FB2020_06, released Dec 22, 2020

Gene: Dmel\Sur

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General Information
Symbol
Dmel\Sur
Species
D. melanogaster
Name
Sulfonylurea receptor
Annotation Symbol
CG5772
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028675
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Sulfonylurea receptor (Sur) encodes a predicted ATP-sensitive K[+] channel expressed almost exclusively in the embryonic heart. Sur loss in the adult heart causes increased oxidative stress and pacing-induced heart failure. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

dSUR

Key Links
Genomic Location
Cytogenetic map
31B1-31B1
Sequence location
2L:10,182,557..10,199,117 [-]
Recombination map

2-40

RefSeq locus
NT_033779 REGION:10182557..10199117
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase activity
inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATPase-coupled transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
NOT involved_in chitin biosynthetic process
inferred from mutant phenotype
(Meyer et al., 2013)
involved_in response to hypoxia
inferred from mutant phenotype
(Akasaka et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000657997
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (Q9VL32)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -
The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).
Protein Function (UniProtKB)
May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.
(UniProt, Q9VL32)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sur for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 6.13

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sur-RC
FBtr0452144
NM_001347812
7393
2223
Additional Transcript Data and Comments
Reported size (kB)

6.5 (northern blot)

(Nasonkin et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Sur-PC
FBpp0402894
248.0
2223
7.03
NP_001334732
API64982
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

2167 (aa); 241.9 (kD predicted)

(Nasonkin et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sur using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
cardioblast
(Lo et al., 2007)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
(Nasonkin et al., 1999)
embryonic stage 10 -- 17
embryonic/larval dorsal vessel
(Nasonkin et al., 1999)
larval stage
(Nasonkin et al., 1999)
embryonic stage 15 -- 17
embryonic/larval salivary gland
(Nasonkin et al., 1999)
embryonic/larval tracheal system
(Nasonkin et al., 1999)
embryonic/larval posterior spiracle
(Nasonkin et al., 1999)
third instar larval stage
embryonic/larval corpus cardiacum
(Kim and Rulifson, 2004)
embryonic/larval corpus allatum
(Kim and Rulifson, 2004)
embryonic stage 1 -- 2
organism | ubiquitous | uniform
(Nasonkin et al., 1999)
embryonic stage 11 -- 12
dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval circulatory system
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
embryonic stage 2
organism | ubiquitous
(Nasonkin et al., 1999)
embryonic stage 12
cardiogenic mesoderm
(Akasaka et al., 2006)
embryonic stage 13 -- 17
cardioblast
(Akasaka et al., 2006)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult heart
(Akasaka et al., 2006)
adult head
(Akasaka et al., 2006)
adult abdomen
(Akasaka et al., 2006)
Additional Descriptive Data

Sur transcript expression begins in late embryonic stage 12, in the cardiac primordium, and continues throughout embryogenesis. From stage 13, Sur transcript expression is limited to tin-positive myocardial cells.

(Akasaka et al., 2006)

Maternally supplied Sur transcript is uniformly distributed in stage 1-2 embryos, but is no longer detectable by embryonic stage 3. Zygotic Sur transcript expression begins at embryonic stage 10, in the developing dorsal vessel. Expression is observed in all parts of the tracheal system beginning at stage 15.

