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Gene Dmel\phtf

General Information
Symbol	Dmel\phtf	Species	D. melanogaster
Name	phtf	Annotation symbol	CG3268
Feature type	protein_coding_gene	FlyBase ID	FBgn0028579
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42C7-42C7	Sequence location	2R:2,629,372..2,633,649 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene phtf is referred to in FlyBase by the symbol Dmel\phtf (CG3268, FBgn0028579). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcription factor homeodomain, male germ-cell. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641378_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of phtf. Gene sequence location is 2R:2629372..2633649.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN21504 HFA05023
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42C7-42C7   Limits computationally determined from genome sequence between P{lacW}geminink14019&P{PZ}Adf101349 and P{lacW}ublk03203&P{PZ}CG328709967
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42C8-42C9     (Raich, 1999.6.7)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\phtf for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) phtf-RA FBtr0086125  NM_136388   3371   880
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein phtf-PA   FBpp0085459   97.6   880   8.45     NP_610232   AAM70823
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor homeodomain, male germ-cell (IPR021980)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202846   AA263972   AA438545   AA940685   AA952263   AE013599 AAM70823   AF181638 AAD55424   AI061666   AI107893   AI109438   AI402141   AI404237   AI945847   AJ242938 CAB62168   BE662028   BE975001   BF485737   BF491511   BF499494   BF500761   BF501427   BF502554   BF503236   BF503852   BF503869   BF504474   BF504814   BF505128   BF505230   BF505271   BG637769   BH759584   BI238552   BI242186   BI356382   BI486195   BI640396   CO189119   CO274075   CO275805   CO281396   CO283363   CO295441   CO299615   CO309689   CO318441   CO318850   CO322348   CO333639   CZ483736   CZ483737   CZ485818   EC052244   EC053832   EC054765   EC054866   EC055329   EC064216   EC064670   EC078278   EC082887   EC085184   EC195411   EC199434   EC201946   EC206412   EC223236   EC232553   EC239894   EC245362   EC246484   EV591742   GH748816   GH756263   GH757170   GH759919   GH772851   GH775057   GH775452   GH775597   GH776954   GH781376   GH782591   GH793523   GH795843   GH806139   GH807374   GH813662   GH819134   GH823917   GH828913   GH829453   GH838579   GH842012   GH842959   GH844298   GH852589   GH854842   GH860543   GH861164   GH861498   GH866239   GH866720   GH867729   GH868023   GH870070   GH872542   GH875276   GH879899   GH886068   GH886522   GH892379   GH894195   GH896102   GH896375   GH897431   GH900334   GH902297   GH904493   GH905897   GH905924   GH908279   GH910404   GH911987   GH912553   GH917544   GH920162   GH920400   GH927986   GH932971   GH935746
UniProtKB/Swiss-Prot	Q9V9A8
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   male germline stem cell   (Yanicostas and Raich, 2003.2.3)
Additional Descriptive Data
	Expression in wild-type and tud males compared by Northern blot (tud animals lack germline cells). Expression almost imperceptible in tud males, supporting conclusion that it is restricted to germline cells in wild-type. (Yanicostas and Raich, 2003.2.3)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028579    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028579 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028579 expression level Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2534) embryo 02-04hr  (2832) embryo 04-06hr  (1637) embryo 06-08hr  (1472) embryo 08-10hr  (1645) embryo 10-12hr  (1380) embryo 12-14hr  (2231) embryo 14-16hr  (2662) embryo 16-18hr  (1498) embryo 18-20hr  (797) embryo 20-22hr  (1096) embryo 22-24hr  (1257) larva L1  (643) larva L2  (628) larva L3 12hr old  (434) larva L3 puffstage 1-2  (627) larva L3 puffstage 3-6  (1028) larva L3 puffstage 7-9  (1114) white prepupae new  (1174) white prepupae 12hr  (1772) white prepupae 24hr  (2142) pupae 2d postWPP  (2800) pupae 3d postWPP  (2135) pupae 4d postWPP  (4140) adult male 01day  (3676) adult male 05day  (4571) adult male 30day  (4313) adult female 01day  (1112) adult female 05day  (1536) adult female 30day  (1573) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2534) embryo 02-04hr  (2832) embryo 04-06hr  (1637) embryo 06-08hr  1472 embryo 08-10hr  (1645) embryo 10-12hr    1380 embryo 12-14hr  (2231) embryo 14-16hr  (2662) embryo 16-18hr  1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr  (1772) white prepupae 24hr  (2142) pupae 2d postWPP  (2800) pupae 3d postWPP  (2135) pupae 4d postWPP  (4140) adult male 01day  (3676) adult male 05day  (4571) adult male 30day  (4313) adult female 01day    1112 adult female 05day  (1536) adult female 30day  (1573) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028579 expression level Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2534) embryo 02-04hr  (2832) embryo 04-06hr  (1637) embryo 06-08hr  (1472) embryo 08-10hr  (1645) embryo 10-12hr  (1380) embryo 12-14hr  (2231) embryo 14-16hr  (2662) embryo 16-18hr  (1498) embryo 18-20hr  (797) embryo 20-22hr  (1096) embryo 22-24hr  (1257) larva L1  (643) larva L2  (628) larva L3 12hr old  (434) larva L3 puffstage 1-2  (627) larva L3 puffstage 3-6  (1028) larva L3 puffstage 7-9  (1114) white prepupae new  (1174) white prepupae 12hr  (1772) white prepupae 24hr  (2142) pupae 2d postWPP  (2800) pupae 3d postWPP  (2135) pupae 4d postWPP  (4140) adult male 01day  (3676) adult male 05day  (4571) adult male 30day  (4313) adult female 01day  (1112) adult female 05day  (1536) adult female 30day  (1573) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2534) embryo 02-04hr  (2832) embryo 04-06hr  1637 embryo 06-08hr  1472 embryo 08-10hr  1645 embryo 10-12hr    1380 embryo 12-14hr  2231 embryo 14-16hr  (2662) embryo 16-18hr  1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr  1772 white prepupae 24hr  2142 pupae 2d postWPP  (2800) pupae 3d postWPP  2135 pupae 4d postWPP  (4140) adult male 01day  (3676) adult male 05day  (4571) adult male 30day  (4313) adult female 01day    1112 adult female 05day  1536 adult female 30day  1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2534 embryo 02-04hr    2832 embryo 04-06hr    1637 embryo 06-08hr    1472 embryo 08-10hr    1645 embryo 10-12hr    1380 embryo 12-14hr    2231 embryo 14-16hr    2662 embryo 16-18hr    1498 embryo 18-20hr    797 embryo 20-22hr    1096 embryo 22-24hr    1257 larva L1    643 larva L2    628 larva L3 12hr old    434 larva L3 puffstage 1-2    627 larva L3 puffstage 3-6    1028 larva L3 puffstage 7-9    1114 white prepupae new    1174 white prepupae 12hr    1772 white prepupae 24hr    2142 pupae 2d postWPP    2800 pupae 3d postWPP    2135 pupae 4d postWPP    4140 adult male 01day    3676 adult male 05day    4571 adult male 30day    4313 adult female 01day    1112 adult female 05day    1536 adult female 30day    1573 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028579    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028579 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028579 expression level Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028579 expression level Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    165.95 Larval Midgut    113.5 Larval Hindgut    115.6 Larval Malpighian Tubules    100.7 Larval Fat Body    145.3 Larval Salivary Gland    97.4 Larval Trachea    106.675 Larval Carcass    91.95 Adult Head    180.4 Adult Eye    285.8 Adult Brain    430.1 Adult Thoracic-Abdominal Ganglion    381.2 Adult Crop    120.9 Adult Midgut    82 Adult Hindgut    116.3 Adult Malpighian Tubules    98.8 Adult Fat Body    164.6 Adult Salivary Gland    185 Adult Heart    196.8 Adult VirginFemale Spermatheca    180 Adult InseminatedFemale Spermatheca    184 Adult Ovary    283.9 Adult Testis    410.5 Adult Male Accessory Gland    107.1 Adult Carcass    123.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    180.4   NA  Eye    285.8   NA  Brain    430.1   165.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    381.2   NA  Crop    120.9   113.5  Midgut    82   115.6  Hindgut    116.3   100.7  Malpighian Tubules    98.8   145.3  Fat Body    164.6   97.4  Salivary Gland    185   NA  Heart    196.8   106.675  Trachea    NA   NA  VirginFemale Spermatheca    180   NA  InseminatedFemale Spermatheca    184   NA  Ovary    283.9   NA  Testis    410.5   NA  Male Accessory Gland    107.1   91.95  Carcass    123.