FlyBase Gene Report: Dmel\Sur

General Information

Symbol

Dmel\Sur

Species

D. melanogaster

Name

Sulfonylurea receptor

Annotation Symbol

CG5772

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028675

Gene Model Status

Current

Stock Availability

15 publicly available

Gene Summary

Sulfonylurea receptor (Sur) encodes a predicted ATP-sensitive K[+] channel expressed almost exclusively in the embryonic heart. Sur loss in the adult heart causes increased oxidative stress and pacing-induced heart failure. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dSUR

Key Links

Genomic Location

Cytogenetic map

31B1-31B1

Sequence location

2L:10,182,557..10,199,117 [-]

Recombination map

2-40

RefSeq locus

NT_033779 REGION:10182557..10199117

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ABC-type transporter activity

inferred from electronic annotation with InterPro:IPR011527

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables ATPase-coupled transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000657997

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in response to hypoxia

inferred from mutant phenotype

(Akasaka et al., 2006)

NOT involved_in chitin biosynthetic process

inferred from mutant phenotype

(Meyer et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000657997

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN000657997

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY

Protein Family (UniProt)

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. (Q9VL32)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ABCC ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCC subfamily are full transporters, encoding the functional transporter in one polypeptide. In humans some members of this class are associated with multidrug resistance. (Adapted from FBrf0224053).

Protein Function (UniProtKB)

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.

(UniProt, Q9VL32)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sur for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VL32)

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Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 6.13

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sur-RC

FBtr0452144

NM_001347812

7393

2223

Additional Transcript Data and Comments

Reported size (kB)

6.5 (northern blot)

(Nasonkin et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sur-PC

FBpp0402894

248.0

2223

7.03

NP_001334732

API64982

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

2167 (aa); 241.9 (kD predicted)

(Nasonkin et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sur using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sur_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

cardioblast

(Lo et al., 2007)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism | ubiquitous | uniform

(Nasonkin et al., 1999)

embryonic stage 2

organism | ubiquitous

(Nasonkin et al., 1999)

embryonic stage 10 -- 17

embryonic/larval dorsal vessel

(Nasonkin et al., 1999)

embryonic stage 11 -- 12

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

embryonic stage 12

cardiogenic mesoderm

(Akasaka et al., 2006)

embryonic stage 13 -- 16

embryonic/larval circulatory system

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic stage 13 -- 17

cardioblast

(Akasaka et al., 2006)

embryonic stage 15 -- 17

embryonic/larval salivary gland

(Nasonkin et al., 1999)

embryonic/larval tracheal system

(Nasonkin et al., 1999)

embryonic/larval posterior spiracle

(Nasonkin et al., 1999)

larval stage

(Nasonkin et al., 1999)

third instar larval stage

embryonic/larval corpus cardiacum

(Kim and Rulifson, 2004)

embryonic/larval corpus allatum

(Kim and Rulifson, 2004)

adult stage

(Nasonkin et al., 1999)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult heart

(Akasaka et al., 2006)

adult head

(Akasaka et al., 2006)

adult abdomen

(Akasaka et al., 2006)

Additional Descriptive Data

Sur transcript expression begins in late embryonic stage 12, in the cardiac primordium, and continues throughout embryogenesis. From stage 13, Sur transcript expression is limited to tin-positive myocardial cells.

(Akasaka et al., 2006)

Maternally supplied Sur transcript is uniformly distributed in stage 1-2 embryos, but is no longer detectable by embryonic stage 3. Zygotic Sur transcript expression begins at embryonic stage 10, in the developing dorsal vessel. Expression is observed in all parts of the tracheal system beginning at stage 15.

(Nasonkin et al., 1999)

Marker for

cardioblast

(Lo et al., 2007)

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Sur-GAL4.B}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13

embryonic dorsal vessel