FlyBase Gene Report: Dmel\CenG1A

General Information

Symbol

Dmel\CenG1A

Species

D. melanogaster

Name

Centaurin gamma 1A

Annotation Symbol

CG31811

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028509

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Centaurin gamma 1A (CenG1A) encodes a GTPase that may have a role in regulating the second to third instar larval transition, which is ecdysone signaling-dependent. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

BG:DS08220.1

Key Links

Genomic Location

Cytogenetic map

34D6-34E2

Sequence location

2L:13,835,564..13,898,712 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:13835564..13898712

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Belongs to the centaurin gamma-like family. (Q9NGC3)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

GTPase activator activity; GTPase activity

Predictions / Assertions

GTP binding; GTPase activator activity

Summaries

Gene Group (FlyBase)

ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEINS -: ArfGAPs are GTPase activating proteins for ARF family GTPases. ARFGAPs contain a characteristic 130 amino acid module, the ArfGAP domain, originally defined as the minimal fragment possessing ArfGAP activity. (Adapted from FBrf0158741, PMID:15731001 and PMID:18809720).

Protein Function (UniProtKB)

GTPase-activating protein for the ADP ribosylation factor family.

(UniProt, Q9NGC3)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\CenG1A or the JBrowse view of Dmel\CenG1A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CenG1A-RA

FBtr0080547

NM_078838

3869

927

CenG1A-RB

FBtr0080546

NM_165067

4444

995

CenG1A-RC

FBtr0080548

NM_165068

3516

763

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CenG1A-PA

FBpp0080124

101.3

927

9.66

NP_523562

AAF53349

CenG1A-PB

FBpp0080123

108.0

995

8.54

NP_723849

AAF53343

CenG1A-PC

FBpp0080125

82.5

763

9.33

NP_723850

AAF53350

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9NGC3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CenG1A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Gene Ontology (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

GTPase activator activity

inferred from mutant phenotype

(Gündner et al., 2014)

GTPase activity

inferred from direct assay

(Gündner et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

GTP binding

inferred from electronic annotation with InterPro:IPR001806

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

GTPase activator activity

inferred from sequence model

(Bernards, 2003)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

medium-term memory

inferred from mutant phenotype

(Gross et al., 2015)

positive regulation of GTPase activity

inferred from direct assay

(Gündner et al., 2014)

inferred from mutant phenotype

(Gündner et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

regulation of GTPase activity

inferred from sequence model

(Bernards, 2003)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

membrane

inferred from sequence or structural similarity with HGNC:16921

(FlyBase Curators, 2008--)

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000572108

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium