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Gene Dmel\Rpn7

General Information
Symbol	Dmel\Rpn7	Species	D. melanogaster
Name	Regulatory particle non-ATPase 7	Annotation symbol	CG5378
Feature type	protein_coding_gene	FlyBase ID	FBgn0028688
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	p42A
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	94A15-94A15	Sequence location	3R:18,286,384..18,287,776 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Regulatory particle non-ATPase 7 is referred to in FlyBase by the symbol Dmel\Rpn7 (CG5378, FBgn0028688). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: cellular process; proteolysis; neurogenesis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 26S proteasome, regulatory subunit Rpn7; Proteasome component (PCI) domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult salivary gland, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633594_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rpn7. Gene sequence location is 3R:18286384..18287776.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 94A15-94A15   Limits computationally determined from genome sequence between P{PZ}l(3)rQ178rQ178 and P{lacW}Dph5L4910
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rpn7 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rpn7-RA FBtr0084294  NM_142791   1393   389
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rpn7-PA   FBpp0083687   45.4   389   6.44     NP_651048   AAF56000
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) 26S proteasome, regulatory subunit Rpn7 (IPR019585) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA940908   AE014297 AAF56000   AF145308 AAF08389   AI113847   AI257008   AI259499   AI296094   AI296428   AI296766   AI297343   AI387197   AI515356   AI944419   AW943886   AX260141   AX260144   AY052008 AAK93432   AY232094   BE975335   BF492015   BF495603   BF497102   BI213217   BI216003   BI232505   BI234248   BI240451   BI354243   BI368166   BI369022   BI372037   BI372323   BI372484   BI565836   BI581688   BI582351   BI591852   BI606585   BI608813   BI613260   BI614034   BI629635   BI634489   BI634572   BP549750   BP549751   BX010632   BX016268   BX042307   BX056744   BX060707   CK131852   CK657440   CK660256   CO155435   CO179322   CO185567   CO279454   CO292280   CO316262   CO317593   CO317663   CO332822   CO339912   EC066660   EC072218   EC077941   EC086549   EC205935   EC213827   EC227033   EC240120   EC251183   EC256997   EC262923   EL884739   EL884740   ES689279   ES694124   ES694843   EV576893   EV580492   EV588648   EV590826   GH752136   GH775872   GH778942   GH801770   GH803901   GH813608   GH814442   GH815196   GH816469   GH820120   GH820944   GH823784   GH829104   GH831598   GH834118   GH837291   GH838334   GH839817   GH843387   GH849596   GH852882   GH862254   GH866953   GH868822   GH873156   GH873870   GH881923   GH885380   GH887958   GH901348   GH901853   GH901993   GH913784   GH915927   GH916463   GH922688   GH924759   GH924982   GH935171   GH938235
UniProtKB/Swiss-Prot	Q9V3G7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
proteasome regulatory particle inferred from direct assay (Sumegi et al., 2003) inferred from direct assay AND inferred from sequence or structural similarity with human PSMD6 (Holzl et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval midgut, larval hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult ovary, adult testis, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult midgut, adult hindgut, adult Malpighian tubules, adult salivary gland, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules    1379.6 Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass    1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (592.7) Larval Midgut  522.5 Larval Hindgut  (651.7) Larval Malpighian Tubules  (1379.6) Larval Fat Body  (570) Larval Salivary Gland  (828) Larval Trachea  (656.225) Larval Carcass  (1075.9) Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body  (542.2) Adult Salivary Gland    280.5 Adult Heart  (630.425) Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary  (677.6) Adult Testis  507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules  (1379.6) Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass  1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules    1379.6 Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass    1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules    1379.6 Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass    1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  592.7 Larval Midgut  522.5 Larval Hindgut  651.7 Larval Malpighian