• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\adat

General Information
Symbol	Dmel\adat	Species	D. melanogaster
Name	adat	Annotation symbol	CG16889
Feature type	protein_coding_gene	FlyBase ID	FBgn0028658
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	BG:DS00941.2, dADAT1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34D1-34D1	Sequence location	2L:13,808,360..13,811,472 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene adat is referred to in FlyBase by the symbol Dmel\adat (CG16889, FBgn0028658). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: tRNA-specific adenosine deaminase activity. There is experimental evidence that it is involved in the biological process: tRNA modification. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Adenosine deaminase/editase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633990_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of adat. Gene sequence location is 2L:13808360..13811472.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Catanese and Matthews, 2011, Biochem. Biophys. Res. Commun. 414(3): 506--511 Sequence features BKN27036 HFA03479
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34D1-34D1   Limits computationally determined from genome sequence between P{lacW}CG7364k07245 and P{lacW}Sosk05224&P{lacW}RpII33k05605
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34D4-34D4     (Keegan, 1999.10.6)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\adat for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) adat-RA FBtr0080573  NM_135832   3001   394
Additional Transcript Data & Comments
Reported size (kB)	4.3, 3.0 (northern blot) (Keegan et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein adat-PA   FBpp0080150   45.3   394   8.24     NP_609676   AAF53333
Additional Polypeptide Data & Comments
Reported size (kDa)	394 (aa); 44 (kD observed); 44 (kD predicted) (Keegan et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenosine deaminase/editase (IPR002466)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53333   AE003408 AAF44818   AF192530 AAF06773   GH920457   L39629
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9V3R6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Keegan et al., 2000) embryonic stage 8 -- 12   ventral neurogenic region   (Keegan et al., 2000) mesoderm   (Keegan et al., 2000) embryonic stage 13 -- 17   ventral nerve cord   (Keegan et al., 2000) embryonic brain   (Keegan et al., 2000) presumptive embryonic/larval central nervous system   (Keegan et al., 2000)
Additional Descriptive Data
	adat transcripts are maternally deposited and are present at high levels in blastoderm embryos. Expression is high in germ band extended embryos, especially in the mesoderm and neurectoderm. From germ band retraction on, transcript levels are high in the CNS (both brain and ventral nerve cord) and remain strong throughout late embryogenesis. (Keegan et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028658    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028658 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028658 expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr  (111) embryo 04-06hr  (230) embryo 06-08hr  (220) embryo 08-10hr  (207) embryo 10-12hr  (135) embryo 12-14hr  (145) embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1  (125) larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6  105 larva L3 puffstage 7-9  (193) white prepupae new  (178) white prepupae 12hr  (140) white prepupae 24hr  (168) pupae 2d postWPP  (134) pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day  (127) adult female 30day  (123) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028658 expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr  111 embryo 04-06hr  (230) embryo 06-08hr  (220) embryo 08-10hr  (207) embryo 10-12hr  135 embryo 12-14hr  (145) embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1  125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6  105 larva L3 puffstage 7-9  (193) white prepupae new  (178) white prepupae 12hr  140 white prepupae 24hr  (168) pupae 2d postWPP  134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day  127 adult female 30day  123 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    111 embryo 04-06hr    230 embryo 06-08hr    220 embryo 08-10hr    207 embryo 10-12hr    135 embryo 12-14hr    145 embryo 14-16hr    65 embryo 16-18hr    66 embryo 18-20hr    47 embryo 20-22hr    63 embryo 22-24hr    86 larva L1    125 larva L2    90 larva L3 12hr old    87 larva L3 puffstage 1-2    100 larva L3 puffstage 3-6    105 larva L3 puffstage 7-9    193 white prepupae new    178 white prepupae 12hr    140 white prepupae 24hr    168 pupae 2d postWPP    134 pupae 3d postWPP    92 pupae 4d postWPP    65 adult male 01day    89 adult male 05day    98 adult male 30day    72 adult female 01day    96 adult female 05day    127 adult female 30day    123 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028658    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028658 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028658 expression level Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028658 expression level Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    31.825 Larval Midgut    4.4 Larval Hindgut    8.2 Larval Malpighian Tubules    1.5 Larval Fat Body    2.4 Larval Salivary Gland    9.9 Larval Trachea no informative data Larval Carcass    4.125 Adult Head no informative data Adult Eye    6.6 Adult Brain    27.5 Adult Thoracic-Abdominal Ganglion    25.5 Adult Crop    8.2 Adult Midgut    6.9 Adult Hindgut    4.3 Adult Malpighian Tubules    6.4 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    1.225 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3 Adult Testis    1.9 Adult Male Accessory Gland    4.4 Adult Carcass    1.