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Gene: Dmel\Rpt4

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General Information
Symbol
Dmel\Rpt4
Species
D. melanogaster
Name
Regulatory particle triple-A ATPase 4
Annotation Symbol
CG3455
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028685
Gene Model Status
Current
Stock Availability
6 publicly available
Enzyme Name (EC)
Adenosinetriphosphatase (3.6.1.3)
Gene Snapshot
Regulatory particle triple-A ATPase 4 (Rpt4) is the 19S proteasomal ATPase, which is a component of the 26S proteosome complex. Rpt4 localizes to the nucleolus and participates in regulating rRNA transcription. Rpt4 physically interacts with the BHD tumor suppressor. [Date last reviewed: 2016-09-01]
Other Summaries
Also Known As
p42D
Key Links
Genomic Location
Cytogenetic map
5E5-5E5
Sequence location
X:6,289,470..6,291,245 [-]
Recombination map
1-16
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
AAA+ ATPase domain; ATPase, AAA-type, core; ATPase, AAA-type, conserved site; 26S proteasome regulatory subunit P45-like; P-loop containing nucleoside triphosphate hydrolase; Proteasomal ATPase OB C-terminal domain; 26S proteasome regulatory subunit 10B
Molecular Function (see GO section for details)
Experimental Evidence
RNA polymerase I regulatory region sequence-specific DNA binding
Predictions / Assertions
ATP binding; ATPase activity; proteasome-activating ATPase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.1.3)
Summaries
Gene Group Membership
PROTEASOME SUBUNITS -
The 26S proteasome degrades polyubiquitinated proteins in the cytoplasm and nucleus. It is formed from a cylindrical catalytic core 20S proteasome capped at each end by a regulatory 19S particle. The 19S regulatory particle recognizes, unfolds, and translocates ubiquitinated proteins into the catalytic core particle in an ATP-dependent manner. (Adapted from FBrf0215459).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Rpt4 or the JBrowse view of Dmel\Rpt4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.50
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rpt4-RB
FBtr0305495
NM_132080
1465
397
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rpt4-PB
FBpp0293948
44.9
397
8.27
NP_572308
AAF46146
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rpt4 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (13 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
RNA polymerase I regulatory region sequence-specific DNA binding
inferred from direct assay
(Gaur et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
ATPase activity
inferred from sequence model
(Wollenberg and Swaffield, 2001)
proteasome-activating ATPase activity
inferred from electronic annotation with InterPro:IPR035263
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
ovarian follicle cell development
inferred from mutant phenotype
(Jia et al., 2015)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
inferred from mutant phenotype
(Gaur et al., 2013)
proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Lőw et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
inferred from biological aspect of ancestor with PANTHER:PTN000553116
(assigned by GO_Central )
(Gaudet et al., 2011)
proteasome-mediated ubiquitin-dependent protein catabolic process
inferred by curator from GO:0005838
(Sumegi et al., 2003)
ubiquitin-dependent ERAD pathway
inferred from biological aspect of ancestor with PANTHER:PTN000553116
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Gaur et al., 2013)
proteasome regulatory particle
inferred from direct assay
(Sumegi et al., 2003, Holzl et al., 2000)
proteasome regulatory particle, base subcomplex
inferred from direct assay
(Nickell et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cytosolic proteasome complex
inferred from biological aspect of ancestor with PANTHER:PTN000553116
(assigned by GO_Central )
(Gaudet et al., 2011)
proteasome regulatory particle
inferred from sequence or structural similarity with HGNC:9553
(Holzl et al., 2000)
proteasome regulatory particle, base subcomplex
inferred from sequence or structural similarity with SGD:S000005785
(Holzl et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000553116
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Gaur et al., 2013)
proteasome regulatory particle
inferred from direct assay
(Sumegi et al., 2003, Holzl et al., 2000)
proteasome regulatory particle, base subcomplex
inferred from direct assay
(Nickell et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rpt4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Allele of Rpt4
Class
Mutagen
Associated Insertion
Stocks
Known lesion
Rpt4G0114
0
--
Rpt4G0345
0
Yes
Rpt4G0227
1
Yes
Rpt4CB-0534-3
    0
    Yes
    Other relevant insertions
    Transgenic Constructs ( 6 )
    Deletions and Duplications ( 1 )
    Summary of Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Download All OrthoDB Orthologs
    Human Orthologs (via DIOPT v7.1)
    Homo sapiens (Human) (1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Hsap\PSMC6
    12 of 15
    Yes
    Yes
    Model Organism Orthologs (via DIOPT v7.1)
    Mus musculus (laboratory mouse) (1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    Isobase
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    RoundUp
    TreeFam
    ZFIN
    Alignment
    Complementation?
