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Gene Dmel\Lnk

General Information
Symbol	Dmel\Lnk	Species	D. melanogaster
Name	Lnk	Annotation symbol	CG17367
Feature type	protein_coding_gene	FlyBase ID	FBgn0028717
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	96F6-96F6	Sequence location	3R:21,714,264..21,718,992 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Lnk is referred to in FlyBase by the symbol Dmel\Lnk (CG17367, FBgn0028717). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: signal transducer activity. There is experimental evidence that it is involved in the biological process: positive regulation of insulin receptor signaling pathway; positive regulation of insulin-like growth factor receptor signaling pathway; female mating behavior; regulation of growth. 21 alleles are reported. The phenotypes of these alleles are annotated with: eye; ovary; oocyte; wing blade; wing; egg chamber; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Phenylalanine zipper; Pleckstrin homology domain; Pleckstrin homology-like domain; SH2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625898_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Lnk. Gene sequence location is 3R:21714264..21718992.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 96F6-96F6   Limits computationally determined from genome sequence between P{PZ}l(3)rQ197rQ197 and P{lacW}scribj7B3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)	ca (Ferguson et al., 2012)
Right of (cM)	e (Ferguson et al., 2012)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Lnk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Lnk-RA FBtr0084937  NM_170246   3113   723 Lnk-RB FBtr0084936  NM_143181   2918   723 Lnk-RC FBtr0084935  NM_170247   3287   723 Lnk-RD FBtr0339160     3128   728 Lnk-RE FBtr0339161     3161   613 Lnk-RF FBtr0339162     2951   608
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Lnk-PA   FBpp0084311   77.0   723   6.63     NP_733125   AAF56523 Lnk-PB   FBpp0084310   77.0   723   6.63     NP_651438   AAF56524 Lnk-PC   FBpp0084309   77.0   723   6.63     NP_733126   AAN14065 Lnk-PD   FBpp0308304   77.5   728   6.63       Lnk-PE   FBpp0308305   65.5   613   6.89       Lnk-PF   FBpp0308306   65.0   608   6.89
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) Pleckstrin homology domain (IPR001849) Pleckstrin homology-like domain (IPR011993) Phenylalanine zipper (IPR015012)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202456   AA391252   AA391870   AA391994   AA536286   AA540820   AA567556   AA567873   AA942100   AE014297 AAF56523   AE014297 AAF56524   AE014297 AAN14065   AF101158   AF101159 AAF08615   AI258469   AW942132   AY069404 AAL39549   BF504477   BG637739   BG639268   BI236097   BI241346   BI354192   BI366318   BI484365   BI484937   BI486770   BI574418   BI577568   BI579203   BI586562   BI587178   BI631550   BP557294   CO190972   CO274132   CO292592   CO294270   CO311373   CO319983   CO340610   CO340705   CZ485176   CZ485177   CZ487667   EC054164   EC064852   EC069581   EC086571   EC201244   EC232573   EC239123   EC241721   EC247339   EC255876   EV598077   GH754454   GH760823   GH811626   GH820393   GH851084
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K137 Q9U8B9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Ferguson et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    226.725 Larval Midgut    135.6 Larval Hindgut    126.8 Larval Malpighian Tubules    126.7 Larval Fat Body    118.1 Larval Salivary Gland    111.7 Larval Trachea    109.25 Larval Carcass    118.025 Adult Head    141.5 Adult Eye    172.7 Adult Brain    283.6 Adult Thoracic-Abdominal Ganglion    294 Adult Crop    135.2 Adult Midgut    116.7 Adult Hindgut    128.9 Adult Malpighian Tubules    125.6 Adult Fat Body    127.1 Adult Salivary Gland    287.3 Adult Heart    102.725 Adult VirginFemale Spermatheca    116.9 Adult InseminatedFemale Spermatheca    132.8 Adult Ovary    328.7 Adult Testis    46.8 Adult Male Accessory Gland    113.5 Adult Carcass    126 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    141.5   NA  Eye    172.7   NA  Brain    283.6   226.