FB2021_02, released April 13, 2021

Gene: Dmel\CenG1A

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General Information
Symbol
Dmel\CenG1A
Species
D. melanogaster
Name
Centaurin gamma 1A
Annotation Symbol
CG31811
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028509
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

BG:DS08220.1

Key Links
Genomic Location
Cytogenetic map
34D6-34E2
Sequence location
2L:13,835,564..13,898,712 [+]
Recombination map
2-50
RefSeq locus
NT_033779 REGION:13835564..13898712
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from mutant phenotype
(Gündner et al., 2014)
enables GTPase activity
inferred from direct assay
(Gündner et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables GTPase activator activity
inferred from sequence model
(Bernards, 2003)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in medium-term memory
inferred from mutant phenotype
(Gross et al., 2015)
involved_in positive regulation of GTPase activity
inferred from direct assay
(Gündner et al., 2014)
inferred from mutant phenotype
(Gündner et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of GTPase activity
inferred from sequence model
(Bernards, 2003)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from sequence or structural similarity with HGNC:16921
(FlyBase Curators, 2008--)
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000572108
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the centaurin gamma-like family. (Q9NGC3)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS -
ArfGAPs are GTPase activating proteins for ARF family GTPases. ARFGAPs contain a characteristic 130 amino acid module, the ArfGAP domain, originally defined as the minimal fragment possessing ArfGAP activity. (Adapted from FBrf0158741, PMID:15731001 and PMID:18809720).
OTHER GTPASES -
Other GTPases are a collection of GTPases that do not fall into any major GTPase groups.
Protein Function (UniProtKB)
GTPase-activating protein for the ADP ribosylation factor family.
(UniProt, Q9NGC3)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\CenG1A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CenG1A-RA
FBtr0080547
NM_078838
3869
927
CenG1A-RB
FBtr0080546
NM_165067
4444
995
CenG1A-RC
FBtr0080548
NM_165068
3516
763
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CenG1A-PA
FBpp0080124
101.3
927
9.66
NP_523562
AAF53349
CenG1A-PB
FBpp0080123
108.0
995
8.54
NP_723849
AAF53343
CenG1A-PC
FBpp0080125
82.5
763
9.33
NP_723850
AAF53350
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CenG1A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CenG1A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CenG1A
Transgenic constructs containing regulatory region of CenG1A
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\AGAP1
13 of 15
Yes
Yes
Hsap\AGAP3
11 of 15
No
Yes
Hsap\AGAP2
9 of 15
No
Yes
Hsap\AGAP4
7 of 15
No
Yes
Hsap\AGAP5
6 of 15
No
Yes
Hsap\AGAP6
6 of 15
No
Yes
Hsap\AGAP7P
4 of 15
No
Yes
Hsap\AGAP9
4 of 15
No
Yes
Hsap\AGAP11
4 of 15
No
Yes
Hsap\AGAP10P
3 of 15
No
Yes
Hsap\ACAP1
2 of 15
No
No
Hsap\ACAP2
2 of 15
No
No
Hsap\ACAP3
2 of 15
No
No
Hsap\ADAP1
1 of 15
No
No
Hsap\ADAP2
1 of 15
No
Yes
Hsap\AGFG1
1 of 15
No
No
Hsap\AGFG2
1 of 15
No
No
Hsap\APPL1
1 of 15
No
Yes
Hsap\APPL2
1 of 15
No
Yes
Hsap\ARAP1
1 of 15
No
No
Hsap\ARAP2
1 of 15
No
No
Hsap\ARAP3
1 of 15
No
No
Hsap\ARFGAP1
1 of 15
No
No
2  
Hsap\ARFGAP2
1 of 15
No
No
1  
Hsap\ARFGAP3
1 of 15
No
No
Hsap\ASAP1
1 of 15
No
No
Hsap\ASAP2
1 of 15
No
No
Hsap\ASAP3
1 of 15
No
No
Hsap\GIT1
1 of 15
No
No
Hsap\GIT2
1 of 15
No
No
Hsap\LOC107984026
1 of 15
No
Yes
Hsap\SMAP1
1 of 15
No
No
Hsap\SMAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (28)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Agap1
13 of 15
Yes
Yes
Mmus\Agap3
11 of 15
No
Yes
Mmus\Agap2
9 of 15
No
Yes
Mmus\Acap1
2 of 15
No
No
Mmus\Acap2
2 of 15
No
No
Mmus\Acap3
2 of 15
No
No
Mmus\9030624G23Rik
1 of 15
No
Yes
Mmus\Adap1
1 of 15
No
Yes
Mmus\Adap2
1 of 15
No
Yes
Mmus\Agfg1
1 of 15
No
No
Mmus\Agfg2
1 of 15
No
No
Mmus\Appl1
1 of 15
No
Yes
Mmus\Appl2
1 of 15
No
Yes
Mmus\Arap1
1 of 15
No
No
Mmus\Arap2
1 of 15
No
No
Mmus\Arap3
1 of 15
No
No
Mmus\Arfgap1
1 of 15
No
No
Mmus\Arfgap2
1 of 15
No
No
Mmus\Arfgap3
1 of 15
No
No
Mmus\Asap1
1 of 15
No
No
Mmus\Asap2
1 of 15
No
No
Mmus\Asap3
1 of 15
No
No
Mmus\Git1
1 of 15
No
No
Mmus\Git2
1 of 15
No
No
Mmus\Gm3944
1 of 15
No
Yes
Mmus\Gm19924
1 of 15
No
Yes
Mmus\Smap1
1 of 15
No
No
Mmus\Smap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (17)
Rnor\Agap2
9 of 13
Yes
Yes
Rnor\Agap1
6 of 13
No
Yes
Rnor\Agap3
4 of 13
No
Yes
Rnor\Acap1
1 of 13
No
No
Rnor\Acap2
1 of 13
No
No
Rnor\Acap3
1 of 13
No
No
Rnor\Adap2
1 of 13
No
Yes
Rnor\Agfg1
1 of 13
No
No
Rnor\Agfg2
1 of 13
No
No
Rnor\Appl1
1 of 13
No
Yes
Rnor\Appl2
1 of 13
No
Yes
Rnor\Arfgap1
1 of 13
No
No
Rnor\Arfgap2