    Transgene?
    Mmus\Psmc6
    12 of 15
    Yes
    Yes
    Rattus norvegicus (Norway rat) (1)
    Rnor\Psmc6
    10 of 13
    Yes
    Yes
    Xenopus tropicalis (Western clawed frog) (1)
    Xtro\psmc6
    6 of 12
    Yes
    Yes
    Danio rerio (Zebrafish) (1)
    Drer\psmc6
    11 of 15
    Yes
    Yes
    Caenorhabditis elegans (Nematode, roundworm) (1)
    Cele\rpt-4
    12 of 15
    Yes
    Yes
    Arabidopsis thaliana (thale-cress) (2)
    Atha\AT1G45000
    6 of 9
    Yes
    No
    Atha\RPT4A
    6 of 9
    Yes
    No
    Saccharomyces cerevisiae (Brewer's yeast) (2)
    Scer\RPT4
    12 of 15
    Yes
    No
    Scer\RIX7
    1 of 15
    No
    No
    Schizosaccharomyces pombe (Fission yeast) (2)
    Spom\rpt4
    9 of 12
    Yes
    No
    Spom\SPBC16E9.10c
    1 of 12
    No
    No
    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190935 )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila melanogaster
    fruit fly
    Dmel\Rpt4
    Drosophila suzukii
    Spotted wing Drosophila
    Dsuz\DS10_00005057
    Drosophila simulans
    Dsim\GD29120
    Drosophila erecta
    Dere\GG17681
    Drosophila yakuba
    Dyak\GE16469
    Drosophila ananassae
    Dana\GF21021
    Drosophila pseudoobscura pseudoobscura
    Dpse\GA17461
    Drosophila persimilis
    Dper\GL20276
    Drosophila willistoni
    Dwil\GK23803
    Drosophila willistoni
    Dwil\GK25687
    Drosophila virilis
    Dvir\GJ15827
    Drosophila mojavensis
    Dmoj\GI16424
    Drosophila grimshawi
    Dgri\GH17814
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915062B )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Mdoa\17006075
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY004279
    Glossina morsitans
    Tsetse fly
    Gmor\GMOY012232
    Lucilia cuprina
    Australian sheep blowfly
    Lcup\FF38_00172
    Mayetiola destructor
    Hessian fly
    Mdes\Mdes008623
    Aedes aegypti
    Yellow fever mosquito
    Aaeg\AAEL004563
    Anopheles darlingi
    American malaria mosquito
    Adar\ADAC004067
    Anopheles gambiae
    Malaria mosquito
    Agam\AGAP001407
    Culex quinquefasciatus
    Southern house mosquito
    Cqui\CPIJ003334
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05FJ )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA007332
    Bombyx mori
    Silkmoth
    Bmor\BGIBMGA010794
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS209519-PA
    Danaus plexippus
    Monarch butterfly
    Dple\DPOGS201696-PA
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL016893
    Heliconius melpomene
    Postman butterfly
    Hmel\HMEL016270
    Apis florea
    Little honeybee
    Aflo\3256908612
    Apis florea
    Little honeybee
    Aflo\3448794244
    Apis mellifera
    Western honey bee
    Amel\Ame.4819
    Apis mellifera
    Western honey bee
    Amel\GB51586
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP10960
    Bombus impatiens
    Common eastern bumble bee
    Bimp\BIMP22152
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15203824
    Bombus terrestris
    Buff-tailed bumblebee
    Bter\15212136
    Linepithema humile
    Argentine ant
    Lhum\LH20858
    Linepithema humile
    Argentine ant
    Lhum\LH10720
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:0008e4
    Megachile rotundata
    Alfalfa leafcutting bee
    Mrot\MROTU:00159e
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG010395
    Nasonia vitripennis
    Parasitic wasp
    Nvit\Nasvi2EG007411
    Dendroctonus ponderosae
    Mountain pine beetle
    Dpod\YQE_06867
    Tribolium castaneum
    Red flour beetle
    Tcas\TC010321
    Tribolium castaneum
    Red flour beetle
    Tcas\TC006492
    Pediculus humanus
    Human body louse
    Phum\PHUM577910
    Pediculus humanus
    Human body louse
    Phum\PHUM164100
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC006898
    Rhodnius prolixus
    Kissing bug
    Rpro\RPRC015385
    Cimex lectularius
    Bed bug
    Clec\CLEC012837
    Cimex lectularius
    Bed bug
    Clec\CLEC002295
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI010231
    Acyrthosiphon pisum
    Pea aphid
    Apim\ACYPI010236
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_07424
    Zootermopsis nevadensis
    Nevada dampwood termite
    Znev\Znev_04068
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05BJ )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strigamia maritima
    European centipede
    Smar\SMAR011647
    Strigamia maritima
    European centipede
    Smar\SMAR002216
    Strigamia maritima
    European centipede
    Smar\SMAR000281
    Strigamia maritima
    European centipede
    Smar\SMAR009975
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW009002
    Ixodes scapularis
    Black-legged tick
    Isca\ISCW008741
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM56657.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM79432.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM80338.1
    Stegodyphus mimosarum
    African social velvet spider
    Smim\KFM60482.1
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur34g01040
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur03g08530
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur11g04560
    Tetranychus urticae
    Two-spotted spider mite
    Turt\tetur08g06190
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_52572
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_308117
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_306359
    Daphnia pulex
    Water flea
    Dpux\DAPPUDRAFT_323838
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G096W )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\SPU_009453gn
