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Gene Dmel\Ercc1

General Information
Symbol	Dmel\Ercc1	Species	D. melanogaster
Name	Ercc1	Annotation symbol	CG10215
Feature type	protein_coding_gene	FlyBase ID	FBgn0028434
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51C5-51C5	Sequence location	2R:10,740,470..10,741,453 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ercc1 is referred to in FlyBase by the symbol Dmel\Ercc1 (CG10215, FBgn0028434). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: reciprocal meiotic recombination; nucleotide-excision repair. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA repair protein rad10; Restriction endonuclease, type II-like; RuvA domain 2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640079_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ercc1. Gene sequence location is 2R:10740470..10741453.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN21604 HFA07424
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51C5-51C5   Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51D1-51D2     (Yildiz et al., 2000) 51D-51D     (Sekelsky, 1999.4.29) 51D1-51D2     (Sekelsky, 1999.9.21)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ercc1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ercc1-RA FBtr0087448  NM_058120   926   259
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ercc1-PA   FBpp0086578   28.6   259   8.44     NP_477468   AAF58196
Additional Polypeptide Data & Comments
Reported size (kDa)	259 (aa) (Sekelsky et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA repair protein rad10 (IPR004579) RuvA domain 2-like (IPR010994) Restriction endonuclease, type II-like (IPR011335)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735926   AE013599 AAF58196   AC010578   AF146797 AAD38010   AW941973   AY060971 AAL28519   CO154918   EC265628
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95S37 Q7KMG7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028434    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028434 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028434 expression level Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1944) embryo 02-04hr  (949) embryo 04-06hr  (178) embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr  (142) embryo 12-14hr  (110) embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2  (139) larva L3 12hr old  (162) larva L3 puffstage 1-2  (280) larva L3 puffstage 3-6  (358) larva L3 puffstage 7-9  (481) white prepupae new  (421) white prepupae 12hr  (534) white prepupae 24hr  (576) pupae 2d postWPP  (322) pupae 3d postWPP  (126) pupae 4d postWPP  (118) adult male 01day  (167) adult male 05day  (207) adult male 30day  (215) adult female 01day  (472) adult female 05day  (992) adult female 30day  (1091) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1944) embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028434 expression level Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1944) embryo 02-04hr  (949) embryo 04-06hr  (178) embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr  142 embryo 12-14hr  110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2  139 larva L3 12hr old  (162) larva L3 puffstage 1-2  (280) larva L3 puffstage 3-6  (358) larva L3 puffstage 7-9  (481) white prepupae new  (421) white prepupae 12hr  (534) white prepupae 24hr  (576) pupae 2d postWPP  (322) pupae 3d postWPP  126 pupae 4d postWPP  118 adult male 01day  (167) adult male 05day  (207) adult male 30day  (215) adult female 01day  (472) adult female 05day  (992) adult female 30day  (1091) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1944 embryo 02-04hr    949 embryo 04-06hr    178 embryo 06-08hr    79 embryo 08-10hr    98 embryo 10-12hr    142 embryo 12-14hr    110 embryo 14-16hr    89 embryo 16-18hr    88 embryo 18-20hr    57 embryo 20-22hr    34 embryo 22-24hr    52 larva L1    84 larva L2    139 larva L3 12hr old    162 larva L3 puffstage 1-2    280 larva L3 puffstage 3-6    358 larva L3 puffstage 7-9    481 white prepupae new    421 white prepupae 12hr    534 white prepupae 24hr    576 pupae 2d postWPP    322 pupae 3d postWPP    126 pupae 4d postWPP    118 adult male 01day    167 adult male 05day    207 adult male 30day    215 adult female 01day    472 adult female 05day    992 adult female 30day    1091 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028434    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028434 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028434 expression level Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028434 expression level Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    57.275 Larval Midgut    9.6 Larval Hindgut    26.6 Larval Malpighian Tubules    26.