1 of 13
No
No
Rnor\Asap3
1 of 13
No
No
Rnor\Git2
1 of 13
No
No
Rnor\Smap1
1 of 13
No
No
Rnor\Smap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\agap1
7 of 12
Yes
Yes
Xtro\agap2
5 of 12
No
Yes
Xtro\agap3
2 of 12
No
Yes
Xtro\acap1
1 of 12
No
No
Xtro\acap2
1 of 12
No
No
Xtro\acap3
1 of 12
No
No
Xtro\adap1l
1 of 12
No
Yes
Xtro\adap1
1 of 12
No
Yes
Xtro\agfg1
1 of 12
No
No
Xtro\appl1
1 of 12
No
Yes
Xtro\appl2
1 of 12
No
Yes
Xtro\arap3
1 of 12
No
No
Xtro\arfgap1
1 of 12
No
No
Xtro\arfgap2
1 of 12
No
No
Xtro\asap1
1 of 12
No
No
Xtro\asap2
1 of 12
No
No
Xtro\git1
1 of 12
No
No
Xtro\git2
1 of 12
No
No
Xtro\smap1
1 of 12
No
No
Xtro\smap2
1 of 12
No
No
Danio rerio (Zebrafish) (27)
Drer\agap1
12 of 15
Yes
Yes
Drer\agap2
6 of 15
No
Yes
Drer\agap3
5 of 15
No
Yes
Drer\acap3a
2 of 15
No
No
Drer\asap1b
2 of 15
No
No
Drer\acap1
1 of 15
No
No
Drer\acap3b
1 of 15
No
No
Drer\adap2
1 of 15
No
Yes
Drer\agfg1a
1 of 15
No
No
Drer\appl1
1 of 15
No
Yes
Drer\appl2
1 of 15
No
Yes
Drer\arap1a
1 of 15
No
No
Drer\arap3
1 of 15
No
No
Drer\arfgap2
1 of 15
No
No
Drer\arfgap3
1 of 15
No
No
Drer\asap2a
1 of 15
No
No
Drer\asap2b
1 of 15
No
No
Drer\git1
1 of 15
No
No
Drer\git2a
1 of 15
No
No
Drer\LOC100005008
1 of 15
No
No
Drer\si:ch211-168b3.1
1 of 15
No
No
Drer\smap1
1 of 15
No
No
Drer\smap2
1 of 15
No
No
Drer\unm_sa1614
1 of 15
No
No
Drer\zgc:92360
1 of 15
No
Yes
Drer\zgc:162872
1 of 15
No
No
Drer\zmp:0000000660
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\cnt-2
13 of 15
Yes
Yes
Cele\cnt-1
2 of 15
No
No
Cele\F07F6.4
1 of 15
No
No
Cele\F07F6.7
1 of 15
No
Yes
Cele\F07F6.8
1 of 15
No
Yes
Cele\F23H11.4
1 of 15
No
No
Cele\git-1
1 of 15
No
No
Cele\K02B12.7
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AGD1
1 of 9
Yes
No
Atha\AGD2
1 of 9
Yes
No
Atha\AGD4
1 of 9
Yes
No
Atha\SFC
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\AGE1
4 of 15
Yes
No
Scer\AGE2
1 of 15
No
No
Scer\GCS1
1 of 15
No
No
Scer\GLO3
1 of 15
No
No
Scer\GTS1
1 of 15
No
No
Scer\SPS18
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\cnt5
2 of 12
Yes
No
Spom\cnt6
2 of 12
Yes
No
Spom\ucp3
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919026H )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001727
Drosophila simulans
Dsim\GD23935
Drosophila sechellia
Dsec\GM15341
Drosophila erecta
Dere\GG23894
Drosophila yakuba
Dyak\GE18693
Drosophila ananassae
Dana\GF14267
Drosophila pseudoobscura pseudoobscura
Dpse\GA16495
Drosophila persimilis
Dper\GL21243
Drosophila willistoni
Dwil\GK15018
Drosophila virilis
Dvir\GJ18155
Drosophila mojavensis
Dmoj\GI12625
Drosophila grimshawi
Dgri\GH11124
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501D5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015587
Musca domestica
House fly
Mdoa\17005431
Musca domestica
House fly
Mdoa\17004329
Musca domestica
House fly
Mdoa\17005434
Glossina morsitans
Tsetse fly
Gmor\GMOY005111
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01729
Mayetiola destructor
Hessian fly
Mdes\Mdes006927
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002660
Anopheles darlingi
American malaria mosquito
Adar\ADAC009943
Anopheles gambiae
Malaria mosquito
Agam\AGAP009160
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015091
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NAG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002390
Danaus plexippus
Monarch butterfly
Dple\DPOGS205566-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205567-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015565
Apis florea
Little honeybee
Aflo\2253640132
Apis mellifera
Western honey bee
Amel\GB49570
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24115
Bombus terrestris
Buff-tailed bumblebee
Bter\15215907
Linepithema humile
Argentine ant
Lhum\LH24409
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002bdc
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09339
Tribolium castaneum
Red flour beetle
Tcas\TC035016
Tribolium castaneum
Red flour beetle
Tcas\TC011430
Pediculus humanus
Human body louse
Phum\PHUM522550
Rhodnius prolixus
Kissing bug
Rpro\RPRC003416
Cimex lectularius
Bed bug
Clec\CLEC003595
Cimex lectularius
Bed bug
Clec\CLEC003594
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010146
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI062510
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15034
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0NJN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004979
Ixodes scapularis
Black-legged tick
Isca\ISCW014072
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58698.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g06250
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44591
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G123A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cntrn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004786
