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FB2021_04, released August 17, 2021

Gene: Dmel\Rpt1

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General Information
Symbol
Dmel\Rpt1
Species
D. melanogaster
Name
Regulatory particle triple-A ATPase 1
Annotation Symbol
CG1341
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028687
Gene Model Status
Current
Stock Availability
12 publicly available
Enzyme Name (EC)
Proteasome ATPase (5.6.1.5)
Gene Summary
Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

p48B, l(2)05643, l(2)43Ed, AAA ATPase

Key Links
Genomic Location
Cytogenetic map
43E7-43E7
Sequence location
2R:7,652,440..7,653,954 [-]
Recombination map
2-57
RefSeq locus
NT_033778 REGION:7652440..7653954
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables ATP hydrolysis activity
inferred from electronic annotation with InterPro:IPR003959, InterPro:IPR003960
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables proteasome-activating activity
inferred from electronic annotation with InterPro:IPR035245
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence model
(Wollenberg and Swaffield, 2001)
enables TBP-class protein binding
inferred from biological aspect of ancestor with PANTHER:PTN000553404
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from mutant phenotype
(Lőw et al., 2013, Wojcik and DeMartino, 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly
inferred from biological aspect of ancestor with PANTHER:PTN000553404
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred by curator from GO:0005838
(Sumegi et al., 2003)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in polytene chromosome
inferred from direct assay
(Szabó et al., 2007)
part_of proteasome regulatory particle, base subcomplex
inferred from direct assay
(Nickell et al., 2009)
part_of proteasome regulatory particle
inferred from direct assay
(Kiss et al., 2005, Sumegi et al., 2003, Holzl et al., 2000)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from electronic annotation with InterPro:IPR005937
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
part_of proteasome regulatory particle, base subcomplex
inferred from biological aspect of ancestor with PANTHER:PTN000553404
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of proteasome regulatory particle
inferred from sequence or structural similarity with HGNC:9548
(Holzl et al., 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O + polypeptide = ADP + phosphate + unfolded polypeptide (5.6.1.5)
Summaries
Gene Snapshot
Regulatory particle triple-A ATPase 1 (Rpt1) encodes an AAA-type ATPase protein that forms part of the heterohexameric ATPase ring of the regulatory complex of the 26S proteasome. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PROTEASOME REGULATORY PARTICLE ATPASES -
The 26S proteasome degrades polyubiquitinated proteins in the cytoplasm and nucleus. It is formed from a cylindrical catalytic core 20S proteasome capped at each end by a regulatory 19S particle. The 19S regulatory particle recognizes, unfolds, and translocates ubiquitinated proteins into the catalytic core particle in an ATP-dependent manner. Within the regulatory particle base, six paralogous AAA-ATPases, termed Rpt1-Rpt6, associate in three pairs (Rpt1-Rpt2, Rpt3-Rpt6, Rpt4-Rpt5), which arrange into a ring to form a trimer of dimers. (Adapted from FBrf0215459 and PMID:28583440.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rpt1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rpt1-RA
FBtr0088947
NM_058125
1515
433
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Rpt1-PA
FBpp0088021
48.5
433
5.82
NP_477473
AAF59219
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rpt1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in polytene chromosome
inferred from direct assay
(Szabó et al., 2007)
part_of proteasome regulatory particle, base subcomplex
inferred from direct assay
(Nickell et al., 2009)
part_of proteasome regulatory particle
inferred from direct assay
(Kiss et al., 2005, Sumegi et al., 2003, Holzl et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rpt1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rpt1
Transgenic constructs containing regulatory region of Rpt1
Aberrations (Deficiencies and Duplications) ( 47 )
Inferred from experimentation ( 47 )
Gene disrupted in
Df(2R)cn9
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2R)cn-S5
(Heitzler et al., 1993)
Df(2R)cn-S6
(Heitzler et al., 1993)
Df(2R)cn-S8
(Heitzler et al., 1993)
Df(2R)Drlrv5
(Heitzler et al., 1993)
Df(2R)Drlrv7
(Heitzler et al., 1993)
Df(2R)Drlrv18
(Heitzler et al., 1993)
Df(2R)Drlrv21
(Heitzler et al., 1993)
Df(2R)Drlrv24
(Heitzler et al., 1993)
Df(2R)Drlrv26
(Heitzler et al., 1993)