(Nasonkin et al., 1999)
Marker for
 
cardioblast
(Lo et al., 2007)
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sur in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sur
Transgenic constructs containing regulatory region of Sur
Deletions and Duplications ( 3 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ABCC9
8 of 15
Yes
Yes
Hsap\ABCC8
6 of 15
No
Yes
Hsap\ABCC1
3 of 15
No
No
1  
Hsap\ABCC2
3 of 15
No
No
Hsap\ABCC3
3 of 15
No
No
Hsap\ABCC4
3 of 15
No
No
1  
Hsap\ABCC5
3 of 15
No
No
1  
Hsap\ABCC6
3 of 15
No
No
Hsap\ABCC10
3 of 15
No
No
Hsap\ABCC11
3 of 15
No
No
Hsap\ABCC12
3 of 15
No
No
Hsap\CFTR
2 of 15
No
No
10  
Hsap\ABCB4
1 of 15
No
No
Hsap\ABCB5
1 of 15
No
No
Hsap\ABCB8
1 of 15
No
No
Hsap\ABCB10
1 of 15
No
No
Hsap\ABCB11
1 of 15
No
No
Hsap\ARG1
1 of 15
No
No
Hsap\TAP1
1 of 15
No
No
Hsap\TAP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (21)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Abcc8
6 of 15
Yes
Yes
Mmus\Abcc9
6 of 15
Yes
Yes
Mmus\Abcc1
3 of 15
No
No
Mmus\Abcc2
3 of 15
No
No
Mmus\Abcc3
3 of 15
No
No
Mmus\Abcc4
3 of 15
No
No
Mmus\Abcc5
3 of 15
No
No
Mmus\Abcc6
3 of 15
No
No
Mmus\Abcc10
3 of 15
No
No
Mmus\Abcc12
3 of 15
No
No
Mmus\Cftr
2 of 15
No
No
Mmus\Abcb1a
1 of 15
No
No
Mmus\Abcb1b
1 of 15
No
No
Mmus\Abcb4
1 of 15
No
No
Mmus\Abcb5
1 of 15
No
No
Mmus\Abcb8
1 of 15
No
No
Mmus\Abcb9
1 of 15
No
Yes
Mmus\Abcb10
1 of 15
No
No
Mmus\Abcb11
1 of 15
No
No
Mmus\Tap1
1 of 15
No
No
Mmus\Tap2
1 of 15
No
No
Rattus norvegicus (Norway rat) (24)
Rnor\Abcc8
7 of 13
Yes
Yes
Rnor\Abcc9
7 of 13
Yes
Yes
Rnor\Abcc1
3 of 13
No
No
Rnor\Abcc2
3 of 13
No
No
Rnor\Abcc3
3 of 13
No
No
Rnor\Abcc4
3 of 13
No
No
Rnor\Abcc5
3 of 13
No
No
Rnor\Abcc6
3 of 13
No
No
Rnor\Abcc10
3 of 13
No
No
Rnor\Abcc12
3 of 13
No
No
Rnor\Abcb1a
1 of 13
No
No
Rnor\Abcb1b
1 of 13
No
No
Rnor\Abcb4
1 of 13
No
No
Rnor\Abcb5
1 of 13
No
No
Rnor\Abcb9
1 of 13
No
No
Rnor\Abcb10
1 of 13
No
No
Rnor\Abcb11
1 of 13
No
No
Rnor\Cftr
1 of 13
No
No
Rnor\LOC688708
1 of 13
No
Yes
Rnor\LOC100912948
1 of 13
No
Yes
Rnor\LOC102550577
1 of 13
No
Yes
Rnor\LOC103689996
1 of 13
No
No
Rnor\Tap1
1 of 13
No
No
Rnor\Tap2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\abcc3
3 of 12
Yes
No
Xtro\abcc4
3 of 12
Yes
No
Xtro\abcc6
3 of 12
Yes
No
Xtro\abcc10
3 of 12
Yes
No
Xtro\LOC101733439
3 of 12
Yes
Yes
Xtro\abcc2
2 of 12
No
Yes
Xtro\abcc5
2 of 12
No
Yes
Xtro\abcc12
2 of 12
No
Yes
Xtro\cftr
2 of 12
No
No
Xtro\LOC100486877
2 of 12
No
Yes
Xtro\LOC100493583
2 of 12
No
Yes
Xtro\LOC101730668
2 of 12
No
Yes
Xtro\abcb8
1 of 12
No
No
Xtro\abcc1
1 of 12
No
No
Xtro\LOC100494740
1 of 12
No
No
Xtro\tap1
1 of 12
No
No
Xtro\tap2
1 of 12
No
No
Danio rerio (Zebrafish) (26)
Drer\abcc9
7 of 15
Yes
Yes
Drer\abcc8
6 of 15
No
Yes
Drer\abcc8b
4 of 15
No
No
Drer\abcc1
3 of 15
No
No
Drer\abcc2
3 of 15
No
No
Drer\abcc4
3 of 15
No
No
Drer\abcc5
3 of 15
No
No
Drer\abcc6a
3 of 15
No
No
Drer\abcc6b.2
3 of 15
No
No
Drer\abcc10
3 of 15
No
No
Drer\abcc12
3 of 15
No
No
Drer\abcc3
2 of 15
No
No
Drer\abcc13
2 of 15
No
No
Drer\cftr
2 of 15
No
No
Drer\wu:fb13g09
2 of 15
No
No
Drer\abcb4
1 of 15
No
No
Drer\abcb5
1 of 15
No
No
Drer\abcb8
1 of 15
No
No
Drer\abcb9
1 of 15
No
No
Drer\abcb10
1 of 15
No
No
Drer\abcb11a
1 of 15
No
No
Drer\abcb11b
1 of 15
No
No
Drer\abcc6b.1
1 of 15
No
No
Drer\tap1
1 of 15
No
No
Drer\tap2a
1 of 15
No
No
Drer\tap2t
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (29)
Cele\mrp-1
3 of 15
Yes
No
Cele\mrp-2
3 of 15
Yes
No
Cele\mrp-3
3 of 15
Yes
No
Cele\mrp-4
3 of 15
Yes
No
Cele\mrp-5
3 of 15
Yes
No
Cele\mrp-6
3 of 15
Yes
No
Cele\mrp-7
3 of 15
Yes
No
Cele\cft-1
2 of 15
No
No
Cele\mrp-8
2 of 15
No
No
Cele\haf-1
1 of 15
No
No
Cele\haf-2
1 of 15
No
No
Cele\haf-3
1 of 15
No
No
Cele\haf-4
1 of 15
No
No
Cele\haf-6
1 of 15
No
No
Cele\haf-7
1 of 15
No
No
Cele\haf-8
1 of 15
No
No
Cele\pgp-1
1 of 15
No
No
Cele\pgp-2
1 of 15
No
No
Cele\pgp-4
1 of 15
No
No
Cele\pgp-5
1 of 15
No
No
Cele\pgp-6
1 of 15
No
No