Gallus gallus
Domestic chicken
Ggal\AGAP3
Gallus gallus
Domestic chicken
Ggal\AGAP1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CenB1A
3 of 10
ArfGAP1
2 of 10
ArfGAP3
2 of 10
Asap
2 of 10
CG8243
2 of 10
drongo
2 of 10
Git
2 of 10
RabX6
1 of 10
RhoGAP15B
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    CenG1AEY01217
    ameliorates  fragile X syndrome
    modeled by Fmr1Δ50M
    (Gross et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    AGAP1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
    13 of 15
    608651
        AGAP3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
        11 of 15
        616813
            AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
            9 of 15
            605476
                AGAP4; ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
                7 of 15
                    AGAP5; ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
                    6 of 15
                        AGAP6; ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
                        6 of 15
                            AGAP7P; ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene
                            4 of 15
                                AGAP9; ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
                                4 of 15
                                    AGAP11; ArfGAP with GTPase domain, ankyrin repeat and PH domain 11
                                    4 of 15
                                        AGAP10P; ArfGAP with GTPase domain, ankyrin repeat and PH domain 10, pseudogene
                                        3 of 15
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            esyN Network Diagram
                                            Show neighbor-neighbor interactions:
                                            Select Layout:
                                            Legend:
                                            Protein
                                            RNA
                                            Selected Interactor(s)
                                            Interactions Browser
                                            View in Interactions Browser
                                            Please see the Physical Interaction reports below for full details
                                            protein-protein
                                            Physical Interaction
                                            Assay
                                            References
                                            CenG1A - AhcyL1
                                            experimental knowledge based
                                            (Guruharsha et al., 2011)
                                            Summary of Genetic Interactions
                                            esyN Network Diagram
                                            esyN Network Key:
                                            Suppression
                                            Enhancement
                                            View in Interactions Browser
                                            Please look at the allele data for full details of the genetic interactions
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Fmr1
                                            suppressible
                                            CenG1A
                                            (Gross et al., 2015)
                                            External Data
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DroID - A comprehensive database of gene and protein interactions.
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            External Data
                                            Linkouts
                                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            2L
                                            Recombination map
                                            2-50
                                            Cytogenetic map
                                            34D6-34E2
                                            Sequence location
                                            2L:13,835,564..13,898,712 [+]
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            34D6-34E2
                                            Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            34E1-34E2
                                            (determined by in situ hybridisation)
                                            (Ashburner et al., 1999, Spradling et al., 1999)
                                            Experimentally Determined Recombination Data
                                            Location

