Dnmt2, dDnmt2, DNMT, DNA methyltransferase 2
Gene model reviewed during 5.43
Gene model reviewed during 5.51
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mt2 using the Feature Mapper tool.
The spliced transcript isoform of Mt2 represents the major species. A minor unspliced transcript isoform is also detected by RT-PCR, particularly in testes.
Mt2 transcripts are observed in embryos and adult females. The female transcripts are retricted to the ovaries.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mt2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Several aspects of the organisation of the divergently transcribed, coordinately expressed Dnmt2 and CG6712 open reading frames suggest that they are components of a transposon-like element (although each of the two open reading frames appears to be encoded by a single copy locus in the genome at 33C--33D). Dnmt2 and CG6712 are tightly linked and neither open reading frame is interrupted by introns. There is a 12bp inverted repeat close to the 3' ends of both the open reading frames. Sequences homologous to Dnmt2 are present in a limited distribution of Drosophila species. Overall orientation not stated: Dnmt2- CG6712+
Identification: on basis of sequence similarity to mammalian dnmt2 and yeast pmt1.