FB2020_06, released Dec 22, 2020

Gene: Dmel\ics

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General Information
Symbol
Dmel\ics
Species
D. melanogaster
Name
icarus
Annotation Symbol
CG9031
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028546
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
icarus (ics) encodes RSU1 (Ras suppressor 1), an adapter protein that participates in integrin-dependent processes by interacting with the integrin effector protein encoded by stck. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

BG:BACR48E02.4 , RSU-1, Rsu1

Key Links
Genomic Location
Cytogenetic map
34C6-34C6
Sequence location
2L:13,639,447..13,642,602 [-]
Recombination map

2-48

RefSeq locus
NT_033779 REGION:13639447..13642602
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces
inferred from mutant phenotype
(Kadrmas et al., 2004)
involved_in integrin-mediated signaling pathway
inferred from genetic interaction with FLYBASE:stck; FB:FBgn0020249
(Elias et al., 2012)
involved_in negative regulation of JNK cascade
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
(Kadrmas et al., 2004)
inferred from genetic interaction with FLYBASE:msn; FB:FBgn0010909
(Kadrmas et al., 2004)
involved_in negative regulation of JUN kinase activity
inferred from mutant phenotype
(Kadrmas et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ics for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ics-RA
FBtr0080511
NM_135821
1335
283
ics-RB
FBtr0342905
NM_001298973
1063
283
ics-RC
FBtr0342906
NM_001298974
1716
283
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ics-PA
FBpp0080089
31.8
283
7.71
NP_609665
AAF53320
ics-PB
FBpp0309703
31.8
283
7.71
NP_001285902
AHN54416
ics-PC
FBpp0309704
31.8
283
7.71
NP_001285903
AHN54417
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

283 aa isoforms: ics-PA, ics-PB, ics-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ics using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ics in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ics
Transgenic constructs containing regulatory region of ics
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RSU1
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rsu1
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Rsu1
7 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\rsu1
13 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\rsu1
12 of 15
Yes
Yes
Drer\pidd1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\rsu-1
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (10)
Atha\PIRL7
4 of 9
Yes
Yes
Atha\PIRL6
3 of 9
No
Yes
Atha\PIRL8
3 of 9
No
Yes
Atha\PIRL1
2 of 9
No
Yes
Atha\PIRL2
2 of 9
No
Yes
Atha\PIRL3
2 of 9
No
Yes
Atha\PIRL9
2 of 9
No
Yes
Atha\AT3G15410
1 of 9
No
No
Atha\AT5G66890
1 of 9
No
Yes
Atha\RLP29
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\CYR1
1 of 15
Yes
No
Scer\SOG2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAC926.06c
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190E0U )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001698
Drosophila simulans
Dsim\GD22052
Drosophila sechellia
Dsec\GM25411
Drosophila erecta
Dere\GG10189
Drosophila yakuba
Dyak\GE11514
Drosophila ananassae
Dana\GF21702
Drosophila pseudoobscura pseudoobscura
Dpse\GA25391
Drosophila persimilis
Dper\GL25689
Drosophila willistoni
Dwil\GK24552
Drosophila virilis
Dvir\GJ18367
Drosophila mojavensis
Dmoj\GI10104
Drosophila grimshawi
Dgri\GH13878
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508ZP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17006303
Glossina morsitans
Tsetse fly
Gmor\GMOY006224
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00476
Mayetiola destructor
Hessian fly
Mdes\Mdes008511
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002678
Anopheles darlingi
American malaria mosquito
Adar\ADAC009946
Anopheles gambiae
Malaria mosquito
Agam\AGAP008785
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016693
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08W4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008020
Danaus plexippus
Monarch butterfly
Dple\DPOGS209798-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008980
Apis florea
Little honeybee
Aflo\3699399380
Apis mellifera
Western honey bee
Amel\ics
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19410
Bombus terrestris
Buff-tailed bumblebee
Bter\15211032
Linepithema humile
Argentine ant
Lhum\LH21564
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00242e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020638
Tribolium castaneum
Red flour beetle
Tcas\TC004946
Pediculus humanus
Human body louse
Phum\PHUM050940
Rhodnius prolixus
Kissing bug
Rpro\RPRC003188
Cimex lectularius
Bed bug
Clec\CLEC009780
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003499
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10868
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CB9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014532
Ixodes scapularis
Black-legged tick
Isca\ISCW001027
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60669.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60668.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g02730
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_200985
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0JL6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Rsu1L
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007978
Gallus gallus
Domestic chicken
Ggal\RSU1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG3408
1 of 10
CG32687
1 of 10
f-cup
1 of 10
Lrch
1 of 10
Lrr47
1 of 10
ltl
1 of 10
Phlpp
1 of 10
Sur-8
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Allele
Disease
Evidence
References
icsG4
model of  alcohol dependence
CEA
(Ojelade et al., 2015)
icsdsRNA.UAS.WIZ
model of  alcohol dependence
CEA
(Ojelade et al., 2015)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RSU1; Ras suppressor protein 1
14 of 15
179555
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      ics - Ilk
      anti tag coimmunoprecipitation, western blot
      (Kadrmas et al., 2004)
      ics - Rac1
      anti tag coimmunoprecipitation, anti tag western blot
      (Ojelade et al., 2015)
      ics - stck
      anti tag coimmunoprecipitation, western blot, pull down, two hybrid, peptide massfingerprinting
      (Pronovost et al., 2013, Yoshigi et al., 2013, Elias et al., 2012, Kadrmas et al., 2004)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      ics
      suppressible
      Ilk
      (Ojelade et al., 2015)
      ics
      suppressible
      Rac1
      (Ojelade et al., 2015)
      ics
      suppressible
      stck
      (Ojelade et al., 2015)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      bsk
      suppressible
      ics
      (Kadrmas et al., 2004)
      msn
      suppressible
      ics
      (Kadrmas et al., 2004)
      mys
      suppressible
      ics
      (Ojelade et al., 2015)
      stck
      suppressible
      ics
      (Elias et al., 2012)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map

      2-48

      Cytogenetic map
      34C6-34C6
      Sequence location
      2L:13,639,447..13,642,602 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      34C6-34C6
      Limits computationally determined from genome sequence between P{PZ}kuz03782&P{lacW}kuzk14817 and P{lacW}CG7364k07245
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      2-48

      (FlyBase, 2016)

      2-44.5

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (34)
      cDNA Clones (55)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Kadrmas et al., 2004)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: BG:BACR48E02.4 CG9031

      (Guan, 1999.11)

      Source for identity of: Rsu-1 CG9031

      (Smith et al., 2005)

      Source for identity of: ics Rsu-1

      (Kadrmas et al., 2004)
      Source for database merge of
      Additional comments
      Other Comments

      Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.

      (Jha et al., 2016)
      Origin and Etymology
      Discoverer
      Etymology

      Named "icarus" after the son of Daedalus who had unstable wings.

      (Kadrmas et al., 2004)
      Identification
      External Crossreferences and Linkouts ( 48 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (13)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (57)