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Gene Dmel\Fmr1

General Information
Symbol	Dmel\Fmr1	Species	D. melanogaster
Name	Fmr1	Annotation symbol	CG6203
Feature type	protein_coding_gene	FlyBase ID	FBgn0028734
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	dfmr1, dFXR, FMRP, dFMRP, dFMR, fmr, FXR, dfxr1, dmfr1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85F10-85F12	Sequence location	3R:5,927,142..5,935,843 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fmr1 is referred to in FlyBase by the symbol Dmel\Fmr1 (CG6203, FBgn0028734). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein self-association; mRNA binding; RNA binding. There is experimental evidence for 35 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; cellular component organization or biogenesis; regulation of developmental process; rhythmic process; learning or memory; synaptic transmission; locomotory behavior; neuron differentiation; multicellular organism reproduction. 76 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; external compound sense organ; peripheral nervous system; cleavage stage embryo; synapse; thoracic segment; extended germ band embryo; rhabdomere R7; elongation stage spermatid; cell part. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Agenet-like domain; K Homology domain; K Homology domain, type 1; RNA-binding domain, S1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval trachea, larval carcass. Gene sequence location is 3R:5927142..5935843.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85F10-85F12   Limits computationally determined from genome sequence between P{lacW}s2681 and P{EP}Fmr1EP3517&P{PZ}tws02414
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85F9-85F12   (determined by in situ hybridisation)   (Zhang et al., 2001) 85F9-85F12     (Zhang, 2000.1.15) 85F12-85F13     (Bailey, 1999.11.16)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Fmr1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_start_codon_CUG ; SO:0001740 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47 Unconventional translation start (CUG) postulated; FBrf0213401.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Fmr1-RA FBtr0082197  NM_137801   3381   684 Fmr1-RB FBtr0082196  NM_169327   2266   529 Fmr1-RC FBtr0082198  NM_169324   4426   681 Fmr1-RD FBtr0082199  NM_169325   2967   681 Fmr1-RE FBtr0082200  NM_169326   3920   643 Fmr1-RF FBtr0301386  NM_001170109   3773   646 Fmr1-RG FBtr0308123  NM_001260088   4426   729 Fmr1-RH FBtr0335048  NM_001275518   2266   577 Fmr1-RI FBtr0335049  NM_001275519   3752   639
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Fmr1-PA   FBpp0081675   76.1   684   8.52     NP_611645   AAF54493 Fmr1-PB   FBpp0081674   59.7   529   6.40     NP_731446   AAN13454 Fmr1-PC   FBpp0081676   75.8   681   8.52     NP_731443   AAN13451 Fmr1-PD   FBpp0081677   75.8   681   8.52     NP_731444   AAN13452 Fmr1-PE   FBpp0081678   71.7   643   9.56     NP_731445   AAN13453 Fmr1-PF   FBpp0290600   72.0   646   9.56     NP_001163580   ACZ94877 Fmr1-PG   FBpp0300445   81.0   729   9.05     NP_001247017   AFH06335 Fmr1-PH   FBpp0307052   64.9   577   6.93     NP_001262447   AGB95829 Fmr1-PI   FBpp0307053   71.3   639   9.79     NP_001262448   AGB95830
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088) RNA-binding domain, S1 (IPR022967) Agenet-like domain (IPR008395)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264877   AA438987   AA696905   AA697960   AA950368   AE014297 AAF54493   AE014297 AAN13451   AE014297 AAN13452   AE014297 AAN13453   AE014297 AAN13454   AE014297 ACZ94877   AF205596 AAF14639   AF205597 AAF14640   AF305881 AAG22045   AE014297 AFH06335   AE014297 AGB95829   AE014297 AGB95830   AI403408   AI406013   AI512859   AI517694   AI531174   AI532367   AI542024   AI542335   AJ271221 CAB66340   AJ413217 CAC88757   AJ422082 CAD19443   AJ422083 CAD19444   AQ073998   AQ254726   AW940873   AX094234   AY060951 AAL28499   AY069182 AAL39327   BF486521   BF489056   BF489636   BF495201   BF496536   BF498210   BF498232   BF503171   BF506468   BG641013   BH214570   BI167376   BI173555   BI212667   BI216831   BI239377   BI355465   BI369472   BI371104   BI371114   BI375747   BI613448   BI636665   BI637171   BP555480   BP555481   BT031124   BT033066   CO177430   CO178005   CO185359   CO188967   CO190779   CO264621   CO273439   CO279905   CO280445   CO281652   CO281657   CO283476   CO284773   CO288317   CO300470   CO305359   CO318290   CO325446   CO331405   CO336544   CO339451   CO344125   CZ480560   CZ480561   EC056962   EC058093   EC060484   EC069344   EC071963   EC078726   EC080244   EC089264   EC195312   EC196211   EC198375   EC199502   EC199530   EC206845   EC210823   EC211175   EC215597   EC221304   EC222689   EC223925   EC230150   EC230195   EC232302   EC238580   EC239604   EC240171   EC240510   EC247680   EC249231   EC255318   EC257441   EC262352   GH941230   GH944897   GH955900   GH958118   GH965622   GH965977   GH966831   GH970155   GH971601   GH979004   GH979890
UniProtKB/Swiss-Prot	Q9NFU0
UniProtKB/TrEMBL	B3LF78
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   organism | faint & ubiquitous   (Schenck et al., 2002) pole cell   (Schenck et al., 2002) embryonic stage 9 -- 17   presumptive embryonic/larval central nervous system   (Schenck et al., 2002) embryonic somatic muscle   (Schenck et al., 2002) embryonic stage 14   presumptive embryonic/larval central nervous system   (Wan et al., 2000) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 16   organism   (Wan et al., 2000) Comment:assayed 0-16 hr AEL; peak at 0-3 hr AEL for short isoform, 6-12 hr AEL for long isoform adult stage | female   ovary   (Wan et al., 2000)
Additional Descriptive Data
	At embryonic stage 5 Fmr1 is ubiquitously expressed at low levels, and enriched in pole cells. By stage 9, expression is observed in the central nervous system and, at a lower level, in the somatic musculature. Expression increases in somatic musculature, and by stage 12 is visible in lateral stripes corresponding to the somatic muscles. (Schenck et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference pupal stage   brain   (Morales et al., 2002) pupal stage & adult stage   neuron   (Morales et al., 2002) adult stage   adult brain   (Morales et al., 2002) cell fractionation Stage Tissue/Position (including subcellular localization) Reference larval stage   organism   • Golgi membrane (Zarnescu et al., 2005) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   somatic cell   (Wan et al., 2000) embryonic stage 9 -- 17   embryonic somatic muscle   (Schenck et al., 2002) embryonic stage 11   mesoderm   (Wan et al., 2000) embryonic stage 12 -- 17   presumptive embryonic/larval central nervous system   (Schenck et al., 2002) embryonic stage 14 -- 16   presumptive embryonic/larval central nervous system   (Wan et al., 2000) embryonic stage 16   somatic muscle   (Wan et al., 2000) embryonic stage 16 -- 17   pharyngeal muscle   (Schenck et al., 2002) gonad   (Schenck et al., 2002) embryonic/larval visceral muscle   (Schenck et al., 2002) embryonic/larval hindgut   (Schenck et al., 2002) scolopidial dendrite   • dendrite terminus (Schenck et al., 2002) tendon cell   (Schenck et al., 2002) larval stage | male   testis   (Zhang et al., 2004) Comment:NOT terminal epithelial cell of testis larval stage | male & spermatogenesis   spermatogonium | faint   • cytoplasm (Zhang et al., 2004) spermatogenesis & larval stage | male   spermatocyte   • cytoplasm (Zhang et al., 2004) first instar larval stage   scolopidial dendrite   (Schenck et al., 2002) third instar larval stage   embryonic/larval central nervous system   (Schenck et al., 2002) embryonic/larval mushroom body   (Schenck et al., 2002) Kenyon cell   (Schenck et al., 2002) ventral nerve cord   • cytoplasm (Schenck et al., 2002) morphogenetic furrow   (Schenck et al., 2002) photoreceptor cell R8   (Schenck et al., 2002) Bolwig nerve   • axon (Schenck et al., 2002) third instar larval stage | male   testis   (Schenck et al., 2002) spermatocyte   • cytoplasm (Schenck et al., 2002) adult stage | male   testis   (Zhang et al., 2004) Comment:NOT terminal epithelial cell of testis oogenesis & adult stage | female   oocyte   (Zarnescu et al., 2005) adult stage | female & oogenesis   ovary   • cytoplasm | granular (Schaefer et al., 2010) adult stage | male & spermatogenesis   spermatogonium | faint   • cytoplasm (Zhang et al., 2004) early elongation stage spermatid   • cytoplasm (Zhang et al., 2004) spermatogenesis & adult stage | male   spermatocyte   • cytoplasm (Zhang et al., 2004)   S2 cell-line   • cytoplasm | granular (Schaefer et al., 2010) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Schenck et al., 2002) embryonic stage 1 -- 17   organism   (Wan et al., 2000) Comment:assayed 0-18 hr AEL adult stage | male   testis   (Zhang et al., 2004)   S2 cell-line   (Wan et al., 2000)