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    50 Larval Carcass no informative data Adult Head    23.9 Adult Eye    14.5 Adult Brain    33.9 Adult Thoracic-Abdominal Ganglion    40 Adult Crop    35.9 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    21.15 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    84.2 Adult Testis    25.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    23.9   NA  Eye    14.5   NA  Brain    33.9   57.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    40   NA  Crop    35.9   9.6  Midgut    no informative data   26.6  Hindgut    no informative data   26.4  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    21.15   50  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    84.2   NA  Testis    25.1   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028434 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10215-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ercc1GD4103 Other Phenotypes Allele chemical sensitive Ercc1X radiation sensitive (with Df(2R)knSA3) Ercc1X radiation sensitive | larval stage Ercc1X Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ercc1 Class Mutagen Stocks Known lesion Ercc15-SZ-3694 0 -- Ercc1X I-CreI endonuclease 0 Yes Ercc1Xdup FLPase SCEI endonuclease recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ercc1 Class Mutagen Stocks Known lesion Ercc1GD4103 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ercc1KK101553 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ercc1X.Scer\SceI.RS in vitro construct 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)knSA3 (Sekelsky, 1999.9.21)
Not disrupted in	Df(2R)Jp1 (Sekelsky, 1999.9.21) Df(2R)XTE-18 (Sekelsky, 1999.9.21)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4103} NA P{KK101553} NA characterization construct P{(FRT.Ercc1X)} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}Ercc15-SZ-3694 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with mei-9 (Yildiz et al., 2002) protein heterodimerization activity inferred from physical interaction with mei-9 (Sekelsky et al., 2000)
Biological Process
CV term Evidence References
nucleotide-excision repair inferred from mutant phenotype (Radford et al., 2005) reciprocal meiotic recombination inferred from mutant phenotype (Radford et al., 2005)
Cellular Component
CV term Evidence References
protein complex inferred from direct assay (Radford et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
damaged DNA binding inferred from electronic annotation with InterPro:IPR004579 (FlyBase Curators et al., 2004-) single-stranded DNA specific endodeoxyribonuclease activity inferred from sequence or structural similarity with UniProtKB:P07903 (FlyBase, 1992-) contributes_to single-stranded DNA specific endodeoxyribonuclease activity inferred from sequence or structural similarity with Saccharomyces RAD1 (Sekelsky et al., 2000)
Biological Process
CV term Evidence References
nucleotide-excision repair, DNA incision, 5'-to lesion inferred from sequence or structural similarity with Saccharomyces RAD1 (Sekelsky et al., 2000)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR004579 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ercc1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62399 DroID - A comprehensive database of gene and protein interactions. • FBgn0028434 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36654
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12823 Dere\GG20484 Dgri\GH22789 Dmoj\GI20584 Dper\GL11250 Dpse\GA10163 Dsec\GM21575 Dsim\GD11080 Dvir\GJ20764 Dwil\GK22170 Dyak\GE13614
Curated drosophilid orthologs	Dpse\GA10163