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    6.6   NA  Brain    27.5   31.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.5   NA  Crop    8.2   4.4  Midgut    6.9   8.2  Hindgut    4.3   1.5  Malpighian Tubules    6.4   2.4  Fat Body    no informative data   9.9  Salivary Gland    no informative data   NA  Heart    1.225   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    3   NA  Testis    1.9   NA  Male Accessory Gland    4.4   4.125  Carcass    1.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028658 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16889-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 adatGD9225 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of adat Class Mutagen Stocks Known lesion adatMB02177 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of adat Class Mutagen Stocks Known lesion adatGD9225 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes adatKK107036 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7059 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9225} NA P{GD10606} NA P{GD17531} NA P{KK107036} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CAH1MB02177 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
tRNA-specific adenosine deaminase activity inferred from direct assay (Keegan et al., 2000)
Biological Process
CV term Evidence References
tRNA modification inferred from direct assay (Keegan et al., 2000)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR002466 (FlyBase Curators et al., 2004-) tRNA-specific adenosine deaminase activity inferred from sequence or structural similarity (Ashburner et al., 1999) inferred from sequence or structural similarity with EMBL:AF052506 (FlyBase, 1992-) non-traceable author statement (Keegan, 1999.10.6)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions adat allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60820 DroID - A comprehensive database of gene and protein interactions. • FBgn0028658 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34787
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15620 Dere\GG10184 Dgri\GH10620 Dmoj\GI19739 Dper\GL21092 Dpse\GA14198 Dsec\GM15122 Dsim\GD22044 Dvir\GJ18090 Dwil\GK16285 Dyak\GE11448
Curated drosophilid orthologs	Dpse\GA14198
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007277-PA Aedes aegypti (mosquito) AGAP009185-PA Anopheles gambiae (mosquito) XP_001121963.1 Apis mellifera (honey bee) At1g01760.1 Arabidopsis thaliana (wall cress) 84784 Batrachochytrium dendrobatidis (chytrid fungus) 204963 Branchiostoma floridae (lancelet) BGIBMGA002445-PA Bombyx mori (silk worm) ENSBTAP00000020810 Bos taurus (bovine) CAL0002843 Candida albicans (a form of yeast) ENSCAFP00000029742 Canis familiaris (dog) CAGL0H07733g Candida glabrata (haploid yeast) ENSCINP00000015770 Ciona intestinalis (sea squirt) cn07098 Cryptococcus neoformans (yeast-like fungus) CPIJ008837 Culex pipens (mosquito) ENSCPOP00000010822 Cavia porcellus (guinea pig) ENSCSAVP00000002249 Ciona savignyi (sedentary tunicate) DDB0230177 Dictyostelium discoideum (amoeba) DEHA2F13574g Debaryomyces Hansenii (yeast) 52553 Daphnia pulex (daphnia) ENSDARP00000081844 Danio rerio (zebra fish) XP_657152 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002834 Gymnopilus aculeatus (mushroom) ENSGALP00000001334 Gallus gallus (chicken) KLLA0A00759g Kluyveromyces lactis (yeast) 231337 Lottia gigantea (owl limpet) LmjF33.0235 Leishmania major (virus) ENSMODP00000002679 Monodelphis domestica (gray opossum) ENSMMUP00000007594 Macaca mulatta (rhesus monkey) XP_001604734.1 Nasonia vitripennis (wasp) ENSORLP00000018984 Oryzias latipes (japanese killifish) LOC_Os04g58690.1 Oryza sativa (asian rice) 34474 Ostreococcus tauri (green alga) PHUM008063-PA Pediculus humanus (human body louse) 144740 Physcomitrella patens (moss) 731067 Populus trichocarpa (black cottonwood) ENSRNOP00000026309 Rattus norvegicus (norway rat) 5042692 Sorghum bicolor (sorghum) YGL243W Saccharomyces cerevisiae (budding yeast) SPBC16A3.06 Schizosaccharomyces pombe (fission yeast) XP_001189835.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201624.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967247.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011699 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007317 Takifugu rubripes (pufferfish Takifugu) 41.m00286 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000007711 Xenopus tropicalis (frog) YALI0B18436g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17141 NV15099 LH24781 ISCW021227 FBgn0229253 FBgn0218287 FBgn0205255 FBgn0193457 FBgn0170042 JGI_V11_52553 FBgn0074227 FBgn0158687 FBgn0142476 FBgn0118101 FBgn0102494 FBgn0092644 CPIJ008837 BGIBMGA002445 ACYPI46899 GB14955 AGAP009186 AGAP009185 AAEL007277 PHUM258700 GLEAN_03839
