• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CG5888

General Information
Symbol	Dmel\CG5888	Species	D. melanogaster
Name		Annotation symbol	CG5888
Feature type	protein_coding_gene	FlyBase ID	FBgn0028523
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	BG:DS02780.1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35F12-36A1	Sequence location	2L:16,400,169..16,448,465 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5888 (FBgn0028523). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane signaling receptor activity. The biological processes in which it is involved are not known. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Leucine-rich repeat; Leucine-rich repeat, typical subtype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1635109_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5888. Gene sequence location is 2L:16400169..16448465.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN24088 HFA01929
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F12-36A1   Limits computationally determined from genome sequence between P{EP}fzyEP1028&P{lacW}mRpL4k14608 and P{PZ}dacP
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5888 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5888-RA FBtr0080880  NM_135950   1883   455
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5888-PA   FBpp0080437   51.7   455   6.78     NP_609794   AAF53534
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141295   AA141297   AE014134 AAF53534   AE003416 AAF45015   AI108855   AW940291   AY119489 AAM50143   BI213128   BI228763   BI234488   BI236145   BI238492   BI241114   BI364712   BI372893   BI577382   BI579584   BI579944   BT125696   CA807776   CO156627   CO186062   CO264566   CO265166   CO265335   CO274966   CO277767   CO279025   CO288540   CO290068   CO310653   CO310867   CO318756   CO323938   CO332592   CZ489799   CZ489800   EC066861   EC071466   EC074734   EC087235   EC087590   EC198841   EC203280   EC207541   EC209894   EC221679   EC229202   EC232765   EC236611   EC237199   EC239776   EC240667   EC242202   EC244289   EC264008   GH749651   GH749875   GH754723   GH758058   GH759324   GH759451   GH760467   GH770793   GH771538   GH776382   GH778763   GH782534   GH789258   GH790310   GH792999   GH793929   GH797645   GH801913   GH805114   GH806507   GH819222   GH820800   GH820812   GH821049   GH822398   GH823065   GH824427   GH824761   GH826942   GH842556   GH844089   GH850172   GH850502   GH850537   GH851751   GH852297   GH856935   GH866171   GH866455   GH872101   GH872790   GH876380   GH878405   GH882802   GH884124   GH895968   GH902859   GH903990   GH906027   GH910176   GH910631   GH915001   GH917161   GH917356   GH920123   GH922140   GH926221   GH926595   GH928614   GH929620   GH934771   GH936371   GH939805   GH939866   GH940199   GH940625
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KT58
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028523    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028523 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028523 expression level Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr    12018 embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (465) embryo 02-04hr  (6449) embryo 04-06hr  (12018) embryo 06-08hr  (6404) embryo 08-10hr  (4495) embryo 10-12hr  (2844) embryo 12-14hr  (3524) embryo 14-16hr  (1493) embryo 16-18hr  (1624) embryo 18-20hr  (1169) embryo 20-22hr  (619) embryo 22-24hr  (1042) larva L1  (419) larva L2  (468) larva L3 12hr old  (309) larva L3 puffstage 1-2  (295) larva L3 puffstage 3-6  (558) larva L3 puffstage 7-9  (1189) white prepupae new  (1716) white prepupae 12hr  (2689) white prepupae 24hr  (2883) pupae 2d postWPP  (1970) pupae 3d postWPP  (1536) pupae 4d postWPP  (376) adult male 01day  (507) adult male 05day  (419) adult male 30day  (255) adult female 01day  (214) adult female 05day  (168) adult female 30day  (128) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr  (6449) embryo 04-06hr  (12018) embryo 06-08hr  (6404) embryo 08-10hr  (4495) embryo 10-12hr  (2844) embryo 12-14hr  (3524) embryo 14-16hr  1493 embryo 16-18hr  (1624) embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new  (1716) white prepupae 12hr  (2689) white prepupae 24hr  (2883) pupae 2d postWPP  (1970) pupae 3d postWPP  (1536) pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr  (12018) embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr    12018 embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028523 expression level Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr    12018 embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (465) embryo 02-04hr  (6449) embryo 04-06hr  (12018) embryo 06-08hr  (6404) embryo 08-10hr  (4495) embryo 10-12hr  (2844) embryo 12-14hr  (3524) embryo 14-16hr  (1493) embryo 16-18hr  (1624) embryo 18-20hr  (1169) embryo 20-22hr  (619) embryo 22-24hr  (1042) larva L1  (419) larva L2  (468) larva L3 12hr