FlyBase Gene Report: Dmel\bdl

Predictions / Assertions

Summaries

Protein Function (UniProtKB)

In the developing eye, has a role in axonal targeting of the R7 photoreceptor where it functions together with tutl. Probably mediates homotypic cell adhesion; the effect is inhibited by Lar.

(UniProt, Q9U4G1)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\bdl or the JBrowse view of Dmel\bdl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

bdl-RA

FBtr0077425

NM_134978

2730

719

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

bdl-PA

FBpp0077115

81.2

719

6.27

NP_608822

AAF51028

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with tutl.

(UniProt, Q9U4G1)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bdl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG16857_1

Linkouts

Gene Ontology (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

inferred from physical interaction with FLYBASE:tutl; FB:FBgn0010473

(Cameron et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

homophilic cell adhesion via plasma membrane adhesion molecules

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

axon ensheathment

inferred from mutant phenotype

(Cameron et al., 2016)

glial cell growth

inferred from mutant phenotype

(Cameron et al., 2016)

inferred from mutant phenotype

(Cameron et al., 2013)

neuron cell-cell adhesion

inferred from mutant phenotype

(Cameron et al., 2013)

R7 cell development

inferred from mutant phenotype

(Cameron et al., 2013)

inferred from genetic interaction with FLYBASE:tutl; FB:FBgn0010473

(Cameron et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

dendrite self-avoidance

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

homophilic cell adhesion via plasma membrane adhesion molecules

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

integral component of plasma membrane

inferred from direct assay

(Cameron et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

axon

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001296633

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

dorsal sensory complex proper primordium

eye

(Xu et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

adult optic lobe | restricted

(Cameron et al., 2013)

lamina | restricted

(Cameron et al., 2013)

medulla | restricted

(Cameron et al., 2013)

medulla layer M6

(Cameron et al., 2013)

medulla layer M3

(Cameron et al., 2013)

pharate adult stage P8

lamina | restricted

(Cameron et al., 2013)

medulla | restricted

(Cameron et al., 2013)

adult optic lobe | restricted

(Cameron et al., 2013)

embryonic/larval optic stalk

(Cameron et al., 2016)

eye disc | restricted

(Cameron et al., 2016)

lamina | restricted

(Cameron et al., 2016)

embryonic/larval optic stalk surface glial cell

(Cameron et al., 2016)

lamina anlage glial cell

(Cameron et al., 2016)

embryonic/larval wrapping glial cell of the eye disc

(Cameron et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

integral component of plasma membrane

adult head

(Cameron et al., 2013)

Additional Descriptive Data

In third instar larvae, bdl staining visualizes cellular processes from the eye disc through the optic stalk, into the developing lamina. bdl is present in wrapping glia processes, but not in photoreceptor cell axons, in third instar larvae where photoreceptor cell axons begin to project into the optic lobe.

(Cameron et al., 2016)

bdl-protein is detected in part of the pupal and adult medulla, lamina and inner optic lobe. Within the medulla, bdl-protein is found in R7- and R8-axon terminals in medulla layers M3 and M6 as well as in other neuronal processes.

(Cameron et al., 2013)

Marker for

Subcellular Localization

CV Term

Evidence

References

inferred from direct assay

(Cameron et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bdl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\bdl

View exonic expression by tissue for Dmel\bdl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028482

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028482

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG16857-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Flygut - An atlas of the Drosophila adult midgut

FBgn0028482

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\bdl

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of bdl

Transgenic constructs containing regulatory region of bdl

Deletions and Duplications ( 3 )

Partially disrupted in

Df(2L)tutl-bdl

(Cameron et al., 2013)

Disrupted in

Df(2L)Exel8011

(Ryder, 2004.4.26)

Df(2L)tutl

(Zhou et al., 2012)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

bdl^GD2597

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

neuroanatomy defective, with Scer\GAL4^GMR.PU

bdl^UAS.Tag:FLAG

neuroanatomy defective | third instar larval stage

bdl^EX2

neuroanatomy defective | third instar larval stage, with Scer\GAL4^Ntan1-Mz97

Phenotype manifest in

Allele

axon, with Scer\GAL4^GMR.PU

bdl^UAS.Tag:FLAG

embryonic/larval optic stalk | third instar larval stage

bdl^EX2

embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4^Ntan1-Mz97

embryonic/larval wrapping glial cell of the eye disc | third instar larval stage

bdl^EX2

embryonic/larval wrapping glial cell of the eye disc | third instar larval stage, with Scer\GAL4^Ntan1-Mz97

rhabdomere R7, with Scer\GAL4^GMR.PU

bdl^UAS.Tag:FLAG

rhabdomere R8, with Scer\GAL4^GMR.PU

bdl^UAS.Tag:FLAG

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (21)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\IGSF9B

5 of 15

Yes

Hsap\IGSF9

5 of 15

Yes

Hsap\CD86

1 of 15

Yes

Hsap\CD276

1 of 15

Yes

Hsap\FCER1A

1 of 15

Yes

Hsap\FCGR1A

1 of 15

Yes

Hsap\FCGR1B

1 of 15

Yes

Hsap\FCGR2A

1 of 15

Yes

Hsap\FCGR2B

1 of 15

Yes

Hsap\FCGR3A

1 of 15

Yes

Hsap\FCGR3B

1 of 15

Yes

Hsap\FCRL3

1 of 15

Yes

Hsap\FCRL4

1 of 15

Yes

Hsap\FCRL5

1 of 15

Yes

Hsap\FCRLA

1 of 15

Yes

Hsap\FCRLB

1 of 15

Yes

Hsap\HEPACAM

1 of 15

Yes

Hsap\IGDCC3

1 of 15

Hsap\IL1R1

1 of 15

Yes

Hsap\MYPN

1 of 15

Hsap\PALLD

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Igsf9

5 of 15

Yes

Mmus\Igsf9b

3 of 15

Mmus\Fcer1a

1 of 15

Yes

Mmus\Fcgr1

1 of 15

Yes

Mmus\Fcgr2b

1 of 15

Yes

Mmus\Fcgr3

1 of 15

Yes

Mmus\Fcgr4

1 of 15

Yes

Mmus\Fcrl5

1 of 15

Yes

Mmus\Fcrla

1 of 15

Yes

Mmus\Fcrlb

1 of 15

Yes

Mmus\Igdcc3

1 of 15

Mmus\Myot

1 of 15

Yes

Mmus\Mypn

1 of 15

Mmus\Nrcam

1 of 15

Rattus norvegicus (Norway rat) (14)

Rnor\Igsf9b

5 of 13

Yes

Rnor\Igsf9

5 of 13

Yes

Rnor\Fcer1a

1 of 13

Yes

Rnor\Fcgr1a

1 of 13

Yes

Rnor\Fcgr2b

1 of 13

Yes

Rnor\Fcgr3a

1 of 13

Yes

Rnor\Fcrla

1 of 13

Yes

Rnor\Fcrlb

1 of 13

Yes

Rnor\LOC100360205

1 of 13

Yes

Rnor\LOC103693683

1 of 13

Yes

Rnor\Myot

1 of 13

Yes

Rnor\Nrcam

1 of 13

Rnor\Pecam1

1 of 13

Yes

Rnor\Siglec15

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\igsf9b

5 of 12

Yes

Xtro\igsf9

5 of 12

Yes

Xtro\fcgr1

1 of 12

Yes

Xtro\fcrl3

1 of 12

Yes

Xtro\hepacam2

1 of 12

Yes

Xtro\igsf11

1 of 12

Yes

Xtro\LOC100486104

1 of 12

Yes

Xtro\LOC100489139

1 of 12

Yes

Xtro\LOC100496351

1 of 12

Yes

Danio rerio (Zebrafish) (9)

Drer\igsf9bb

5 of 15

Yes

4 of 15

3 of 15

3 of 15

1 of 15

1 of 15

Yes

Drer\si:ch211-57n23.4

1 of 15

Yes

Drer\si:dkeyp-97a10.3

1 of 15

Yes

Drer\zgc:154125

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\igcm-2

3 of 15

Yes

Cele\dim-1

1 of 15

Yes

Cele\ncam-1

1 of 15

Cele\zig-1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\zig-7

1 of 15

Yes

Cele\zig-11

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919035Z )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14181

Drosophila persimilis

Dper\GL14021

Drosophila willistoni

Dwil\GK24612

Drosophila virilis

Dvir\GJ16223

Drosophila mojavensis

Dmoj\GI16510

Drosophila grimshawi

Dgri\GH10067

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507NC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017524

Glossina morsitans

Tsetse fly

Gmor\GMOY003356

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_09030

Mayetiola destructor

Hessian fly

Mdes\Mdes005077

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014457

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003586

Anopheles darlingi

American malaria mosquito

Adar\ADAC009477

Anopheles gambiae

Malaria mosquito

Agam\AGAP008943

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004822

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004821

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W081K )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005854

Danaus plexippus

Monarch butterfly

Dple\DPOGS209476-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004491

Apis florea

Little honeybee

Aflo\2213826276

Apis mellifera

Western honey bee

Amel\GB53013

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10513

Bombus terrestris

Buff-tailed bumblebee

Bter\15204854

Linepithema humile

Argentine ant

Lhum\LH17787

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0021b4

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011341

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_11896

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08292

Rhodnius prolixus

Kissing bug

Rpro\RPRC006126

Cimex lectularius

Bed bug

Clec\CLEC006385

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08326

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02TX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3f_4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fn3/Ig_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004965

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001450

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000022603

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (11)

Gene Symbol

Score

Source

Alignment

3 of 10

Bsg

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

IGSF9B; immunoglobulin superfamily member 9B

5 of 15

613773

IGSF9; immunoglobulin superfamily member 9

5 of 15

609738

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

bead aggregation assay, fluorescence microscopy, inferred by author

(Cameron et al., 2013)

bdl - tutl

anti tag coimmunoprecipitation, anti tag western blot

(Cameron et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Lar

(Cameron et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lar

suppressible

(Cameron et al., 2013)

tutl

suppressible