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    294   NA  Crop    135.2   135.6  Midgut    116.7   126.8  Hindgut    128.9   126.7  Malpighian Tubules    125.6   118.1  Fat Body    127.1   111.7  Salivary Gland    287.3   NA  Heart    102.725   109.25  Trachea    NA   NA  VirginFemale Spermatheca    116.9   NA  InseminatedFemale Spermatheca    132.8   NA  Ovary    328.7   NA  Testis    46.8   NA  Male Accessory Gland    113.5   118.025  Carcass    126 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    12 central nervous system, larvae L3    15 central nervous system, pupae P8    12 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    9 head, mated 1-day female    9 head, mated 4-day female    9 head, mated 20-day female    9 head, mated 1-day male    14 head, mated 4-day male    14 head, mated 20-day male    19 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    5 fat body, pupae P8    17 carcass, larvae L3 wandering    11 carcass, 1-day adult    8 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    17 ovary, mated 4-day female    16 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (45) embryo 04-06hr  (31) embryo 06-08hr  (31) embryo 08-10hr  (30) embryo 10-12hr  26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr  (30) embryo 22-24hr  (28) larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (45) embryo 04-06hr  31 embryo 06-08hr  31 embryo 08-10hr  30 embryo 10-12hr  26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr  30 embryo 22-24hr  28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    45 embryo 04-06hr    31 embryo 06-08hr    31 embryo 08-10hr    30 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    22 embryo 16-18hr    17 embryo 18-20hr    21 embryo 20-22hr    30 embryo 22-24hr    28 larva L1    15 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    13 larva L3 puffstage 7-9    14 white prepupae new    15 white prepupae 12hr    16 white prepupae 24hr    21 pupae 2d postWPP    14 pupae 3d postWPP    6 pupae 4d postWPP    12 adult male 01day    13 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    25 adult female 30day    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    26 Schneider line 2 Sg4    12 embryonic 1182-4H    20 embryonic GM2    12 embryonic Kc167    13 embryonic S1    18 embryonic S3    10 leg disc CME L1    12 wing disc CME-W2    7 wing disc ML-DmD8    11 wing disc ML-DmD9    13 wing disc ML-DmD16-c3    13 wing disc ML-DmD21    9 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    12 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    12 CNS ML-DmBG2-c2    11 tumorous blood cells mbn2    10 ovary fGS/OSS    22 ovary OSC    10 ovary OSS    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    7 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    7 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    13 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028717 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17367-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Lnkd07478 LnkR32F3 viable, with Scer\GAL4pnr-MD237 LnkGD9362 Sterility Allele female semi-sterile | recessive Lnkd07478 female sterile Lnkd07478 female sterile (with Lnk4Q3) Lnk6S2 female sterile (with Lnk6S2) Lnk4Q3 female sterile | recessive LnkDel29 fertile Lnkd07478 male fertile Lnkd07478 Other Phenotypes Allele decreased cell number Lnkd07478 LnkDel29 decreased cell number | somatic clone Lnk4Q3 decreased cell size Lnkd07478 LnkDel29 long lived Lnkd07478 long lived | recessive Lnkd07478 LnkDel29 mating defective LnkDel29 oxidative stress response defective Lnkd07478 LnkDel29 oxidative stress response defective, with Scer\GAL4Act.PU LnkScer\UAS.cSa oxidative stress response defective, with Scer\GAL4elav.PU LnkScer\UAS.cSa short lived, with Scer\GAL4Act.PU LnkScer\UAS.cSa short lived, with Scer\GAL4elav.PU LnkScer\UAS.cSa small body (with Df(3R)Espl3) LnkDel29 small body (with Lnkd07478) LnkDel29 small body (with LnkDel29) Lnkd07478 small body | adult stage Lnkd07478 small body | adult stage (with Lnk4Q3) Lnk6S2 small body | adult stage (with Lnk6S2) Lnk4Q3 small body | pupal stage (with Lnk4Q3) Lnk6S2 small body | pupal stage (with Lnk6S2) Lnk4Q3 small body | recessive Lnkd07478 LnkDel29 small body | third instar larval stage Lnkd07478 starvation stress response defective Lnkd07478 LnkDel29 Lnkf02642 starvation stress response defective, with Scer\GAL4Act.PU LnkScer\UAS.cSa starvation stress response defective, with Scer\GAL4Adh.PF LnkScer\UAS.cSa starvation stress response defective, with Scer\GAL4elav.PU LnkScer\UAS.cSa starvation stress response defective (with Lnkd07478) Lnkf02642 starvation stress response defective (with Lnkf02642) Lnkd07478 visible | somatic clone Lnk4H2 Lnk4Q3 Lnk6S2 Lnk7K1 Phenotype manifest in Allele egg chamber Lnkd07478 eye (with Lnk4Q3) Lnk6S2 eye (with Lnk6S2) Lnk4Q3 eye photoreceptor cell | somatic clone Lnk4Q3 head | somatic clone Lnk4Q3 Lnk6S2 Lnk4H2 Lnk7K1 ommatidium (with Lnk4Q3) Lnk6S2 ommatidium (with Lnk6S2) Lnk4Q3 oocyte (with Lnk4Q3) Lnk6S2 oocyte (with Lnk6S2) Lnk4Q3 ovary (with Lnk4Q3) Lnk6S2 ovary (with Lnk6S2) Lnk4Q3 rhabdomere | somatic clone Lnk4Q3 wing Lnkd07478 LnkDel29 wing (with Df(3R)Espl3) LnkDel29 wing (with Lnkd07478) LnkDel29 wing (with LnkDel29) Lnkd07478 wing blade Lnkd07478 wing disc | somatic clone Lnk4Q3