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Psmc6
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Psmc2
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Psmc
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\SPU_023064gn
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Wdr12
    Strongylocentrotus purpuratus
    Purple sea urchin
    Spur\Sp-Psmc5
    Ciona intestinalis
    Vase tunicate
    Cint\LOC100185096
    Ciona intestinalis
    Vase tunicate
    Cint\LOC100187162
    Ciona intestinalis
    Vase tunicate
    Cint\LOC100187378
    Ciona intestinalis
    Vase tunicate
    Cint\LOC100184778
    Gallus gallus
    Domestic chicken
    Ggal\PSMC2
    Gallus gallus
    Domestic chicken
    Ggal\WDR12
    Gallus gallus
    Domestic chicken
    Ggal\PSMC5
    Gallus gallus
    Domestic chicken
    Ggal\PSMC6
    Human Disease Model Data
    FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      PSMC6; proteasome 26S subunit, ATPase 6
      12 of 15
      602708
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please look at the Interaction Group reports for full details of the physical interactions
        RNA-protein
        Interacting group
        Assay
        References
        Rpt4 - orb2
        pull down, western blot
        (Mastushita-Sakai et al., 2010)
        protein-protein
        Interacting group
        Assay
        References
        Rpt4 - ATPsynγ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Agpat3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Akt1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt4 - BHD
        two hybrid, anti tag coimmunoprecipitation, anti tag western blot
        (Gaur et al., 2013)
        Rpt4 - CCT2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CCT3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CCT6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG11885
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG12321
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG1416
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG2046
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG2064
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - CG9588
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Droj2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Dsor1
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Rpt4 - GCS2β
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Pdk1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt4 - Pi3K92E
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt4 - Pomp
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosα7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Prosβ7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn11
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn13
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn8
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpn9
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpt1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpt2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpt3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - Rpt5
        two hybrid, experimental knowledge based
        (Hu et al., 2017.6.13, Guruharsha et al., 2011)
        Rpt4 - Rpt6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - TrpRS
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - UQCR-C2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - foxo
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt4 - ref(2)P
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt4 - rictor
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt4 - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Ras85D
        suppressible
        Rpt4
        (Gaur et al., 2013)
        Ras85D
        enhanceable
        Rpt4
        (Gaur et al., 2013)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-16
        Cytogenetic map
        5E5-5E5
        Sequence location
        X:6,289,470..6,291,245 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        5E5-5E5
        Limits computationally determined from genome sequence between P{EP}EP1311&P{EP}EP1384 and P{EP}EP1402&P{EP}CG15893EP1634
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        5F1-5F3
        (determined by in situ hybridisation) 5F1--2 (determined by in situ hybridisation) 5F (determined by in situ hybridisation)
        (Peter et al., 2002)
        5F-5F
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.12.2)
        5F1-5F2
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.12.14)
        5F1-5F3
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.6.15)
        Experimentally Determined Recombination Data
        Location
        1-16
        (FlyBase, 2016)
        1-16.3
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (7)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (106)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: Rpt4 l(1)G0345 l(1)G0227 l(1)G0114
          (Peter et al., 2002)
          Additional comments
          The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.
          (FlyBase, 2009-)
          Other Comments
          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
          (Boutros et al., 2004)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 78 )
          Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          InterPro - A database of protein families, domains and functional sites
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Synonyms and Secondary IDs (12)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (76)