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Gene Dmel\CG4119

General Information
Symbol	Dmel\CG4119	Species	D. melanogaster
Name		Annotation symbol	CG4119
Feature type	protein_coding_gene	FlyBase ID	FBgn0028474
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	5A10-5A11	Sequence location	X:5,560,127..5,564,586 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4119 (FBgn0028474). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: regulation of alternative nuclear mRNA splicing, via spliceosome. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain; Splicing factor PWI. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1632051_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4119. Gene sequence location is X:5560127..5564586.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	Sequence features HFA17741 BKN22490
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5A10-5A11   Limits computationally determined from genome sequence between P{EP}CG3249EP1400 and P{EP}Tre1EP496
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4119 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4119-RA FBtr0070799  NM_132014   3716   998
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4119-PA   FBpp0070765   112.7   998   6.40     NP_572242   AAF46056
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Splicing factor PWI (IPR002483) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201894   AA202166   AA433207   AA440385   AA441505   AA536488   AA538946   AA539290   AA541019   AA816485   AA820162   AA941298   AA942579   AA949133   AA949186   AA949540   AA951174   AA978860   AE014298 AAF46056   AF181653 AAD55438   AI109149   AI405695   AI455349   AI456932   AI512959   AI514977   AI518179   AI518525   AI530779   AI531230   AI534321   AI541619   AI543021   AI543340   AI544227   AI546138   BE975972   BE976046   BE978411   BG638843   BI173468   BI236544   BI238595   BI243334   BI356053   BI636272   BI636595   BI637391   CO262394   CO273840   CO291323   CO292161   CO339782   CO343832   DN154025   EC051565   EC055080   EC056391   EC059011   EC059012   EC061948   EC063595   EC068819   EC078768   EC199663   EC209419   EC251514   EC254985   EV577995   GH747972   GH756021   GH756024   GH770442   GH772973   GH794514   GH794818   GH804794   GH809079   GH810400   GH811232   GH812211   GH815311   GH819704   GH824682   GH825409   GH833366   GH834488   GH837865   GH842925   GH851635   GH861432   GH867063   GH871279   GH871465   GH872426   GH875221   GH881819   GH881827   GH882496   GH884046   GH887926   GH888479   GH891010   GH891423   GH895005   GH907182   GH908502   GH910391   GH919094   GH919483   GH921710   GH927564   GH929865   GH930104   GH936512   GH938305   GH940050
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3Y5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028474    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028474 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028474 expression level Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4769) embryo 02-04hr  (5365) embryo 04-06hr  (3874) embryo 06-08hr  (4322) embryo 08-10hr  (3865) embryo 10-12hr  (3174) embryo 12-14hr  (2215) embryo 14-16hr  (2426) embryo 16-18hr  (1864) embryo 18-20hr  (1335) embryo 20-22hr  (2725) embryo 22-24hr  (2048) larva L1  (1391) larva L2  (987) larva L3 12hr old  (841) larva L3 puffstage 1-2  (768) larva L3 puffstage 3-6  (1155) larva L3 puffstage 7-9  (1106) white prepupae new  (1198) white prepupae 12hr  (1516) white prepupae 24hr  (1816) pupae 2d postWPP  (1102) pupae 3d postWPP  (742) pupae 4d postWPP  (532) adult male 01day  (631) adult male 05day  (732) adult male 30day  (640) adult female 01day  (1588) adult female 05day  (2566) adult female 30day  (2575) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4769) embryo 02-04hr  (5365) embryo 04-06hr  (3874) embryo 06-08hr  (4322) embryo 08-10hr  (3865) embryo 10-12hr  (3174) embryo 12-14hr  (2215) embryo 14-16hr  (2426) embryo 16-18hr  (1864) embryo 18-20hr    1335 embryo 20-22hr  (2725) embryo 22-24hr  (2048) larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr  (1516) white prepupae 24hr  (1816) pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day  (1588) adult female 05day  (2566) adult female 30day  (2575) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028474 expression level Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4769) embryo 02-04hr  (5365) embryo 04-06hr  (3874) embryo 06-08hr  (4322) embryo 08-10hr  (3865) embryo 10-12hr  (3174) embryo 12-14hr  (2215) embryo 14-16hr  (2426) embryo 16-18hr  (1864) embryo 18-20hr  (1335) embryo 20-22hr  (2725) embryo 22-24hr  (2048) larva L1  (1391) larva L2  (987) larva L3 12hr old  (841) larva L3 puffstage 1-2  (768) larva L3 puffstage 3-6  (1155) larva L3 puffstage 7-9  (1106) white prepupae new  (1198) white prepupae 12hr  (1516) white prepupae 24hr  (1816) pupae 2d postWPP  (1102) pupae 3d postWPP  (742) pupae 4d postWPP  (532) adult male 01day  (631) adult male 05day  (732) adult male 30day  (640) adult female 01day  (1588) adult female 05day  (2566) adult female 30day  (2575) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4769) embryo 02-04hr  (5365) embryo 04-06hr  (3874) embryo 06-08hr  (4322) embryo 08-10hr  (3865) embryo 10-12hr  (3174) embryo 12-14hr  2215 embryo 14-16hr  2426 embryo 16-18hr  1864 embryo 18-20hr    1335 embryo 20-22hr  (2725) embryo 22-24hr  2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr  1516 white prepupae 24hr  1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day  1588 adult female 05day  (2566) adult female 30day  (2575) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4769 embryo 02-04hr    5365 embryo 04-06hr    3874 embryo 06-08hr    4322 embryo 08-10hr    3865 embryo 10-12hr    3174 embryo 12-14hr    2215 embryo 14-16hr    2426 embryo 16-18hr    1864 embryo 18-20hr    1335 embryo 20-22hr    2725 embryo 22-24hr    2048 larva L1    1391 larva L2    987 larva L3 12hr old    841 larva L3 puffstage 1-2    768 larva L3 puffstage 3-6    1155 larva L3 puffstage 7-9    1106 white prepupae new    1198 white prepupae 12hr    1516 white prepupae 24hr    1816 pupae 2d postWPP    1102 pupae 3d postWPP    742 pupae 4d postWPP    532 adult male 01day    631 adult male 05day    732 adult male 30day    640 adult female 01day    1588 adult female 05day    2566 adult female 30day    2575 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028474    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028474 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028474 expression level Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028474 expression level Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    228.65 Larval Midgut    53.5 Larval Hindgut    99.2 Larval Malpighian Tubules    78.3 Larval Fat Body    58.5 Larval Salivary Gland    175 Larval Trachea    130.675 Larval Carcass    98.175 Adult Head    59.4 Adult Eye    88.15 Adult Brain    126.5 Adult Thoracic-Abdominal Ganglion    109.6 Adult Crop    100.5 Adult Midgut    61.6 Adult Hindgut    77.9 Adult Malpighian Tubules    108.8 Adult Fat Body    48.9 Adult Salivary Gland    114 Adult Heart    57.825 Adult VirginFemale Spermatheca    70.5 Adult InseminatedFemale Spermatheca    85.5 Adult Ovary    239.5 Adult Testis    37.7 Adult Male Accessory Gland    113.4 Adult Carcass    55 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    59.4   NA  Eye    88.15   NA  Brain    126.5   228.