FlyBase Gene Report: Dmel\Mtpα

General Information

Symbol

Dmel\Mtpα

Species

D. melanogaster

Name

Mitochondrial trifunctional protein α subunit

Annotation Symbol

CG4389

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028479

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Snapshot

Mitochondrial trifunctional protein α subunit (Mtpα) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the β-oxidation of long-chain fatty acids. [Date last reviewed: 2019-09-12]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

BcDNA:GH12558

Key Links

Genomic Location

Cytogenetic map

30B12-30B12

Sequence location

2L:9,573,563..9,576,769 [-]

Recombination map

2-35

RefSeq locus

NT_033779 REGION:9573563..9576769

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables enoyl-CoA hydratase activity

inferred from sequence or structural similarity with UniProtKB:Q64428

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000592895

(assigned by GO_Central )

(Gaudet et al., 2011)

enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity

inferred from biological aspect of ancestor with PANTHER:PTN000592895

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with UniProtKB:Q64428

(FlyBase Curators, 2008--)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

inferred from mutant phenotype

(Kishita et al., 2012)

involved_in fatty acid beta-oxidation

inferred from mutant phenotype

(Kishita et al., 2012)

involved_in response to starvation

inferred from mutant phenotype

(Kishita et al., 2012)

involved_in wound healing

inferred from high throughput mutant phenotype

(Campos et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in fatty acid beta-oxidation

inferred from sequence or structural similarity with UniProtKB:Q64428

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000592895

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in oxidation-reduction process

inferred from electronic annotation with InterPro:IPR006108, InterPro:IPR006176, InterPro:IPR008927, InterPro:IPR012803

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009, Alonso et al., 2005)

located_in peroxisome

inferred from direct assay

(Faust et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of mitochondrial fatty acid beta-oxidation multienzyme complex

inferred from biological aspect of ancestor with PANTHER:PTN000592780

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in mitochondrion

inferred from sequence model

(Faust et al., 2012)

located_in peroxisome

inferred from sequence or structural similarity with HGNC:3247

(Faust et al., 2012)

inferred from sequence model

(Faust et al., 2012)

Gene Group (FlyBase)

OTHER HYDRO-LYASES

3-HYDROXYACYL-COA DEHYDROGENASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

OTHER HYDRO-LYASES -: The Other Hydro-lyases is a collection of Hydro-lyases that do not fit into any of the other major Hydro-lyase groups.
3-HYDROXYACYL-COA DEHYDROGENASES -: 3-hydroxyacyl-CoA dehydrogenases are enzymes of mitochondrial fatty acid oxidation that catalyze oxidation of straight-chain 3-hydroxyacyl-CoA esters to 3-ketoacyl esters. (Adapted from PMID:9133619).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mtpα for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mtpα-RA

FBtr0079858

NM_135455

2725

783

Mtpα-RB

FBtr0079857

NM_164860

2886

744

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Mtpα-PA

FBpp0079454

84.1

783

9.72

NP_609299

AAF52789

Mtpα-PB

FBpp0079453

79.6

744

9.31

NP_723470

AAN10697

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mtpα using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrion

inferred from high throughput direct assay

(Tan et al., 2009, Alonso et al., 2005)

located_in peroxisome

inferred from direct assay

(Faust et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mtpα in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mtpα

View exonic expression by tissue for Dmel\Mtpα

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028479

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028479

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4389-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4389

Flygut - An atlas of the Drosophila adult midgut

FBgn0028479

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mtpα

Transgenic constructs containing regulatory region of Mtpα

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation

Gene disrupted in

Df(2L)Exel7042

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Mtpα^KO

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mtpα^GD11299

viable, with Scer\GAL4^Mef2.PR

Mtpα^GD11299

viable, with Scer\GAL4^pnr-MD237

Mtpα^GD11299

viable, with Scer\GAL4^tin.CΔ4

Mtpα^GD11299

Sterility

Allele

fertile

Mtpα^KO

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

Mtpα^KO

abnormal starvation stress response | adult stage

Mtpα^KO

short lived

Mtpα^KO

Phenotype manifest in

Allele

adult fat body

Mtpα^KO

lipid droplet

Mtpα^KO

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\HADHA

15 of 15

Yes

Hsap\EHHADH

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (12)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Hadha

13 of 15

Yes

Mmus\Ehhadh

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Hadha

12 of 13

Yes

Rnor\Ehhadh

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\hadha

9 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\hibch

1 of 12

Xtro\LOC100135367

1 of 12

Danio rerio (Zebrafish) (12)

Drer\hadhaa

14 of 15

Yes

Drer\hadhab

10 of 15

Yes

Drer\ehhadh

3 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\ech-1.2

15 of 15

Yes

Cele\ech-1.1

14 of 15

Yes

Cele\ech-8

2 of 15

Yes

Cele\ech-9

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\AIM1

5 of 9

Yes

Atha\MFP2

5 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\DCI1

1 of 15

Yes

Scer\ECI1

1 of 15

Yes

Scer\EHD3

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190323 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18151

Drosophila persimilis

Dper\GL19219

Drosophila willistoni

Dwil\GK23812

Drosophila virilis

Dvir\GJ17917

Drosophila mojavensis

Dmoj\GI17575

Drosophila grimshawi

Dgri\GH11058

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502GL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013466