old  (309) larva L3 puffstage 1-2  (295) larva L3 puffstage 3-6  (558) larva L3 puffstage 7-9  (1189) white prepupae new  (1716) white prepupae 12hr  (2689) white prepupae 24hr  (2883) pupae 2d postWPP  (1970) pupae 3d postWPP  (1536) pupae 4d postWPP  (376) adult male 01day  (507) adult male 05day  (419) adult male 30day  (255) adult female 01day  (214) adult female 05day  (168) adult female 30day  128 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr  (6449) embryo 04-06hr  (12018) embryo 06-08hr  (6404) embryo 08-10hr  (4495) embryo 10-12hr  (2844) embryo 12-14hr  (3524) embryo 14-16hr  1493 embryo 16-18hr  1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new  1716 white prepupae 12hr  (2689) white prepupae 24hr  (2883) pupae 2d postWPP  1970 pupae 3d postWPP  1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr  12018 embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    465 embryo 02-04hr    6449 embryo 04-06hr    12018 embryo 06-08hr    6404 embryo 08-10hr    4495 embryo 10-12hr    2844 embryo 12-14hr    3524 embryo 14-16hr    1493 embryo 16-18hr    1624 embryo 18-20hr    1169 embryo 20-22hr    619 embryo 22-24hr    1042 larva L1    419 larva L2    468 larva L3 12hr old    309 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    558 larva L3 puffstage 7-9    1189 white prepupae new    1716 white prepupae 12hr    2689 white prepupae 24hr    2883 pupae 2d postWPP    1970 pupae 3d postWPP    1536 pupae 4d postWPP    376 adult male 01day    507 adult male 05day    419 adult male 30day    255 adult female 01day    214 adult female 05day    168 adult female 30day    128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028523    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028523 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028523 expression level Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion  532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028523 expression level Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion  532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    235.9 Larval Midgut    5.9 Larval Hindgut no informative data Larval Malpighian Tubules    14.9 Larval Fat Body    29.9 Larval Salivary Gland    6.8 Larval Trachea    84.95 Larval Carcass    44.9 Adult Head    179.1 Adult Eye    141.05 Adult Brain    321.5 Adult Thoracic-Abdominal Ganglion    532.1 Adult Crop no informative data Adult Midgut    3.4 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    62.7 Adult Heart    100.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    31.3 Adult Testis    17.6 Adult Male Accessory Gland    8.4 Adult Carcass    45.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    179.1   NA  Eye    141.05   NA  Brain    321.5   235.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    532.1   NA  Crop    no informative data   5.9  Midgut    3.4   no informative data  Hindgut    no informative data   14.9  Malpighian Tubules    no informative data   29.9  Fat Body    no informative data   6.8  Salivary Gland    62.7   NA  Heart    100.325   84.95  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    31.3   NA  Testis    17.6   NA  Male Accessory Gland    8.4   44.9  Carcass    45.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028523 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5888-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG5888 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG5888f07042 viable, with Scer\GAL4pnr-MD237 CG5888GD5404 Sterility Allele fertile CG5888f07042 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of CG5888 Class Mutagen Stocks Known lesion CG5888e02257 piggyBac transposase 3 -- CG5888f07042 piggyBac transposase 2 -- CG5888MB00188 1 -- CG5888MB01297 1 -- CG5888MB09289 1 -- CG5888Roi-1 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5888 Class Mutagen Stocks Known lesion CG5888GD5404 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7065 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5404} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}CG5888e02257 NA PBac{WH}CG5888f07042 NA insertion of enhancer trap binary system Mi{ET1}CG5888MB00188 No Mi{ET1}CG5888MB01297 No Mi{ET1}CG5888MB09289 No
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
transmembrane signaling receptor activity inferred from sequence or structural similarity with EMBL:U88879 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5888 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60989 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028523 DroID - A comprehensive database of gene and protein interactions. • FBgn0028523 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34980
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15883 Dere\GG20127 Dgri\GH25030 Dmoj\GI13835 Dper\GL18481 Dpse\GA19205 Dsec\GM17176 Dsim\GD21911 Dvir\GJ17454 Dwil\GK24324 Dyak\GE12815
Curated drosophilid orthologs	Dpse\GA19205
