• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Sur

General Information
Symbol	Dmel\Sur	Species	D. melanogaster
Name	Sulfonylurea receptor	Annotation symbol	CG5772
Feature type	protein_coding_gene	FlyBase ID	FBgn0028675
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	dSUR
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,182,557..10,199,112 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sulfonylurea receptor is referred to in FlyBase by the symbol Dmel\Sur (CG5772, FBgn0028675). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sulfonylurea receptor activity. There is experimental evidence that it is involved in the biological process: response to hypoxia. 11 alleles are reported. The phenotype of these alleles is annotated with: adult heart. It has one annotated transcript and one annotated polypeptide. Protein features are: ABC transporter, conserved site; ABC transporter, integral membrane type 1; ABC transporter, transmembrane domain; ABC transporter, transmembrane domain, type 1; ABC transporter-like; ATPase, AAA+ type, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. Comments on Affy2 ProbeSet: ProbeSet 1632337_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sur. Gene sequence location is 2L:10182557..10199112.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Lo et al., 2007, Dev. Biol. 311(2): 287--296 Sequence features HFA03447 BKN26264
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}l(2)k06324k06324 and P{lacW}me31Bk06607
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31B3-31B3     (Thomas, 1999.7.9)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sur for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone SD08664 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sur-RB FBtr0290268  NM_058124   7232   2171
Additional Transcript Data & Comments
Reported size (kB)	6.5 (northern blot) (Nasonkin et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sur-PB   FBpp0288707   242.4   2171   6.95     NP_477472   AAF52866
Additional Polypeptide Data & Comments
Reported size (kDa)	2167 (aa); 241.9 (kD predicted) (Nasonkin et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) ATPase, AAA+ type, core (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, integral membrane type 1 (IPR017940) ABC transporter, conserved site (IPR017871)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142272   AE014134 AAF52866   AC005734   AC009849   AF167431 AAF06736   AI534523   AI542370   AW944566   AY069841 AAL39986   BF485710   BI633397   BI635513   BI641236   BP540356   BP540357   BP544185   BP544186   CA807182   CO279168   CZ469399   EC217276   GH959967   GH961018   GH961508   GH964950   GH979600
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T9B5 Q9U6Z2 Q9VL32
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Nasonkin et al., 1999) embryonic stage 1 -- 2   organism | ubiquitous & uniform   (Nasonkin et al., 1999) embryonic stage 10 -- 17   embryonic/larval dorsal vessel   (Nasonkin et al., 1999) embryonic stage 15 -- 17   embryonic/larval salivary gland   (Nasonkin et al., 1999) embryonic/larval tracheal system   (Nasonkin et al., 1999) embryonic/larval posterior spiracle   (Nasonkin et al., 1999) larval stage     (Nasonkin et al., 1999) third instar larval stage   embryonic/larval corpus cardiacum   (Kim and Rulifson, 2004) embryonic/larval corpus allatum   (Kim and Rulifson, 2004) adult stage     (Nasonkin et al., 1999)
Additional Descriptive Data
	Maternally supplied Sur transcript is uniformly distributed in stage 1-2 embryos, but is no longer detectable by embryonic stage 3. Zygotic Sur transcript expression begins at embryonic stage 10, in the developing dorsal vessel. Expression is observed in all parts of the tracheal system beginning at stage 15. (Nasonkin et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028675    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028675 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028675 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr  107 embryo 14-16hr  (472) embryo 16-18hr  (995) embryo 18-20hr  (869) embryo 20-22hr  (406) embryo 22-24hr  (444) larva L1  (201) larva L2  (130) larva L3 12hr old  (112) larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr  (168) white prepupae 24hr    59 pupae 2d postWPP  (143) pupae 3d postWPP  (181) pupae 4d postWPP  (169) adult male 01day  (111) adult male 05day  102 adult male 30day  (108) adult female 01day  (110) adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028675 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr  107 embryo 14-16hr  (472) embryo 16-18hr  (995) embryo 18-20hr  (869) embryo 20-22hr  (406) embryo 22-24hr  (444) larva L1  (201) larva L2  130 larva L3 12hr old  112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr  (168) white prepupae 24hr    59 pupae 2d postWPP  143 pupae 3d postWPP  (181) pupae 4d postWPP  (169) adult male 01day  111 adult male 05day  102 adult male 30day  108 adult female 01day  110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    11 embryo 08-10hr    25 embryo 10-12hr    66 embryo 12-14hr    107 embryo 14-16hr    472 embryo 16-18hr    995 embryo 18-20hr    869 embryo 20-22hr    406 embryo 22-24hr    444 larva L1    201 larva L2    130 larva L3 12hr old    112 larva L3 puffstage 1-2    58 larva L3 puffstage 3-6    65 larva L3 puffstage 7-9    75 white prepupae new    70 white prepupae 12hr    168 white prepupae 24hr    59 pupae 2d postWPP    143 pupae 3d postWPP    181 pupae 4d postWPP    169 adult male 01day    111 adult male 05day    102 adult male 30day    108 adult female 01day    110 adult female 05day    83 adult female 30day    75 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028675    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028675 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028675 expression level Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028675 expression level Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.325 Larval Midgut    23.6 Larval Hindgut    47.1 Larval Malpighian Tubules    23.3 Larval Fat Body    8.4 Larval Salivary Gland    4.4 Larval Trachea    5.85 Larval Carcass    51.475 Adult Head    14.8 Adult Eye    12.05 Adult Brain    24.2 Adult Thoracic-Abdominal Ganglion    29.1 Adult Crop    213.2 Adult Midgut    41.6 Adult Hindgut    80 Adult Malpighian Tubules    28.1 Adult Fat Body    6 Adult Salivary Gland no informative data Adult Heart    52.275 Adult VirginFemale Spermatheca    3.7 Adult InseminatedFemale Spermatheca    9 Adult Ovary    15.8 Adult Testis    11 Adult Male Accessory Gland    43.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    14.8   NA  Eye    12.05   NA  Brain    24.2   15.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    29.1   NA  Crop    213.2   23.6  Midgut    41.6   47.1  Hindgut    80   23.3  Malpighian Tubules    28.1   8.4  Fat Body    6   4.4  Salivary Gland    no informative data   NA  Heart    52.275   5.85  Trachea    NA   NA  VirginFemale Spermatheca    3.7   NA  InseminatedFemale Spermatheca    9   NA  Ovary    15.8   NA  Testis    11   NA  Male Accessory Gland    43.5   51.475  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_12