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of Lnk Class Mutagen Stocks Known lesion Lnkd07478 amorphic allele - genetic evidence P-element activity 2 Yes Lnkf02642 piggyBac transposase 1 -- Lnkf05062 piggyBac transposase 1 -- LnkMB00388 1 -- Lnk4H2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Lnk4Q3 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Lnk6S2 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Lnk7K1 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes LnkDel29 amorphic allele - genetic evidence FLPase 0 Yes LnkCR642 loss of function allele ethyl methanesulfonate 0 Yes LnkDG10204 0 -- LnkR32F3 hexamethylphosphoramide 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Lnk Class Mutagen Stocks Known lesion LnkGD9362 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LnkHMS02448 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LnkKK105731 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Lnk+t6 in vitro construct - genomic fragment 0 Yes Lnk+tSF10 in vitro construct - genomic fragment 0 Yes LnkScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes LnkScer\UAS.P\T.cFa in vitro construct - regulatory fusion 0 Yes LnkT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes LnkY720F in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3R)SpplBW1 (Casso et al., 2012)
Disrupted in	Df(3R)Espl3 (Werz et al., 2009)
Not disrupted in	Df(3R)ME61 (Werz et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9362} NA P{KK105731} NA P{TRiP.HMS02448} NA P{UAS-Lnk.S} NA P{UASp-Lnk.F} NA characterization construct P{EGFP-Lnk.SF11} NA P{Lnk.SF10} NA P{Lnk.Y720F} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}Lnkd07478 NA PBac{RB5.WH5}LnkDel29 NA miscellaneous insertions P{wHy}LnkDG10204 NA PBac{WH}Lnkf02642 NA PBac{WH}Lnkf05062 NA insertion of enhancer trap binary system Mi{ET1}LnkMB00388 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
female mating behavior inferred from mutant phenotype (Wigby et al., 2011) positive regulation of insulin-like growth factor receptor signaling pathway inferred from mutant phenotype (Ferguson et al., 2012) positive regulation of insulin receptor signaling pathway inferred from mutant phenotype (Werz et al., 2009) regulation of growth inferred from mutant phenotype (Song et al., 2010)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Ferguson et al., 2012)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
phospholipid binding inferred from electronic annotation with InterPro:IPR001849 (FlyBase Curators et al., 2004-) signal transducer activity inferred from electronic annotation with InterPro:IPR015012 (FlyBase Curators et al., 2004-) non-traceable author statement (Brody et al., 2002)
Biological Process
CV term Evidence References
intracellular signal transduction inferred from electronic annotation with InterPro:IPR015012 (FlyBase Curators et al., 2004-) signal transduction non-traceable author statement (Brody et al., 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Lnk - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Lnk - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Lnk - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Lnk allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68034 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028717 DroID - A comprehensive database of gene and protein interactions. • FBgn0028717 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43130 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7K137
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B2TGS Dipteran inclusive ortholog search EOG63XVBQ Insect inclusive ortholog search EOG6H18QV Arthropod inclusive ortholog search EOG6GF1W8 Metazoa inclusive ortholog search EOG6F5543
Orthologs in Drosophila Species (EOG6B2TGS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Lnk     Drosophila simulans   Dsim\GD21241 Y   Drosophila sechellia   Dsec\GM10272 Y   Drosophila erecta   Dere\GG11431 Y   Drosophila ananassae   Dana\GF16779 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14482 Y   Drosophila persimilis   Dper\GL21796 Y   Drosophila willistoni   Dwil\GK12864 Y   Drosophila virilis   Dvir\GJ22738 Y   Drosophila mojavensis   Dmoj\GI22976 Y   Drosophila grimshawi   Dgri\GH22307 Y
Orthologs in non-Drosophila Dipterans (EOG63XVBQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004125   Anopheles gambiae Malaria mosquito  Agam\AGAP003863   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013686
