FB2020_01, released Feb 12, 2020

Gene: Dmel\x16

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General Information
Symbol
Dmel\x16
Species
D. melanogaster
Name
x16 splicing factor
Annotation Symbol
CG10203
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028554
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
x16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. [Date last reviewed: 2019-09-19]
Other Summaries
Also Known As

xl6, 9G8, Dxl6, d9G8, l(2)k00230

Key Links
Genomic Location
Cytogenetic map
27C4-27C4
Sequence location
2L:6,914,301..6,920,210 [-]
Recombination map

2-23

RefSeq locus
NT_033779 REGION:6914301..6920210
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
mRNA binding
Predictions / Assertions
mRNA binding; RNA binding; zinc ion binding
Summaries
Gene Group (FlyBase)
CANONICAL SERINE AND ARGININE RICH SPLICING FACTORS -
Canonical serine and arginine rich splicing factors contain 1-2 RNA-binding motifs and an RS domain. They are involved in the recruitment of spliceosomal components, interacting with pre-mRNA exonic sequences to regulate splice site selection. (Adapted from FBrf0243536.)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\x16 or the JBrowse view of Dmel\x16 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
x16-RA
FBtr0079368
NM_164718
1707
258
x16-RB
FBtr0332328
NM_001273239
1784
257
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
x16-PA
FBpp0078996
27.9
258
12.06
NP_723226
AAF52454
x16-PB
FBpp0304606
27.7
257
12.03
NP_001260168
AGB92704
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

258 (aa)

(Vorbruggen et al., 2000)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\x16 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
mRNA binding
inferred from direct assay
(Bradley et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
mRNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000567445
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence model
(Vorbruggen et al., 2000)
zinc ion binding
inferred from electronic annotation with InterPro:IPR001878
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
regulation of alternative mRNA splicing, via spliceosome
inferred from mutant phenotype
(Bradley et al., 2015)
regulation of gene expression
inferred from mutant phenotype
(Bradley et al., 2015)
regulation of mRNA 3'-end processing
inferred from mutant phenotype
(Bradley et al., 2015)
regulation of transcriptional start site selection at RNA polymerase II promoter
inferred from mutant phenotype
(Bradley et al., 2015)
RNA splicing
(Wan et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
mRNA cis splicing, via spliceosome
inferred from biological aspect of ancestor with PANTHER:PTN000567445
(assigned by GO_Central )
(Gaudet et al., 2011)
mRNA splicing, via spliceosome
inferred from sequence or structural similarity with HGNC:10785
(Vorbruggen et al., 2000)
inferred by curator from GO:0071011,GO:0071013
(Herold et al., 2009)
regulation of alternative mRNA splicing, via spliceosome
inferred from biological aspect of ancestor with PANTHER:PTN000567445
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
nucleus
inferred from direct assay
(Wan et al., 2008, Allemand et al., 2002)
precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nuclear speck
inferred from biological aspect of ancestor with PANTHER:PTN000567445
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000567445
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
ventral thoracic disc | restricted
(Vorbruggen et al., 2000)
eye-antennal disc | restricted
(Vorbruggen et al., 2000)
embryonic stage 5 -- 11
organism | ubiquitous
(Vorbruggen et al., 2000)
embryonic stage 14 -- 16
presumptive embryonic/larval central nervous system
(Vorbruggen et al., 2000)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14 -- 16
embryonic brain
(Vorbruggen et al., 2000)
embryonic stage 11
ventral neurectoderm
(Vorbruggen et al., 2000)
third instar larval stage
wing disc | restricted
(Vorbruggen et al., 2000)
adult stage & oogenesis
nurse cell
(Vorbruggen et al., 2000)
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data

x16 transcripts are first detected during oogenesis, primarily in the nurse cells. As oogenesis proceeds, transcripts are detected in the oocyte, indicating that they are transported from the nurse cells to the oocyte. x16 transcripts are detected ubiquitously in early embryos, but localized expression is detected following the onset of zygotic expression. By embryonic stage 11 transcripts are detected in the neurectoderm and become increasingly localized to the central nervous system until the completion of embryogenesis. During larval stages, transcripts are expressed at low levels in a ubiquitous pattern, but in the imaginal discs, localized expression is noted.

