Apparent introns not annotated: probable artifacts due to repetitive sequence.
Low-frequency RNA-Seq exon junction(s) not annotated.
Most of large exon composed of repeat unit.
Gene model reviewed during 5.45
Gene model reviewed during 5.55
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\prc using the Feature Mapper tool.
prc was shown to be expressed through development by northern blots with the highest levels in embryos and first and second instar larvae. From stage 13 onwards, it is expressed in cardioblasts and pericardial cells as well as in oenocytes. Expression is also observed in the ring gland.
prc protein is found predominantly along the basal side of cardial cells (cardiomyocytes). It colocalizes with loh protein. It forms an integral part of the basal cardiac extracellular matrix. In larvae, it is mainly produced in the fat body. prc is locally produced by cardiac cells in embryos but in later stages is mostly secreted by the fat body.
prc is located around the periphery of pericardial cells and at the the basal surface of the cardioblasts in close proximity to the ectoderm in embryonic stages 14,15. It is particularly abundant at the boundary between the cardioblasts and the dorsal epithelium. It is also expressed in two of every six cardial cells that correspond to the svp-expressing cells and in the attachment sites to the alary muscles. By stage 17, prc is detectable only in the extracellular space around the pericardial cells and on the basal surface of cardiomyocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\prc in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The expression pattern of the "Mab3" epitope is identical to the expression pattern recognised by the "EC11" antibody (which recognises "prc"), so it is possible that the "Mab3" epitope corresponds to part of the "prc" protein (although this has not been tested).