo et al., 2020, Meadows, 2017.1.11, Hallier et al., 2015, Hu et al., 2015, Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Perkins et al., 2009.1.15)

CT13538

(Littleton and Ganetzky, 2000)

DGluRIID

(Owald et al., 2010)

DKaiR-IA

(Volkner et al., 1999)

DmelGluRIID

(Croset et al., 2010)

GluR-IID

(Qin et al., 2005)

GluRIA

(Littleton and Ganetzky, 2000)

Kai-RIA

KaiRIA

(Japanese National Institute of Genetics, 2012.5.21, Tsubouchi et al., 2012, Christensen et al., 2008.4.15)

brec

(Rohrbough and Broadie, 2010, Featherstone, 2004.10.16, Featherstone, 2002.3.5, Featherstone et al., 2001)

gluRIID

(Peng et al., 2019, Kim et al., 2012)

kaiRIA

(Hallier et al., 2015)

Name Synonyms

Glutamate receptor IID

KaiRIA

bad reception

(Featherstone et al., 2001)

Secondary FlyBase IDs

FBgn0038817
FBgn0061176
FBgn0082321

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (75)

The following external sites may use different assemblies or annotations than FlyBase.

Report Sections