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028675 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5772-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Sur Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4how-24B, Scer\GAL4twi.PG SurdsRNA.Scer\UAS.1-2 SurdsRNA.Scer\UAS.3 SurdsRNA.Scer\UAS.4 viable, with Scer\GAL4pnr-MD237 SurGD398 viable, with Scer\GAL4tub.PU SurdsRNA.Scer\UAS.1-2 SurdsRNA.Scer\UAS.3 SurdsRNA.Scer\UAS.4 Other Phenotypes Allele immune response defective, with Scer\GAL4hs.PB SurdsRNA.Scer\UAS.1-2 immune response defective, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa SurdsRNA.Scer\UAS.1-2 stress response defective, with Scer\GAL4how-24B, Scer\GAL4twi.PG SurdsRNA.Scer\UAS.1-2 SurdsRNA.Scer\UAS.3 stress response defective, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa SurdsRNA.Scer\UAS.1-2 SurdsRNA.Scer\UAS.3 Phenotype manifest in Allele adult heart, with Scer\GAL4Scer\UAS.cHa, Scer\GAL4tin.cBa SurdsRNA.Scer\UAS.1-2 SurdsRNA.Scer\UAS.3 SurdsRNA.Scer\UAS.4
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Sur Class Mutagen Stocks Known lesion Sure00744 piggyBac transposase 3 -- SurG7604 P-element activity 1 -- SurMB07175 1 -- SurMI02189 1 -- Surc04651 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sur Class Mutagen Stocks Known lesion SurGD398 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SurGL00506 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SurKK106264 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SurdsRNA.Scer\UAS.1-2 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SurdsRNA.Scer\UAS.3 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SurdsRNA.Scer\UAS.4 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6026 (Ryder, 2004.4.26) Df(2L)Exel8024 (Ryder, 2004.4.26) Df(2L)Exel9032 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{Sur.En1-LacZ} No P{Sur.En2-LacZ} No P{Sur.En3.mP2-LacZ} No P{Sur.En3.mP2P3-LacZ} No P{Sur.En3.mP2T1T2-LacZ} No P{Sur.En3.mP3-LacZ} No P{Sur.En3.mT1-LacZ} No P{Sur.En3.mT1T2-LacZ} No P{Sur.En3.mT1T2P3-LacZ} No P{Sur.En3.mT1T2T3-LacZ} No P{Sur.En3.mT2-LacZ} No P{Sur.En3.mT2T3-LacZ} No P{Sur.En3.mT3-LacZ} No P{Sur.En3.mT4-LacZ} No P{Sur.En3.S-LacZ} No P{Sur.En3.SS.mP2P3-LacZ} No P{Sur.En3.SS-LacZ} No P{Sur.En3.SSS.mT3-LacZ} No P{Sur.En3.SSS-LacZ} No P{Sur.En3-LacZ} No UAS construct P{GD398} NA P{KK106264} NA P{TRiP.GL00506} NA P{UAS-Sur.RNAi.1-2} NA P{UAS-Sur.RNAi.3} NA P{UAS-Sur.RNAi.4} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}SurMI02189 NA P{wHy}DG10207 NA PBac{PB}Surc04651 NA PBac{RB}Sure00744 NA insertion of enhancer trap binary system Mi{ET1}SurMB07175 No insertion of mobile activating element P{EP}SurG7604 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to hypoxia inferred from mutant phenotype (Akasaka et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATPase activity, coupled to transmembrane movement of substances inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-) ATP binding inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871 (FlyBase Curators et al., 2004-) sulfonylurea receptor activity inferred from sequence or structural similarity (Thomas, 1999.7.9) inferred from sequence or structural similarity with EMBL:AF019628 (FlyBase, 1992-)
Biological Process
CV term Evidence References
heart development non-traceable author statement (Cripps and Olson, 2002) transmembrane transport inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
ATP-sensitive potassium channel complex inferred from sequence or structural similarity (Thomas, 1999.7.9) integral to membrane inferred from electronic annotation with InterPro:IPR001140, InterPro:IPR011527 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sur allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60441 DroID - A comprehensive database of gene and protein interactions. • FBgn0028675 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34350
