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Gene Dmel\CG15817

General Information
Symbol	Dmel\CG15817	Species	D. melanogaster
Name		Annotation symbol	CG15817
Feature type	protein_coding_gene	FlyBase ID	FBgn0028476
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	99A1-99A1	Sequence location	3R:25,054,883..25,061,024 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG15817 (FBgn0028476). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin thiolesterase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: ubiquitin-dependent protein catabolic process. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2; Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1633233_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG15817. Gene sequence location is 3R:25054883..25061024.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99A1-99A1   Limits computationally determined from genome sequence between P{PZ}l(3)0470804708 and P{PZ}l(3)0674306743
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG15817 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG15817-RC FBtr0300832  NM_170403   4704   1078 CG15817-RD FBtr0300833  NM_143430   4864   1078 CG15817-RE FBtr0333818  NM_001276132   4844   1078
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG15817-PC   FBpp0290056   116.4   1078   7.23     NP_733282   AAN14167 CG15817-PD   FBpp0290057   116.4   1078   7.23     NP_651687   AAF56881 CG15817-PE   FBpp0305952   116.4   1078   7.23     NP_001263061   AGB96441
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263751   AA264394   AA390410   AA817321   AA817324   AA817453   AA978700   AA990761   AE014297 AAF56881   AE014297 AAN14167   AF181650 AAD55436   AE014297 AGB96441   AI108629   AI455307   AI518257   AI946070   BF499898   BF504248   BG632403   BI161763   BT001496 AAN71251   CK661909   CO265101   CO276737   CO277464   CO283876   CO293177   CO296066   CO310693   CO314705   CO341225   CO341510   CZ470165   CZ470180   DN154167   EC064053   EC072772   EC075206   EC202108   EC213035   EC220535   EC220631   EC246635   EC252196   EC259349   GH944000   GH950756   GH957192   GH958885
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8I077
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    259.475 Larval Midgut    168.2 Larval Hindgut    148.8 Larval Malpighian Tubules    52.4 Larval Fat Body    125 Larval Salivary Gland    152.8 Larval Trachea    132.925 Larval Carcass    155.55 Adult Head    156.4 Adult Eye    136.225 Adult Brain    337.8 Adult Thoracic-Abdominal Ganglion    298.5 Adult Crop    230.5 Adult Midgut    285.4 Adult Hindgut    139.3 Adult Malpighian Tubules    146.8 Adult Fat Body    126.7 Adult Salivary Gland    135 Adult Heart    86.675 Adult VirginFemale Spermatheca    194.2 Adult InseminatedFemale Spermatheca    151.4 Adult Ovary    394.2 Adult Testis    27.6 Adult Male Accessory Gland    92 Adult Carcass    87.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    156.4   NA  Eye    136.225   NA  Brain    337.8   259.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    298.5   NA  Crop    230.5   168.2  Midgut    285.4   148.8  Hindgut    139.3   52.4  Malpighian Tubules    146.8   125  Fat Body    126.7   152.8  Salivary Gland    135   NA  Heart    86.675   132.925  Trachea    NA   NA  VirginFemale Spermatheca    194.2   NA  InseminatedFemale Spermatheca    151.4   NA  Ovary    394.2   NA  Testis    27.6   NA  Male Accessory Gland    92   155.55  Carcass    87.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (45) testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (55) ovary, mated 4-day female  (45) testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    16 central nervous system, pupae P8    12 head, virgin 1-day female    9 head, virgin 4-day female    10 head, virgin 20-day female    9 head, mated 1-day female    8 head, mated 4-day female    12 head, mated 20-day female    7 head, mated 1-day male    14 head, mated 4-day male    16 head, mated 20-day male    17 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    16 digestive system, 4-day adult    18 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    7 fat body, pupae P8    8 carcass, larvae L3 wandering    10 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    55 ovary, mated 4-day female    45 testis, mated 4-day male    19 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (41) embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr  (29) embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr  (34) embryo 22-24hr  (28) larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day  (35) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (58) embryo 02-04hr  (41) embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr  29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr  (34) embryo 22-24hr  28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day  (35) adult female 30day  (35) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    58 embryo 02-04hr    41 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    29 embryo 10-12hr    19 embryo 12-14hr    19 embryo 14-16hr    25 embryo 16-18hr    20 embryo 18-20hr    12 embryo 20-22hr    34 embryo 22-24hr    28 larva L1    10 larva L2    8 larva L3 12hr old    6 larva L3 puffstage 1-2    5 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    10 