(Vorbruggen et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
catalytic step 2 spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
nucleus
inferred from direct assay
(Wan et al., 2008, Allemand et al., 2002)
precatalytic spliceosome
inferred from high throughput direct assay
(Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\x16 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of x16
Transgenic constructs containing regulatory region of x16
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SRSF7
9 of 15
Yes
Yes
 
Hsap\SRSF3
8 of 15
No
Yes
 
Hsap\BBS1
1 of 15
No
No
Hsap\HNRNPC
1 of 15
No
No
 
Hsap\NONO
1 of 15
No
No
Hsap\PSPC1
1 of 15
No
No
 
Hsap\RBM4B
1 of 15
No
No
Hsap\RBM4
1 of 15
No
No
 
Hsap\RBM14-RBM4
1 of 15
No
No
Hsap\RBM15B
1 of 15
No
No
Hsap\RBM15
1 of 15
No
No
Hsap\SFPQ
1 of 15
No
No
Hsap\SPEN
1 of 15
No
No
Hsap\SRSF4
1 of 15
No
No
Hsap\SRSF5
1 of 15
No
No
Hsap\SRSF6
1 of 15
No
No
 
Hsap\SRSF9
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Srsf7
9 of 15
Yes
Yes
Mmus\Srsf3
7 of 15
No
No
Mmus\Gm21992
1 of 15
No
No
Mmus\Nono
1 of 15
No
No
Mmus\Pspc1
1 of 15
No
No
Mmus\Rbm4b
1 of 15
No
No
Mmus\Rbm4
1 of 15
No
No
Mmus\Rbm15b
1 of 15
No
No
Mmus\Rbm15
1 of 15
No
No
Mmus\Sfpq
1 of 15
No
No
Mmus\Spen
1 of 15
No
No
Mmus\Srsf4
1 of 15
No
No
Mmus\Srsf5
1 of 15
No
No
Mmus\Srsf6
1 of 15
No
No
Mmus\Srsf9
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
Rnor\Srsf7
9 of 13
Yes
Yes
Rnor\Srsf3
8 of 13
No
Yes
Rnor\Nono
1 of 13
No
No
Rnor\Pspc1
1 of 13
No
No
Rnor\Rbm4b
1 of 13
No
No
Rnor\Rbm4
1 of 13
No
No
Rnor\Rbm14
1 of 13
No
No
Rnor\Rbm15b
1 of 13
No
No
Rnor\Rbm15
1 of 13
No
No
Rnor\Srsf1
1 of 13
No
No
Rnor\Srsf4
1 of 13
No
No
Rnor\Srsf5
1 of 13
No
No
Rnor\Srsf6
1 of 13
No
No
Rnor\Srsf9
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\srsf3
6 of 12
Yes
Yes
Xtro\srsf7
5 of 12
No
Yes
Xtro\rbm4b
1 of 12
No
No
Xtro\rbm15
1 of 12
No
No
Xtro\sfpq
1 of 12
No
No
Xtro\srsf5
1 of 12
No
No
Danio rerio (Zebrafish) (19)
Drer\srsf7a
9 of 15
Yes
Yes
Drer\srsf3a
8 of 15
No
Yes
Drer\srsf3b
7 of 15
No
No
Drer\srsf7b
3 of 15
No
No
Drer\nono
1 of 15
No
No
Drer\pspc1
1 of 15
No
No
Drer\rbm4.2
1 of 15
No
No
Drer\rbm4.3
1 of 15
No
No
Drer\rbm14b
1 of 15
No
No
Drer\rbm15
1 of 15
No
No
Drer\sfpq
1 of 15
No
No
Drer\spen
1 of 15
No
No
Drer\srsf1a
1 of 15
No
No
Drer\srsf4
1 of 15
No
No
Drer\srsf5a
1 of 15
No
No
Drer\srsf5b
1 of 15
No
No
Drer\srsf9
1 of 15
No
No
Drer\ugt2a6
1 of 15
No
No
Drer\wu:fb69f10
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\rsp-6
7 of 15
Yes
No
Cele\Y57G11A.5
3 of 15
No
No
Cele\grld-1
1 of 15
No
No
Cele\nono-1
1 of 15
No
No
Cele\rnp-1
1 of 15
No
No
Cele\rsp-1
1 of 15
No
No
Cele\rsp-2
1 of 15
No
No
Cele\rsp-3
1 of 15
No
No
Cele\rsp-5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\RSZ22
7 of 9
Yes
Yes
Atha\RSZ21
6 of 9
No
Yes
Atha\RSZ22a
6 of 9
No
Yes
Atha\RS2Z32
2 of 9
No
Yes
Atha\RS2Z33
2 of 9
No
Yes
Atha\AT4G12640
1 of 9
No
No
Atha\FPA
1 of 9
No
No
Atha\RS31a
1 of 9
No
No
Atha\RS31
1 of 9
No
No
Atha\RS40
1 of 9
No
No
Atha\RS41
1 of 9
No
No
Atha\SR30
1 of 9
No
No
Atha\SR34a
1 of 9
No
No
Atha\SR34
1 of 9
No
No
Atha\SR34b
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\NAB3
1 of 15
Yes
No
Scer\NPL3
1 of 15
Yes
No
Scer\RNP1
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\mug24
1 of 12
Yes
No
Spom\SPAC222.18
1 of 12
Yes
Yes
Spom\srp1
1 of 12
Yes
No
Spom\srp2
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190J0Z )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\x16
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001440
Drosophila simulans
Dsim\GD22534
Drosophila sechellia
Dsec\GM13734
Drosophila erecta
Dere\GG23573
Drosophila yakuba
Dyak\GE18395
Drosophila ananassae
Dana\GF14472
Drosophila ananassae
Dana\GF27950
Drosophila pseudoobscura pseudoobscura
Dpse\GA30013
Drosophila willistoni
Dwil\GK24251
Drosophila virilis
Dvir\GJ17569
Drosophila mojavensis
Dmoj\GI17744
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150GW1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013387
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02933
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL017082
Anopheles darlingi
American malaria mosquito
Adar\ADAC009483
Anopheles gambiae
Malaria mosquito
Agam\AGAP008303
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013237
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NID )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010396
Bombyx mori
Silkmoth
