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Gene Dmel\x16

General Information
Symbol	Dmel\x16	Species	D. melanogaster
Name		Annotation symbol	CG10203
Feature type	protein_coding_gene	FlyBase ID	FBgn0028554
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	Xl6, 9G8, Dxl6, d9G8, dx16, TN166, l(2)k00230
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27C4-27C4	Sequence location	2L:6,914,300..6,920,210 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\x16 (CG10203, FBgn0028554). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: RNA splicing. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye; trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain; Zinc finger, CCHC-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval salivary gland, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624496_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of xl6. Gene sequence location is 2L:6914300..6920210.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27C4-27C4   Limits computationally determined from genome sequence between P{PZ}Rca103300&P{lacW}l(2)k09022k09022 and P{lacW}xl6k00230&P{EP}Hrb27CEP748
Experimentally Determined Cytological Location
Cytogenetic map Notes References 27C4-27C5     (Bourbon, 2000.2.9) 27C4-27C5     (Vorbrueggen, 1999.9.14) 27C4-27C5   (determined by in situ hybridisation)   (Spradling et al., 1999) 27C4-27C5   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\x16 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) x16-RA FBtr0079368  NM_164718   1707   258 x16-RB FBtr0332328  NM_001273239   1785   257
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein x16-PA   FBpp0078996   27.9   258   12.06     NP_723226   AAF52454 x16-PB   FBpp0304606   27.7   257   12.03     NP_001260168   AGB92704
Additional Polypeptide Data & Comments
Reported size (kDa)	258 (aa) (Vorbruggen et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, CCHC-type (IPR001878) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202325   AA202757   AA438920   AA536359   AA540664   AA696472   AA951596   AE014134 AAF52454   AC004277   AF232774 AAF43414   AE014134 AGB92704   AI544124   AJ249466 CAB60724   AQ025682   AW943839   AX093954   AY095057 AAM11385   BF496385   BG636281   BG637765   BI162895   BI165563   BI167934   BI168689   BI169728   BI172727   BI173754   BI212359   BI214350   BI215020   BI228675   BI230293   BI232162   BI236012   BI236729   BI356629   BI357919   BI362864   BI368615   BI370341   BI371132   BI373328   BI374245   BI374873   BI375341   BI483002   BI484273   BI486398   BI486768   BI577459   BI578468   BI579928   BI580934   BI635422   CK134113   CK657948   CL526106   CO177993   CO178295   CO189107   CO274127   CO276036   CO276425   CO277668   CO278389   CO279727   CO288489   CO292817   CO293865   CO296763   CO305316   CO306819   CO308400   CO311320   CO315789   CO329745   DN153943   DN154226   EC052754   EC061153   EC064337   EC064611   EC066245   EC066757   EC069752   EC072350   EC075133   EC080765   EC089744   EC090247   EC198105   EC198355   EC198683   EC198782   EC201355   EC202939   EC207616   EC224197   EC230198   EC232068   EC237093   EC238398   EC244049   EC249013   EL874278   EV580618   EV585628   EV586225   FE862617   FE862626   FE863172   FE863235   FE863266   FE863301   GH739501   GH740201   GH741777   GH742584   GH743103   GH743127   GH743292   GH744278   GH745556   GH747172   GH747402   GH747590   GH762364   GH762549   GH762633   GH764259   GH764767   GH765377   GH766422   GH766948   GH768381   GH769965   GH770024   GH770059   GH770100   GH770101
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3V0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 11   organism | ubiquitous   (Vorbruggen et al., 2000) embryonic stage 14 -- 16   presumptive embryonic/larval central nervous system   (Vorbruggen et al., 2000) third instar larval stage   ventral thoracic disc | restricted   (Vorbruggen et al., 2000) eye-antennal disc | restricted   (Vorbruggen et al., 2000) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11   ventral neurectoderm   (Vorbruggen et al., 2000) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 14 -- 16   embryonic brain   (Vorbruggen et al., 2000) third instar larval stage   wing disc | restricted   (Vorbruggen et al., 2000) adult stage & oogenesis   nurse cell   (Vorbruggen et al., 2000)
Additional Descriptive Data