Additional Descriptive Data
	The Fmr1 protein is cytoplasmic and present in discrete granules. Upon heat shock, Fmr1 protein concentrates in large cytoplasmic granules. (Schaefer et al., 2010) The 85 kD band is detectable via Western blot at all embryonic stages and in S2 cells. THe 82 kD band is observed in S2 cells and in embryos colleced 9-12 hours AEL. Embryonic expression of Fmr1 protein is first detectable in the somatic musculature at embryonic stage 9. By stage 12, Fmr1 protein accumulates in the brain and ventral nerve cord. In late embryos high levels of expression are observed in the pharyngeal muscle, gonads, visceral muscle and hindgut. Expression is also observed in the tips of scolopidial dendrites in thoracic and abdominal segments, and at muscle attachment sites. In first instar larvae, the expression in scolopidial neurons extend to the entire scolopidial dendrite. In third instar larvae, expression persists in muscles, but is primarily localized to the central nervous system. Fmr1 protein is heavily expressed in the larval mushroom body, and accumulates in the cell bodies, dendrites, and axons of Kenyon cells. Expression is widespread in the ventral nerve cord, where it is cytoplasmically localized. In the larval testis, expression is localized cytoplasmically in spermatocytes, but is excluded from spermatogonia. In the eye disc, Fmr1 protein is observed at the morphogenetic furrow, in the axon of the Bolwig nerve, and in maturing ommatidia. Ommatidial expression appears to be restricted to photoreceptor cell R8. (Schenck et al., 2002) Fmr1 protein expression is enriched in the brain. It is expressed specifically in neurons and is excluded from glia. In pupal and adult brains, it is expressed in most, if not all neurons. (Morales et al., 2002) Fmr1 protein is expressed in the larval and adult testis. Expression is modest in spermatogonia, strong in spermatocytes, and undetectable in terminal epithelial cells of testis. Fmr1 protein is present at a low level in elongated spermatids, but absent in late-stage elongated spermatids. (Zhang et al., 2004)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2001) lipid particle inferred from direct assay (Cermelli et al., 2006) RNA-induced silencing complex inferred from physical interaction with AGO2 (Caudy et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    151 central nervous system, larvae L3    199 central nervous system, pupae P8    111 head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female    152 ovary, mated 4-day female    263 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (151) central nervous system, larvae L3  (199) central nervous system, pupae P8  (111) head, virgin 1-day female  (39) head, virgin 4-day female  (39) head, virgin 20-day female    15 head, mated 1-day female  (44) head, mated 4-day female  (34) head, mated 20-day female    18 head, mated 1-day male  (45) head, mated 4-day male  (46) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  (29) digestive system, 1-day adult    16 digestive system, 4-day adult  (40) digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae  (55) fat body, pupae P8  (51) carcass, larvae L3 wandering  (97) carcass, 1-day adult  (31) carcass, 4-day adult  (42) carcass, 20-day adult    25 ovary, virgin 4-day female  (152) ovary, mated 4-day female  (263) testis, mated 4-day male  (80) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (151) central nervous system, larvae L3  (199) central nervous system, pupae P8  (111) head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female  (152) ovary, mated 4-day female  (263) testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    151 central nervous system, larvae L3    199 central nervous system, pupae P8    111 head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female    152 ovary, mated 4-day female    263 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    151 central nervous system, larvae L3    199 central nervous system, pupae P8    111 head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female    152 ovary, mated 4-day female    263 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (151) central nervous system, larvae L3  (199) central nervous system, pupae P8  (111) head, virgin 1-day female  (39) head, virgin 4-day female  (39) head, virgin 20-day female    15 head, mated 1-day female  (44) head, mated 4-day female  (34) head, mated 20-day female    18 head, mated 1-day male  (45) head, mated 4-day male  (46) head, mated 20-day male  (36) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering  29 digestive system, 1-day adult    16 digestive system, 4-day adult  (40) digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae  (55) fat body, pupae P8  (51) carcass, larvae L3 wandering  (97) carcass, 1-day adult  31 carcass, 4-day adult  (42) carcass, 20-day adult    25 ovary, virgin 4-day female  (152) ovary, mated 4-day female  (263) testis, mated 4-day male  (80) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (151) central nervous system, larvae L3  (199) central nervous system, pupae P8  111 head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female  (152) ovary, mated 4-day female  (263) testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    151 central nervous system, larvae L3    199 central nervous system, pupae P8    111 head, virgin 1-day female    39 head, virgin 4-day female    39 head, virgin 20-day female    15 head, mated 1-day female    44 head, mated 4-day female    34 head, mated 20-day female    18 head, mated 1-day male    45 head, mated 4-day male    46 head, mated 20-day male    36 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    18 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    16 digestive system, 4-day adult    40 digestive system, 20-day adult    21 fat body, larvae L3 wandering    22 fat body, white prepupae    55 fat body, pupae P8    51 carcass, larvae L3 wandering    97 carcass, 1-day adult    31 carcass, 4-day adult    42 carcass, 20-day adult    25 ovary, virgin 4-day female    152 ovary, mated 4-day female    263 testis, mated 4-day male    80 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr  (33) embryo 12-14hr  (35) embryo 14-16hr  (45) embryo 16-18hr  (34) embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  (31) larva L3 puffstage 7-9  (37) white prepupae new  (40) white prepupae 12hr  (42) white prepupae 24hr  (53) pupae 2d postWPP  (38) pupae 3d postWPP  (27) pupae 4d postWPP    16 adult male 01day    24 adult male 05day  (31) adult male 30day  (28) adult female 01day  (43) adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (80) embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr  (33) embryo 12-14hr  (35) embryo 14-16hr  (45) embryo 16-18hr  (34) embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6  31 larva L3 puffstage 7-9  (37) white prepupae new  (40) white prepupae 12hr  (42) white prepupae 24hr  (53) pupae 2d postWPP  (38) pupae 3d postWPP  27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day  31 adult male 30day  28 adult female 01day  (43) adult female 05day  (61) adult female 30day  (61) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    80 embryo 02-04hr    18 embryo 04-06hr    17 embryo 06-08hr    19 embryo 08-10hr    23 embryo 10-12hr    33 embryo 12-14hr    35 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    15 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    22 larva L2    20 larva L3 12hr old    17 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    37 white prepupae new    40 white prepupae 12hr    42 white prepupae 24hr    53 pupae 2d postWPP    38 pupae 3d postWPP    27 pupae 4d postWPP    16 adult male 01day    24 adult male 05day    31 adult male 30day    28 adult female 01day    43 adult female 05day    61 adult female 30day    61 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    205 Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2    176 embryonic Kc167    100 embryonic S1    88 embryonic S3    109 leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    217 wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    139 CNS ML-DmBG2-c2    108 tumorous blood cells mbn2    153 ovary fGS/OSS    131 ovary OSC    241 ovary OSS    193 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (205) Schneider line 2 Sg4  (72) embryonic 1182-4H  (97) embryonic GM2  (176) embryonic Kc167  (100) embryonic S1  (88) embryonic S3  (109) leg disc CME L1  (91) wing disc CME-W2  (75) wing disc ML-DmD8  (60) wing disc ML-DmD9  (67) wing disc ML-DmD16-c3  (217) wing disc ML-DmD21  (56) wing disc ML-DmD32  (93) haltere disc ML-DmD17-c3  (96) eye-antennal disc ML-DmD11  (59) antennal disc ML-DmD20-c5  (57) mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (139) CNS ML-DmBG2-c2  (108) tumorous blood cells mbn2  (153) ovary fGS/OSS  (131) ovary OSC  (241) ovary OSS  (193) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (205) Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2  (176) embryonic Kc167    100 embryonic S1    88 embryonic S3  (109) leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3  (217) wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (139) CNS ML-DmBG2-c2  (108) tumorous blood cells mbn2  (153) ovary fGS/OSS  (131) ovary OSC  (241) ovary OSS  (193) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    205 Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2    176 embryonic Kc167    100 embryonic S1    88 embryonic S3    109 leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    217 wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    139 CNS ML-DmBG2-c2    108 tumorous blood cells mbn2    153 ovary fGS/OSS    131 ovary OSC    241 ovary OSS    193 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    205 Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2    176 embryonic Kc167    100 embryonic S1    88 embryonic S3    109 leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    217 wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    139 CNS ML-DmBG2-c2    108 tumorous blood cells mbn2    153 ovary fGS/OSS    131 ovary OSC    241 ovary OSS    193 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (205) Schneider line 2 Sg4  (72) embryonic 1182-4H  (97) embryonic GM2  (176) embryonic Kc167  (100) embryonic S1  (88) embryonic S3  (109) leg disc CME L1  (91) wing disc CME-W2  (75) wing disc ML-DmD8  (60) wing disc ML-DmD9  (67) wing disc ML-DmD16-c3  (217) wing disc ML-DmD21  (56) wing disc ML-DmD32  (93) haltere disc ML-DmD17-c3  (96) eye-antennal disc ML-DmD11  (59) antennal disc ML-DmD20-c5  (57) mixed discs ML-DmD4-c1  (108) CNS ML-DmBG1-c1  (139) CNS ML-DmBG2-c2  (108) tumorous blood cells mbn2  (153) ovary fGS/OSS  (131) ovary OSC  (241) ovary OSS  (193) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (205) Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2  (176) embryonic Kc167    100 embryonic S1    88 embryonic S3  109 leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3  (217) wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1  108 CNS ML-DmBG1-c1  139 CNS ML-DmBG2-c2  108 tumorous blood cells mbn2  (153) ovary fGS/OSS  131 ovary OSC  (241) ovary OSS  (193) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    205 Schneider line 2 Sg4    72 embryonic 1182-4H    97 embryonic GM2    176 embryonic Kc167    100 embryonic S1    88 embryonic S3    109 leg disc CME L1    91 wing disc CME-W2    75 wing disc ML-DmD8    60 wing disc ML-DmD9    67 wing disc ML-DmD16-c3    217 wing disc ML-DmD21    56 wing disc ML-DmD32    93 haltere disc ML-DmD17-c3    96 eye-antennal disc ML-DmD11    59 antennal disc ML-DmD20-c5    57 mixed discs ML-DmD4-c1    108 CNS ML-DmBG1-c1    139 CNS ML-DmBG2-c2    108 tumorous blood cells mbn2    153 ovary fGS/OSS    131 ovary OSC    241 ovary OSS    193 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    112 cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult    193 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    310 Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult    133 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    164 Caffeine 25 mg/ml 48 hrs, 4-day adult    135 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (112) cold shock, 4-day adult  (84) heat shock, 4-day adult  (65) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  (29) Cadmium 50 mM 48 hrs, 4-day adult  (85) Cadmium 100 mM 48 hrs, 4-day adult  (193) Copper 0.5 mM 12 hrs, larvae L3  (68) Copper 15 mM 48 hrs, 4-day adult  (310) Zinc 5 mM 12 hrs, larvae L3  (50) Zinc 4.5 mM 48 hrs, 4-day adult  (133) Ethanol 2.5% 3 hrs, larvae L3  (106) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (164) Caffeine 25 mg/ml 48 hrs, 4-day adult  (135) Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult  (78) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (112) cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult  (193) Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult  (310) Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult  (133) Ethanol 2.5% 3 hrs, larvae L3  106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (164) Caffeine 25 mg/ml 48 hrs, 4-day adult  (135) Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    112 cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult    193 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    310 Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult    133 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    164 Caffeine 25 mg/ml 48 hrs, 4-day adult    135 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    112 cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult    193 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    310 Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult    133 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    164 Caffeine 25 mg/ml 48 hrs, 4-day adult    135 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (112) cold shock, 4-day adult  (84) heat shock, 4-day adult  (65) Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3  29 Cadmium 50 mM 48 hrs, 4-day adult  (85) Cadmium 100 mM 48 hrs, 4-day adult  (193) Copper 0.5 mM 12 hrs, larvae L3  (68) Copper 15 mM 48 hrs, 4-day adult  (310) Zinc 5 mM 12 hrs, larvae L3  (50) Zinc 4.5 mM 48 hrs, 4-day adult  (133) Ethanol 2.5% 3 hrs, larvae L3  (106) Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (164) Caffeine 25 mg/ml 48 hrs, 4-day adult  (135) Paraquat 5 mM 48 hrs, 4-day adult  (119) Paraquat 10 mM 48 hrs, 4-day adult  (78) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  112 cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult  (193) Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult  (310) Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult  133 Ethanol 2.5% 3 hrs, larvae L3  106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (164) Caffeine 25 mg/ml 48 hrs, 4-day adult  135 Paraquat 5 mM 48 hrs, 4-day adult  119 Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    112 cold shock, 4-day adult    84 heat shock, 4-day adult    65 Cadmium 50 mM 6 hrs, larvae L3    24 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    85 Cadmium 100 mM 48 hrs, 4-day adult    193 Copper 0.5 mM 12 hrs, larvae L3    68 Copper 15 mM 48 hrs, 4-day adult    310 Zinc 5 mM 12 hrs, larvae L3    50 Zinc 4.5 mM 48 hrs, 4-day adult    133 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    22 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    164 Caffeine 25 mg/ml 48 hrs, 4-day adult    135 Paraquat 5 mM 48 hrs, 4-day adult    119 Paraquat 10 mM 48 hrs, 4-day adult    78 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM08679 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028734 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6203-RB;CG6203-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Fmr1I307N.Z.Scer\UAS, Scer\GAL4elav-C155 Fmr1Scer\UAS.cZa lethal, with Fmr1Scer\UAS.cZa, Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS lethal, with Scer\GAL4αTub84B.PL Fmr1EP3517 lethal | adult stage, with Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa lethal | partially | pharate adult stage Fmr1Δ83M Fmr1Δ113M lethal | partially | pharate adult stage, with Scer\GAL4[-]: Fmr1EP3517 lethal | pharate adult stage Fmr1EP3517 Fmr1Δ50M lethal | pupal stage, with Scer\GAL4G7 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa lethal | pupal stage, with Scer\GAL4Mhc.PW Fmr1I244N.I307N.Scer\UAS partially lethal - majority die | embryonic stage | maternal effect Fmr13 partially lethal - majority live Fmr13 Fmr1Δ113M viable Fmr12 Fmr13 Fmr14.L Fmr19N Fmr1Δ50M Fmr1Δ83M Fmr1Δ113M Fmr1Δ192N viable, with Scer\GAL4[-]: Fmr1EP3422 Fmr1EP3517 viable, with mir-277+tLa, mir-34null Fmr1+tLa viable, with Scer\GAL4pnr-MD237 Fmr1GD1288 viable, with Scer\GAL4αTub84B.PL Fmr1A158V.EP3517 Fmr1E68K.EP3517 Fmr1G80D.EP3517 Fmr1G220E.EP3517 Fmr1G269E.EP3517 Fmr1L186H.EP3517 Fmr1Q378P.EP3517 Fmr1R47C.EP3517 Fmr1R115C.EP3517 Fmr1R115H.EP3517 Fmr1R279C.EP3517 Fmr1S174F.EP3517 Fmr1V354E.EP3517 viable (with Fmr11) Fmr14.L viable (with Fmr12.L) Fmr14.L viable (with Fmr14.L) Fmr11 Fmr12.L Sterility Allele fertile Fmr19N fertile, with Scer\GAL4[-]: Fmr1EP3517 male sterile Fmr13 semi-sterile Fmr1Δ50M Other Phenotypes Allele courtship behavior defective Fmr1unspecified courtship behavior defective, with Fmr13 Fmr1FS Fmr1I244N Fmr1I307N courtship behavior defective, with Fmr1FS Fmr13 courtship behavior defective, with Fmr1I244N Fmr13 courtship behavior defective, with Fmr1I307N Fmr13 courtship behavior defective (with Fmr13) Fmr1I244N Fmr1I307N courtship behavior defective (with Fmr1I244N) Fmr13 courtship behavior defective (with Fmr1I307N) Fmr13 courtship behavior defective | male Fmr13 eclosion rhythm defective Fmr13 eclosion rhythm defective | recessive Fmr1Δ113M endomitotic cell cycle defective Fmr13 Fmr1Δ50M flight defective (with Df(3R)by62) Fmr1Δ50M flight defective (with Df(3R)by62), with Scer\GAL4[-]: Fmr1EP3422 Fmr1EP3517 flightless, with Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa flightless, with Scer\GAL4Mhc.PW Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa gravitaxis defective | conditional, with mir-277+tLa, mir-34null Fmr1+tLa heat stress response defective | conditional, with mir-277+tLa, mir-34null Fmr1+tLa increased cell death, with Scer\GAL4hs.2sev Fmr1Scer\UAS.cWa learning defective | adult stage Fmr1Δ50M locomotor behavior defective | larval stage, with Scer\GAL4109(2)80 Fmr1Scer\UAS.cWa locomotor behavior defective | larval stage (with Fmr11) Fmr14.L locomotor behavior defective | larval stage (with Fmr13) Fmr14.L locomotor behavior defective | larval stage (with Fmr14.L) Fmr11 Fmr13 locomotor behavior defective | larval stage | recessive Fmr14.L locomotor rhythm defective Fmr13 Fmr1B55 Fmr1unspecified locomotor rhythm defective, with Fmr13 Fmr1I244N Fmr1I307N locomotor rhythm defective, with Fmr1I244N Fmr13 locomotor rhythm defective, with Fmr1I307N Fmr13 locomotor rhythm defective, with Scer\GAL4tim.PE Fmr1EP3517 Fmr1NE3-4 locomotor rhythm defective (with Fmr13) Fmr1I244N Fmr1I307N locomotor rhythm defective (with Fmr1I244N) Fmr13 locomotor rhythm defective (with Fmr1I307N) Fmr13 locomotor rhythm defective | dominant Fmr1Δ113M locomotor rhythm defective | recessive Fmr1Δ113M memory defective Fmr13 Fmr1B55 memory defective, with Fmr13 Fmr1FS memory defective, with Fmr1FS Fmr13 memory defective, with Scer\GAL4c747 Fmr1dsRNA.280.Scer\UAS Fmr1dsRNA.500.Scer\UAS memory defective, with Scer\GAL4ey-OK107 Fmr1dsRNA.280.Scer\UAS Fmr1dsRNA.500.Scer\UAS memory defective (with Fmr13) Fmr1B55 memory defective (with Fmr1B55) Fmr13 memory defective | male Fmr13 memory defective | temperature conditional, with Scer\GAL4hs.PB Fmr1Scer\UAS.cZa mitotic cell cycle defective | embryonic stage Fmr13 neuroanatomy defective Fmr13 Fmr1B55 Fmr1EP3517 Fmr1Δ50M Fmr1Δ83M Fmr1Δ113M neuroanatomy defective, with Fmr13 Fmr1I244N Fmr1I307N neuroanatomy defective, with Fmr1I244N Fmr13 neuroanatomy defective, with Fmr1I307N Fmr13 neuroanatomy defective, with Scer\GAL4ato.3.6 Fmr1I307N.Scer\UAS Fmr1Scer\UAS.cZa neuroanatomy defective, with Scer\GAL4c747 Fmr1Scer\UAS.cZa neuroanatomy defective, with Scer\GAL4elav-C155 Fmr1EP3517 Fmr1Scer\UAS.cZa neuroanatomy defective, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa neuroanatomy defective, with Scer\GAL4Mhc.PW Fmr1Scer\UAS.cZa neuroanatomy defective, with Scer\GAL4P2.4.Pdf Fmr1E68K.EP3517 Fmr1EP3517 Fmr1G220E.EP3517 Fmr1G269E.EP3517 Fmr1Q378P.EP3517 Fmr1Scer\UAS.cZa Fmr1V354E.EP3517 neuroanatomy defective (with Df(3R)by62) Fmr1Δ83M neuroanatomy defective (with Fmr13) Fmr1I244N Fmr1I307N Fmr1Δ83M Fmr1Δ113M neuroanatomy defective (with Fmr1E68K.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1EP3517) Fmr1Δ113M neuroanatomy defective (with Fmr1EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1G269E.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1I244N) Fmr13 neuroanatomy defective (with Fmr1I307N) Fmr13 neuroanatomy defective (with Fmr1L186H.