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    109.6   NA  Crop    100.5   53.5  Midgut    61.6   99.2  Hindgut    77.9   78.3  Malpighian Tubules    108.8   58.5  Fat Body    48.9   175  Salivary Gland    114   NA  Heart    57.825   130.675  Trachea    NA   NA  VirginFemale Spermatheca    70.5   NA  InseminatedFemale Spermatheca    85.5   NA  Ovary    239.5   NA  Testis    37.7   NA  Male Accessory Gland    113.4   98.175  Carcass    55 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028474 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4119-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG4119GD11222 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG4119 Class Mutagen Stocks Known lesion CG4119GS7456 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4119 Class Mutagen Stocks Known lesion CG4119GD11222 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG4119KK102409 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11222} NA P{KK102409} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{GSV2}CG4119GS7456 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of alternative nuclear mRNA splicing, via spliceosome inferred from mutant phenotype (Park et al., 2004)
Cellular Component
CV term Evidence References
precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011 (Herold et al., 2009)
Cellular Component
CV term Evidence References
nucleus inferred by curator from GO:0000381 (Park et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4119 allele Gene References unspecified Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57987 DroID - A comprehensive database of gene and protein interactions. • FBgn0028474 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31481
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21364 Dere\GG18771 Dgri\GH12667 Dmoj\GI16247 Dper\GL18235 Dpse\GA27913 Dsec\GM12423 Dsim\GD16738 Dvir\GJ16712 Dwil\GK19968 Dyak\GE16414
Curated drosophilid orthologs	Dpse\GA17971
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004886-PA Aedes aegypti (mosquito) AGAP004546-PA Anopheles gambiae (mosquito) XP_001947291.1 Acyrthosiphon pisum (pea aphid) At1g60200.1 Arabidopsis thaliana (wall cress) 125811 Branchiostoma floridae (lancelet) BGIBMGA009625-PA Bombyx mori (silk worm) ENSBTAP00000022826 Bos taurus (bovine) CN26812 Caenorhabditis brenneri (small nematode) CBP24483 Caenorhabditis briggsae (nematode) ENSCAFP00000024725 Canis familiaris (dog) Chro.60500 Cryptosporidium hominis (obligate parasite) ENSCINP00000016201 Ciona intestinalis (sea squirt) cn03677 Cryptococcus neoformans (yeast-like fungus) cgd6_4370 Cryptosporidium parvum (protozoan parasite) CPIJ008698 Culex pipens (mosquito) ENSCPOP00000002258 Cavia porcellus (guinea pig) ENSCSAVP00000017160 Ciona savignyi (sedentary tunicate) DDB0252841 Dictyostelium discoideum (amoeba) 306802 Daphnia pulex (daphnia) ENSDARP00000006694 Danio rerio (zebra fish) ENSECAP00000011446 Equus caballus (horse) ENSGACP00000017895 Gymnopilus aculeatus (mushroom) ENSGALP00000015182 Gallus gallus (chicken) 114533 Hypsipyla robusta (cedar shoot borer) ENSP00000261973 Homo sapiens (human) ISCW020279-PA Ixodes scapularis (deer tick) 217154 Lottia gigantea (owl limpet) ENSMODP00000010437 Monodelphis domestica (gray opossum) ENSMMUP00000003122 Macaca mulatta (rhesus monkey) ENSMUSP00000010752 Mus musculus (house mouse) XP_001605486.1 Nasonia vitripennis (wasp) ENSOANP00000001682 Ornithorynchus anatinus (platypus) ENSORLP00000014878 Oryzias latipes (japanese killifish) LOC_Os08g32100.1 Oryza sativa (asian rice) 36755 Ostreococcus tauri (green alga) PFF0505c Plasmodium falciparum (protozoal parasite) PHUM006526-PA Pediculus humanus (human body louse) PP00586 Pristionchus pacificus (nematode) 822012 Populus trichocarpa (black cottonwood) ENSPTRP00000011043 Pan troglodytes (chimpanzee) PVX_113660 Plasmodium vivax (protozoal parasite) ENSRNOP00000003834 Rattus norvegicus (norway rat) 5007811 Sorghum bicolor (sorghum) Smp_078610 Schistosoma mansoni (trematode parasite) 61221 Trichoplax adhaerens (metazoa) XP_969690.