Df(2R)Drlrv30
(Heitzler et al., 1993)
Df(2R)Exel6053
(Ryder, 2004.4.26)
Df(2R)Exel7092
(Ryder, 2004.4.26)
Df(2R)nap16
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2R)NCX8
(Eeken et al., 2001, Heitzler et al., 1993)
Df(2R)NCX9
(Heitzler et al., 1993)
Df(2R)NCX11
(Heitzler et al., 1993)
Df(2R)NCX13
(Eeken et al., 2001)
Df(2R)Npk-rv1
(Roote and Ashburner, 2005.6)
Df(2R)pk78s
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2R)sple-N3
(Heitzler et al., 1993)
Df(2R)ST1
(Eeken et al., 2001, BDGP Project Members, 1994-1999)
Gene not disrupted in
Df(2R)CA53
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2R)cos-2
(Heitzler et al., 1993)
Df(2R)cos-3
(Heitzler et al., 1993)
Df(2R)Drlrv3
(Heitzler et al., 1993)
Df(2R)Drlrv15
(Heitzler et al., 1993)
Df(2R)Drlrv17
(Heitzler et al., 1993)
Df(2R)Drlrv20
(Heitzler et al., 1993)
Df(2R)Drlrv22
(Heitzler et al., 1993)
Df(2R)Drlrv25
(Heitzler et al., 1993)
Df(2R)Drlrv28
(Heitzler et al., 1993)
Df(2R)DX1
(Heitzler et al., 1993)
Df(2R)DX14
(Heitzler et al., 1993)
Df(2R)EW60
(Heitzler et al., 1993)
Df(2R)H23
(Heitzler et al., 1993)
Df(2R)nap2
(Heitzler et al., 1993)
Df(2R)NCX5
(Heitzler et al., 1993)
Df(2R)NCX10
(Heitzler et al., 1993)
Df(2R)pk-N5
(Heitzler et al., 1993)
Df(2R)pwn5
(Heitzler et al., 1993)
Df(2R)sple-D1
(Heitzler et al., 1993)
Df(2R)sple-D2
(Heitzler et al., 1993)
Df(2R)sple-D3
(Heitzler et al., 1993)
Df(2R)sple-J1
(Heitzler et al., 1993)
Df(2R)sple-J2
(Heitzler et al., 1993)
In(2LR)pkD1-rv11
(Roote, 1997.6.6)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PSMC2
14 of 15
Yes
Yes
Hsap\PSMC1
2 of 15
No
No
Hsap\PSMC5
2 of 15
No
No
Hsap\ATAD2B
1 of 15
No
Yes
Hsap\ATAD2
1 of 15
No
Yes
Hsap\FGGY
1 of 15
No
No
1  
Hsap\GK2
1 of 15
No
No
Hsap\GK5
1 of 15
No
No
1  
Hsap\GK
1 of 15
No
No
1  
Hsap\KATNA1
1 of 15
No
No
1  
Hsap\KATNAL1
1 of 15
No
No
Hsap\KATNAL2
1 of 15
No
No
Hsap\PSMC3
1 of 15
No
No
Hsap\PSMC4
1 of 15
No
No
Hsap\PSMC6
1 of 15
No
No
Hsap\SHPK
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Psmc2
15 of 15
Yes
Yes
Mmus\Psmc1
2 of 15
No
No
Mmus\Psmc5
2 of 15
No
No
Mmus\Atad2b
1 of 15
No
Yes
Mmus\Atad2
1 of 15
No
Yes
Mmus\Fggy
1 of 15
No
No
Mmus\Gk2
1 of 15
No
No
Mmus\Gk5
1 of 15
No
No
Mmus\Gk
1 of 15
No
No
Mmus\Gykl1
1 of 15
No
No
Mmus\Katna1
1 of 15
No
No
Mmus\Katnal1
1 of 15
No
No
Mmus\Katnal2
1 of 15
No
No
Mmus\Psmc4
1 of 15
No
No
Mmus\Psmc6
1 of 15
No
No
Mmus\Shpk
1 of 15
No
No
Rattus norvegicus (Norway rat) (17)
Rnor\Psmc2
13 of 13
Yes
Yes
Rnor\Psmc1
2 of 13
No
No
Rnor\Psmc5
2 of 13
No
No
Rnor\Atad2
1 of 13
No
Yes
Rnor\Cyp11a1
1 of 13
No
No
Rnor\Fggy
1 of 13
No
No
Rnor\Gk2
1 of 13
No
No
Rnor\Gk5
1 of 13
No
No
Rnor\Gk
1 of 13
No
No
Rnor\Gykl1
1 of 13
No
No
Rnor\Katna1
1 of 13
No
No
Rnor\Katnal1
1 of 13
No
No
Rnor\Katnal2
1 of 13
No
No
Rnor\LOC103690050
1 of 13
No
No
Rnor\Psmc3
1 of 13
No
No
Rnor\Psmc6
1 of 13
No
No
Rnor\Shpk
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\psmc2
9 of 12
Yes
Yes
Xtro\psmc1
2 of 12
No
No
Xtro\psmc5
2 of 12
No
No
Xtro\atad2b
1 of 12
No
Yes
Xtro\atad2
1 of 12
No
Yes
Xtro\fggy
1 of 12
No
No
Xtro\gk
1 of 12
No
No
Xtro\katna1
1 of 12
No
No
Xtro\psmc3
1 of 12
No
No
Xtro\psmc4
1 of 12
No
No
Xtro\psmc6
1 of 12
No
No
Xtro\shpk
1 of 12
No
No
Danio rerio (Zebrafish) (16)
Drer\psmc2
14 of 15
Yes
Yes
Drer\psmc1a
2 of 15
No
No
Drer\psmc1b
2 of 15
No
No
Drer\psmc5
2 of 15
No
No
Drer\atad2b
1 of 15
No
Yes
Drer\atad2
1 of 15
No
Yes
Drer\fggy
1 of 15
No
No
Drer\gk5
1 of 15
No
No
Drer\katna1
1 of 15
No
No
Drer\katnal1
1 of 15
No
No
Drer\katnal2
1 of 15
No
No
Drer\psmc3
1 of 15
No
No
Drer\psmc4
1 of 15
No
No
Drer\psmc6
1 of 15
No
No
Drer\shpk
1 of 15
No
No
Drer\zgc:172295
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\rpt-1
13 of 15
Yes
Yes
Cele\C10G11.8
2 of 15
No
No
Cele\F56F11.4
2 of 15
No
No
Cele\rpt-2
2 of 15
No
No
Cele\rpt-6
2 of 15
No
No
Cele\C55B6.1
1 of 15
No
No
Cele\lex-1
1 of 15
No
Yes
Cele\mei-1
1 of 15
No
No
Cele\rpt-3
1 of 15
No
No
Cele\rpt-4
1 of 15
No
No
Cele\rpt-5
1 of 15
No
No
Cele\T25C8.1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\RPT1A
9 of 9
Yes
Yes
Atha\AT1G53780
8 of 9
No
Yes
Atha\AT1G45000
1 of 9
No
No
Atha\AT5G20000
1 of 9
No
No
Atha\RPT2a
1 of 9
No
No
Atha\RPT2b
1 of 9
No
No
Atha\RPT3
1 of 9
No
No
Atha\RPT4A
1 of 9
No
No
Atha\RPT5A
1 of 9
No
No
Atha\RPT5B
1 of 9
No
No
Atha\RPT6A
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\RPT1
14 of 15
Yes
Yes
Scer\GUT1
1 of 15
No
No
Scer\MPA43
1 of 15
No
No
Scer\RPT2
1 of 15
No
No
Scer\RPT6
1 of 15
No
No
Scer\YDR109C
1 of 15
No
No
Scer\YTA7
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rpt1
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908S5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005694
Drosophila simulans
Dsim\GD29001