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1R47C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1R115C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1R279C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M neuroanatomy defective (with Fmr1Δ50M) Fmr1Δ113M neuroanatomy defective (with Fmr1Δ83M) Fmr13 Fmr1Δ113M neuroanatomy defective (with Fmr1Δ113M) Fmr13 Fmr1EP3517 Fmr1Δ50M Fmr1Δ83M neuroanatomy defective (with Fmr1Δ113M), with Scer\GAL4[-]: Fmr1E68K.EP3517 Fmr1EP3517 Fmr1G269E.EP3517 Fmr1L186H.EP3517 Fmr1R47C.EP3517 Fmr1R115C.EP3517 Fmr1R279C.EP3517 neuroanatomy defective | adult stage Fmr13 neuroanatomy defective | conditional, with mir-277+tLa, mir-34null Fmr1+tLa neuroanatomy defective | dominant Fmr1unspecified neuroanatomy defective | larval stage Fmr13 Fmr1EP3517 Fmr1unspecified Fmr1Δ50M neuroanatomy defective | pharate adult stage Fmr13 neuroanatomy defective | recessive Fmr1Δ113M neuroanatomy defective | recessive, with Scer\GAL4[-]: Fmr1EP3517 neuroanatomy defective | semidominant Fmr1Δ113M neuroanatomy defective | somatic clone Fmr13 Fmr1Δ50M neuroanatomy defective | somatic clone, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa neuroanatomy defective | third instar larval stage Fmr13 Fmr1Δ50M neurophysiology defective Fmr13 Fmr1Δ50M neurophysiology defective, with Scer\GAL4hs.2sev Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa short lived, with mir-277+tLa, mir-34null Fmr1+tLa suppressor of variegation, with P{hsp26-pt-T}118E-10 Fmr13 uncoordinated, with Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa visible, with Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa visible, with Scer\GAL4GMR.PF Fmr1EP3517 visible, with Scer\GAL4hs.2sev Fmr1EP3517 visible | dominant Fmr1sev.PW wild-type Fmr1+t14 wild-type (with Df(3R)by62) Fmr19N Phenotype manifest in Allele adult brain | conditional, with mir-277+tLa, mir-34null Fmr1+tLa adult mushroom body, with Scer\GAL4c747 Fmr1Scer\UAS.cZa anterior crossvein, with Scer\GAL4dpp.blk1 Fmr1Scer\UAS.cWa bouton, with Scer\GAL4elav-C155 Fmr1Scer\UAS.cZa bouton | somatic clone Fmr1Δ50M centrosome | embryonic stage Fmr13 condensed chromosome | embryonic stage Fmr13 cycle 12 embryo Fmr13 cycle 13 embryo Fmr13 dendritic arborizing neuron Fmr14.L dendritic arborizing neuron, with Scer\GAL4109(2)80 Fmr1Scer\UAS.cWa dorsal cluster neuron, with Scer\GAL4ato.3.6 Fmr1I307N.Scer\UAS Fmr1Scer\UAS.cZa dorsal cluster neuron (with Fmr1EP3517) Fmr1Δ113M dorsal cluster neuron (with Fmr1Δ50M) Fmr1Δ113M dorsal cluster neuron (with Fmr1Δ83M) Fmr1Δ113M dorsal cluster neuron (with Fmr1Δ113M) Fmr1Δ50M Fmr1Δ83M Fmr1EP3517 dorsal cluster neuron & neurite Fmr1Δ113M dorsal cluster neuron & neurite, with Scer\GAL4ato.3.6 Fmr1I307N.Scer\UAS dorsal cluster neuron & neurite (with Fmr1EP3517), with Scer\GAL4[-]: Fmr1Δ113M dorsal cluster neuron & neurite (with Fmr1Δ50M) Fmr1Δ113M dorsal cluster neuron & neurite (with Fmr1Δ113M) Fmr1Δ50M dorsal cluster neuron & neurite (with Fmr1Δ113M), with Scer\GAL4[-]: Fmr1EP3517 egg chamber Fmr13 embryonic/larval neuromuscular junction Fmr1Δ50M Fmr1EP3517 embryonic/larval neuromuscular junction | third instar larval stage Fmr1Δ50M eye Fmr1sev.PW eye, with Scer\GAL4GMR.PF Fmr1EP3517 eye, with Scer\GAL4hs.2sev Fmr1EP3517 Fmr1I244N.Scer\UAS Fmr1I307N.Scer\UAS Fmr1Scer\UAS.cWa eye photoreceptor cell, with Scer\GAL4hs.2sev Fmr1Scer\UAS.cWa Fmr1Scer\UAS.cZa gamma-lobe & neuron | somatic clone Fmr1Δ50M Fmr13 gamma-lobe & neuron | somatic clone, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa germ cell & egg chamber Fmr13 germline cell Fmr13 LNv neuron Fmr1Δ113M Fmr13 Fmr1B55 LNv neuron, with Scer\GAL4[-]: Fmr1EP3517 LNv neuron, with Scer\GAL4P2.4.Pdf Fmr1EP3517 Fmr1Scer\UAS.cZa Fmr1E68K.EP3517 Fmr1G220E.EP3517 Fmr1G269E.EP3517 Fmr1V354E.EP3517 Fmr1Q378P.EP3517 LNv neuron (with Fmr1E68K.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1G269E.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1L186H.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1R47C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1R115C.EP3517) Fmr1Δ113M LNv neuron (with Fmr1R115C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1R279C.EP3517), with Scer\GAL4[-]: Fmr1Δ113M LNv neuron (with Fmr1Δ50M) Fmr1Δ113M LNv neuron (with Fmr1Δ83M) Fmr1Δ113M LNv neuron (with Fmr1Δ113M) Fmr1Δ50M Fmr1Δ83M Fmr1R115C.EP3517 LNv neuron (with Fmr1Δ113M), with Scer\GAL4[-]: Fmr1EP3517 Fmr1E68K.EP3517 Fmr1R47C.EP3517 Fmr1L186H.EP3517 Fmr1G269E.EP3517 Fmr1R279C.EP3517 Fmr1R115C.EP3517 mushroom body Fmr1Δ113M Fmr1Δ50M Fmr1Δ83M Fmr1EP3517 mushroom body (with Df(3R)by62) Fmr1Δ83M mushroom body (with Fmr13) Fmr1Δ113M Fmr1Δ83M mushroom body (with Fmr1Δ50M) Fmr1Δ113M mushroom body (with Fmr1Δ83M) Fmr1Δ113M Fmr13 mushroom body (with Fmr1Δ113M) Fmr1Δ50M Fmr1Δ83M Fmr13 mushroom body & neuron & dendrite | somatic clone Fmr1Δ50M Fmr13 mushroom body & neuron & dendrite | somatic clone, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa mushroom body & neuron | somatic clone Fmr1Δ50M Fmr13 mushroom body & neuron | somatic clone, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa mushroom body alpha-lobe Fmr1Δ83M Fmr1EP3517 mushroom body alpha-lobe (with Df(3R)by62) Fmr1Δ83M mushroom body alpha-lobe (with Fmr13) Fmr1Δ83M mushroom body alpha-lobe (with Fmr1Δ50M) Fmr1Δ113M mushroom body alpha-lobe (with Fmr1Δ83M) Fmr1Δ113M Fmr13 mushroom body alpha-lobe (with Fmr1Δ113M) Fmr1Δ50M Fmr1Δ83M mushroom body beta'-lobe, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa mushroom body beta-lobe Fmr1Δ113M Fmr1Δ50M Fmr1Δ83M Fmr13 Fmr1B55 Fmr1EP3517 mushroom body beta-lobe, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa mushroom body beta-lobe (with Df(3R)by62) Fmr1Δ83M mushroom body beta-lobe (with Fmr13) Fmr1Δ113M Fmr1Δ83M mushroom body beta-lobe (with Fmr1Δ50M) Fmr1Δ113M mushroom body beta-lobe (with Fmr1Δ83M) Fmr1Δ113M Fmr13 mushroom body beta-lobe (with Fmr1Δ113M) Fmr1Δ50M Fmr1Δ83M Fmr13 mushroom body beta-lobe | pharate adult stage Fmr13 mushroom body gamma-lobe, with Scer\GAL4ey-OK107 Fmr1Scer\UAS.cZa neuromuscular junction Fmr1Δ50M Fmr13 neuromuscular junction, with Scer\GAL4elav-C155 Fmr1Scer\UAS.cZa neuromuscular junction, with Scer\GAL4Mhc.PW Fmr1Scer\UAS.cZa neuromuscular junction & synapse Fmr1unspecified neuromuscular junction & synapse, with Scer\GAL4elav-C155 Fmr1EP3517 neuron & beta-lobe Fmr1unspecified neuron & beta-lobe, with Fmr13 Fmr1I244N Fmr1I307N neuron & beta-lobe, with Fmr1I244N Fmr13 neuron & beta-lobe, with Fmr1I307N Fmr13 neuron & beta-lobe (with Fmr13) Fmr1I244N Fmr1I307N neuron & beta-lobe (with Fmr1I244N) Fmr13 neuron & beta-lobe (with Fmr1I307N) Fmr13 NMJ bouton Fmr1Δ50M Fmr1EP3517 NMJ bouton | larval stage Fmr13 NMJ bouton | larval stage | supernumerary Fmr13 NMJ bouton | supernumerary | third instar larval stage Fmr1Δ50M nucleus | embryonic cycle 13 Fmr13 nurse cell Fmr13 nurse cell (with Fmr13) Fmr1Δ50M nurse cell (with Fmr1Δ50M) Fmr13 nurse cell | supernumerary Fmr13 nurse cell | supernumerary (with Fmr13) Fmr1Δ50M nurse cell | supernumerary (with Fmr1Δ50M) Fmr13 ommatidium Fmr1sev.PW ommatidium, with Scer\GAL4GMR.PF Fmr1EP3517 ommatidium, with Scer\GAL4hs.2sev Fmr1I244N.Scer\UAS Fmr1I307N.Scer\UAS Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cWa Fmr1Scer\UAS.cZa oocyte | ectopic Fmr13 photoreceptor cell, with Scer\GAL4hs.2sev Fmr1I307N.Z.Scer\UAS photoreceptor cell & synapse & lamina receptor cell Fmr1Δ50M photoreceptor cell & synapse & lamina receptor cell, with Scer\GAL4hs.2sev Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa pigment cell, with Scer\GAL4hs.2sev Fmr1Scer\UAS.cWa pole bud Fmr13 pole cell Fmr13 pole cell | germline clone | maternal effect Fmr13 retina Fmr1sev.PW retina, with Scer\GAL4hs.2sev Fmr1Scer\UAS.cZa rhabdomere, with Scer\GAL4hs.2sev Fmr1I307N.Scer\UAS Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cWa Fmr1Scer\UAS.cZa rhabdomere R7, with Scer\GAL4Rh3.PP Fmr1GS11541 s-LNv Pdf neuron | supernumerary | third instar larval stage Fmr1Δ50M spermatid Fmr1Δ50M spermatid axoneme Fmr1Δ50M synapse Fmr1Δ113M Fmr13 synapse, with Scer\GAL4elav-C155 Fmr1EP3517 synapse & larval neuromuscular junction Fmr13 synaptic vesicle | somatic clone | supernumerary Fmr1Δ50M testis Fmr1Δ50M type I bouton Fmr13 type I bouton | supernumerary Fmr1unspecified type I bouton | supernumerary | third instar larval stage Fmr13 ventral adult lateral neuron & commissure Fmr1Δ113M Fmr1B55 ventral adult lateral neuron & commissure, with Scer\GAL4[-]: Fmr1EP3517 wing, with Scer\GAL4dpp.blk1 Fmr1Scer\UAS.cWa wing, with Scer\GAL4elav-C155 Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa wing, with Scer\GAL4Mhc.PW Fmr1I307N.Z.Scer\UAS Fmr1Scer\UAS.cZa wing, with Scer\GAL4vg.PM Fmr1Scer\UAS.cWa wing cell, with Scer\GAL4dpp.blk1 Fmr1Scer\UAS.cWa wing cell, with Scer\GAL4vg.PM Fmr1Scer\UAS.cWa wing margin, with Scer\GAL4vg.PM Fmr1Scer\UAS.cWa