	x16 transcripts are first detected during oogenesis, primarily in the nurse cells. As oogenesis proceeds, transcripts are detected in the oocyte, indicating that they are transported from the nurse cells to the oocyte. x16 transcripts are detected ubiquitously in early embryos, but localized expression is detected following the onset of zygotic expression. By embryonic stage 11 transcripts are detected in the neurectoderm and become increasingly localized to the central nervous system until the completion of embryogenesis. During larval stages, transcripts are expressed at low levels in a ubiquitous pattern, but in the imaginal discs, localized expression is noted. (Vorbruggen et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleus inferred from direct assay (Allemand et al., 2002, Wan et al., 2008) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, larval salivary gland, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1102.3 Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1102.3) Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea  (542.3) Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary  (821.2) Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1102.3) Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1102.3 Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1102.3 Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1102.3) Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea  542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary  (821.2) Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1102.3 Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1102.3 Larval Midgut    140.5 Larval Hindgut    262.4 Larval Malpighian Tubules    100.3 Larval Fat Body    80.7 Larval Salivary Gland    285.7 Larval Trachea    542.3 Larval Carcass    288.775 Adult Head    205.7 Adult Eye    252.85 Adult Brain    483.8 Adult Thoracic-Abdominal Ganglion    395.7 Adult Crop    88.4 Adult Midgut    79.3 Adult Hindgut    77.3 Adult Malpighian Tubules    68 Adult Fat Body    83.9 Adult Salivary Gland    25.3 Adult Heart    61.9 Adult VirginFemale Spermatheca    88.3 Adult InseminatedFemale Spermatheca    92 Adult Ovary    821.2 Adult Testis    102.6 Adult Male Accessory Gland    38.5 Adult Carcass    62.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    205.7   NA  Eye    252.85   NA  Brain    483.8   1102.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    395.7   NA  Crop    88.4   140.5  Midgut    79.3   262.4  Hindgut    77.3   100.3  Malpighian Tubules    68   80.7  Fat Body    83.9   285.7  Salivary Gland    25.3   NA  Heart    61.9   542.3  Trachea    NA   NA  VirginFemale Spermatheca    88.3   NA  InseminatedFemale Spermatheca    92   NA  Ovary    821.2   NA  Testis    102.6   NA  Male Accessory Gland    38.5   288.775  Carcass    62.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3  (68) central nervous system, pupae P8  (35) head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering  (27) carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  (98) ovary, mated 4-day female  (52) testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (51) central nervous system, larvae L3  (68) central nervous system, pupae P8  (35) head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering  27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female  (98) ovary, mated 4-day female  (52) testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    51 central nervous system, larvae L3    68 central nervous system, pupae P8    35 head, virgin 1-day female    6 head, virgin 4-day female    8 head, virgin 20-day female    9 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    8 head, mated 1-day male    11 head, mated 4-day male    12 head, mated 20-day male    12 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    5 digestive system, 4-day adult    8 digestive system, 20-day adult    8 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    24 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    8 carcass, 20-day adult    7 ovary, virgin 4-day female    98 ovary, mated 4-day female    52 testis, mated 4-day male    10 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    165 embryo 02-04hr    268 embryo 04-06hr    307 embryo 06-08hr    226 embryo 08-10hr    164 embryo 10-12hr    140 embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (165) embryo 02-04hr  (268) embryo 04-06hr  (307) embryo 06-08hr  (226) embryo 08-10hr  (164) embryo 10-12hr  (140) embryo 12-14hr  (81) embryo 14-16hr  (97) embryo 16-18hr  (63) embryo 18-20hr  (35) embryo 20-22hr  (75) embryo 22-24hr  (56) larva L1  (31) larva L2  (27) larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  (32) larva L3 puffstage 7-9  (39) white prepupae new  (43) white prepupae 12hr  (44) white prepupae 24hr  (53) pupae 2d postWPP  26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day  (44) adult female 05day  (79) adult female 30day  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (165) embryo 02-04hr  (268) embryo 04-06hr  (307) embryo 06-08hr  (226) embryo 