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Gene Dmel\NimB2

General Information
Symbol	Dmel\NimB2	Species	D. melanogaster
Name	Nimrod B2	Annotation symbol	CG31839
Feature type	protein_coding_gene	FlyBase ID	FBgn0028543
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	BG:DS00180.7, NimB2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34E5-34E5	Sequence location	2L:13,965,012..13,967,022 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nimrod B2 is referred to in FlyBase by the symbol Dmel\nimB2 (CG31839, FBgn0028543). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: bacterial cell surface binding. There is experimental evidence that it is involved in the biological process: mesoderm development. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine rich repeat, tripleX; Epidermal growth factor-like domain; Growth factor, receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1635283_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of nimB2. Gene sequence location is 2L:13965012..13967022.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34E5-34E5   Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\NimB2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) NimB2-RA FBtr0080618  NM_165075   1439   421
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein NimB2-PA   FBpp0080191   45.8   421   7.75     NP_723857   AAN10861
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like growth factor binding protein, N-terminal (IPR009030) Epidermal growth factor-like domain (IPR000742) Cysteine rich repeat, tripleX (IPR003341)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567553   AE014134 AAN10861   AE003408 AAF44840   AI107195   AI108535   AI113998   AI134153   AI261102   AI387866   AI404412   AI404487   BG632390   BI564868   BI566877   BI571205   BI576522   BI591545   BI593159   BI606515   BI616940   BI620535   BI621552   BI623352   BI631444   BI631453   BP554600   BP554601   BT012496   CO192602   EC088047   EV599203   GH912547
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KTA1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body    2093.3 Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head    1161.9 Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body    2346.5 Adult Salivary Gland    30.4 Adult Heart    1918.075 Adult VirginFemale Spermatheca    2482.5 Adult InseminatedFemale Spermatheca    2342.3 Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass    1283.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body  (2093.3) Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head  (1161.9) Adult Eye  536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body  (2346.5) Adult Salivary Gland    30.4 Adult Heart  (1918.075) Adult VirginFemale Spermatheca  (2482.5) Adult InseminatedFemale Spermatheca  (2342.3) Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass  (1283.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body  (2093.3) Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head  (1161.9) Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body  (2346.5) Adult Salivary Gland    30.4 Adult Heart  (1918.075) Adult VirginFemale Spermatheca  (2482.5) Adult InseminatedFemale Spermatheca  (2342.3) Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass  (1283.9) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body    2093.3 Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head    1161.9 Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body    2346.5 Adult Salivary Gland    30.4 Adult Heart    1918.075 Adult VirginFemale Spermatheca    2482.5 Adult InseminatedFemale Spermatheca    2342.3 Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass    1283.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body    2093.3 Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head    1161.9 Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body    2346.5 Adult Salivary Gland    30.4 Adult Heart    1918.075 Adult VirginFemale Spermatheca    2482.5 Adult InseminatedFemale Spermatheca    2342.3 Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass    1283.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body  (2093.3) Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head  (1161.9) Adult Eye  536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body  (2346.5) Adult Salivary Gland    30.4 Adult Heart  (1918.075) Adult VirginFemale Spermatheca  (2482.5) Adult InseminatedFemale Spermatheca  (2342.3) Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass  (1283.9) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body  (2093.3) Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head  1161.9 Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body  (2346.5) Adult Salivary Gland    30.4 Adult Heart  (1918.075) Adult VirginFemale Spermatheca  (2482.5) Adult InseminatedFemale Spermatheca  (2342.3) Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass  1283.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.575 Larval Midgut    33.1 Larval Hindgut    373.4 Larval Malpighian Tubules    14.8 Larval Fat Body    2093.3 Larval Salivary Gland    87.5 Larval Trachea    314.825 Larval Carcass    62.075 Adult Head    1161.9 Adult Eye    536.9 Adult Brain    62.4 Adult Thoracic-Abdominal Ganglion    48.3 Adult Crop    132.7 Adult Midgut    3.7 Adult Hindgut    356.5 Adult Malpighian Tubules    22.8 Adult Fat Body    2346.5 Adult Salivary Gland    30.4 Adult Heart    1918.075 Adult VirginFemale Spermatheca    2482.5 Adult InseminatedFemale Spermatheca    2342.3 Adult Ovary    3 Adult Testis    17 Adult Male Accessory Gland    3.4 Adult Carcass    1283.