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of Fmr1 Class Mutagen Stocks Known lesion Fmr1B55 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence P-element activity 1 Yes Fmr1Δ113M amorphic allele - genetic evidence, loss of function allele Delta2-3 1 Yes Fmr1Δ50M amorphic allele - genetic evidence, loss of function allele Delta2-3 1 Yes Fmr15-HA-1014 1 -- Fmr15-HA-1895 1 -- Fmr1CB-0950-3 1 -- Fmr1e02790 piggyBac transposase 1 -- Fmr1EP3517 hypomorphic allele - genetic evidence P-element activity 1 Yes Fmr1GS11541 1 Yes Fmr1KG00715 P-element activity 1 -- Fmr1R115C.EP3517 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes Fmr13 amorphic allele - genetic evidence, loss of function allele Delta2-3 0 Yes Fmr1Δ83M amorphic allele - genetic evidence, loss of function allele Delta2-3 0 Yes Fmr11 loss of function allele ethyl methanesulfonate 0 Yes Fmr12.L loss of function allele ethyl methanesulfonate 0 Yes Fmr12 Delta2-3 0 Yes Fmr14.L loss of function allele ethyl methanesulfonate 0 Yes Fmr19N Delta2-3 0 Yes Fmr1A158V.EP3517 ethyl methanesulfonate 0 Yes Fmr1E68K.EP3517 ethyl methanesulfonate 0 Yes Fmr1EP3422 hypomorphic allele - genetic evidence P-element activity 0 Yes Fmr1G220E.EP3517 ethyl methanesulfonate 0 Yes Fmr1G269E.EP3517 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Fmr1G80D.EP3517 ethyl methanesulfonate 0 Yes Fmr1L186H.EP3517 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Fmr1L 0 Yes Fmr1NE3-4 P-element activity 0 Yes Fmr1Q378P.EP3517 ethyl methanesulfonate 0 Yes Fmr1R115H.EP3517 ethyl methanesulfonate 0 Yes Fmr1R279C.EP3517 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Fmr1R47C.EP3517 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Fmr1S174F.EP3517 ethyl methanesulfonate 0 Yes Fmr1unspecified 0 -- Fmr1V354E.EP3517 ethyl methanesulfonate 0 Yes Fmr1Δ192N loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 41 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fmr1 Class Mutagen Stocks Known lesion Fmr1GD1288 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fmr1GL00075 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fmr1HMS00248 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fmr1JF02634 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Fmr1Scer\UAS.cZa in vitro construct - regulatory fusion 1 Yes Fmr1+mIa in vitro construct - minigene 0 Yes Fmr1+t14 in vitro construct - genomic fragment 0 Yes Fmr1+tJa in vitro construct - minigene 0 -- Fmr1+tLa 0 Yes Fmr1Act5C.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Fmr1dsRNA.280.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Fmr1dsRNA.500.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Fmr1dsRNA.cCa in vitro construct - RNAi 0 Yes Fmr1dsRNA.cDa in vitro construct - RNAi 0 Yes Fmr1dsRNA.cIa in vitro construct - RNAi 0 Yes Fmr1dsRNA.cKa in vitro construct - RNAi 0 Yes Fmr1FS in vitro construct 0 Yes Fmr1I244N.I307N.Scer\UAS in vitro construct - amino acid replacement 0 Yes Fmr1I244N.Scer\UAS in vitro construct - amino acid replacement 0 Yes Fmr1I244N in vitro construct - amino acid replacement 0 Yes Fmr1I307N.MtnA.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1I307N.Scer\UAS in vitro construct - amino acid replacement 0 Yes Fmr1I307N.Z.Scer\UAS in vitro construct - amino acid replacement 0 Yes Fmr1I307N in vitro construct - amino acid replacement 0 Yes Fmr1MtnA.O.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1MtnA.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1MtnA.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1MtnA.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1QN.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Fmr1Scer\UAS.cWa in vitro construct - regulatory fusion 0 Yes Fmr1Scer\UAS.T:Avic\GFP-YFP 0 Yes Fmr1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1Scer\UAS.T:Disc\RFP-mRFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Fmr1sev.PW in vitro construct - regulatory fusion 0 Yes Fmr1WTR-LN in vitro construct - site directed mutagenesis 0 Yes Fmr1WTR-SN in vitro construct - site directed mutagenesis 0 Yes Fmr1WTR in vitro construct - genomic fragment 0 -- Fmr1WTRLN-ATG in vitro construct - site directed mutagenesis 0 Yes Fmr1Δ150 in vitro construct 0 Yes Fmr1ΔQN in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by62 (Wan et al., 2000, Zhang et al., 2001, Dockendorff et al., 2002, Michel et al., 2004) Df(3R)Exel6265 (Ryder, 2004.4.26, Bushey et al., 2009, Papoulas et al., 2010)
Partially disrupted in	Df(3R)mir-34 (Liu et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1288} NA P{TRiP.GL00075} NA P{TRiP.HMS00248} NA P{TRiP.JF02634} NA P{UAS-Fmr1.B} NA P{UAS-Fmr1.dsRNA.280} NA P{UAS-Fmr1.dsRNA.500} NA P{UAS-Fmr1.GFP} NA P{UAS-Fmr1.I244N.I307N} NA P{UAS-Fmr1.I244N} NA P{UAS-Fmr1.I307N.Z} NA P{UAS-Fmr1.I307N} NA P{UAS-Fmr1.QN.GFP} NA P{UAS-Fmr1.W} NA P{UAS-Fmr1.YFP} NA P{UAS-Fmr1.Z} NA P{UAS-mRFP-Fmr1} NA characterization construct P{dfmr1} NA P{Fmr1.14} NA P{Fmr1.FS} NA P{Fmr1.WTR} NA P{Fmr1.WTR-LN} NA P{Fmr1.WTRLN-ATG} NA P{Fmr1.WTR-SN} NA P{Fmr1.ΔQN} NA P{Fmr1I244N} NA P{Fmr1I307N} NA P{mir-277-Fmr1+tLa} NA P{sev-Fmr1.W} NA P{UAS-CGG60-EGFP} NA P{UAS-CGG90-EGFP} NA P{WTfmr1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Fmr1EP3422 NA P{EP}Fmr1EP3517 NA P{EP}Fmr1NE3-4 NA P{GSV6}Fmr1GS11541 NA miscellaneous insertions P{RS3}Fmr1CB-0950-3 NA P{RS5}Fmr15-HA-1014 NA P{RS5}Fmr15-HA-1895 NA P{SUPor-P}Fmr1KG00715 NA PBac{RB}Fmr1e02790 NA
Gene Ontology: Function, Process & Cellular Component ( 48 unique terms )
Terms Based on Experimental Evidence ( 45 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2001) protein binding inferred from physical interaction with AGO2 (Ishizuka et al., 2002) inferred from physical interaction with Dcr-1 (Ishizuka et al., 2002) inferred from physical interaction with futsch (assigned by UniProtKB) (Zhang et al., 2001) inferred from physical interaction with piwi (Megosh et al., 2006) inferred from physical interaction with Rm62 (Ishizuka et al., 2002) inferred from physical interaction with RpL5 (Ishizuka et al., 2002) inferred from physical interaction with RpL11 (Ishizuka et al., 2002) inferred from physical interaction with vas (Megosh et al., 2006) protein self-association inferred from direct assay (Siomi et al., 2002) RNA binding inferred from direct assay (Siomi et al., 2002, Papoulas et al., 2010)
Biological Process
CV term Evidence References
axonal fasciculation inferred from mutant phenotype (Reeve et al., 2005) axon guidance inferred from genetic interaction with Sra-1 AND inferred from mutant phenotype (Schenck et al., 2003) inferred from mutant phenotype (Morales et al., 2002) brain development inferred from mutant phenotype (Reeve et al., 2005) cellularization inferred from direct assay (Monzo et al., 2006) inferred from genetic interaction with Capr (Papoulas et al., 2010) NOT chemotaxis inferred from mutant phenotype (Dockendorff et al., 2002) circadian rhythm inferred from mutant phenotype (Morales et al., 2002, Dockendorff et al., 2002) circadian sleep/wake cycle, sleep inferred from mutant phenotype (Bushey et al., 2009) dendrite morphogenesis inferred from mutant phenotype (Xu et al., 2008) germarium-derived oocyte fate determination inferred from mutant phenotype (Costa et al., 2005) germ cell development inferred from genetic interaction with ban (Yang et al., 2009) inferred from mutant phenotype (Costa et al., 2005) germ-line cyst formation inferred from genetic interaction with Cbl (Epstein et al., 2009) inferred from mutant phenotype (Epstein et al., 2009) heterochromatin assembly inferred from mutant phenotype (Deshpande et al., 2006) larval locomotory behavior inferred from mutant phenotype (Xu et al., 2004) locomotor