Tubules  (1379.6) Larval Fat Body  570 Larval Salivary Gland  (828) Larval Trachea  656.225 Larval Carcass  (1075.9) Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body  542.2 Adult Salivary Gland    280.5 Adult Heart  630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary  677.6 Adult Testis  507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules  1379.6 Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass  1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    592.7 Larval Midgut    522.5 Larval Hindgut    651.7 Larval Malpighian Tubules    1379.6 Larval Fat Body    570 Larval Salivary Gland    828 Larval Trachea    656.225 Larval Carcass    1075.9 Adult Head    255.1 Adult Eye    259.825 Adult Brain    175.3 Adult Thoracic-Abdominal Ganglion    201.7 Adult Crop    434.1 Adult Midgut    423.1 Adult Hindgut    358.1 Adult Malpighian Tubules    493.9 Adult Fat Body    542.2 Adult Salivary Gland    280.5 Adult Heart    630.425 Adult VirginFemale Spermatheca    298 Adult InseminatedFemale Spermatheca    319.9 Adult Ovary    677.6 Adult Testis    507.9 Adult Male Accessory Gland    383.5 Adult Carcass    433.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    255.1   NA  Eye    259.825   NA  Brain    175.3   592.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    201.7   NA  Crop    434.1   522.5  Midgut    423.1   651.7  Hindgut    358.1   1379.6  Malpighian Tubules    493.9   570  Fat Body    542.2   828  Salivary Gland    280.5   NA  Heart    630.425   656.225  Trachea    NA   NA  VirginFemale Spermatheca    298   NA  InseminatedFemale Spermatheca    319.9   NA  Ovary    677.6   NA  Testis    507.9   NA  Male Accessory Gland    383.5   1075.9  Carcass    433.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering    188 carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female    116 ovary, mated 4-day female    96 testis, mated 4-day male    217 accessory gland, mated 4-day male    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3  (84) central nervous system, pupae P8  (32) head, virgin 1-day female  (27) head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male  (30) head, mated 4-day male  (30) head, mated 20-day male  (44) salivary gland, larvae L3 wandering  (35) salivary gland, white prepupae  (80) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult  (49) digestive system, 4-day adult  (46) digestive system, 20-day adult  (47) fat body, larvae L3 wandering    25 fat body, white prepupae  (94) fat body, pupae P8  (50) carcass, larvae L3 wandering  (188) carcass, 1-day adult  (35) carcass, 4-day adult  (38) carcass, 20-day adult  (34) ovary, virgin 4-day female  (116) ovary, mated 4-day female  (96) testis, mated 4-day male  (217) accessory gland, mated 4-day male  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering  (180) digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering  (188) carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female  (116) ovary, mated 4-day female    96 testis, mated 4-day male  (217) accessory gland, mated 4-day male    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering    188 carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female    116 ovary, mated 4-day female    96 testis, mated 4-day male    217 accessory gland, mated 4-day male    43 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering    188 carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female    116 ovary, mated 4-day female    96 testis, mated 4-day male    217 accessory gland, mated 4-day male    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (109) central nervous system, larvae L3  (84) central nervous system, pupae P8  32 head, virgin 1-day female  27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male  30 head, mated 4-day male  30 head, mated 20-day male  (44) salivary gland, larvae L3 wandering  (35) salivary gland, white prepupae  (80) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult  (49) digestive system, 4-day adult  (46) digestive system, 20-day adult  (47) fat body, larvae L3 wandering    25 fat body, white prepupae  (94) fat body, pupae P8  (50) carcass, larvae L3 wandering  (188) carcass, 1-day adult  (35) carcass, 4-day adult  (38) carcass, 20-day adult  (34) ovary, virgin 4-day female  (116) ovary, mated 4-day female  (96) testis, mated 4-day male  (217) accessory gland, mated 4-day male  (43) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  109 central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering  (180) digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering  (188) carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female  