Orthologs in non-Dipteran Insects (EOG6H18QV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552012   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009529   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16342   Atta cephalotes Leafcutter ant  Acep\ACEP20204   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21724   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16421   Linepithema humile Argentine ant  Lhum\LH18603   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12363   Solenopsis invicta Red fire ant  Sinv\SINV25987   Acyrthosiphon pisum Pea aphid  Apim\ACYPI010201   Bombyx mori Silkmoth  Bmor\BGIBMGA013262   Pediculus humanus Human body louse  Phum\PHUM231600   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15430
Orthologs in non-Insect Arthropods (EOG6GF1W8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Abo   Ixodes scapularis Deer tick  Isca\ISCW005171
Orthologs in non-Arthropod Metazoa (EOG6F5543)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027685gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21241 Drosophila sechellia Dsec\GM10272 Drosophila erecta Dere\GG11431 Drosophila yakuba Dyak\GE23626 Drosophila ananassae Dana\GF16779 Drosophila pseudoobscura pseudoobscura Dpse\GA14482 Drosophila persimilis Dper\GL21796 Drosophila willistoni Dwil\GK12864 Drosophila virilis Dvir\GJ22738 Drosophila mojavensis Dmoj\GI22976 Drosophila grimshawi Dgri\GH22307
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	19274 w1118; P{XP}Lnkd07478 22783 y1 w67c23; Mi{ET1}LnkMB00388 42613 y1 sc* v1; P{TRiP.HMS02448}attP2
Harvard	- P{XP}Lnkd07478 - PBac{WH}Lnkf02642 - PBac{WH}Lnkf05062
VDRC	v103646 P{KK105731}VIE-260B v32892 w1118; P{GD9362}v32892
Genomic Clones ( 2 )
	BACR06K17 BACR22N13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10453
Other clones	DPiM_LD10453
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05845 GM26770 HL01449 HL01920 LD10907 LD10947 LD16809 LD20640 LD26138 RE32096 RE38384 RE51828 RE67454 RE68132 RE70234 RE71267 RE73193 RH23441 RH26625 RH27665 RH61141
Other clones	12205 71857 73439 76712 102138 176810 CK01.63B.B8 CK01.73C.B6 Dmel_neb_009262_0915_2129 EC054164 EC255876 EK050328 EK113264 EK200529 EK206452 EK224318 EK281639 EP11007 EP11156 FGM308E02 LD02183 LP01675 RP003041237 RP003102956 RP003229798 RP003262989 RP003351248
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028717 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43130
Antibody Information
	polyclonal (Ferguson et al., 2012, Song et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Lnk CG5908 CG17367 (Bayraktaroglu, 2000.4.17)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143181 NM_170246 NM_170247 RefSeq (Proteins) • NP_651438 NP_733125 NP_733126 DDBJ / EMBL / GenBank • AA391252 AAF08615 AAF56523 AAF56524 AAL39549 AAN14065 AF101158 AF101159 AW942132 AY069404 CZ485176 CZ485177 CZ487667 Entrez Gene - A searchable database of RefSeq genes. • 43130 UniProtKB/TrEMBL • Q7K137 Q9U8B9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SH2 domain (IPR000980) Pleckstrin homology domain (IPR001849) Pleckstrin homology-like domain (IPR011993) Phenylalanine zipper (IPR015012)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68034 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028717 DroID - A comprehensive database of gene and protein interactions. • FBgn0028717 DRSC - Results from RNAi screens. • FBgn0028717 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028717 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17367-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028717 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43130 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43130 modMine - Data generated by the modENCODE project. • FBgn0028717 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7K137
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG5908 (Brody et al., 2002, ) CG17367 (Song et al., 2010, Keleman et al., 2009.8.5, Nairz et al., 2004, Ni et al., 2010.12.1) CG 17367 (Werz et al., 2009) dSH2B (Song et al., 2010) lnk (Werz et al., 2006, Werz et al., 2007, Werz et al., 2009, Ferguson et al., 2012) Lnk (Slack et al., 2010, Yepiskoposyan et al., 2006, Slack et al., 2011, Alic et al., 2011, Wigby et al., 2011)
Name Synonym	Lnk
Secondary FlyBase IDs
	FBgn0039383 FBgn0039384
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Curated genome annotation  ( 3 )
Recent research papers ( 5 )
	Casso et al., 2012, PLoS ONE 7(3): e33827 Expression and Characterization of Drosophila Signal Peptide Peptidase-Like (sppL), a Gene That Encodes an Intramembrane Protease. [FBrf0217861] Ferguson et al., 2012, J. Cell Sci. 125(6): 1407--1419 Modulation of gurken translation by insulin and TOR signaling in Drosophila. [FBrf0218097] Alic et al., 2011, Mol. Syst. Biol. 7: 502 Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. [FBrf0214014] Slack et al., 2011, Aging Cell 10(5): 735--748 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229] Wigby et al., 2011, Proc. Biol. Sci. 278(1704): 424--431 Insulin signalling regulates remating in female Drosophila. [FBrf0212666] Show all research papers ...