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028579 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3268-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for phtf Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 phtfGD1833 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of phtf Class Mutagen Stocks Known lesion phtff01263 piggyBac transposase 1 -- phtff03278 piggyBac transposase 1 -- phtfKG05190 P-element activity 1 -- phtfGS7145 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of phtf Class Mutagen Stocks Known lesion phtfGD1833 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes phtfKK101453 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6050 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1833} NA P{KK101453} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0531SH0531 No miscellaneous insertions P{SUPor-P}phtfKG05190 NA PBac{WH}phtff01263 NA PBac{WH}phtff03278 NA insertion of mobile activating element P{GSV2}phtfGS7145 NA insertion of enhancer trap binary system P{GawB}9-2209-220 No
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions phtf allele Gene References unspecified Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61479 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028579 DroID - A comprehensive database of gene and protein interactions. • FBgn0028579 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35583
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11068 Dere\GG23220 Dgri\GH21753 Dmoj\GI19299 Dper\GL11117 Dpse\GA17066 Dsec\GM20896 Dsim\GD10421 Dvir\GJ22176 Dwil\GK22139 Dyak\GE19073
Curated drosophilid orthologs	Dpse\GA17066
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010838-PA Aedes aegypti (mosquito) AGAP006451-PA Anopheles gambiae (mosquito) XP_624274.2 Apis mellifera (honey bee) BGIBMGA000001-PA Bombyx mori (silk worm) ENSBTAP00000006730 Bos taurus (bovine) ENSCAFP00000006473 Canis familiaris (dog) CPIJ017151 Culex pipens (mosquito) ENSCPOP00000003230 Cavia porcellus (guinea pig) 227509 Capitella spl (polychaete worm) ENSDARP00000074802 Danio rerio (zebra fish) ENSECAP00000006888 Equus caballus (horse) ENSGACP00000025980 Gymnopilus aculeatus (mushroom) ENSGALP00000038897 Gallus gallus (chicken) ENSP00000248550 Homo sapiens (human) ENSMODP00000000962 Monodelphis domestica (gray opossum) ENSMMUP00000011798 Macaca mulatta (rhesus monkey) ENSMUSP00000114087 Mus musculus (house mouse) XP_001606308.1 Nasonia vitripennis (wasp) ENSOANP00000023722 Ornithorynchus anatinus (platypus) ENSORLP00000017143 Oryzias latipes (japanese killifish) PHUM000181-PA Pediculus humanus (human body louse) ENSPPYP00000001178 Pongo pygmaeus (orangutan) 73848 Phytophthora ramorum (sudden oak death pathogen) 127780 Phytophthora sojae (root rot pathogen) ENSPTRP00000033081 Pan troglodytes (chimpanzee) ENSRNOP00000018494 Rattus norvegicus (norway rat) XP_973928.2 Tribolium castaneum (red flour beetle) ENSTNIP00000021784 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027311 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042706 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13698 NV12539 LH19984 ISCW009148 FBgn0236434 FBgn0224124 FBgn0209289 FBgn0182192 FBgn0175777 JGI_V11_217520 JGI_V11_8633 FBgn0077080 FBgn0148727 FBgn0142038 FBgn0129214 FBgn0115371 FBgn0088108 CPIJ017151 CPIJ020130 BGIBMGA000001 GB11475 GB10270 AGAP006451 AAEL012375 AAEL010838 PHUM128970 GLEAN_01020
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	13880 y1 w67c23; P{SUPor-P}phtfKG05190
Harvard	- PBac{WH}phtff01263 - PBac{WH}phtff03278
VDRC	v103578 P{KK101453}VIE-260B v3988 w1118; P{GD1833}v3988 v3989 w1118; P{GD1833}v3989
Genomic Clones ( 1 )
	BACR07J20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 123 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08636
Other clones	DPiM_GH08636
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05069 AT05088 AT05841 AT06844 AT07295 AT07414 AT07461 AT14059 AT15783 AT16753 AT18222 AT19177 AT19693 AT28267 GH05774 GH23873 LD06589 LD12344 LD22773 LD29375 LD33740 RE35041 RE39456 RE42513 RE69585 SD23239