Cele\pgp-7
1 of 15
No
No
Cele\pgp-8
1 of 15
No
No
Cele\pgp-9
1 of 15
No
No
Cele\pgp-10
1 of 15
No
No
Cele\pgp-11
1 of 15
No
No
Cele\pgp-12
1 of 15
No
No
Cele\pgp-13
1 of 15
No
No
Cele\pgp-14
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (16)
Atha\ABCC1
1 of 9
Yes
No
Atha\ABCC2
1 of 9
Yes
No
Atha\ABCC3
1 of 9
Yes
No
Atha\ABCC4
1 of 9
Yes
No
Atha\ABCC5
1 of 9
Yes
No
Atha\ABCC6
1 of 9
Yes
No
Atha\ABCC7
1 of 9
Yes
No
Atha\ABCC8
1 of 9
Yes
No
Atha\ABCC9
1 of 9
Yes
No
Atha\ABCC10
1 of 9
Yes
No
Atha\ABCC11
1 of 9
Yes
No
Atha\ABCC12
1 of 9
Yes
No
Atha\ABCC13
1 of 9
Yes
No
Atha\ABCC14
1 of 9
Yes
No
Atha\ABCC15
1 of 9
Yes
No
Atha\NAP5
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\BPT1
2 of 15
Yes
No
Scer\STE6
2 of 15
Yes
No
1  
Scer\VMR1
2 of 15
Yes
No
Scer\YBT1
2 of 15
Yes
No
Scer\YCF1
2 of 15
Yes
No
Scer\YKR104W
2 of 15
Yes
No
Scer\YOR1
2 of 15
Yes
No
Scer\MDL1
1 of 15
No
No
Scer\MDL2
1 of 15
No
No
Scer\NFT1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\abc2
1 of 12
Yes
No
Spom\abc3
1 of 12
Yes
No
Spom\abc4
1 of 12
Yes
No
Spom\ybt1
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900A5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000441
Drosophila simulans
Dsim\GD22301
Drosophila sechellia
Dsec\GM11960
Drosophila erecta
Dere\GG23976
Drosophila yakuba
Dyak\GE26395
Drosophila ananassae
Dana\GF14135
Drosophila pseudoobscura pseudoobscura
Dpse\GA25872
Drosophila persimilis
Dper\GL19182
Drosophila willistoni
Dwil\GK18392
Drosophila willistoni
Dwil\GK18732
Drosophila virilis
Dvir\GJ18290
Drosophila mojavensis
Dmoj\GI10862
Drosophila grimshawi
Dgri\GH10652
Drosophila grimshawi
Dgri\GH13883
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500AW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17005312
Glossina morsitans
Tsetse fly
Gmor\GMOY010220
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07459
Mayetiola destructor
Hessian fly
Mdes\Mdes009344
Mayetiola destructor
Hessian fly
Mdes\Mdes015611
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013215
Anopheles darlingi
American malaria mosquito
Adar\ADAC006763
Anopheles gambiae
Malaria mosquito
Agam\AGAP009799
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019757
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006119
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W006S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2426601092
Apis mellifera
Western honey bee
Amel\GB55764
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13902
Bombus terrestris
Buff-tailed bumblebee
Bter\15215360
Linepithema humile
Argentine ant
Lhum\LH19567
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0003ac
Rhodnius prolixus
Kissing bug
Rpro\RPRC001202
Cimex lectularius
Bed bug
Clec\CLEC001854
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004985
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12088
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X006J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80791.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80795.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80792.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g05990
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_442500
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (19)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cftr
4 of 10
CG4562
4 of 10
CG7627
4 of 10
CG7806
4 of 10
CG9270
4 of 10
CG10505
4 of 10
CG11898
4 of 10
CG31792
4 of 10
CG31793
4 of 10
l(2)03659
4 of 10
Mrp4
4 of 10
MRP
4 of 10
rdog
4 of 10
CG1824
1 of 10
CG3156
1 of 10
CG10226
1 of 10
Mdr49
1 of 10
Mdr50
1 of 10
Mdr65
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 6 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ABCC9; ATP binding cassette subfamily C member 9
    8 of 15
    601439
    ABCC8; ATP binding cassette subfamily C member 8
    6 of 15
    600509
    ABCC1; ATP binding cassette subfamily C member 1
    3 of 15
    158343
       