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	23422 w1118; Mi{ET1}CAH1MB02177 adatMB02177
VDRC	v101177 P{KK107036}VIE-260B v32765 w1118 P{GD9225}v32765 v32766 w1118 P{GD9225}v32766
Genomic Clones ( 2 )
	BACR16P12 BACR30I21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	RP003303020
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028658 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34787
Antibody Information
	polyclonal (Keegan et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "f04739" Exelixis line (PBac{WH}CG16865f04739) was originally assigned to the adat gene in FBrf0179797, resulting in the "adatf04739" (FBal0159517) allele. However, FBrf0184340 shows that the insertion is actually within CG16865. (Bloomington Drosophila Stock Center, 2004.11.6) "adat" probably does not correspond to "l(2)34Db", because "adat" is expected to be included in the P{Sos+.B} transgene (FBrf0057637) which fails to rescue "l(2)34Db" alleles. (Ashburner et al., 1999)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135832 RefSeq (Proteins) • NP_609676 DDBJ / EMBL / GenBank • AAF06773 AAF44818 AAF53333 AE003408 AF192530 L39629 Entrez Gene - A searchable database of RefSeq genes. • 34787 UniProtKB/TrEMBL • Q9V3R6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenosine deaminase/editase (IPR002466)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60820 DroID - A comprehensive database of gene and protein interactions. • FBgn0028658 DRSC - Results from RNAi screens. • FBgn0028658 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028658 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16889-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028658 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34787 InParanoid A subset of ortholog calls from InParanoid. • AAEL007277-PA Aedes aegypti (mosquito) AGAP009185-PA Anopheles gambiae (mosquito) XP_001121963.1 Apis mellifera (honey bee) At1g01760.1 Arabidopsis thaliana (wall cress) 84784 Batrachochytrium dendrobatidis (chytrid fungus) 204963 Branchiostoma floridae (lancelet) BGIBMGA002445-PA Bombyx mori (silk worm) ENSBTAP00000020810 Bos taurus (bovine) CAL0002843 Candida albicans (a form of yeast) ENSCAFP00000029742 Canis familiaris (dog) CAGL0H07733g Candida glabrata (haploid yeast) ENSCINP00000015770 Ciona intestinalis (sea squirt) cn07098 Cryptococcus neoformans (yeast-like fungus) CPIJ008837 Culex pipens (mosquito) ENSCPOP00000010822 Cavia porcellus (guinea pig) ENSCSAVP00000002249 Ciona savignyi (sedentary tunicate) DDB0230177 Dictyostelium discoideum (amoeba) DEHA2F13574g Debaryomyces Hansenii (yeast) 52553 Daphnia pulex (daphnia) ENSDARP00000081844 Danio rerio (zebra fish) XP_657152 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000002834 Gymnopilus aculeatus (mushroom) ENSGALP00000001334 Gallus gallus (chicken) KLLA0A00759g Kluyveromyces lactis (yeast) 231337 Lottia gigantea (owl limpet) LmjF33.0235 Leishmania major (virus) ENSMODP00000002679 Monodelphis domestica (gray opossum) ENSMMUP00000007594 Macaca mulatta (rhesus monkey) XP_001604734.1 Nasonia vitripennis (wasp) ENSORLP00000018984 Oryzias latipes (japanese killifish) LOC_Os04g58690.1 Oryza sativa (asian rice) 34474 Ostreococcus tauri (green alga) PHUM008063-PA Pediculus humanus (human body louse) 144740 Physcomitrella patens (moss) 731067 Populus trichocarpa (black cottonwood) ENSRNOP00000026309 Rattus norvegicus (norway rat) 5042692 Sorghum bicolor (sorghum) YGL243W Saccharomyces cerevisiae (budding yeast) SPBC16A3.06 Schizosaccharomyces pombe (fission yeast) XP_001189835.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201624.1 Strongylocentrotus purpuratus (purple sea urchin) XP_967247.2 Tribolium castaneum (red flour beetle) ENSTNIP00000011699 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007317 Takifugu rubripes (pufferfish Takifugu) 41.m00286 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000007711 Xenopus tropicalis (frog) YALI0B18436g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34787 modMine - Data generated by the modENCODE project. • FBgn0028658 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17141 NV15099 LH24781 ISCW021227 FBgn0229253 FBgn0218287 FBgn0205255 FBgn0193457 FBgn0170042 JGI_V11_52553 FBgn0074227 FBgn0158687 FBgn0142476 FBgn0118101 FBgn0102494 FBgn0092644 CPIJ008837 BGIBMGA002445 ACYPI46899 GB14955 AGAP009186 AGAP009185 AAEL007277 PHUM258700 GLEAN_03839
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Adat   adat   BG:DS00941.2 (Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999, ) CG16889 (Keleman et al., 2009.8.5) dADAT1 (Gerber and Keller, 2001, Maas et al., 2003, Keegan et al., 2000)
Name Synonym	adat
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Catanese and Matthews, 2011, Biochem. Biophys. Res. Commun. 414(3): 506--511 Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. [FBrf0216523] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...