08-10hr  (164) embryo 10-12hr  (140) embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    165 embryo 02-04hr    268 embryo 04-06hr    307 embryo 06-08hr    226 embryo 08-10hr    164 embryo 10-12hr    140 embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    165 embryo 02-04hr    268 embryo 04-06hr    307 embryo 06-08hr    226 embryo 08-10hr    164 embryo 10-12hr    140 embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (165) embryo 02-04hr  (268) embryo 04-06hr  (307) embryo 06-08hr  (226) embryo 08-10hr  (164) embryo 10-12hr  (140) embryo 12-14hr  (81) embryo 14-16hr  (97) embryo 16-18hr  (63) embryo 18-20hr  (35) embryo 20-22hr  (75) embryo 22-24hr  (56) larva L1  31 larva L2  27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  32 larva L3 puffstage 7-9  (39) white prepupae new  (43) white prepupae 12hr  (44) white prepupae 24hr  (53) pupae 2d postWPP  26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day  (44) adult female 05day  (79) adult female 30day  (81) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (165) embryo 02-04hr  (268) embryo 04-06hr  (307) embryo 06-08hr  (226) embryo 08-10hr  (164) embryo 10-12hr  140 embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    165 embryo 02-04hr    268 embryo 04-06hr    307 embryo 06-08hr    226 embryo 08-10hr    164 embryo 10-12hr    140 embryo 12-14hr    81 embryo 14-16hr    97 embryo 16-18hr    63 embryo 18-20hr    35 embryo 20-22hr    75 embryo 22-24hr    56 larva L1    31 larva L2    27 larva L3 12hr old    17 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    32 larva L3 puffstage 7-9    39 white prepupae new    43 white prepupae 12hr    44 white prepupae 24hr    53 pupae 2d postWPP    26 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    44 adult female 05day    79 adult female 30day    81 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    126 embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    121 wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4  (126) embryonic 1182-4H  (37) embryonic GM2  (31) embryonic Kc167  (60) embryonic S1  (42) embryonic S3  (75) leg disc CME L1  (75) wing disc CME-W2  (59) wing disc ML-DmD8  (61) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (81) wing disc ML-DmD21  (121) wing disc ML-DmD32  (55) haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (49) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (66) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (73) ovary fGS/OSS    22 ovary OSC  (46) ovary OSS  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4  (126) embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21  (121) wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    126 embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    121 wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    126 embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    121 wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (74) Schneider line 2 Sg4  (126) embryonic 1182-4H  (37) embryonic GM2  31 embryonic Kc167  (60) embryonic S1  (42) embryonic S3  (75) leg disc CME L1  (75) wing disc CME-W2  (59) wing disc ML-DmD8  (61) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (81) wing disc ML-DmD21  (121) wing disc ML-DmD32  (55) haltere disc ML-DmD17-c3  (55) eye-antennal disc ML-DmD11  (49) antennal disc ML-DmD20-c5  (61) mixed discs ML-DmD4-c1  (66) CNS ML-DmBG1-c1  (50) CNS ML-DmBG2-c2  (54) tumorous blood cells mbn2  (73) ovary fGS/OSS    22 ovary OSC  (46) ovary OSS  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4  126 embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21  121 wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    74 Schneider line 2 Sg4    126 embryonic 1182-4H    37 embryonic GM2    31 embryonic Kc167    60 embryonic S1    42 embryonic S3    75 leg disc CME L1    75 wing disc CME-W2    59 wing disc ML-DmD8    61 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    81 wing disc ML-DmD21    121 wing disc ML-DmD32    55 haltere disc ML-DmD17-c3    55 eye-antennal disc ML-DmD11    49 antennal disc ML-DmD20-c5    61 mixed discs ML-DmD4-c1    66 CNS ML-DmBG1-c1    50 CNS ML-DmBG2-c2    54 tumorous blood cells mbn2    73 ovary fGS/OSS    22 ovary OSC    46 ovary OSS    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult  (30) Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  (30) Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult  30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (42) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (50) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (38) Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult  (36) Paraquat 10 mM 48 hrs, 4-day adult  