Drosophila erecta
Dere\GG26376
Drosophila yakuba
Dyak\GE28503
Drosophila ananassae
Dana\GF27387
Drosophila pseudoobscura pseudoobscura
Dpse\GA12266
Drosophila willistoni
Dwil\GK27340
Drosophila willistoni
Dwil\GK10708
Drosophila willistoni
Dwil\GK10072
Drosophila virilis
Dvir\GJ25832
Drosophila mojavensis
Dmoj\GI27046
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504T4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17024190
Glossina morsitans
Tsetse fly
Gmor\GMOY009727
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00411
Mayetiola destructor
Hessian fly
Mdes\Mdes015667
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012943
Anopheles darlingi
American malaria mosquito
Adar\ADAC009038
Anopheles gambiae
Malaria mosquito
Agam\AGAP011174
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013344
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05FJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007332
Bombyx mori
Silkmoth
Bmor\BGIBMGA010794
Danaus plexippus
Monarch butterfly
Dple\DPOGS209519-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201696-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016893
Heliconius melpomene
Postman butterfly
Hmel\HMEL016270
Apis florea
Little honeybee
Aflo\3256908612
Apis florea
Little honeybee
Aflo\3448794244
Apis mellifera
Western honey bee
Amel\Ame.4819
Apis mellifera
Western honey bee
Amel\GB51586
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10960
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22152
Bombus terrestris
Buff-tailed bumblebee
Bter\15203824
Bombus terrestris
Buff-tailed bumblebee
Bter\15212136
Linepithema humile
Argentine ant
Lhum\LH20858
Linepithema humile
Argentine ant
Lhum\LH10720
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0008e4
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00159e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010395
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007411
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06867
Tribolium castaneum
Red flour beetle
Tcas\TC010321
Tribolium castaneum
Red flour beetle
Tcas\TC006492
Pediculus humanus
Human body louse
Phum\PHUM577910
Pediculus humanus
Human body louse
Phum\PHUM164100
Rhodnius prolixus
Kissing bug
Rpro\RPRC006898
Rhodnius prolixus
Kissing bug
Rpro\RPRC015385
Cimex lectularius
Bed bug
Clec\CLEC012837
Cimex lectularius
Bed bug
Clec\CLEC002295
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010231
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI010236
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07424
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04068
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05BJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011647
Strigamia maritima
European centipede
Smar\SMAR002216
Strigamia maritima
European centipede
Smar\SMAR000281
Strigamia maritima
European centipede
Smar\SMAR009975
Ixodes scapularis
Black-legged tick
Isca\ISCW009002
Ixodes scapularis
Black-legged tick
Isca\ISCW008741
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56657.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79432.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80338.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60482.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur34g01040
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g08530
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g04560
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g06190
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_52572
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308117
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306359
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_323838
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G096W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_009453gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Psmc6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Psmc2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Psmc
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_023064gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Wdr12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Psmc5
Ciona intestinalis
Vase tunicate
Cint\LOC100185096
Ciona intestinalis
Vase tunicate
Cint\LOC100187162
Ciona intestinalis
Vase tunicate
Cint\LOC100187378
Ciona intestinalis
Vase tunicate
Cint\LOC100184778
Gallus gallus
Domestic chicken
Ggal\PSMC2
Gallus gallus
Domestic chicken
Ggal\WDR12
Gallus gallus
Domestic chicken
Ggal\PSMC5
Gallus gallus
Domestic chicken
Ggal\PSMC6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (16)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rpt2
4 of 10
Rpt6
4 of 10
Rpt6R
4 of 10
Rpt3
3 of 10