116 ovary, mated 4-day female    96 testis, mated 4-day male  (217) accessory gland, mated 4-day male    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    109 central nervous system, larvae L3    84 central nervous system, pupae P8    32 head, virgin 1-day female    27 head, virgin 4-day female    21 head, virgin 20-day female    22 head, mated 1-day female    22 head, mated 4-day female    22 head, mated 20-day female    23 head, mated 1-day male    30 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    35 salivary gland, white prepupae    80 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    49 digestive system, 4-day adult    46 digestive system, 20-day adult    47 fat body, larvae L3 wandering    25 fat body, white prepupae    94 fat body, pupae P8    50 carcass, larvae L3 wandering    188 carcass, 1-day adult    35 carcass, 4-day adult    38 carcass, 20-day adult    34 ovary, virgin 4-day female    116 ovary, mated 4-day female    96 testis, mated 4-day male    217 accessory gland, mated 4-day male    43 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    212 embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr    104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    186 larva L3 puffstage 7-9    246 white prepupae new    279 white prepupae 12hr    128 white prepupae 24hr    123 pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP    150 adult male 01day    101 adult male 05day    103 adult male 30day    108 adult female 01day    140 adult female 05day    144 adult female 30day    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (212) embryo 02-04hr  (51) embryo 04-06hr  (96) embryo 06-08hr  (104) embryo 08-10hr  (83) embryo 10-12hr  (92) embryo 12-14hr  (50) embryo 14-16hr  (61) embryo 16-18hr  (42) embryo 18-20hr  (39) embryo 20-22hr  (32) embryo 22-24hr  (31) larva L1  (60) larva L2  (94) larva L3 12hr old  (72) larva L3 puffstage 1-2  (109) larva L3 puffstage 3-6  (186) larva L3 puffstage 7-9  (246) white prepupae new  (279) white prepupae 12hr  (128) white prepupae 24hr  (123) pupae 2d postWPP  (81) pupae 3d postWPP  (68) pupae 4d postWPP  (150) adult male 01day  (101) adult male 05day  (103) adult male 30day  (108) adult female 01day  (140) adult female 05day  (144) adult female 30day  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (212) embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr  104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2  (109) larva L3 puffstage 3-6  (186) larva L3 puffstage 7-9  (246) white prepupae new  (279) white prepupae 12hr  (128) white prepupae 24hr  (123) pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP  (150) adult male 01day  101 adult male 05day  103 adult male 30day  (108) adult female 01day  (140) adult female 05day  (144) adult female 30day  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    212 embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr    104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    186 larva L3 puffstage 7-9    246 white prepupae new    279 white prepupae 12hr    128 white prepupae 24hr    123 pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP    150 adult male 01day    101 adult male 05day    103 adult male 30day    108 adult female 01day    140 adult female 05day    144 adult female 30day    143 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    212 embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr    104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    186 larva L3 puffstage 7-9    246 white prepupae new    279 white prepupae 12hr    128 white prepupae 24hr    123 pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP    150 adult male 01day    101 adult male 05day    103 adult male 30day    108 adult female 01day    140 adult female 05day    144 adult female 30day    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (212) embryo 02-04hr  (51) embryo 04-06hr  (96) embryo 06-08hr  (104) embryo 08-10hr  (83) embryo 10-12hr  (92) embryo 12-14hr  (50) embryo 14-16hr  (61) embryo 16-18hr  (42) embryo 18-20hr  (39) embryo 20-22hr  32 embryo 22-24hr  31 larva L1  (60) larva L2  (94) larva L3 12hr old  (72) larva L3 puffstage 1-2  (109) larva L3 puffstage 3-6  (186) larva L3 puffstage 7-9  (246) white prepupae new  (279) white prepupae 12hr  (128) white prepupae 24hr  (123) pupae 2d postWPP  (81) pupae 3d postWPP  (68) pupae 4d postWPP  (150) adult male 01day  (101) adult male 05day  (103) adult male 30day  (108) adult female 01day  (140) adult female 05day  (144) adult female 30day  (143) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (212) embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr  104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2  109 larva L3 puffstage 3-6  (186) larva L3 puffstage 7-9  (246) white prepupae new  (279) white prepupae 12hr  128 white prepupae 24hr  123 pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP  (150) adult male 01day  101 adult male 05day  103 adult male 30day  108 adult female 01day  140 adult female 05day  (144) adult female 30day  143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    212 embryo 02-04hr    51 embryo 04-06hr    96 embryo 06-08hr    104 embryo 08-10hr    83 embryo 10-12hr    92 embryo 12-14hr    50 embryo 14-16hr    61 embryo 16-18hr    42 embryo 18-20hr    39 embryo 20-22hr    32 embryo 22-24hr    31 larva L1    60 larva L2    94 larva L3 12hr old    72 larva L3 puffstage 1-2    109 larva L3 puffstage 3-6    186 larva L3 puffstage 7-9    246 white prepupae new    279 white prepupae 12hr    128 white prepupae 24hr    123 pupae 2d postWPP    81 pupae 3d postWPP    68 pupae 4d postWPP    150 adult male 01day    101 adult male 05day    103 adult male 30day    108 adult female 01day    140 adult female 05day    144 adult female 30day    143 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    318 Schneider line 2 Sg4    178 embryonic 1182-4H    72 embryonic GM2    127 embryonic Kc167    40 embryonic S1    184 embryonic S3    113 leg disc CME L1    142 wing disc CME-W2    99 wing disc ML-DmD8    110 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    159 wing disc ML-DmD21    142 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    142 eye-antennal disc ML-DmD11    106 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    162 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    180 tumorous blood cells mbn2    103 ovary fGS/OSS    109 ovary OSC    106 ovary OSS    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (318) Schneider line 2 Sg4  (178) embryonic 1182-4H  (72) embryonic GM2  (127) embryonic Kc167  (40) embryonic S1  (184) embryonic S3  (113) leg disc CME L1  (142) wing disc CME-W2  (99) wing disc ML-DmD8  (110) wing disc ML-DmD9  (115) wing disc ML-DmD16-c3  (159) wing disc ML-DmD21  (142) wing disc ML-DmD32  (93) haltere disc ML-DmD17-c3  (142) eye-antennal disc ML-DmD11  (106) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (162) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (180) tumorous blood cells mbn2  (103) ovary fGS/OSS  (109) ovary OSC  (106) ovary OSS  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (318) Schneider line 2 Sg4  (178) embryonic 1182-4H    72 embryonic GM2  (127) embryonic Kc167    40 embryonic S1  (184) embryonic S3  (113) leg disc CME L1  (142) wing disc CME-W2    99 wing disc ML-DmD8  (110) wing disc ML-DmD9  (115) wing disc ML-DmD16-c3  (159) wing disc ML-DmD21  (142) wing disc ML-DmD32    93 haltere disc ML-DmD17-c3  (142) eye-antennal disc ML-DmD11  106 antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (162) CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2  (180) tumorous blood cells mbn2  103 ovary fGS/OSS  (109) ovary OSC  106 ovary OSS    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    318 Schneider line 2 Sg4    178 embryonic 1182-4H    72 embryonic GM2    127 embryonic Kc167    40 embryonic S1    184 embryonic S3    113 leg disc CME L1    142 wing disc CME-W2    99 wing disc ML-DmD8    110 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    159 wing disc ML-DmD21    142 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    142 eye-antennal disc ML-DmD11    106 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    162 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    180 tumorous blood cells mbn2    103 ovary fGS/OSS    109 ovary OSC    106 ovary OSS    51 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    318 Schneider line 2 Sg4    178 embryonic 1182-4H    72 embryonic GM2    127 embryonic Kc167    40 embryonic S1    184 embryonic S3    113 leg disc CME L1    142 wing disc CME-W2    99 wing disc ML-DmD8    110 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    159 wing disc ML-DmD21    142 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    142 eye-antennal disc ML-DmD11    106 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    162 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    180 tumorous blood cells mbn2    103 ovary fGS/OSS    109 ovary OSC    106 ovary OSS    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (318) Schneider line 2 Sg4  (178) embryonic 1182-4H  (72) embryonic GM2  (127) embryonic Kc167  (40) embryonic S1  (184) embryonic S3  (113) leg disc CME L1  (142) wing disc CME-W2  (99) wing