FlyBase Gene Report: Dmel\Non1

General Information

Symbol

Dmel\Non1

Species

D. melanogaster

Name

Novel nucleolar protein 1

Annotation Symbol

CG8801

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028473

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Required for normal assembly of the mitotic spindle (PubMed:24255106). May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs (PubMed:24255106). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539, PubMed:35413237). (UniProt, Q9V411)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

BcDNA:LD23830

Key Links

Genomic Location

Cytogenetic map

45D2-45D3

Sequence location

2R:9,396,265..9,398,734 [-]

Recombination map

2-60

RefSeq locus

NT_033778 REGION:9396265..9398734

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

enzyme

regulator

receptor

receptor binding

transporter

structural molecule

cytoskeletal binding

DNA binding

RNA binding

transcription factor

small molecule binding

metal ion binding

lipid binding

carbohydrate binding

other molecular_function

molecular function

cell cycle/proliferation

cell organization/biogenesis

transport/localization

development

reproduction

immune system

nervous system process

behavior

response to stimulus

signaling

gene expression

protein metabolism

DNA metabolism

small molecule metabolism

other biological_process

biological process

extracellular region

cytosol

cytoskeleton

mitochondrion

nucleus

chromosome

membrane

cell periphery

cell junction

cell projection

endomembrane system

synapse

macromolecular complex

other cellular_component

cellular component

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR005225, InterPro:IPR006073, InterPro:IPR010674, InterPro:IPR031167

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from sequence or structural similarity with UniProtKB:Q9BZE4

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000193648

(GO Reference Genome Project, 2011-)

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000193648

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in ribosomal large subunit biogenesis

inferred from biological aspect of ancestor with PANTHER:PTN000193648

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:Q02892

(Gene Ontology Curators, 2002-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in nucleolus

inferred from direct assay

(Moutinho-Pereira et al., 2013)

located_in nucleus

inferred from high throughput direct assay

(Sarov et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleolus

inferred from biological aspect of ancestor with PANTHER:PTN000193649

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED GTPASES

Protein Family (UniProt)

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (Q9V411)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Model and Products

Expression Data

Gene ToolKit

The gene 'ToolKit' contains a set of key genetic reagents that can be used to study a gene. A single reagent for each category is chosen based on frequency of usage, and stock availability. Click "See all" to view all the reagents for the category.

Category	Common alleles (# stocks)
Classical and Insertion Alleles
Loss of function allele
Amorphic allele
Fluorescently-tagged allele
Transgenic Constructs
UAS RNAi
UAS wild-type cDNA
Untagged genomic rescue
Fluorescently-tagged genomic rescue
Aberrations
Deficiency
Duplication

Alleles, Insertions, Transgenic Constructs, and Aberrations

Variants

Phenotypes

Orthologs

Paralogs

Human Disease Associations

Functional Complementation Data

Interactions

Pathways

Class of Gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-60

Cytogenetic map

45D2-45D3

Sequence location

2R:9,396,265..9,398,734 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

45D2-45D3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-60

(FlyBase, 2016)

2-58.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Other Comments

Relationship to Other Genes

Nomenclature History

Synonyms and Secondary IDs (6)

Datasets (0)

External Crossreferences and Linkouts ( 43 )

References (45)

The following external sites may use different assemblies or annotations than FlyBase.

GO Summary Ribbons

Expression Summary Ribbons

-0.77

Gene ToolKit

Disease Model Summary Ribbon

Report Sections