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH10652 Dmoj\GI10862 Dsim\GD22300 Dvir\GJ18290 Dwil\GK18392
Curated drosophilid orthologs	Dsim\Sur (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013215-PA Aedes aegypti (mosquito) AGAP009799-PA Anopheles gambiae (mosquito) XP_394420.3 Apis mellifera (honey bee) XP_001944768.1 Acyrthosiphon pisum (pea aphid) 84399 Branchiostoma floridae (lancelet) BGIBMGA006882-PA Bombyx mori (silk worm) ENSBTAP00000043950 Bos taurus (bovine) ENSCAFP00000017907 Canis familiaris (dog) CPIJ006119 Culex pipens (mosquito) 301462 Daphnia pulex (daphnia) ENSDARP00000014386 Danio rerio (zebra fish) ENSECAP00000018853 Equus caballus (horse) ENSGACP00000014596 Gymnopilus aculeatus (mushroom) ENSGALP00000009950 Gallus gallus (chicken) 67618 Hypsipyla robusta (cedar shoot borer) ENSP00000261200 Homo sapiens (human) ISCW010722-PA Ixodes scapularis (deer tick) ENSMODP00000036088 Monodelphis domestica (gray opossum) ENSMMUP00000031039 Macaca mulatta (rhesus monkey) ENSMUSP00000098390 Mus musculus (house mouse) ENSOANP00000012233 Ornithorynchus anatinus (platypus) ENSORLP00000021373 Oryzias latipes (japanese killifish) ENSPPYP00000004978 Pongo pygmaeus (orangutan) ENSPTRP00000008131 Pan troglodytes (chimpanzee) PVX_124085 Plasmodium vivax (protozoal parasite) TA10030 Theileria annulata (apicomplexan parasite) TA17150 Theileria annulata (apicomplexan parasite) TA17365 Theileria annulata (apicomplexan parasite) ENSTNIP00000009423 Tetraodon nigroviridis (green spotted pufferfish) TP01_0011 Theileria parva (parasitic protozoan) TP02_0016 Theileria parva (parasitic protozoan) TP04_0914 Theileria parva (parasitic protozoan) ENSTRUP00000014542 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17900 LH19567 ISCW010722 FBgn0243421 FBgn0220730 FBgn0220390 FBgn0205451 FBgn0193708 FBgn0193707 FBgn0166901 JGI_V11_301462 FBgn0247249 FBgn0156781 FBgn0133625 FBgn0121359 FBgn0118133 FBgn0116115 FBgn0091162 CPIJ006119 ACYPI004985 GB13238 AGAP009799 AAEL013215
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	25638 w1118; Mi{ET1}SurMB07175 17882 w1118; PBac{RB}Sure00744/CyO 27966 y1 w*; P{EP}SurG7604 34288 y1 w*; Mi{MIC}SurMI02189 36087 y1 sc* v1; P{TRiP.GL00506}attP2
Harvard	- PBac{RB}Sure00744
Kyoto	114483 yd2 w1118 P{ey-FLP.N}2; PBac{RB}Sure00744 P{neoFRT}40A/CyO y+
VDRC	v104241 P{KK106264}VIE-260B v6750 w1118; P{GD398}v6750
Genomic Clones ( 2 )
	BACR07H08 BACR29P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD08664
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19659 SD07410 SD27469
Other clones	CK00325 EK133702 ESG016c.E21_E11 FGA002E12 FGC024E07 RP004248890 RP004497420 RP004534812 RP004539869 RP004550098 SD16881 SD24456
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028675 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34350
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Sur BEST:CK00325 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	Identification: cDNA screen for secreted and transmembrane proteins expressed during embryogenesis. (Kopczynski et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058124 RefSeq (Proteins) • NP_477472 DDBJ / EMBL / GenBank • AA142272 AAF06736 AAF52866 AAL39986 AC005734 AC009849 AF167431 AI542370 AW944566 AY069841 CZ469399 Entrez Gene - A searchable database of RefSeq genes. • 34350 UniProtKB/TrEMBL • Q8T9B5 Q9U6Z2 Q9VL32