30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    23 cold shock, 4-day adult    19 heat shock, 4-day adult    30 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    18 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    42 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    22 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    50 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    38 Caffeine 25 mg/ml 48 hrs, 4-day adult    20 Paraquat 5 mM 48 hrs, 4-day adult    36 Paraquat 10 mM 48 hrs, 4-day adult    30 Rotenone 2 μg 12 hrs, larvae L3    16 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD46359 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028554 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10203-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive x16k00230 viable x16CB03248 x16EY09353 viable, with Scer\GAL4pnr-MD237 x16GD6898 Sterility Allele fertile x16EY09353 Other Phenotypes Allele visible, with Scer\GAL4GMR.PF x16Scer\UAS.cXa visible, with Scer\GAL4pnr-MD237 x16GD6898 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF x16Scer\UAS.cXa trichogen cell, with Scer\GAL4pnr-MD237 x16GD6898
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of x16 Class Mutagen Stocks Known lesion x16k00230 P-element activity 2 -- x16EY09353 P-element activity 1 -- x16NP0786 1 -- x16SH1297 1 -- x16CB03248 P-element activity 0 Yes x16SH1176 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of x16 Class Mutagen Stocks Known lesion x16GD6898 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes x16KK107171 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes x16NIG.10203R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes x16Scer\UAS.cXa 0 -- x16T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes x16ΔRRM.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes x16ΔRS.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.10203R} NA P{UAS-x16.X} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}x16k00230 No P{lacW}x16SH1176 No P{lacW}x16SH1297 No insertion of mobile activating element P{EPgy2}x16EY09353 NA P{Mae-UAS.6.11}B1511B1511 NA insertion of enhancer trap binary system P{GawB}x16NP0786 No miscellaneous insertions P{PTT-GB}x16CB03248 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Trn-SR (Allemand et al., 2002)
Biological Process
CV term Evidence References
RNA splicing inferred from physical interaction with CG7564, Doa, Rbp1 (Wan et al., 2008)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) nucleus inferred from direct assay (Allemand et al., 2002, Wan et al., 2008) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000, Hirota et al., 2003) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504, InterPro:IPR001878, InterPro:IPR013084 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-) RNA binding inferred from sequence model (Vorbruggen et al., 2000) zinc ion binding inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR013084 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA splice site selection inferred from sequence or structural similarity with NCBI:NP_006267 (Mount and Salz, 2000) mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity with human SFRS3 (Vorbruggen et al., 2000) inferred from sequence or structural similarity with NCBI:NP_006267 (Mount and Salz, 2000) non-traceable author statement (Vorbrueggen, 1999.9.14, Bourbon, 2000.2.9) nervous system development non-traceable author statement (Hirota et al., 2003)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Vorbrueggen, 1999.9.14) spliceosomal complex non-traceable author statement (Vorbrueggen, 1999.9.14, Bourbon, 2000.2.9)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions x16 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028554 DroID - A comprehensive database of gene and protein interactions. • FBgn0028554 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33967
Orthologs
OrthoDB Orthologs (91) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FXRV8 Dipteran inclusive ortholog search EOG6HQDTX Insect inclusive ortholog search EOG6THTQZ Arthropod inclusive ortholog search EOG60P2QM Metazoa inclusive ortholog search EOG6M0SWZ
Orthologs in Drosophila Species (EOG6FXRV8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\x16     Drosophila sechellia   Dsec\GM13734 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA30013
Orthologs in non-Drosophila Dipterans (EOG6HQDTX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL017082   Anopheles gambiae Malaria mosquito  Agam\AGAP008303   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013237