white prepupae new    11 white prepupae 12hr    16 white prepupae 24hr    16 pupae 2d postWPP    14 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    11 adult male 05day    15 adult male 30day    16 adult female 01day    23 adult female 05day    35 adult female 30day    35 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    11 embryonic 1182-4H    11 embryonic GM2    10 embryonic Kc167    13 embryonic S1    17 embryonic S3    9 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    10 wing disc ML-DmD9    10 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    12 wing disc ML-DmD32    9 haltere disc ML-DmD17-c3    15 eye-antennal disc ML-DmD11    11 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    10 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    14 ovary fGS/OSS    15 ovary OSC    14 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  (36) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    9 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    25 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    36 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • LD22910 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15817-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG15817c05664 viable, with Scer\GAL4pnr-MD237 CG15817GD9128 Sterility Allele fertile CG15817c05664 Other Phenotypes Allele locomotor behavior defective | adult stage, with Scer\GAL4elav.PU CG15817KK106492 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG15817 Class Mutagen Stocks Known lesion CG15817c05664 piggyBac transposase 2 -- CG15817c05678 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG15817 Class Mutagen Stocks Known lesion CG15817GD9128 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG15817JF02992 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG15817KK106492 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6212 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9128} NA P{KK106492} NA P{TRiP.JF02992} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG15817c05664 NA PBac{PB}CG15817c05678 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
ubiquitin thiolesterase activity inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG15817 - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG15817 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0028476 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43462
Orthologs
OrthoDB Orthologs (4) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VQB8W Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6VQB8W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG15817     Drosophila sechellia   Dsec\GM12779 Y   Drosophila erecta   Dere\GG11658 Y   Drosophila yakuba   Dyak\GE23847 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21429 Drosophila sechellia Dsec\GM12779 Drosophila erecta Dere\GG11658 Drosophila yakuba Dyak\GE23847 Drosophila ananassae Dana\GF16609 Drosophila pseudoobscura pseudoobscura Dpse\GA13968 Drosophila persimilis Dper\GL13883 Drosophila willistoni Dwil\GK22674 Drosophila virilis Dvir\GJ14517 Drosophila mojavensis Dmoj\GI10403 Drosophila grimshawi Dgri\GH14306
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	28356 y1 v1; P{TRiP.JF02992}attP2 17719 w1118; PBac{PB}CG15817c05664
Harvard	- PBac{PB}CG15817c05664 - PBac{PB}CG15817c05678
VDRC	v100992 P{KK106492}VIE-260B v41605 w1118; P{GD9128}v41605 v41604 w1118; P{GD9128}v41604/CyO
Genomic Clones ( 1 )
	BACR22E21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22910 LD32685
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05567 AT14676 LD07002 LD08189 LD09302 LD22561 LD22564 LD34621 LD37724 LP21711 RE01175
Other clones	800 5940 31577 64707 73258 77480 80230 99669 214317.13 214475.13 bs20e06 EK121938 EK124815 EK141535 EK164715 EK192948 EK202013 EK212619 EK222311 EK237506 EP12056 EP12562 GH07834 RP004020359 RP004063786 RP004168431 RP004246925
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43462
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143430 NM_170403 NM_001276132 RefSeq (Proteins) • NP_651687 NP_733282 NP_001263061 DDBJ / EMBL / GenBank • AA817453 AA978700 AAD55436 AAF56881 AAN14167 AAN71251 AF181650 AGB96441 AI455307 BT001496 CZ470165 CZ470180 Entrez Gene - A searchable database of RefSeq genes. • 43462 UniProtKB/TrEMBL • Q8I077
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394) Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22910
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0028476 DRSC - Results from RNAi screens. • FBgn0028476 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028476 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15817-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028476 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43462 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43462 modMine - Data generated by the modENCODE project. • FBgn0028476
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:LD22910   CG15817 (Zhang et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Zhang et al., 2008, Tsou et al., 2012) LD22910 (Chen and Fischer, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 11 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Tsou et al., 2012, PLoS ONE 7(8): e43112 Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes. [FBrf0219256] Show all research papers ...