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1161.9   NA  Eye    536.9   NA  Brain    62.4   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    48.3   NA  Crop    132.7   no informative data  Midgut    3.7   373.4  Hindgut    356.5   no informative data  Malpighian Tubules    no informative data   2093.3  Fat Body    2346.5   87.5  Salivary Gland    no informative data   NA  Heart    1918.075   314.825  Trachea    NA   NA  VirginFemale Spermatheca    2482.5   NA  InseminatedFemale Spermatheca    2342.3   NA  Ovary    3   NA  Testis    no informative data   NA  Male Accessory Gland    3.4   62.075  Carcass    1283.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female    163 head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female    130 head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male    128 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering    277 fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult    128 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  (54) head, virgin 4-day female  (72) head, virgin 20-day female  (163) head, mated 1-day female  (57) head, mated 4-day female  (73) head, mated 20-day female  (130) head, mated 1-day male  (66) head, mated 4-day male  (64) head, mated 20-day male  (128) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (277) fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult  (76) carcass, 4-day adult  (62) carcass, 20-day adult  (128) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female  (163) head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female  (130) head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male  (128) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (277) fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult  (128) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female    163 head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female    130 head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male    128 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering    277 fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult    128 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female    163 head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female    130 head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male    128 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering    277 fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult    128 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female  (54) head, virgin 4-day female  (72) head, virgin 20-day female  (163) head, mated 1-day female  (57) head, mated 4-day female  (73) head, mated 20-day female  (130) head, mated 1-day male  (66) head, mated 4-day male  (64) head, mated 20-day male  (128) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (277) fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult  (76) carcass, 4-day adult  (62) carcass, 20-day adult  (128) ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female  (163) head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female  130 head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male  128 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering  (277) fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult  128 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    2 central nervous system, pupae P8    1 head, virgin 1-day female    54 head, virgin 4-day female    72 head, virgin 20-day female    163 head, mated 1-day female    57 head, mated 4-day female    73 head, mated 20-day female    130 head, mated 1-day male    66 head, mated 4-day male    64 head, mated 20-day male    128 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    11 digestive system, 4-day adult    5 digestive system, 20-day adult    8 fat body, larvae L3 wandering    277 fat body, white prepupae    12 fat body, pupae P8    24 carcass, larvae L3 wandering    7 carcass, 1-day adult    76 carcass, 4-day adult    62 carcass, 20-day adult    128 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, at stages throughout the larval period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr    149 embryo 20-22hr    107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old    217 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    108 larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP    123 adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr  (53) embryo 16-18hr  (85) embryo 18-20hr  (149) embryo 20-22hr  (107) embryo 22-24hr  (96) larva L1  (89) larva L2  (93) larva L3 12hr old  (217) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (108) larva L3 puffstage 7-9  (28) white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP  (123) adult male 01day  (77) adult male 05day  (87) adult male 30day  (94) adult female 01day  (74) adult female 05day  (49) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr  (149) embryo 20-22hr  107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old  (217) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (108) larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP  (123) adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr    149 embryo 20-22hr    107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old    217 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    108 larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP    123 adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr    149 embryo 