disc ML-DmD8  (110) wing disc ML-DmD9  (115) wing disc ML-DmD16-c3  (159) wing disc ML-DmD21  (142) wing disc ML-DmD32  (93) haltere disc ML-DmD17-c3  (142) eye-antennal disc ML-DmD11  (106) antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (162) CNS ML-DmBG1-c1  (107) CNS ML-DmBG2-c2  (180) tumorous blood cells mbn2  (103) ovary fGS/OSS  (109) ovary OSC  (106) ovary OSS  (51) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (318) Schneider line 2 Sg4  (178) embryonic 1182-4H    72 embryonic GM2  127 embryonic Kc167    40 embryonic S1  (184) embryonic S3  113 leg disc CME L1  142 wing disc CME-W2    99 wing disc ML-DmD8  110 wing disc ML-DmD9  115 wing disc ML-DmD16-c3  (159) wing disc ML-DmD21  142 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3  142 eye-antennal disc ML-DmD11  106 antennal disc ML-DmD20-c5  (156) mixed discs ML-DmD4-c1  (162) CNS ML-DmBG1-c1  107 CNS ML-DmBG2-c2  (180) tumorous blood cells mbn2  103 ovary fGS/OSS  109 ovary OSC  106 ovary OSS    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    318 Schneider line 2 Sg4    178 embryonic 1182-4H    72 embryonic GM2    127 embryonic Kc167    40 embryonic S1    184 embryonic S3    113 leg disc CME L1    142 wing disc CME-W2    99 wing disc ML-DmD8    110 wing disc ML-DmD9    115 wing disc ML-DmD16-c3    159 wing disc ML-DmD21    142 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    142 eye-antennal disc ML-DmD11    106 antennal disc ML-DmD20-c5    156 mixed discs ML-DmD4-c1    162 CNS ML-DmBG1-c1    107 CNS ML-DmBG2-c2    180 tumorous blood cells mbn2    103 ovary fGS/OSS    109 ovary OSC    106 ovary OSS    51 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3    121 Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    116 Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult    109 Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (70) cold shock, 4-day adult  (68) heat shock, 4-day adult  (87) Cadmium 50 mM 6 hrs, larvae L3  (92) Cadmium 50 mM 12 hrs, larvae L3  (121) Cadmium 50 mM 48 hrs, 4-day adult  (75) Cadmium 100 mM 48 hrs, 4-day adult  (80) Copper 0.5 mM 12 hrs, larvae L3  (84) Copper 15 mM 48 hrs, 4-day adult  (46) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (43) Ethanol 2.5% 3 hrs, larvae L3  (116) Ethanol 5% 3 hrs, larvae L3  (58) Ethanol 10% 3 hrs, larvae L3  (67) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (71) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (79) Caffeine 25 mg/ml 48 hrs, 4-day adult  (65) Paraquat 5 mM 48 hrs, 4-day adult  (86) Paraquat 10 mM 48 hrs, 4-day adult  (109) Rotenone 2 μg 12 hrs, larvae L3  (71) Rotenone 8 μg 12 hrs, larvae L3  (79) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3  (121) Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3  (116) Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult  (109) Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3    121 Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    116 Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult    109 Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3    121 Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    116 Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult    109 Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (70) cold shock, 4-day adult  (68) heat shock, 4-day adult  (87) Cadmium 50 mM 6 hrs, larvae L3  (92) Cadmium 50 mM 12 hrs, larvae L3  (121) Cadmium 50 mM 48 hrs, 4-day adult  (75) Cadmium 100 mM 48 hrs, 4-day adult  (80) Copper 0.5 mM 12 hrs, larvae L3  (84) Copper 15 mM 48 hrs, 4-day adult  (46) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (43) Ethanol 2.5% 3 hrs, larvae L3  (116) Ethanol 5% 3 hrs, larvae L3  (58) Ethanol 10% 3 hrs, larvae L3  (67) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (71) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (79) Caffeine 25 mg/ml 48 hrs, 4-day adult  (65) Paraquat 5 mM 48 hrs, 4-day adult  (86) Paraquat 10 mM 48 hrs, 4-day adult  (109) Rotenone 2 μg 12 hrs, larvae L3  (71) Rotenone 8 μg 12 hrs, larvae L3  (79) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3  121 Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3  116 Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult  109 Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    70 cold shock, 4-day adult    68 heat shock, 4-day adult    87 Cadmium 50 mM 6 hrs, larvae L3    92 Cadmium 50 mM 12 hrs, larvae L3    121 Cadmium 50 mM 48 hrs, 4-day adult    75 Cadmium 100 mM 48 hrs, 4-day adult    80 Copper 0.5 mM 12 hrs, larvae L3    84 Copper 15 mM 48 hrs, 4-day adult    46 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    43 Ethanol 2.5% 