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ABC transporter, transmembrane domain (IPR001140) ABC transporter-like (IPR003439) ATPase, AAA+ type, core (IPR003593) ABC transporter, transmembrane domain, type 1 (IPR011527) ABC transporter, integral membrane type 1 (IPR017940) ABC transporter, conserved site (IPR017871)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60441 DroID - A comprehensive database of gene and protein interactions. • FBgn0028675 DRSC - Results from RNAi screens. • FBgn0028675 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028675 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5772-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028675 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34350 InParanoid A subset of ortholog calls from InParanoid. • AAEL013215-PA Aedes aegypti (mosquito) AGAP009799-PA Anopheles gambiae (mosquito) XP_394420.3 Apis mellifera (honey bee) XP_001944768.1 Acyrthosiphon pisum (pea aphid) 84399 Branchiostoma floridae (lancelet) BGIBMGA006882-PA Bombyx mori (silk worm) ENSBTAP00000043950 Bos taurus (bovine) ENSCAFP00000017907 Canis familiaris (dog) CPIJ006119 Culex pipens (mosquito) 301462 Daphnia pulex (daphnia) ENSDARP00000014386 Danio rerio (zebra fish) ENSECAP00000018853 Equus caballus (horse) ENSGACP00000014596 Gymnopilus aculeatus (mushroom) ENSGALP00000009950 Gallus gallus (chicken) 67618 Hypsipyla robusta (cedar shoot borer) ENSP00000261200 Homo sapiens (human) ISCW010722-PA Ixodes scapularis (deer tick) ENSMODP00000036088 Monodelphis domestica (gray opossum) ENSMMUP00000031039 Macaca mulatta (rhesus monkey) ENSMUSP00000098390 Mus musculus (house mouse) ENSOANP00000012233 Ornithorynchus anatinus (platypus) ENSORLP00000021373 Oryzias latipes (japanese killifish) ENSPPYP00000004978 Pongo pygmaeus (orangutan) ENSPTRP00000008131 Pan troglodytes (chimpanzee) PVX_124085 Plasmodium vivax (protozoal parasite) TA10030 Theileria annulata (apicomplexan parasite) TA17150 Theileria annulata (apicomplexan parasite) TA17365 Theileria annulata (apicomplexan parasite) ENSTNIP00000009423 Tetraodon nigroviridis (green spotted pufferfish) TP01_0011 Theileria parva (parasitic protozoan) TP02_0016 Theileria parva (parasitic protozoan) TP04_0914 Theileria parva (parasitic protozoan) ENSTRUP00000014542 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34350 modMine - Data generated by the modENCODE project. • FBgn0028675 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17900 LH19567 ISCW010722 FBgn0243421 FBgn0220730 FBgn0220390 FBgn0205451 FBgn0193708 FBgn0193707 FBgn0166901 JGI_V11_301462 FBgn0247249 FBgn0156781 FBgn0133625 FBgn0121359 FBgn0118133 FBgn0116115 FBgn0091162 CPIJ006119 ACYPI004985 GB13238 AGAP009799 AAEL013215
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	BEST:CK00325   CG5772 (Dean et al., 2001, Mayer et al., 2009, Croker et al., 2007, Shah et al., 2008, Keleman et al., 2009.8.5, Hazelett et al., 2009, Ni et al., 2011.7.19) CK00325 (Kopczynski et al., 1998) CYO (Mayer et al., 2009) cyo (Mayer et al., 2009) Dme_CG5772 (Tarnay et al., 2004) dSUR (Bier and Bodmer, 2004, Akasaka et al., 2005, Akasaka et al., 2006, Akasaka et al., 2006, Tountas and Fortini, 2007, Eleftherianos et al., 2008, Ocorr et al., 2007, Ocorr et al., 2007, Croker et al., 2007, Deddouche et al., 2008, Qian and Bodmer, 2009) Dsur (Lockwood and Bodmer, 2002, Nikitin and Thomas, 2000, Nikitin and Thomas, 2000, Nasonkin et al., 1999) dsur (Akasaka et al., 2006) dSur (Liu et al., 2009) sur (Cripps and Olson, 2002) SUR (Thomas, 1999.7.9, Abo-Elghar et al., 2004, Wang et al., 2004) Sur (Zaffran et al., 2006, Hendren et al., 2007, Lo et al., 2007, Davidson and Erwin, 2006, Zeitouni et al., 2007, Hazelett et al., 2009)
Name Synonym	sulfonyl urea receptor (Thomas, 1999.7.9) Sulfonylurea receptor (Nasonkin et al., 1999) sulfonylurea receptor (Lo et al., 2007, Deddouche et al., 2008) Sulphonylurea receptor (Hendren et al., 2007)
Secondary FlyBase IDs
	FBgn0025710
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 4 ) Review  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...