Orthologs in non-Dipteran Insects (EOG6THTQZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB40798   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033202   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21195   Atta cephalotes Leafcutter ant  Acep\ACEP26708   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13822   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17163   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22063   Solenopsis invicta Red fire ant  Sinv\SINV14455   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002998   Bombyx mori Silkmoth  Bmor\BGIBMGA010396   Pediculus humanus Human body louse  Phum\PHUM241330   Pediculus humanus Human body louse  Phum\PHUM284060   Tribolium castaneum Red flour beetle  Tcas\TC010640
Orthologs in non-Insect Arthropods (EOG60P2QM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Clic6 Y Daphnia pulex Water flea  Dpux\POP5 Y Ixodes scapularis Deer tick  Isca\ISCW006562 Y
Orthologs in non-Arthropod Metazoa (EOG6M0SWZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y57G11A.5 Y Caenorhabditis elegans Nematode  Cele\rsp-5 Y Caenorhabditis elegans Nematode  Cele\rsp-1 Y Caenorhabditis elegans Nematode  Cele\rsp-6 Y Caenorhabditis elegans Nematode  Cele\rsp-2 Y Caenorhabditis elegans Nematode  Cele\rsp-3 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016548gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016547gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024060gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025909gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008919gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003133gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002681gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002716gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005520gn Y Danio rerio Zebrafish  Drer\srsf5b Y Danio rerio Zebrafish  Drer\srsf1b Y Danio rerio Zebrafish  Drer\srsf3b Y Danio rerio Zebrafish  Drer\srsf1a Y Danio rerio Zebrafish  Drer\sfrs6 Y Danio rerio Zebrafish  Drer\srsf4 Y Danio rerio Zebrafish  Drer\srsf6a Y Danio rerio Zebrafish  Drer\srsf3a Y Danio rerio Zebrafish  Drer\srsf9 Y Danio rerio Zebrafish  Drer\srsf5a Y Danio rerio Zebrafish  Drer\DKEY-85K8.3 Y Xenopus tropicalis Western clawed frog  Xtro\srsf1 Y Xenopus tropicalis Western clawed frog  Xtro\srsf4 Y Xenopus tropicalis Western clawed frog  Xtro\srsf7 Y Xenopus tropicalis Western clawed frog  Xtro\srsf9 Y Xenopus tropicalis Western clawed frog  Xtro\srsf5 Y Xenopus tropicalis Western clawed frog  Xtro\srsf6 Y Xenopus tropicalis Western clawed frog  Xtro\srsf3 Y Xenopus tropicalis Western clawed frog  Xtro\krt5.1 Y Gallus gallus Domestic chicken  Ggal\SRSF7 Y Gallus gallus Domestic chicken  Ggal\SRSF3 Y Gallus gallus Domestic chicken  Ggal\SFRS5 Y Gallus gallus Domestic chicken  Ggal\SRSF6 Y Gallus gallus Domestic chicken  Ggal\SRSF4 Y Gallus gallus Domestic chicken  Ggal\SRSF5A Y Gallus gallus Domestic chicken  Ggal\SRSF1 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000013825 Y Mus musculus House mouse  Mmus\Srsf7 Y Mus musculus House mouse  Mmus\Srsf3 Y Mus musculus House mouse  Mmus\Gm12355 Y Mus musculus House mouse  Mmus\Srsf5 Y Mus musculus House mouse  Mmus\Srsf1 Y Mus musculus House mouse  Mmus\Srsf4 Y Mus musculus House mouse  Mmus\Srsf9 Y Mus musculus House mouse  Mmus\Srsf6 Y Rattus norvegicus Norway rat  Rnor\Srsf3 Y Rattus norvegicus Norway rat  Rnor\Srsf5 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042217 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038402 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027360 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000028626 Y Rattus norvegicus Norway rat  Rnor\Srsf1 Y Rattus norvegicus Norway rat  Rnor\LOC362264 Y Rattus norvegicus Norway rat  Rnor\Srsf9 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025091 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033319 Y Rattus norvegicus Norway rat  Rnor\Srsf4 Y Homo sapiens Human  Hsap\SRSF5 Y Homo sapiens Human  Hsap\SRSF9 Y Homo sapiens Human  Hsap\SRSF1 Y Homo sapiens Human  Hsap\SRSF6 Y Homo sapiens Human  Hsap\SFRS3 Y Homo sapiens Human  Hsap\SRSF7 Y Homo sapiens Human  Hsap\SRSF4 Y
Human Orthologs (7)
Gene OMIM HGNC Hsap\SRSF5     Hsap\SRSF9     Hsap\SRSF1     Hsap\SRSF6     Hsap\SFRS3     Hsap\SRSF7     Hsap\SRSF4
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13734
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	17561 y1 w67c23; P{EPgy2}x16EY09353 10472 y1 w67c23; P{lacW}x16k00230/CyO 29494 w*; P{lacW}x16SH1297 P{neoFRT}40A, l(2)SH1297SH1297/CyO
Kyoto	103763 w*; P{GawB}x16NP0786 / CyO 111121 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}x16k00230 P{neoFRT}40A/CyO y+
VDRC	v100226 P{KK107171}VIE-260B v31203 w1118; P{GD6898}v31203 v31202 w1118; P{GD6898}v31202/TM3
Genomic Clones ( 2 )