Glossina morsitans

Tsetse fly

Gmor\GMOY004743

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08075

Mayetiola destructor

Hessian fly

Mdes\Mdes007737

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010146

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015524

Anopheles darlingi

American malaria mosquito

Adar\ADAC006160

Anopheles gambiae

Malaria mosquito

Agam\AGAP007784

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ020263

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0293 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002967

Danaus plexippus

Monarch butterfly

Dple\DPOGS211087-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012486

Apis florea

Little honeybee

Aflo\4053806468

Apis mellifera

Western honey bee

Amel\LOC410325

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15031

Bombus terrestris

Buff-tailed bumblebee

Bter\15212386

Linepithema humile

Argentine ant

Lhum\LH19427

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0028b8

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003309

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_04268

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03425

Tribolium castaneum

Red flour beetle

Tcas\TC014680

Pediculus humanus

Human body louse

Phum\PHUM238600

Rhodnius prolixus

Kissing bug

Rpro\RPRC006225

Cimex lectularius

Bed bug

Clec\CLEC010637

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006589

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03494

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01G2 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR006931

Ixodes scapularis

Black-legged tick

Isca\ISCW005458

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69376.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g06130

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_302417

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02LF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hadha

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Htpalpha

Ciona intestinalis

Vase tunicate

Cint\LOC100181980

Gallus gallus

Domestic chicken

Ggal\HADHA

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (13)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Dci

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial trifunctional protein deficiency, HADHA-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Mtpα^KO

model of fatty liver disease

CEA

(Kishita et al., 2012)

model of lipid metabolism disorder

CEA

(Kishita et al., 2012)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

model of mitochondrial trifunctional protein deficiency

IEA

(FlyBase, 2019-)

EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

model of Fanconi renotubular syndrome 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

15 of 15

600890

mitochondrial trifunctional protein deficiency

EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

3 of 15

607037

FANCONI RENOTUBULAR SYNDROME 3; FRTS3

Fanconi renotubular syndrome 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Mtpα - CG7407

experimental knowledge based

(Guruharsha et al., 2011)

Mtpα - Mtpβ

experimental knowledge based

(Guruharsha et al., 2011)

Mtpα - ds

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Mtpα - fj

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Mtpα - ft

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Mtpα - su(Hw)

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Mtpα - wts

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cln3

enhanceable

Mtpα

(Llavero Hurtado et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60375

DroID - A comprehensive database of gene and protein interactions.

FBgn0028479

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34276

MIST (protein-protein) - An integrated Molecular Interaction Database

Mtpalpha

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-35

Cytogenetic map

30B12-30B12

Sequence location

2L:9,573,563..9,576,769 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

30B12-30B12

Limits computationally determined from genome sequence between P{EP}Oatp30B^EP890 and P{EP}EP361&P{EP}pelo^EP2160

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-35

(FlyBase, 2016)

2-30.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

18373

w¹¹¹⁸; PBac{WH}Mtpα^f00822/CyO

77201

y¹ sc^* v¹ sev²¹; P{TKO.GS00727}attP40

32873

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00660}attP2

Kyoto

114520

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; PBac{WH}Mtpα^f00822 P{neoFRT}40A/CyO y⁺

VDRC

v100021

P{KK102959}VIE-260B

v21845

w¹¹¹⁸; P{GD11299}v21845

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (106)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH12558

Other clones

DPiM_GH12558

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028479

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028479

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34276

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Mtpα CG4389

(Kishita et al., 2012)

Source for database merge of

Additional comments

It is not clear whether or not " NEST:bs09e08 " and " BcDNA:GH12558 " represent a single gene or two neighbouring genes transcribed in the same direction.

(Andrews et al., 2000)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34276

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028479

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028479

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4389

Flygut - An atlas of the Drosophila adult midgut

FBgn0028479

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34276

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4389

modMine - A data warehouse for the modENCODE project

FBgn0028479

Linkouts

BioGRID - A database of protein and genetic interactions.

60375

DPiM - Drosophila Protein interaction map

FBgn0028479

DroID - A comprehensive database of gene and protein interactions.

FBgn0028479

DRSC - Results frm RNAi screens

FBgn0028479

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028479

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4389-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028479

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

FlyMine - An integrated database for Drosophila genomics

FBgn0028479

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34276

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Mtpalpha

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

BcDNA:GH12558

(Giot et al., 2003)

CG 4389

(Alonso et al., 2005)

HADHA

(Baron et al., 2016)

Hadha

(Llavero Hurtado et al., 2017)

LBP

(Anderson-Baron and Simmonds, 2018)

Mtpalpha

(Stobdan et al., 2019, Marygold, 2018.6.26, Laflamme et al., 2017, Paiardi et al., 2017, Transgenic RNAi Project members, 2017-, Kwon et al., 2013)

Mtpα

(Pridie et al., 2020, Hughes and Simmonds, 2019, Anderson-Baron and Simmonds, 2018, O'Sullivan et al., 2013, Kishita et al., 2012)

Name Synonyms

Mitochondrial trifunctional protein α subunit

(Anderson-Baron and Simmonds, 2018)

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