3 hrs, larvae L3    116 Ethanol 5% 3 hrs, larvae L3    58 Ethanol 10% 3 hrs, larvae L3    67 Caffeine 1.5 mg/ml 4 hrs, larvae L3    71 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    79 Caffeine 25 mg/ml 48 hrs, 4-day adult    65 Paraquat 5 mM 48 hrs, 4-day adult    86 Paraquat 10 mM 48 hrs, 4-day adult    109 Rotenone 2 μg 12 hrs, larvae L3    71 Rotenone 8 μg 12 hrs, larvae L3    79 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD47143 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5378-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Rpn7GD11629 lethal | pupal stage, with Scer\GAL4pnr-MD237 Rpn7GD11629 Other Phenotypes Allele neuroanatomy defective | larval stage Rpn7GD11629 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage Rpn7GD11629 ganglion mother cell | larval stage Rpn7GD11629
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Rpn7 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rpn7 Class Mutagen Stocks Known lesion Rpn7GD11629 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Rpn7HMS00096 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rpn7KK109250 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rpn7NIG.5378R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6191 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11629} NA P{KK109250} NA P{NIG.5378R} NA P{TRiP.HMS00096} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
contributes_to endopeptidase activity inferred from direct assay (Holzl et al., 2000)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Boutros et al., 2004) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) proteolysis inferred from direct assay AND inferred from sequence or structural similarity with human PSMD6 AND inferred from sequence or structural similarity with Saccharomyces RPN7 (Holzl et al., 2000)
Cellular Component
CV term Evidence References
proteasome regulatory particle inferred from direct assay (Sumegi et al., 2003) inferred from direct assay AND inferred from sequence or structural similarity with human PSMD6 (Holzl et al., 2000)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
proteasomal ubiquitin-dependent protein catabolic process inferred by curator from GO:0005838 (Sumegi et al., 2003) proteolysis non-traceable author statement (Swiss-Prot Project Members, 2002.3.1)
Cellular Component
CV term Evidence References
proteasome regulatory particle non-traceable author statement (Swiss-Prot Project Members, 2002.3.1) proteasome regulatory particle, lid subcomplex inferred from sequence or structural similarity with Saccharomyces RPN7 (Holzl et al., 2000) non-traceable author statement (Hoelzl, 1999.4.23)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rpn7 - CG2046 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - CG3689 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - FK506-bp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - Prosα2 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosα3 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosα4 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosα5 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosα6 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosα7 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosβ1 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosβ2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Rpn7 - Prosβ3 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosβ4 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosβ5 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rpn7 - Prosβ7 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - Rpn1 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn11 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rpn7 - Rpn12 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn13 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn2 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn3 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn5 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn6 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn8 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpn9 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpt2 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpt3 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpt4 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpt5 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Rpt6 experimental knowledge based (Guruharsha et al., 2011) Rpn7 - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - Uch-L5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rpn7 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rpn7 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67596 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028688 DroID - A comprehensive database of gene and protein interactions. • FBgn0028688 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42641