	BACR13J07 BACR20B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 118 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD46359
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10172 GM07743 LD02483 LD13317 LD16937 LD20430 LD32211 RE02168 RE05483 RE08448 RE08973 RE09534 RE10987 RE15389 RE16850 RE17439 RE20127 RE21206 RE26295 RE28180 RE29187 RE31992 RE32836 RE42818 RE44547 RE47541 RE51451 RE54618 RE56822 RE57957 RE60588 RE61787 RE62558 RE63122 RE65821 RE67351 RE69824 RE70232 RE71140 RE72342 RE74036 RE75184 SD13917 SD16772
Other clones	12135 14720 17837 28140 74908 105911 118174 154329 159378 191168 CK01.68C.H7 CK01.70D.A4 CK01.87A.E5 CK01.147C.E7 Dmel_dig_016437_0626_2521 Dmel_dig_017530_0613_0725 Dmel_dig_018205_0614_2720 EC052754 EK043035 EK054932 EK056334 EK068619 EK113251 EK119513 EK120820 EK125744 EK129944 EK135743 EK139114 EK201020 EK202054 EK205016 EK215117 EK224136 EK248213 EK252463 EK257852 EK262443 EK293644 IP14305 LD02992 RM05171 RM05271 RM06271 RM06371 RM06471 RM06571 RP001000752 RP001001796 RP001002136 RP001003644 RP001004143 RP001007121 RP001009930 RP001010538 RP001011787 RP001014814 RP001016921 RP001019786 RP001029004 RP001031342 RP001033252 RP001034160 RP001036354 RP001038907 RP001039217 RP001041898 RP001042106 RP001043926 RP001046039 RP001048403 RP001053400 RP001056066
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028554 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33967
Antibody Information
Other Information
Discoverer
Etymology
	Named after the mouse ortholog. (Vorbruggen et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: xl6 TN166 (Hirota, 2004.11.8)
Source for database merge of	Source for merge of: xl6 9G8 (FlyBase, 1996-) Source for merge of: xl6 anon-WO0118547.78 (FlyBase, 1996-)
Additional comments	snoRNA:nop5-x16-a is encoded in an intron of nop5 or x16. (Graveley et al., 2011) Source for merge of xl6 anon-WO0118547.78 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of xl6 9G8 was sequence comparison (date:000411). (FlyBase, 1996-)
Other Comments
	Forced xl6 expression in the larval brain with a strong Scer\GAL4 driver caused remarkable increase of the number of neuroblasts in this region. (Hirota et al., 2003) Area matching Drosophila EST AA202757 (inverted). (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164718 NM_001273239 RefSeq (Proteins) • NP_723226 NP_001260168 DDBJ / EMBL / GenBank • AA202325 AA202757 AAF43414 AAF52454 AAM11385 AC004277 AF232774 AGB92704 AI544124 AJ249466 AQ025682 AW943839 AX093954 AY095057 CAB60724 CL526106 Entrez Gene - A searchable database of RefSeq genes. • 33967 UniProtKB/TrEMBL • Q9V3V0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Zinc finger, CCHC-type (IPR001878) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD46359
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028554 DroID - A comprehensive database of gene and protein interactions. • FBgn0028554 DRSC - Results from RNAi screens. • FBgn0028554 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028554 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10203-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028554 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33967 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33967 modMine - Data generated by the modENCODE project. • FBgn0028554
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	2/30 (Roch et al., 1998) 9G8 (Kumar and Lopez, 2005, Kumar and Lopez, 2004, Mount and Salz, 2000, Bourbon, 2000.2.9, Sciabica and Hertel, 2006) anon-WO0118547.78   CG10203 (Allemand et al., 2001, Mount and Salz, 2000, Wagner et al., 2007, Grieder et al., 2007, Qin et al., 2005, Keleman et al., 2009.8.5, Herold et al., 2009, Ritson et al., 2010) d9G8 (Allemand et al., 2002, Allemand et al., 2001, Gabut et al., 2007) dx16 (Wan et al., 2008, Xu et al., 2008) Dx16 (Vorbruggen et al., 2000) Dxl6 (Xie et al., 2001, Vorbruggen et al., 2000, Vorbruggen et al., 2000, Vorbrueggen, 1999.9.14, ) dxl6 (Wagner et al., 2007) l(2)k00230 (Spradling et al., 1999, BDGP Project Members, 1994-1999, ) RBP1-like (Price et al., 2000) TN166 (Hirota, 2004.11.8, Hirota et al., 2003) x16 (Grieder et al., 2007, Ritson et al., 2010, Graveley et al., 2011) X16/9G8 (Mount and Salz, 2000) Xl6 (Lasko, 2000) xl6 (Buszczak et al., 2007, Qin et al., 2005, Graveley et al., 2011, Herold et al., 2009, Ritson et al., 2010, Japanese National Institute of Genetics, 2012.5.21) XL6 (Wagner et al., 2007)
Name Synonym	xl6
Secondary FlyBase IDs
	FBgn0022271 FBgn0040511 FBgn0061658
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Graveley et al., 2011, Nature 471(7339): 473--479 The developmental transcriptome of Drosophila melanogaster. [FBrf0213330] Show all research papers ...