FlyBase Gene Report: Dmel\CG31775

General Information

Symbol

Dmel\CG31775

Species

D. melanogaster

Name

Annotation Symbol

CG31775

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028537

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

BG:DS00810.2

Key Links

Genomic Location

Cytogenetic map

35B5-35B5

Sequence location

2L:14,737,090..14,737,769 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14737090..14737769

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG31775 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KT85)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0080691

613

FBtr0301739

371

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG31775-PA

FBpp0080253

9.1

3.66

FBpp0290953

9.1

3.66

Q7KT85

NP_001162976

ACZ94262

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

89 aa isoforms: CG31775-PA, CG31775-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KT85

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG31775 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval fat body

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG31775 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG31775

View exonic expression by tissue for Dmel\CG31775

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028537

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318935/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028537

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028537

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028537

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31775

Flygut - An atlas of the Drosophila adult midgut

FBgn0028537

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG31775

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG31775

Transgenic constructs containing regulatory region of CG31775

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel8033

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\nlp-24

1 of 14

Yes

Cele\nlp-29

1 of 14

Yes

Cele\nlp-30

1 of 14

Yes

Cele\nlp-31

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG31775. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

CG4440

1 of 13

CG15282

1 of 13

CG42586

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

77218

DroID - A comprehensive database of gene and protein interactions.

FBgn0028537

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

35B5-35B5

Sequence location

2L:14,737,090..14,737,769 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35B5-35B5

Limits computationally determined from genome sequence between P{EP}elB^EP2039&P{PZ}osp^rJ571 and P{lacW}Su(H)^k07904

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-47.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

62832

y¹ v¹; P{TRiP.HMJ23769}attP40

59578

y¹ w^*; Mi{MIC}CG31775^MI14936

NIG-Fly

HMJ23769

y¹ v¹; P{TRiP.HMJ23769}attP40/CyO

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (95)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028537

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028537

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG31775) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Identified with: LP08165 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(BDGP Project Members, 2000-)

EST LP08165 is chimeric; the 5' portion matches part of AE on the opposite strand to l(1)G0232, the 3' portion corresponds to part of CG31775.

(FlyBase, 1996-)

Relationship to Other Genes

Source for database merge of

Source for merge of: BG:DS00810.2 BcDNA:RE38252

(FlyBase, 1996-)

Source for merge of: BG:DS00810.2 BcDNA:RH25462

(FlyBase, 1996-)

Source for merge of: BG:DS00810.2 CG31775

(FlyBase, 1996-)

Additional comments

Source for merge of BG:DS00810.2 BcDNA:RE38252 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Source for merge of BG:DS00810.2 BcDNA:RH25462 was TrEMBL update ( date:020807 ).

(FlyBase, 1996-)

Source for merge of BG:DS00810.2 CG31775 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

BG:DS00810.2

(Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

BcDNA:LP08165

BcDNA:RE38252

BcDNA:RH25462

CG31775

(Icreverzi et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Short and Lazzaro, 2013, Herranz et al., 2012, Buffin and Gho, 2010, Fernández-Ayala et al., 2010, Zhang et al., 2010, Lebo et al., 2009, Perkins et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBgn0047030
FBgn0047116
FBgn0051775
FBgn0063098

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318935

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KT85

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7KT85

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KT85

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028537

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318935/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028537

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028537

FlyMine - An integrated database for Drosophila genomics

FBgn0028537

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31775

MARRVEL_MODEL - MARRVEL (model organism gene)

318935

Linkouts

BioGRID - A database of protein and genetic interactions.

77218

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028537

DroID - A comprehensive database of gene and protein interactions.

FBgn0028537

DRSC - Results frm RNAi screens

FBgn0028537

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028537

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028537

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31775

Flygut - An atlas of the Drosophila adult midgut

FBgn0028537

References (25)

The following external sites may use different assemblies or annotations than FlyBase.

-0.26

Report Sections