20-22hr    107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old    217 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    108 larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP    123 adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr  (53) embryo 16-18hr  (85) embryo 18-20hr  (149) embryo 20-22hr  (107) embryo 22-24hr  (96) larva L1  (89) larva L2  (93) larva L3 12hr old  (217) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  (108) larva L3 puffstage 7-9  28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP  (123) adult male 01day  (77) adult male 05day  (87) adult male 30day  (94) adult female 01day  (74) adult female 05day  (49) adult female 30day  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr  (149) embryo 20-22hr  107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old  (217) larva L3 puffstage 1-2  (173) larva L3 puffstage 3-6  108 larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP  123 adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    53 embryo 16-18hr    85 embryo 18-20hr    149 embryo 20-22hr    107 embryo 22-24hr    96 larva L1    89 larva L2    93 larva L3 12hr old    217 larva L3 puffstage 1-2    173 larva L3 puffstage 3-6    108 larva L3 puffstage 7-9    28 white prepupae new    9 white prepupae 12hr    13 white prepupae 24hr    12 pupae 2d postWPP    15 pupae 3d postWPP    21 pupae 4d postWPP    123 adult male 01day    77 adult male 05day    87 adult male 30day    94 adult female 01day    74 adult female 05day    49 adult female 30day    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (61) wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3  (61) wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    8 embryonic Kc167    0 embryonic S1    9 embryonic S3    12 leg disc CME L1    9 wing disc CME-W2    2 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    61 wing disc ML-DmD21    1 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    4 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3    110 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3    114 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult  (56) Cadmium 50 mM 6 hrs, larvae L3  (110) Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (63) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (65) Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3  (38) Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (31) Ethanol 5% 3 hrs, larvae L3  (97) Ethanol 10% 3 hrs, larvae L3  (114) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3  (98) Rotenone 8 μg 12 hrs, larvae L3  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3  (110) Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3  (114) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3    110 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3    114 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    140 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3    110 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3    114 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult  (56) Cadmium 50 mM 6 hrs, larvae L3  (110) Cadmium 50 mM 12 hrs, larvae L3  (50) Cadmium 50 mM 48 hrs, 4-day adult  (63) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (65) Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3  (38) Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  31 Ethanol 5% 3 hrs, larvae L3  (97) Ethanol 10% 3 hrs, larvae L3  (114) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (109) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult  (38) Rotenone 2 μg 12 hrs, larvae L3  (98) Rotenone 8 μg 12 hrs, larvae L3  (140) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3  110 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3  114 Caffeine 1.5 mg/ml 4 hrs, larvae L3  109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3  140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    56 Cadmium 50 mM 6 hrs, larvae L3    110 Cadmium 50 mM 12 hrs, larvae L3    50 Cadmium 50 mM 48 hrs, 4-day adult    63 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    65 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    38 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    31 Ethanol 5% 3 hrs, larvae L3    97 Ethanol 10% 3 hrs, larvae L3    114 Caffeine 1.5 mg/ml 4 hrs, larvae L3    109 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    38 Rotenone 2 μg 12 hrs, larvae L3    98 Rotenone 8 μg 12 hrs, larvae L3    140 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028543 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31839-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 NimB2GD5393 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of NimB2 Class Mutagen Stocks Known lesion NimB2MI07504 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of NimB2 Class Mutagen Stocks Known lesion NimB2KK106789 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes NimB2GD5393 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes NimB2NIG.31839R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}NimB2MI07504 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mesoderm development inferred from expression pattern (Furlong et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
bacterial cell surface binding inferred from sequence or structural similarity with UniProtKB:Q1HAY7 (Kurucz et al., 2007)
Biological Process
CV term Evidence References