Bmor\BGIBMGA007656
Danaus plexippus
Monarch butterfly
Dple\DPOGS208794-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201992-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004981
Heliconius melpomene
Postman butterfly
Hmel\HMEL004917
Apis florea
Little honeybee
Aflo\2850085860
Apis florea
Little honeybee
Aflo\5192553636
Apis florea
Little honeybee
Aflo\2473702788
Apis mellifera
Western honey bee
Amel\GB40798
Apis mellifera
Western honey bee
Amel\GB50718
Apis mellifera
Western honey bee
Amel\GB47741
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24003
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22759
Bombus terrestris
Buff-tailed bumblebee
Bter\15208497
Bombus terrestris
Buff-tailed bumblebee
Bter\15215273
Linepithema humile
Argentine ant
Lhum\LH18882
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0008da
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000bc5
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG033202
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG022298
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04326
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01603
Tribolium castaneum
Red flour beetle
Tcas\TC010640
Tribolium castaneum
Red flour beetle
Tcas\TC004361
Pediculus humanus
Human body louse
Phum\PHUM565080
Pediculus humanus
Human body louse
Phum\PHUM241330
Pediculus humanus
Human body louse
Phum\PHUM284060
Pediculus humanus
Human body louse
Phum\PHUM357390
Rhodnius prolixus
Kissing bug
Rpro\RPRC006998
Rhodnius prolixus
Kissing bug
Rpro\RPRC011376
Cimex lectularius
Bed bug
Clec\CLEC006061
Cimex lectularius
Bed bug
Clec\CLEC002820
Cimex lectularius
Bed bug
Clec\CLEC003561
Cimex lectularius
Bed bug
Clec\CLEC012802
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006120
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006320
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002998
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18197
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07036
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0MR9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR014846
Strigamia maritima
European centipede
Smar\SMAR013742
Ixodes scapularis
Black-legged tick
Isca\ISCW006562
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74863.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73334.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g13690
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304081
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51367
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G17YQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_34
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfrs7l
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfrs7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Sfrs3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_1408
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011663
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003530
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023459
Gallus gallus
Domestic chicken
Ggal\SRSF7
Gallus gallus
Domestic chicken
Ggal\SRSF3
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013825
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rbp1-like
6 of 10
Rbp1
6 of 10
Rsf1
5 of 10
B52
2 of 10
lark
2 of 10
SF2
2 of 10
CG3335
1 of 10
CG5213
1 of 10
CG14230
1 of 10
nito
1 of 10
nonA-l
1 of 10
nonA
1 of 10
SC35
1 of 10
spen
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    x16GD6898
    ameliorates  neurodegenerative disease
    modeled by TER94R152H.UAS.R
    (Ritson et al., 2010)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SRSF7; serine and arginine rich splicing factor 7
    9 of 15
    600572
         
        SRSF3; serine and arginine rich splicing factor 3
        8 of 15
        603364
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            x16 - CG7564
            pull down, western blot, two hybrid
            (Wan et al., 2008)
            x16 - Doa
            enzymatic study, autoradiography, two hybrid, pull down, western blot
            (Wan et al., 2008)
            x16 - Rbp1
            pull down, western blot, two hybrid
            (Wan et al., 2008)
            x16 - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            TER94
            suppressible
            x16
            (Ritson et al., 2010)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-23