                                            2-50

                                            (FlyBase, 2016)

                                            2-45.1

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (14)
                                            Genomic Clones (44)
                                            cDNA Clones (173)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                            Drosophila Genomics Resource Center cDNA clones

                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                            cDNA Clones, End Sequenced (ESTs)
                                            BDGP DGC clones
                                            Other clones
                                            RNAi and Array Information
                                            Linkouts
                                            DRSC - Results frm RNAi screens
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            Antibody Information
                                            Laboratory Generated Antibodies
                                             
                                            Commercially Available Antibodies
                                             
                                            Other Information
                                            Relationship to Other Genes
                                            Source for database identify of

                                            Source for identity of: BG:DS08220.1 CG7982

                                            (Guan, 1999.11)

                                            Source for identity of: CenG1A cenG1A

                                            (FlyBase, 2009-)
                                            Source for database merge of

                                            Source for merge of: cenG1A CG16867 CG7982

                                            (FlyBase, 1996-)

                                            Source for merge of: CG16866 CG16867 CG7982

                                            (FlyBase Genome Annotators, 2002-2003)
                                            Additional comments

                                            Annotations CG16866, CG16867 and CG7982 merged as CG31811 in release 3 of the genome annotation.

                                            (FlyBase Genome Annotators, 2002-2003)

                                            Source for merge of cenG1A CG16867 CG7982 was sequence comparison ( date:000501 ).

                                            (FlyBase, 1996-)
                                            Other Comments

                                            Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

                                            (Junger et al., 2003)

                                            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                            (Kiger et al., 2003)

                                            Area matching Drosophila EST AA390942.

                                            (Davies, 2001.3.15)
                                            Origin and Etymology
                                            Discoverer
                                            Etymology
                                            Identification
                                            External Crossreferences and Linkouts ( 75 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                            Other crossreferences
                                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            modMine - A data warehouse for the modENCODE project
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DPiM - Drosophila Protein interaction map
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Synonyms and Secondary IDs (16)
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            References (89)