defense response to bacterium inferred from sequence or structural similarity with UniProtKB:Q1HAY7 (Kurucz et al., 2007)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence model (Kurucz et al., 2007) inferred from sequence or structural similarity with human TNXB (FlyBase Genome Annotators, 2002-2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
NimB2 - 14-3-3ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - CG10527 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) NimB2 - CG7194 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - Pdi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) NimB2 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions NimB2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 76307 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028543 DroID - A comprehensive database of gene and protein interactions. • FBgn0028543 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 260645
Orthologs
OrthoDB Orthologs (14) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PK2TP Dipteran inclusive ortholog search EOG6W9JCB Insect inclusive ortholog search EOG6C5BDS Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6PK2TP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\NimB2     Drosophila simulans   Dsim\GD22027 Y   Drosophila sechellia   Dsec\GM15024 Y   Drosophila erecta   Dere\GG10170 Y   Drosophila yakuba   Dyak\GE25257 Y   Drosophila ananassae   Dana\GF15608 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA29058 Y   Drosophila persimilis   Dper\GL21066 Y   Drosophila willistoni   Dwil\GK15110 Y   Drosophila virilis   Dvir\GJ18075 Y   Drosophila mojavensis   Dmoj\GI17397 Y   Drosophila grimshawi   Dgri\GH10607 Y
Orthologs in non-Drosophila Dipterans (EOG6W9JCB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009116
Orthologs in non-Dipteran Insects (EOG6C5BDS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\NimB
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22027 Drosophila sechellia Dsec\GM15024 Drosophila erecta Dere\GG10170 Drosophila yakuba Dyak\GE25257 Drosophila ananassae Dana\GF15608 Drosophila pseudoobscura pseudoobscura Dpse\GA29058 Drosophila persimilis Dper\GL21066 Drosophila willistoni Dwil\GK15110 Drosophila virilis Dvir\GJ18075 Drosophila mojavensis Dmoj\GI17397 Drosophila grimshawi Dgri\GH10607
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v105925 P{KK106789}VIE-260B
Genomic Clones ( 2 )
	BACR09N24 BACR16P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL01444
Other clones	DPiM_HL01444
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06520 GH07717 GH10608 GH11529 GH18544 GH24107 GH24228 LP05182 RH06039 RH06266 RH11106 RH33102 RH36657 RH47117 RH51702 RH52909 RH55490 RH61019 RH61028 RH62396 RH73025
Other clones	106270 Dmel_neb_010639_0851_2951 EC34134 FGM230G03 RP003194230
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028543 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 260645
Antibody Information
Other Information
Discoverer
Etymology
	The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282). (Kurucz et al., 2007)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: nimB2 CG31839 (Kurucz et al., 2007) Source for identity of: NimB2 nimB2 (FlyBase, 2009-)
Source for database merge of
Additional comments	Release 4.3 annotation CG34003 corresponds to a part of the release 2 annotation CG16882 which was not annotated on the genome in release 3 (CG16882 was split into CG33115 and CG31839 in release 3 of the genome annotation). CG34003 thus represents the 3rd split product from release 2 annotation CG16882. (FlyBase Genome Annotators, 2005) Annotation CG16882 split into CG33115 and CG31839 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165075 RefSeq (Proteins) • NP_723857 DDBJ / EMBL / GenBank • AA567553 AAF44840 AAN10861 AE003408 AI108535 BG632390 Entrez Gene - A searchable database of RefSeq genes. • 260645 UniProtKB/TrEMBL • Q7KTA1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like growth factor binding protein, N-terminal (IPR009030) Epidermal growth factor-like domain (IPR000742) Cysteine rich repeat, tripleX (IPR003341)
Linkouts
	BioGRID - A database of protein and genetic interactions • 76307 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028543 DroID - A comprehensive database of gene and protein interactions. • FBgn0028543 DRSC - Results from RNAi screens. • FBgn0028543 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028543 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG31839-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028543 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 260645 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 260645 modMine - Data generated by the modENCODE project. • FBgn0028543
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BG:DS00180.7 (Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, Giot et al., 2003, ) CG16882 (Furlong et al., 2001, ) CG31839 (Bhutkar et al., 2008, Kurucz et al., 2007, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) CT37470 (Hynes and Zhao, 2000) DS00180.7 (Reese et al., 2000) NimB2 (Kurucz et al., 2007, ) nimB2 (Kurucz et al., 2007)
Name Synonym	CG31839   nimrod B2 (Radyuk et al., 2012, ) Nimrod B2
Secondary FlyBase IDs
	FBgn0027908 FBgn0051839
References ( 28 )
Generate a list of	All references relating to this gene ( 28 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Radyuk et al., 2012, Mech. Ageing Dev. 133(6): 401--413 Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. [FBrf0218740] Spasic et al., 2012, PLoS Genet. 8(1): e1002433 Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm. [FBrf0217189] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...