Rpt3R
3 of 10
Rpt4
3 of 10
Rpt4R
3 of 10
Rpt5
3 of 10
CG1271
1 of 10
CG8298
1 of 10
CG10793
1 of 10
CG11594
1 of 10
Gk1
1 of 10
Gk2
1 of 10
Kat60
1 of 10
kat-60L1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PSMC2; proteasome 26S subunit, ATPase 2
    14 of 15
    154365
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        RNA-protein
        Physical Interaction
        Assay
        References
        Rpt1 - orb2
        pull down, western blot
        (Mastushita-Sakai et al., 2010)
        protein-protein
        Physical Interaction
        Assay
        References
        Rpt1 - ATPsynγ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Akt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt1 - Arf79F
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Arl8
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - AsnRS
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CCT8
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CG11885
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CG12321
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CG1416
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CG2064
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - CG33303
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Chc
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Cnx99A
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Cyp12d1-p
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Droj2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - GCS2β
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Gale
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Gfat2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Gp93
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Hel25E
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Hsp22
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Hsp27
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Hsp70Aa
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Idh3a
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Ipo9
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Ldh
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - MRP
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Mcad
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Mec2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Nfs1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - PSMG1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Past1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Pdk1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt1 - Pomp
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Pp2A-29B
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosα7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Prosβ7
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rab5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Raf
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        Rpt1 - Rap1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rheb
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt1 - Rpn1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn11
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn13
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpn9
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpt2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpt3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpt4
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpt5
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Rpt6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - SERCA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Sc2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - ScsβA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - ScsβG
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - Tapδ
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - UQCR-C2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - hyd
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - ref(2)P
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Rpt1 - spidey
        experimental knowledge based
        (Guruharsha et al., 2011)
        Rpt1 - wal
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map
        2-57
        Cytogenetic map
        43E7-43E7
        Sequence location
        2R:7,652,440..7,653,954 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        43E7-43E7
        Limits computationally determined from genome sequence between P{PZ}scra03427&P{EP}EP2179 and P{PZ}l(2)0849208492
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        43E4-43E6
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        43E4-43E6
        43E7--10
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-57