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008081-PA Aedes aegypti (mosquito) AAEL013693-PA Aedes aegypti (mosquito) AGAP004029-PA Anopheles gambiae (mosquito) XP_623717.2 Apis mellifera (honey bee) XP_001944270.1 Acyrthosiphon pisum (pea aphid) At3g05210.1 Arabidopsis thaliana (wall cress) 90338 Batrachochytrium dendrobatidis (chytrid fungus) 82543 Branchiostoma floridae (lancelet) XP_001898669.1 Brugia malayi (roundworm nematode) BGIBMGA002482-PA Bombyx mori (silk worm) ENSBTAP00000023078 Bos taurus (bovine) CAL0001589 Candida albicans (a form of yeast) CN05265 Caenorhabditis brenneri (small nematode) CBP27899 Caenorhabditis briggsae (nematode) CE30750 Caenorhabditis elegans (worm) ENSCAFP00000006641 Canis familiaris (dog) CAGL0L00363g Candida glabrata (haploid yeast) Chro.60302 Cryptosporidium hominis (obligate parasite) JA06467 Caenorhabditis japonica (nematode) CMG079C Cyanidioschyzon merolae (red alga) cn06364 Cryptococcus neoformans (yeast-like fungus) cgd6_2610 Cryptosporidium parvum (protozoan parasite) CPIJ013903 Culex pipens (mosquito) ENSCPOP00000014074 Cavia porcellus (guinea pig) 102433 Chlamidomonas reinhardtii (green alga) RP32416 Caenorhabditis remanei (nematode) 166856 Capitella spl (polychaete worm) DEHA2D02134g Debaryomyces Hansenii (yeast) 61546 Daphnia pulex (daphnia) ENSDARP00000041750 Danio rerio (zebra fish) ENSECAP00000009371 Equus caballus (horse) XP_652464 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008337 Gymnopilus aculeatus (mushroom) 63358 Hypsipyla robusta (cedar shoot borer) ENSP00000013807 Homo sapiens (human) KLLA0D10307g Kluyveromyces lactis (yeast) 140017 Lottia gigantea (owl limpet) 2344 Monocosta brevicollis (choanoflagellate) ENSMODP00000026918 Monodelphis domestica (gray opossum) ENSMMUP00000000972 Macaca mulatta (rhesus monkey) ENSMUSP00000003645 Mus musculus (house mouse) 31564 Nematostella vectensis (starlet anemone) XP_001603974.1 Nasonia vitripennis (wasp) ENSOANP00000007190 Ornithorynchus anatinus (platypus) LOC_Os10g37490.1 Oryza sativa (asian rice) 5975 Ostreococcus tauri (green alga) PFB0160w Plasmodium falciparum (protozoal parasite) PHUM004616-PA Pediculus humanus (human body louse) 135142 Physcomitrella patens (moss) 14858 Physcomitrella patens (moss) ENSPPYP00000011319 Pongo pygmaeus (orangutan) 81660 Phytophthora ramorum (sudden oak death pathogen) 130469 Phytophthora sojae (root rot pathogen) 295106 Populus trichocarpa (black cottonwood) ENSPTRP00000019141 Pan troglodytes (chimpanzee) PVX_003600 Plasmodium vivax (protozoal parasite) ENSRNOP00000024113 Rattus norvegicus (norway rat) 4774847 Sorghum bicolor (sorghum) YML095C Saccharomyces cerevisiae (budding yeast) Smp_022470 Schistosoma mansoni (trematode parasite) SPBC4F6.15c Schizosaccharomyces pombe (fission yeast) XP_001181183.1 Strongylocentrotus purpuratus (purple sea urchin) 61989 Trichoplax adhaerens (metazoa) TA16745 Theileria annulata (apicomplexan parasite) XP_970360.2 Tribolium castaneum (red flour beetle) Tc00.1047053510165.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511807.64 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019553 Tetraodon nigroviridis (green spotted pufferfish) 34629 Thalassiosira pseudonana (marine diatom) ENSTRUP00000033451 Takifugu rubripes (pufferfish Takifugu) 83472.m00557 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000055209 Xenopus tropicalis (frog) YALI0D25762g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13367 NV15497 LH18988 ISCW022860 FBgn0231273 FBgn0224155 FBgn0207901 FBgn0182837 FBgn0176455 JGI_V11_61546 FBgn0070222 FBgn0148859 FBgn0143319 FBgn0130246 FBgn0112674 FBgn0089857 CPIJ013903 BGIBMGA002482 ACYPI004030 GB17552 AGAP004029 AAEL013693 AAEL008081 PHUM004550 GLEAN_11086
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v12622 w1118; P{GD4103}v12622 v12624 w1118; P{GD4103}v12624/CyO
Genomic Clones ( 1 )
	BACR03K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM10122
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	524253 EN05031
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028434 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36654
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Ercc1 mutants are hypersensitive to DNA damaging agents and show some reduction in the number of meiotic crossovers. (Radford et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058120 RefSeq (Proteins) • NP_477468 DDBJ / EMBL / GenBank • AA735926 AAD38010 AAF58196 AAL28519 AC010578 AF146797 AW941973 AY060971 Entrez Gene - A searchable database of RefSeq genes. • 36654 UniProtKB/TrEMBL • Q7KMG7 Q95S37