Other clones	11989 42284 43690 50153 58841 62720 79767 84085 99031 167095 282157 bs09h04 bs17e08 bs37e07 CK01.28D.C6 CK01.53B.G4 CK01.144A.G11 Dmel_neb_011976_0376_1836 EC052244 EC053832 EC054765 EC054866 EC055329 EK043058 EK113045 EK118726 EK157042 EK162938 EK175938 EK187938 EK209840 EK218916 EK272141 EK274506 EK307524 LD03175 RP003030545 RP003031164 RP003033509 RP003044385 RP003046724 RP003047513 RP003068077 RP003069360 RP003083933 RP003102281 RP003105558 RP003137501 RP003138416 RP003147355 RP003148168 RP003148524 RP003161688 RP003162520 RP003173148 RP003192640 RP003194377 RP003196178 RP003200494 RP003211859 RP003217648 RP003228020 RP003237653 RP003240261 RP003259510 RP003266068 RP003272134 RP003272930 RP003291062 RP003291970 RP003294687 RP003302966 RP003323346 RP003329536 RP003334634 RP003345808 RP003347048 RP003359840 RP003405262 RP003414798 RP003500572 RP003502987 RP003514838 RP003519448 RP003533807 RP003541909 RP003544490 RP003555952 RP003563863 RP003590589 RP003601183 RP003630015 RP003654435 RP003659663 RP003666004
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028579 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35583
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: phtf BcDNA:GH08636 (FlyBase, 1996-)
Additional comments	"phtf" may correspond to "Scim22". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim22" near/in "phtf". (Dobie and Karpen, 2001.4.18) Source for merge of phtf BcDNA:GH08636 was sequence comparison (date:991227). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136388 RefSeq (Proteins) • NP_610232 DDBJ / EMBL / GenBank • AA202846 AA940685 AAD55424 AAM70823 AF181638 AI109438 AI402141 AI945847 AJ242938 BE662028 BH759584 CAB62168 CZ483736 CZ483737 CZ485818 Entrez Gene - A searchable database of RefSeq genes. • 35583 UniProtKB/Swiss-Prot • Q9V9A8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor homeodomain, male germ-cell (IPR021980)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61479 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028579 DroID - A comprehensive database of gene and protein interactions. • FBgn0028579 DRSC - Results from RNAi screens. • FBgn0028579 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028579 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3268-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028579 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35583 InParanoid A subset of ortholog calls from InParanoid. • AAEL010838-PA Aedes aegypti (mosquito) AGAP006451-PA Anopheles gambiae (mosquito) XP_624274.2 Apis mellifera (honey bee) BGIBMGA000001-PA Bombyx mori (silk worm) ENSBTAP00000006730 Bos taurus (bovine) ENSCAFP00000006473 Canis familiaris (dog) CPIJ017151 Culex pipens (mosquito) ENSCPOP00000003230 Cavia porcellus (guinea pig) 227509 Capitella spl (polychaete worm) ENSDARP00000074802 Danio rerio (zebra fish) ENSECAP00000006888 Equus caballus (horse) ENSGACP00000025980 Gymnopilus aculeatus (mushroom) ENSGALP00000038897 Gallus gallus (chicken) ENSP00000248550 Homo sapiens (human) ENSMODP00000000962 Monodelphis domestica (gray opossum) ENSMMUP00000011798 Macaca mulatta (rhesus monkey) ENSMUSP00000114087 Mus musculus (house mouse) XP_001606308.1 Nasonia vitripennis (wasp) ENSOANP00000023722 Ornithorynchus anatinus (platypus) ENSORLP00000017143 Oryzias latipes (japanese killifish) PHUM000181-PA Pediculus humanus (human body louse) ENSPPYP00000001178 Pongo pygmaeus (orangutan) 73848 Phytophthora ramorum (sudden oak death pathogen) 127780 Phytophthora sojae (root rot pathogen) ENSPTRP00000033081 Pan troglodytes (chimpanzee) ENSRNOP00000018494 Rattus norvegicus (norway rat) XP_973928.2 Tribolium castaneum (red flour beetle) ENSTNIP00000021784 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027311 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042706 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35583 modMine - Data generated by the modENCODE project. • FBgn0028579 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13698 NV12539 LH19984 ISCW009148 FBgn0236434 FBgn0224124 FBgn0209289 FBgn0182192 FBgn0175777 JGI_V11_217520 JGI_V11_8633 FBgn0077080 FBgn0148727 FBgn0142038 FBgn0129214 FBgn0115371 FBgn0088108 CPIJ017151 CPIJ020130 BGIBMGA000001 GB11475 GB10270 AGAP006451 AAEL012375 AAEL010838 PHUM128970 GLEAN_01020
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	BcDNA:GH08636   BcDNA.GH08636 (Rubin, 1999.8.27) CG3268 (Kai et al., 2005, Dobie and Karpen, 2001.4.18, Laviolette et al., 2005, Keleman et al., 2009.8.5) d-phtf (Manuel et al., 2000) phtf (LaFerriere et al., 2008, Laviolette et al., 2005)
Name Synonym	phtf   putative homeodomain transcription factor (LaFerriere et al., 2008)
Secondary FlyBase IDs
	FBgn0028488
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...