Orthologs
OrthoDB Orthologs (59) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6QC1R8 Dipteran inclusive ortholog search EOG6TQMJM Insect inclusive ortholog search EOG6JM6KT Arthropod inclusive ortholog search EOG6DR7VG Metazoa inclusive ortholog search EOG6C2W51
Orthologs in Drosophila Species (EOG6QC1R8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rpn7     Drosophila simulans   Dsim\GD18456 Y   Drosophila sechellia   Dsec\GM23647 Y   Drosophila erecta   Dere\GG12513 Y   Drosophila yakuba   Dyak\Rpn7 Y   Drosophila ananassae   Dana\GF16564 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18834 Y   Drosophila persimilis   Dper\GL23337 Y   Drosophila willistoni   Dwil\GK11396 Y   Drosophila virilis   Dvir\GJ14389 Y   Drosophila mojavensis   Dmoj\GI10792 Y   Drosophila grimshawi   Dgri\GH18475 Y
Orthologs in non-Drosophila Dipterans (EOG6TQMJM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010048   Anopheles gambiae Malaria mosquito  Agam\AGAP002061   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ003351
Orthologs in non-Dipteran Insects (EOG6JM6KT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552319   Apis mellifera Western honey bee  Amel\LOC100576286   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008806   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009228   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11017   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14607   Atta cephalotes Leafcutter ant  Acep\ACEP19094   Atta cephalotes Leafcutter ant  Acep\ACEP20027   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18466   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20871   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13383   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22913   Linepithema humile Argentine ant  Lhum\LH16622   Linepithema humile Argentine ant  Lhum\LH26171   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15271   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19294   Solenopsis invicta Red fire ant  Sinv\SINV25754   Solenopsis invicta Red fire ant  Sinv\SINV24440   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009718   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003543   Bombyx mori Silkmoth  Bmor\BGIBMGA003212   Pediculus humanus Human body louse  Phum\PHUM091510   Pediculus humanus Human body louse  Phum\PHUM451910   Tribolium castaneum Red flour beetle  Tcas\TC006375
Orthologs in non-Insect Arthropods (EOG6DR7VG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\Zc3h13   Ixodes scapularis Deer tick  Isca\ISCW011710   Ixodes scapularis Deer tick  Isca\ISCW020845
Orthologs in non-Arthropod Metazoa (EOG6C2W51)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\R02D3.8   Caenorhabditis elegans Nematode  Cele\M02B7.2   Caenorhabditis elegans Nematode  Cele\rpn-7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018597gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014778gn   Danio rerio Zebrafish  Drer\psmd6   Xenopus tropicalis Western clawed frog  Xtro\psmd6   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030397   Gallus gallus Domestic chicken  Ggal\PSMD6   Gallus gallus Domestic chicken  Ggal\ERI3   Mus musculus House mouse  Mmus\Psmd6   Mus musculus House mouse  Mmus\Eri3   Rattus norvegicus Norway rat  Rnor\Psmd6   Rattus norvegicus Norway rat  Rnor\Eri3   Homo sapiens Human  Hsap\PSMD6   Homo sapiens Human  Hsap\ERI3
Human Orthologs (2)
Gene OMIM HGNC Hsap\PSMD6     Hsap\ERI3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18456 Drosophila sechellia Dsec\GM23647 Drosophila erecta Dere\GG12513 Drosophila yakuba Dyak\Rpn7 Drosophila ananassae Dana\GF16564 Drosophila pseudoobscura pseudoobscura Dpse\GA18834 Drosophila persimilis Dper\GL23337 Drosophila willistoni Dwil\GK11396 Drosophila virilis Dvir\GJ14389 Drosophila mojavensis Dmoj\GI10792 Drosophila grimshawi Dgri\GH18475
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34787 y1 sc* v1; P{TRiP.HMS00096}attP2
VDRC	v101467 P{KK109250}VIE-260B v22103 w1118; P{GD11629}v22103 v22104 w1118; P{GD11629}v22104
Genomic Clones ( 2 )
	BACR30J14 BACR48C17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 109 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47143
Other clones	DPiM_LD47143 yak-ad_Rpn7