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA repair protein rad10 (IPR004579) RuvA domain 2-like (IPR010994) Restriction endonuclease, type II-like (IPR011335)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62399 DroID - A comprehensive database of gene and protein interactions. • FBgn0028434 DRSC - Results from RNAi screens. • FBgn0028434 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028434 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10215-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028434 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36654 InParanoid A subset of ortholog calls from InParanoid. • AAEL008081-PA Aedes aegypti (mosquito) AAEL013693-PA Aedes aegypti (mosquito) AGAP004029-PA Anopheles gambiae (mosquito) XP_623717.2 Apis mellifera (honey bee) XP_001944270.1 Acyrthosiphon pisum (pea aphid) At3g05210.1 Arabidopsis thaliana (wall cress) 90338 Batrachochytrium dendrobatidis (chytrid fungus) 82543 Branchiostoma floridae (lancelet) XP_001898669.1 Brugia malayi (roundworm nematode) BGIBMGA002482-PA Bombyx mori (silk worm) ENSBTAP00000023078 Bos taurus (bovine) CAL0001589 Candida albicans (a form of yeast) CN05265 Caenorhabditis brenneri (small nematode) CBP27899 Caenorhabditis briggsae (nematode) CE30750 Caenorhabditis elegans (worm) ENSCAFP00000006641 Canis familiaris (dog) CAGL0L00363g Candida glabrata (haploid yeast) Chro.60302 Cryptosporidium hominis (obligate parasite) JA06467 Caenorhabditis japonica (nematode) CMG079C Cyanidioschyzon merolae (red alga) cn06364 Cryptococcus neoformans (yeast-like fungus) cgd6_2610 Cryptosporidium parvum (protozoan parasite) CPIJ013903 Culex pipens (mosquito) ENSCPOP00000014074 Cavia porcellus (guinea pig) 102433 Chlamidomonas reinhardtii (green alga) RP32416 Caenorhabditis remanei (nematode) 166856 Capitella spl (polychaete worm) DEHA2D02134g Debaryomyces Hansenii (yeast) 61546 Daphnia pulex (daphnia) ENSDARP00000041750 Danio rerio (zebra fish) ENSECAP00000009371 Equus caballus (horse) XP_652464 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008337 Gymnopilus aculeatus (mushroom) 63358 Hypsipyla robusta (cedar shoot borer) ENSP00000013807 Homo sapiens (human) KLLA0D10307g Kluyveromyces lactis (yeast) 140017 Lottia gigantea (owl limpet) 2344 Monocosta brevicollis (choanoflagellate) ENSMODP00000026918 Monodelphis domestica (gray opossum) ENSMMUP00000000972 Macaca mulatta (rhesus monkey) ENSMUSP00000003645 Mus musculus (house mouse) 31564 Nematostella vectensis (starlet anemone) XP_001603974.1 Nasonia vitripennis (wasp) ENSOANP00000007190 Ornithorynchus anatinus (platypus) LOC_Os10g37490.1 Oryza sativa (asian rice) 5975 Ostreococcus tauri (green alga) PFB0160w Plasmodium falciparum (protozoal parasite) PHUM004616-PA Pediculus humanus (human body louse) 135142 Physcomitrella patens (moss) 14858 Physcomitrella patens (moss) ENSPPYP00000011319 Pongo pygmaeus (orangutan) 81660 Phytophthora ramorum (sudden oak death pathogen) 130469 Phytophthora sojae (root rot pathogen) 295106 Populus trichocarpa (black cottonwood) ENSPTRP00000019141 Pan troglodytes (chimpanzee) PVX_003600 Plasmodium vivax (protozoal parasite) ENSRNOP00000024113 Rattus norvegicus (norway rat) 4774847 Sorghum bicolor (sorghum) YML095C Saccharomyces cerevisiae (budding yeast) Smp_022470 Schistosoma mansoni (trematode parasite) SPBC4F6.15c Schizosaccharomyces pombe (fission yeast) XP_001181183.1 Strongylocentrotus purpuratus (purple sea urchin) 61989 Trichoplax adhaerens (metazoa) TA16745 Theileria annulata (apicomplexan parasite) XP_970360.2 Tribolium castaneum (red flour beetle) Tc00.1047053510165.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511807.64 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019553 Tetraodon nigroviridis (green spotted pufferfish) 34629 Thalassiosira pseudonana (marine diatom) ENSTRUP00000033451 Takifugu rubripes (pufferfish Takifugu) 83472.m00557 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000055209 Xenopus tropicalis (frog) YALI0D25762g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36654 modMine - Data generated by the modENCODE project. • FBgn0028434 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13367 NV15497 LH18988 ISCW022860 FBgn0231273 FBgn0224155 FBgn0207901 FBgn0182837 FBgn0176455 JGI_V11_61546 FBgn0070222 FBgn0148859 FBgn0143319 FBgn0130246 FBgn0112674 FBgn0089857 CPIJ013903 BGIBMGA002482 ACYPI004030 GB17552 AGAP004029 AAEL013693 AAEL008081 PHUM004550 GLEAN_11086
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG10215 (Gandhi et al., 2007, Keleman et al., 2009.8.5) ERCC1 (Yildiz et al., 2004, Giot et al., 2003, Yildiz et al., 2000) Ercc1 (Radford et al., 2005, Sekelsky et al., 2000, Joyce et al., 2009, Telonis-Scott et al., 2009)
Name Synonym	Ercc1
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...