            Cytogenetic map
            27C4-27C4
            Sequence location
            2L:6,914,301..6,920,210 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            27C4-27C4
            Limits computationally determined from genome sequence between P{PZ}Rca103300&P{lacW}l(2)k09022k09022 and P{lacW}xl6k00230&P{EP}Hrb27CEP748
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            27C4-27C5
            (Bourbon, 2000.2.9, Vorbrüggen, 1999.9.14)
            27C4-27C5
            (determined by in situ hybridisation)
            (Spradling et al., 1999, BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            2-23

            (FlyBase, 2016)

            2-22.2

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (20)
            cDNA Clones (117)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: xl6 TN166

              (Hirota, 2004.11.8)
              Source for database merge of

              Source for merge of: xl6 9G8

              (FlyBase, 1996-)

              Source for merge of: xl6 anon-WO0118547.78

              (FlyBase, 1996-)
              Additional comments

              snoRNA:nop5-x16-a is encoded in an intron of nop5 or x16.

              (Graveley et al., 2011)

              Source for merge of xl6 9G8 was sequence comparison ( date:000411 ).

              (FlyBase, 1996-)

              Source for merge of xl6 anon-WO0118547.78 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Other Comments

              Forced xl6 expression in the larval brain with a strong Scer\GAL4 driver caused remarkable increase of the number of neuroblasts in this region.

              (Hirota et al., 2003)

              Area matching Drosophila EST AA202757 (inverted).

              (Davies, 2001.3.15)
              Origin and Etymology
              Discoverer
              Etymology

              Named after the mouse ortholog.

              (Vorbruggen et al., 2000)
              Identification
              External Crossreferences and Linkouts ( 51 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DPiM - Drosophila Protein interaction map
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (19)
              Reported As
              Symbol Synonym
              2/30
              (Roch et al., 1998)
              9G8
              (Tang et al., 2018, Pons et al., 2017, Sciabica and Hertel, 2006, Kumar and Lopez, 2005, Kumar and Lopez, 2004, Bourbon, 2000.2.9, Mount and Salz, 2000)
              CG10203
              (Kolkhof et al., 2017, Çiçek et al., 2016, Brooks et al., 2015, Ni et al., 2010.12.1, Ritson et al., 2010, Herold et al., 2009, Keleman et al., 2009.8.5, Grieder et al., 2007, Wagner et al., 2007, Qin et al., 2005, Allemand et al., 2001, Mount and Salz, 2000)
              Dx16
              (Vorbruggen et al., 2000)
              Dxl6
              (Xie et al., 2001, Vorbruggen et al., 2000, Vorbruggen et al., 2000, Vorbrüggen, 1999.9.14)
              RBP1-like
              (Price et al., 2000)
              TN166
              (Hirota, 2004.11.8, Hirota et al., 2003)
              X16
              (Ustaoglu et al., 2019, Ng et al., 2016, Kwong et al., 2015, He et al., 2014, Saccone et al., 2014)
              X16/9G8
              (Mount and Salz, 2000)
              XL6
              (Zhang et al., 2018, Bradley et al., 2015, Wagner et al., 2007)
              Xl6
              (Lasko, 2000)
              anon-WO0118547.78
              d9G8
              (Gabut et al., 2007, Allemand et al., 2002, Allemand et al., 2001)
              dx16
              (Wan et al., 2008, Xu et al., 2008)
              dxl6
              (Wagner et al., 2007)
              l(2)k00230
              (Spradling et al., 1999, BDGP Project Members, 1994-1999)
              x16
              (Fingerhut et al., 2019, Gene Disruption Project members, 2018-, Clandinin and Owens, 2016-, Lee et al., 2016, Sarov et al., 2016, Brooks et al., 2015, Kwong et al., 2015, Zabidi et al., 2015, Olesnicky et al., 2014, Sopko et al., 2014, Kwon et al., 2013, Graveley et al., 2011, Ritson et al., 2010, Grieder et al., 2007)
              xl6
              (Sen and Cox, 2016, Tikhonov et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Graveley et al., 2011, Ritson et al., 2010, Herold et al., 2009, Buszczak et al., 2007, Qin et al., 2005)
              Name Synonyms
              x16 splicing factor
              xl6
              Secondary FlyBase IDs
              • FBgn0022271
              • FBgn0040511
              • FBgn0061658
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (87)