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04552 AT11175 AT28877 GH10329 GH17651 GM15891 LD23239 LP02923 LP04290 LP09907 LP10311 LP10837 LP11625 LP12878 LP18667 LP23743 RE18573 RE22787 RE28581 RE29922 RE37296 RE54085 RE55103 RE57363 RE59260 RE59456 RH07648 RH13516 RH19225 RH20365 RH38656 RH38753 RH42373 RH43316 RH58533 RH63663 RH73162
Other clones	20894 71597 104860 160791 164152 164167 277591 292040 bs01b11 bs41e04 CK01.6D.B8 CK01.112D.F9 Dmel_dig_006120_0644_3510 Dmel_dig_013133_0682_1960 Dmel_neb_008970_0104_3272 Dmel_neb_013933_0381_1403 EC256997 EK010228 EK059117 EK134348 EK199710 EK264242 EK268559 EK268727 EK304743 EN06038 EP09635 FGM103C06 IP15989 RP003041974 RP003051884 RP003080559 RP003128596 RP003133581 RP003165745 RP003178396 RP003182831 RP003214417 RP003215106 RP003225449 RP003231097 RP003234796 RP003238335 RP003242741 RP003246565 RP003253868 RP003254373 RP003273935 RP003298104 RP003307045 RP003334227 RP003340245 RP003356565 RP003357432 RP003380297 RP003422119 RP003450180 RP003468751 RP003482163 RP003485236 RP003504155 RP003508604 RP003523694 RP003530369 RP003569174 RP003576884 RP003646334 RP003659498 RP003672918
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028688 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42641
Antibody Information
	monoclonal (Lipinszki et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rpn7 anon-WO0172774.103 anon-WO0172774.106 (FlyBase, 1996-)
Additional comments	The nomenclature of genes encoding subunits of the 26S proteasome of D. melanogaster have been standardized according to FBrf0215459. These symbols/names largely follow those used already in FlyBase, and largely mirror fly community usage. HOWEVER, note that at least one other nomenclature system exists that is followed by the HUGO Gene Nomenclature Committee (HGNC), for example, with the unfortunate result that several D. melanogaster genes have shared synonyms. (FlyBase, 2009-) Source for merge of Rpn7 anon-WO0172774.103 anon-WO0172774.106 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142791 RefSeq (Proteins) • NP_651048 DDBJ / EMBL / GenBank • AAF08389 AAF56000 AAK93432 AF145308 AI113847 AI515356 AI944419 AW943886 AX260141 AX260144 AY052008 Entrez Gene - A searchable database of RefSeq genes. • 42641 UniProtKB/Swiss-Prot • Q9V3G7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) 26S proteasome, regulatory subunit Rpn7 (IPR019585) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD47143
Linkouts
	BioGRID - A database of protein and genetic interactions • 67596 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028688 DroID - A comprehensive database of gene and protein interactions. • FBgn0028688 DRSC - Results from RNAi screens. • FBgn0028688 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028688 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5378-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028688 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 99113 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42641 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42641 modMine - Data generated by the modENCODE project. • FBgn0028688
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	141231_at (Kristensen et al., 2005) anon-WO0172774.103   anon-WO0172774.106   CG5378 (Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Ma et al., 2002, Ni et al., 2011.7.19, Lundgren et al., 2005, Belote and Zhong, 2009, Yano et al., 2012) p42A (Sumegi et al., 2003, Kurucz et al., 2002, Holzl et al., 2000, Lipinszki et al., 2012, Lipinszki et al., 2011, Ma et al., 2002, Lipinszki et al., 2009, Lundgren et al., 2005) Rpn7 (Lipinszki et al., 2012, Geng and MacDonald, 2007, Nickell et al., 2009, Barbash and Lorigan, 2007, Nie et al., 2009, Liu and Lehmann, 2008, Ma et al., 2002, Lipinszki et al., 2009, Zhou et al., 2008, Neumüller et al., 2011, Lundgren et al., 2005, Belote and Zhong, 2009, Yano et al., 2012, Japanese National Institute of Genetics, 2012.5.21) S10a (Lundgren et al., 2005)
Name Synonym	Regulatory particle non-ATPase 7   Rpn7
Secondary FlyBase IDs
	FBgn0046486 FBgn0046488
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 7 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers ( 5 )
	Lipinszki et al., 2012, Biochemistry 51(12): 2461--2470 Ubiquitylation of Drosophila p54/Rpn10/S5a Regulates Its Interaction with the UBA-UBL Polyubiquitin Receptors. [FBrf0217849] Yano et al., 2012, J. Neurogenet. 26(1): 53--63 Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843] Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Lipinszki et al., 2011, FEBS J. 278(24): 4833--4844 Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. [FBrf0216858] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...