        (FlyBase, 2016)

        2-56.9

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (12)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (97)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Rpt1 CG1341

          (Gabrielian, 1999.11)
          Source for database merge of

          Source for merge of: Rpt1 l(2)05643

          (Misra, 2000.11.18)

          Source for merge of: Rpt1 l(2)05643 l(2)43Ed

          (Salz, 2000.11.28)

          Source for merge of: Rpt1 anon-WO0118547.90

          (FlyBase, 1996-)
          Additional comments

          The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms.

          (FlyBase, 2009-)

          Source for merge of Rpt1 anon-WO0118547.90 was sequence comparison ( date:051113 ).

          (FlyBase, 1996-)
          Other Comments

          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

          (Boutros et al., 2004)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

          (Boutros et al., 2004)

          Area matching Drosophila EST AA803545. This EST overlaps ESTS AA697132 and has sequence similarity to frog/human MSS1.

          (Davies, 2001.3.15)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 91 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB
          EMBL-EBI Single Cell Expression Atlas
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (16)
          Reported As
          Symbol Synonym
          1341
          (Ravi et al., 2009)
          CG1341
          (Kolkhof et al., 2017, Hosono et al., 2015, Fukuoh et al., 2014, Wang et al., 2014, Schertel et al., 2013, Yoshigi et al., 2013, Ni et al., 2010.12.1, Belote and Zhong, 2009, Keleman et al., 2009.8.5, Barbash and Lorigan, 2007, Lundgren et al., 2005, Ma et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Salz, 2000.11.28)
          Dm_Rpt1
          (Wollenberg and Swaffield, 2001)
          Dmp48B
          (Frohlich, 2001)
          Q7KMQ0_DROME
          (Fukuyama et al., 2012)
          Rpt1
          (Moutaoufik and Tanguay, 2021, Palacios et al., 2021, Walls et al., 2020, Hall et al., 2019, Kurshakova et al., 2019, Transgenic RNAi Project members, 2017-, Zirin et al., 2015, Wang et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Lőw et al., 2013, Schertel et al., 2013, Yoshigi et al., 2013, Gurudatta et al., 2012, Friedman et al., 2011, Toku et al., 2011, Mastushita-Sakai et al., 2010, Belote and Zhong, 2009, Nickell et al., 2009, Hoopfer et al., 2008, Sathyanarayanan et al., 2008, Zhou et al., 2008, Barbash and Lorigan, 2007, Kaltenbach et al., 2007, Szabó et al., 2007, Lundgren et al., 2005, Ma et al., 2002)
          S7
          (Lundgren et al., 2005)
          anon-WO0118547.90
          dRpt1
          (Wojcik and DeMartino, 2002)
          l(2)05643
          (Nagengast and Salz, 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999)
          l(2)43Ed
          (Eeken et al., 2001, Nagengast and Salz, 2001, Heitzler et al., 1993)
          p48B
          (Lipinszki et al., 2009, Szabó et al., 2007, Kiss et al., 2005, Lundgren et al., 2005, Sumegi et al., 2003, Kurucz et al., 2002, Ma et al., 2002, Holzl et al., 2000)
          Name Synonyms
          19S complex subunit Rpt1
          (Grimberg et al., 2011)
          AAA ATPase
          (Kraut et al., 2001, Kraut et al., 2001)
          Regulatory particle triple-A ATPase 1
          Rpt1
          lethal(2)43Ed
          Secondary FlyBase IDs
          • FBgn0004135
          • FBgn0010606
          • FBgn0061531
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (99)