      ABCC2; ATP binding cassette subfamily C member 2
      3 of 15
      601107
      ABCC3; ATP binding cassette subfamily C member 3
      3 of 15
      604323
          ABCC4; ATP binding cassette subfamily C member 4
          3 of 15
          605250
               
              ABCC5; ATP binding cassette subfamily C member 5
              3 of 15
              605251
                   
                  ABCC6; ATP binding cassette subfamily C member 6
                  3 of 15
                  603234
                  ABCC10; ATP binding cassette subfamily C member 10
                  3 of 15
                  612509
                      ABCC11; ATP binding cassette subfamily C member 11
                      3 of 15
                      607040
                        ABCC12; ATP binding cassette subfamily C member 12
                        3 of 15
                        607041
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Interactions Browser
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            External Data
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Linkouts
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            2L
                            Recombination map

                            2-40

                            Cytogenetic map
                            31B1-31B1
                            Sequence location
                            2L:10,182,557..10,199,117 [-]
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            31B1-31B1
                            Limits computationally determined from genome sequence between P{lacW}l(2)k06324k06324 and P{lacW}me31Bk06607
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            31B3-31B3
                            (Thomas, 1999.7.9)
                            Experimentally Determined Recombination Data
                            Location

                            2-40

                            (FlyBase, 2016)

                            2-34.2

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (14)
                            Genomic Clones (22)
                            cDNA Clones (11)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for database merge of

                              Source for merge of: Sur BEST:CK00325

                              (Bayraktaroglu, 2000.11.2)
                              Additional comments
                              Other Comments

                              Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis.

                              (Kopczynski et al., 1998)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 40 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              Synonyms and Secondary IDs (20)
                              Reported As
                              Symbol Synonym
                              BEST:CK00325
                              CG5772
                              (Yurgel et al., 2019, Transgenic RNAi Project members, 2017-, Hosono et al., 2015, Meyer et al., 2013, Paulsen et al., 2013, Ni et al., 2011.7.19, Hazelett et al., 2009, Keleman et al., 2009.8.5, Mayer et al., 2009, Perkins et al., 2009, Shah et al., 2008, Croker et al., 2007, Dean et al., 2001)
                              CK00325
                              (Kopczynski et al., 1998)
                              CYO
                              (Mayer et al., 2009)
                              DSur
                              (Ocorr et al., 2014)
                              DmSUR
                              (He et al., 2019)
                              Dme_CG5772
                              (Tarnay et al., 2004)
                              Dsur
                              (Lockwood and Bodmer, 2002, Nikitin and Thomas, 2000, Nikitin and Thomas, 2000, Nasonkin et al., 1999)
                              Ir
                              (Alfa and Kim, 2016)
                              SUR
                              (Abo-Elghar et al., 2004, Wang et al., 2004, Thomas, 1999.7.9)
                              Sur
                              (Allebrandt et al., 2017, Transgenic RNAi Project members, 2017-, Alfa and Kim, 2016, Fogle et al., 2016, Gene Disruption Project members, 2015-, Kwon et al., 2013, Meyer et al., 2013, Bryantsev and Cripps, 2012, Reim and Frasch, 2010, Hazelett et al., 2009, Hendren et al., 2007, Lo et al., 2007, Zeitouni et al., 2007, Davidson and Erwin, 2006, Zaffran et al., 2006)
                              cyo
                              (Mayer et al., 2009)
                              dSUR
                              (Yurgel et al., 2019, Zhu et al., 2017, Cannon and Bodmer, 2016, Eleftherianos and Castillo, 2012, Eleftherianos et al., 2011, Qian et al., 2011, Qian and Bodmer, 2009, Deddouche et al., 2008, Eleftherianos et al., 2008, Croker et al., 2007, Ocorr et al., 2007, Ocorr et al., 2007, Tountas and Fortini, 2007, Akasaka et al., 2006, Akasaka et al., 2006, Akasaka et al., 2005, Bier and Bodmer, 2004)
                              dSur
                              (Ly et al., 2018, Freeman et al., 2013, Fridell et al., 2009, Liu et al., 2009)
                              dsur
                              (Akasaka et al., 2006)
                              sur
                              (Dermauw and Van Leeuwen, 2014, Cripps and Olson, 2002)
                              Name Synonyms
                              Sulfonylurea receptor
                              (Bryantsev and Cripps, 2012, Nasonkin et al., 1999)
                              Sulphonylurea receptor
                              (Hendren et al., 2007)
                              sulfonyl urea receptor
                              (Thomas, 1999.7.9)
                              sulfonylurea receptor
                              (Deddouche et al., 2008)
                              Secondary FlyBase IDs
                              • FBgn0025710
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (95)