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230535 FBgn0226284 FBgn0204626 FBgn0193328 FBgn0172087 FBgn0244718 FBgn0079202 FBgn0156082 FBgn0136589 FBgn0132485 FBgn0112321 FBgn0092906
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	19034 w1118; PBac{WH}CG5888f07042 26146 w1118; Mi{ET1}CG5888MB09289 22724 y1 w67c23; Mi{ET1}CG5888MB00188 23051 y1 w67c23; Mi{ET1}CG5888MB01297 18031 w1118; PBac{RB}CG5888e02257 Idgf2e02257/CyO
Harvard	- PBac{RB}CG5888e02257 - PBac{WH}CG5888f07042
Kyoto	114499 yd2 w1118 P{ey-FLP.N}2; PBac{RB}CG5888e02257 Idgf2e02257 P{neoFRT}40A/CyO y+
VDRC	v12413 w1118; P{GD5404}v12413
Genomic Clones ( 2 )
	BACR01N08 BACR33A07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 113 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08155
Other clones	DPiM_GH08155 RT10185
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE18460 RE26406 RE30192 RE32157 RE34972 RE38129 RE49880 RE60085 RE71049 RE73642 RE74052
Other clones	15728 31699 31998 65378 81574 99415 100111 107274 125121 172949 277266 528054 CK01.15B.A10 CK01.15B.D9 CK01.93C.H8 CK01.142D.E4 CK01518 EK015533 EK068836 EK072964 EK116050 EK126249 EK133305 EK139627 EK141721 EK142316 EK192011 EK222221 EK222844 EK273745 EK304012 EN08433 ESG019c.E21_C05 RP003000223 RP003004613 RP003009512 RP003014251 RP003022499 RP003035390 RP003052408 RP003058137 RP003059040 RP003069877 RP003085856 RP003094733 RP003114002 RP003159972 RP003174776 RP003176700 RP003195175 RP003212546 RP003212967 RP003219709 RP003233203 RP003235711 RP003235896 RP003241926 RP003250470 RP003256587 RP003260414 RP003263357 RP003267636 RP003283375 RP003285363 RP003286752 RP003288697 RP003296862 RP003298060 RP003319036 RP003322349 RP003323904 RP003325376 RP003339962 RP003344482 RP003379238 RP003384048 RP003391590 RP003433018 RP003439757 RP003446739 RP003467797 RP003473630 RP003485166 RP003523113 RP003523409 RP003544572 RP003546150 RP003557521 RP003584860 RP003590450 RP003609918 RP003630130 RP003636828 RP003654130 RP003654456 RP003656110 RP003675728 RP003678148 RP003680248
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028523 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34980
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	The "Roi" rough eye mutant allele is due to an inversion between 36A and 37A (In(2L)Roi1). The proximal breakpoint is 2.6kb downstream of "amos" and is within the last exon of CG15160. The distal breakpoint is within the first intron of CG5888. Several lines of evidence suggest that the "Roi" phenotype is caused by a gain-of-function allele of "amos" rather than being due to an effect of the inversion on another gene; "amos" is expressed in high levels in a broad area surrounding the morphogenetic furrow in "Roi" third instar larvae (in contrast to wild type), overexpression of "amos" in the eye disc can produce a phenotype similar to that of "Roi" and reversion of the phenotype has been achieved by the insertion of a P-element a few kilobases downstream of "amos" which is associated with a severe reduction of "amos" expression in the eye. In addition, although the location of the In(2L)Roi1 breakpoints means that a chimeric gene could potentially be formed from the 5' portion of CG5888 and the 3' portion of CG15160, this chimeric RNA has not been detected in "Roi" mutants and although dac is also within the inverted segment it does not appear to be implicated in the "Roi" phenotype. (Chanut et al., 2002)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135950 RefSeq (Proteins) • NP_609794 DDBJ / EMBL / GenBank • AA141295 AA141297 AAF45015 AAF53534 AAM50143 AE003416 AI108855 AW940291 AY119489 CZ489799 CZ489800 Entrez Gene - A searchable database of RefSeq genes. • 34980 UniProtKB/TrEMBL • Q7KT58
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60989 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028523 DroID - A comprehensive database of gene and protein interactions. • FBgn0028523 DRSC - Results from RNAi screens. • FBgn0028523 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028523 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5888-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028523 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34980 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34980 modMine - Data generated by the modENCODE project. • FBgn0028523 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230535 FBgn0226284 FBgn0204626 FBgn0193328 FBgn0172087 FBgn0244718 FBgn0079202 FBgn0156082 FBgn0136589 FBgn0132485 FBgn0112321 FBgn0092906
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BG:DS02780.1 (Chanut et al., 2002, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, Giot et al., 2003, ) CG5888 (Moorman et al., 2006, Hollien and Weissman, 2006, Hollien and Weissman, 2006, Aerts et al., 2007, Maisonhaute et al., 2007, Lu et al., 2009, Zúñiga et al., 2009) CT18477 (Hynes and Zhao, 2000)
Name Synonym
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...