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015188 Tetraodon nigroviridis (green spotted pufferfish) TP04_0318 Theileria parva (parasitic protozoan) ENSTRUP00000007182 Takifugu rubripes (pufferfish Takifugu) 1.m01053 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047298 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17392 NV11168 LH25169 ISCW020279 FBgn0233941 FBgn0221965 FBgn0203893 FBgn0188326 FBgn0167360 JGI_V11_306802 FBgn0249277 FBgn0155837 FBgn0138996 FBgn0120146 FBgn0110979 FBgn0098366 CPIJ008698 BGIBMGA009625 ACYPI004008 GB18610 AGAP004546 AAEL004886 PHUM077870 GLEAN_03127
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Kyoto	201267 y1 w67c23 P{GSV2}CG4119GS7456/Binsinscy
VDRC	v106696 P{KK102409}VIE-260B v26395 w1118; P{GD11222}v26395
Genomic Clones ( 2 )
	BACR27C07 BACR27J18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 111 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23634
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH08260 GH25806 LD01912 LD02281 LD04045 LD14968 LD16465 LD17119 LD18625 LD18974 LD20791 LD25362 LD26888 LD27913 LD27987 LD28375 LD31507 LD33035 LD37104 LD38065 LD45133 LD46229 LD46627 LD47688 RE16381 RE32615 RE35091 RE40940 RE42082 SD01382 SD02175 SD05633 SD07117 SD09587 SD10065 SD17904 SD18332 SD19391
Other clones	11914 42126 46244 71430 183519 214279.57 214469.3 bs46c05 bs46f08 bs78d09 CK01.22A.E11 CK01.101A.A2 Dmel_dig_005826_0670_2453 EC051565 EC055080 EC056391 EK077633 EK085233 EK112426 EK155214 EK199341 EP09411 EP18201 LD37621 RP003005270 RP003014101 RP003069601 RP003077976 RP003091807 RP003092516 RP003122404 RP003123262 RP003147173 RP003152302 RP003169654 RP003169936 RP003222642 RP003228560 RP003229554 RP003234186 RP003234209 RP003265134 RP003278681 RP003279249 RP003282878 RP003283470 RP003284934 RP003289453 RP003295834 RP003311017 RP003329555 RP003410412 RP003421712 RP003436891 RP003437964 RP003444586 RP003446070 RP003449822 RP003452784 RP003477957 RP003482948 RP003540171 RP003540703 RP003542626 RP003550364 RP003556201 RP003577214 RP003578691 RP003583968 RP003587348 RP003629354 RP003640511
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028474 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31481
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	"l(1)G0384" may affect "CG4119". (Peter et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132014 RefSeq (Proteins) • NP_572242 DDBJ / EMBL / GenBank • AA820162 AAD55438 AAF46056 AF181653 AI455349 Entrez Gene - A searchable database of RefSeq genes. • 31481 UniProtKB/TrEMBL • Q9V3Y5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Splicing factor PWI (IPR002483) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57987 DroID - A comprehensive database of gene and protein interactions. • FBgn0028474 DRSC - Results from RNAi screens. • FBgn0028474 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028474 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4119-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028474 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31481 InParanoid A subset of ortholog calls from InParanoid. • AAEL004886-PA Aedes aegypti (mosquito) AGAP004546-PA Anopheles gambiae (mosquito) XP_001947291.1 Acyrthosiphon pisum (pea aphid) At1g60200.1 Arabidopsis thaliana (wall cress) 125811 Branchiostoma floridae (lancelet) BGIBMGA009625-PA Bombyx mori (silk worm) ENSBTAP00000022826 Bos taurus (bovine) CN26812 Caenorhabditis brenneri (small nematode) CBP24483 Caenorhabditis briggsae (nematode) ENSCAFP00000024725 Canis familiaris (dog) Chro.60500 Cryptosporidium hominis (obligate parasite) ENSCINP00000016201 Ciona intestinalis (sea squirt) cn03677 Cryptococcus neoformans (yeast-like fungus) cgd6_4370 Cryptosporidium parvum (protozoan parasite) CPIJ008698 Culex pipens (mosquito) ENSCPOP00000002258 Cavia porcellus (guinea pig) ENSCSAVP00000017160 Ciona savignyi (sedentary tunicate) DDB0252841 Dictyostelium discoideum (amoeba) 306802 Daphnia pulex (daphnia) ENSDARP00000006694 Danio rerio (zebra fish) ENSECAP00000011446 Equus caballus (horse) ENSGACP00000017895 Gymnopilus aculeatus (mushroom) ENSGALP00000015182 Gallus gallus (chicken) 114533 Hypsipyla robusta (cedar shoot borer) ENSP00000261973 Homo sapiens (human) ISCW020279-PA Ixodes scapularis (deer tick) 217154 Lottia gigantea (owl limpet) ENSMODP00000010437 Monodelphis domestica (gray opossum) ENSMMUP00000003122 Macaca mulatta (rhesus monkey) ENSMUSP00000010752 Mus musculus (house mouse) XP_001605486.1 Nasonia vitripennis (wasp) ENSOANP00000001682 Ornithorynchus anatinus (platypus) ENSORLP00000014878 Oryzias latipes (japanese killifish) LOC_Os08g32100.1 Oryza sativa (asian rice) 36755 Ostreococcus tauri (green alga) PFF0505c Plasmodium falciparum (protozoal parasite) PHUM006526-PA Pediculus humanus (human body louse) PP00586 Pristionchus pacificus (nematode) 822012 Populus trichocarpa (black cottonwood) ENSPTRP00000011043 Pan troglodytes (chimpanzee) PVX_113660 Plasmodium vivax (protozoal parasite) ENSRNOP00000003834 Rattus norvegicus (norway rat) 5007811 Sorghum bicolor (sorghum) Smp_078610 Schistosoma mansoni (trematode parasite) 61221 Trichoplax adhaerens (metazoa) XP_969690.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015188 Tetraodon nigroviridis (green spotted pufferfish) TP04_0318 Theileria parva (parasitic protozoan) ENSTRUP00000007182 Takifugu rubripes (pufferfish Takifugu) 1.m01053 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000047298 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31481 modMine - Data generated by the modENCODE project. • FBgn0028474 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17392 NV11168 LH25169 ISCW020279 FBgn0233941 FBgn0221965 FBgn0203893 FBgn0188326 FBgn0167360 JGI_V11_306802 FBgn0249277 FBgn0155837 FBgn0138996 FBgn0120146 FBgn0110979 FBgn0098366 CPIJ008698 BGIBMGA009625 ACYPI004008 GB18610 AGAP004546 AAEL004886 PHUM077870 GLEAN_03127
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:LD23634 (Peter et al., 2002, ) cg4119 (Lasko, 2000) CG4119 (Laviolette et al., 2005, Ramos et al., 2006, Keleman et al., 2009.8.5, Herold et al., 2009, Wasbrough et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 18 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Ramos et al., 2006, Genetics 172(4): 2337--2349 Genomic organization of gypsy chromatin insulators in Drosophila melanogaster. [FBrf0190762] Laviolette et al., 2005, Genetics 170(2): 779--792 A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. [FBrf0187645] Foley and O'Farrell, 2004, PLoS Biol. 2(8): 1091--1106 Functional dissection of an innate immune response by a genome-wide RNAi screen. [FBrf0179207] Park et al., 2004, Proc. Natl. Acad. Sci. USA 101(45): 15974--15979 Identification of alternative splicing regulators by RNA interference in Drosophila. [FBrf0180650] Lasko, 2000, J. Cell Biol. 150(2): F51--F56 The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Peter et al., 2002, EMBO Rpts 3(1): Supplementary material. PX-lines.txt. [FBrf0173176]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]