rhythm inferred from mutant phenotype (Inoue et al., 2002, Reeve, 2005, Banerjee et al., 2010) long-term memory inferred from mutant phenotype (Bolduc et al., 2008, Banerjee et al., 2010) male courtship behavior inferred from mutant phenotype (Banerjee et al., 2010) mitotic cell cycle, embryonic inferred from mutant phenotype (Megosh et al., 2006) mRNA transport inferred from mutant phenotype (Estes et al., 2008) mushroom body development inferred from mutant phenotype (Michel et al., 2004) negative regulation of dendrite morphogenesis inferred from mutant phenotype (Pan et al., 2004) negative regulation of synapse assembly inferred from mutant phenotype (Zarnescu et al., 2005, Coffee et al., 2012) negative regulation of translation inferred from direct assay AND inferred from expression pattern (Zhang et al., 2001) neuromuscular junction development inferred from mutant phenotype (Reeve et al., 2008) neuron projection morphogenesis inferred from mutant phenotype (Reeve et al., 2008) neurotransmitter secretion inferred from mutant phenotype (assigned by UniProtKB) (Zhang et al., 2001) olfactory learning inferred from mutant phenotype (Bolduc et al., 2008, Coffee et al., 2012) oocyte dorsal/ventral axis specification inferred from genetic interaction with orb (Costa et al., 2005) NOT phototaxis inferred from mutant phenotype (Dockendorff et al., 2002) pole cell formation inferred from mutant phenotype (Deshpande et al., 2006, Megosh et al., 2006) regulation of cell proliferation inferred from genetic interaction with Cbl (Epstein et al., 2009) inferred from mutant phenotype (Epstein et al., 2009) regulation of dendrite morphogenesis inferred from mutant phenotype (Lee et al., 2003) regulation of mitotic cell cycle, embryonic inferred from genetic interaction with Capr (Papoulas et al., 2010) regulation of synapse organization inferred from genetic interaction with Sra-1 AND inferred from mutant phenotype (Schenck et al., 2003) inferred from mutant phenotype (Pan et al., 2004) regulation of synaptic growth at neuromuscular junction inferred from mutant phenotype (assigned by UniProtKB) (Zhang et al., 2001) regulation of translation inferred from mutant phenotype (Costa et al., 2005) short-term memory inferred from mutant phenotype (Banerjee et al., 2010) sperm axoneme assembly inferred from mutant phenotype (Zhang et al., 2004) NOT synaptic transmission inferred from mutant phenotype (Morales et al., 2002)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (assigned by UniProtKB) (Zhang et al., 2001) lipid particle inferred from direct assay (Cermelli et al., 2006) RNA-induced silencing complex inferred from physical interaction with AGO2 (Caudy et al., 2002)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity with UniProtKB:P51116 (FlyBase, 1992-) non-traceable author statement (Zhang, 2000.1.15)
Biological Process
CV term Evidence References
circadian rhythm traceable author statement (Jin and Warren, 2003) locomotion traceable author statement (Jin and Warren, 2003) male courtship behavior traceable author statement (Jin and Warren, 2003) regulation of translation non-traceable author statement (Oostra, 2002) synapse assembly non-traceable author statement (Oostra, 2002)
Cellular Component
CV term Evidence References
micro-ribonucleoprotein complex traceable author statement (Nelson et al., 2003) RNA-induced silencing complex traceable author statement (Nelson et al., 2003, Murchison and Hannon, 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Fmr1 - Adar tandem affinity purification, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting (Bhogal et al., 2011) Fmr1 - Atg7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Baldspot anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG10103 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG10465 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG10958 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG11109 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG11714 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG11961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG12519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG1265 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG12725 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG12796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG13284 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG1607 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG17562 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG1774 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG18619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG2118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG30172 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG3077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG3106 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG31769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG31776 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG31798 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG32016 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG32137 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG32649 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG33695 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG3568 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG4164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG4270 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG42724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG43164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG4619 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG4908 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG6665 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG6686 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG6933 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG7102 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG7164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG7739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG8336 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CG9634 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CHOp24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CalpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Capr anti bait coimmunoprecipitation, western blot, peptide massfingerprinting (Papoulas et al., 2010) Fmr1 - Cchl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Cdk5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CenG1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - CkIIα-i3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Cpr31A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Cyp4c3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - EndoG anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - HDAC6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Hex-A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Irp-1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Liprin-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Lst8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Mcm7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Mnt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - ND42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Nak anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Oamb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - PCID2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - PH4αSG1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Pitslre anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Pof anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Rbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Rcc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - RnrS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - RpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - SNF4Aγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Sar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Skp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Spt5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Tpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Ublcp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Ubx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - VhaSFD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Vinc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - Wsck anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - ap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - cbx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - coro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - eIF4G anti bait coimmunoprecipitation, peptide massfingerprinting, western blot (Papoulas et al., 2010) Fmr1 - galectin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - hep anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - kuk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - lwr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - mab-21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - nopo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - pes anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - pgant8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - phm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - polo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - poly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - rumi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - sc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - sgg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - slbo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - su(Hw) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - svp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - twe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Fmr1 - twin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fmr1 allele Gene References Fmr14.L ppk (Xu et al., 2004) Fmr1EP3517 pnr (Pena-Rangel et al., 2002) Rac1 (Schenck et al., 2003) Sra-1 (Schenck et al., 2003, Schenck et al., 2004) Fmr1Scer\UAS.cWa Rac1 (Lee et al., 2003) Fmr1sev.PW th (Wan et al., 2000) Fmr1unspecified Hem (Schenck et al., 2004) SCAR (Schenck et al., 2004) Sra-1 (Schenck et al., 2004) Fmr1Δ50M futsch (Zhang et al., 2001) unspecified Abl (Rusch et al., 2002) chic (Reeve et al., 2005) futsch (Bettencourt da Cruz et al., 2005) Rac1 (Reeve et al., 2005) tral (Monzo et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63147 DroID - A comprehensive database of gene and protein interactions. • FBgn0028734 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37528
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG66Q7C7 Dipteran inclusive ortholog search EOG647G2K Insect inclusive ortholog search EOG6GB62C Arthropod inclusive ortholog search EOG6KKWJ6 Metazoa inclusive ortholog search EOG64N9K1
Orthologs in Drosophila Species (EOG66Q7C7)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Fmr1     Drosophila simulans   Dsim\GD20735 Y   Drosophila sechellia   Dsec\GM26187 Y   Drosophila erecta   Dere\GG17303 Y   Drosophila yakuba   Dyak\GE24705 Y   Drosophila ananassae   Dana\GF17134 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19437 Y   Drosophila persimilis   Dper\GL27278 Y   Drosophila willistoni   Dwil\GK12202 Y   Drosophila virilis   Dvir\GJ10720 Y   Drosophila mojavensis   Dmoj\GI24444 Y   Drosophila grimshawi   Dgri\GH14068 Y
Orthologs in non-Drosophila Dipterans (EOG647G2K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009326   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019402
Orthologs in non-Dipteran Insects (EOG6GB62C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50259   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013697   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15243   Atta cephalotes Leafcutter ant  Acep\ACEP19209   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16937   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12621   Linepithema humile Argentine ant  Lhum\LH20427   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24336   Solenopsis invicta Red fire ant  Sinv\SINV21114   Solenopsis invicta Red fire ant  Sinv\SINV21113   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009834   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003423   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008553   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005362   Acyrthosiphon pisum Pea aphid  Apim\ACYPI087276   Acyrthosiphon pisum Pea aphid  Apim\ACYPI084292   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000321   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000203   Pediculus humanus Human body louse  Phum\PHUM440700   Tribolium castaneum Red flour beetle  Tcas\TC003774
Orthologs in non-Insect Arthropods (EOG6KKWJ6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\HA1   Ixodes scapularis Deer tick  Isca\ISCW002912
Orthologs in non-Arthropod Metazoa (EOG64N9K1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026447gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007049gn   Danio rerio Zebrafish  Drer\fxr2   Danio rerio Zebrafish  Drer\fxr1   Danio rerio Zebrafish  Drer\fmr1   Xenopus tropicalis Western clawed frog  Xtro\fxr1   Xenopus tropicalis Western clawed frog  Xtro\fmr1   Gallus gallus Domestic chicken  Ggal\FXR1   Gallus gallus Domestic chicken  Ggal\FMR1   Mus musculus House mouse  Mmus\Fxr1   Mus musculus House mouse  Mmus\Fxr2   Mus musculus House mouse  Mmus\Fmr1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011938   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011900   Rattus norvegicus Norway rat  Rnor\Fxr2   Homo sapiens Human  Hsap\FMR1   Homo sapiens Human  Hsap\FXR2   Homo sapiens Human  Hsap\FXR1
Human Orthologs (3)
Gene OMIM HGNC Hsap\FMR1     Hsap\FXR2     Hsap\FXR1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20735 Drosophila sechellia Dsec\GM26187 Drosophila erecta Dere\GG17303 Drosophila yakuba Dyak\GE24705 Drosophila ananassae Dana\GF17134 Drosophila pseudoobscura pseudoobscura Dpse\GA19437 Drosophila persimilis Dper\GL27278 Drosophila willistoni Dwil\GK12202 Drosophila virilis Dvir\GJ10720 Drosophila mojavensis Dmoj\GI24444 Drosophila grimshawi Dgri\GH14068
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	6931 w1118; P{UAS-Fmr1.Z}3 6928 w1118; P{EP}Fmr1EP3517 27484 y1 v1; P{TRiP.JF02634}attP2 6930 w1118; Fmr1Δ50M/TM6B, Tb1 6929 w1118; Fmr1Δ113M/TM6B, Tb1 35200 y1 sc* v1; P{TRiP.GL00075}attP2
Harvard	- PBac{RB}Fmr1e02790
Kyoto	109026 w*; Fmr1B55 123391 w1118; P{RS3}Fmr1CB-0950-3 125009 w1118; P{RS5}Fmr15-HA-1014 125458 w1118; P{RS5}Fmr15-HA-1895
VDRC	v8933 w1118; P{GD1288}v8933
	More stocks available...
Genomic Clones ( 1 )
	BACR39F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 103 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH22839 GM08679 LD09557 LD13401 RE61538
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04068 AT08945 AT10304 AT12584 AT12610 AT19085 AT20847 AT24755 AT25740 GH26194 GH28743 GM30906 HL03533 LD28903 LD44933 RE07749 RE16492 RE17792 RE24113 RE35852 RE55657 RE57927 RE57938 RE63618 RH42606 SD02107 SD03860 SD08054 SD08624 SD12232 SD18431 SD19109
Other clones	7786 10827 10966 28524 30621 43242 43276 43764 50854 52063 69582 81601 145681 158653 162842 166374 181608 214251.33 214405.49 272734 557969 CK01.5B.B6 CK01.19D.F1 CK01.23C.D6 CK01.49B.E11 CK01.52C.G6 CK01.53C.F1 CK01.61D.F3 CK01.64C.E10 CK01.68C.F2 CK01.86C.F11 CK01.114C.C8 EK008739 EK042559 EK049622 EK053438 EK054953 EK068224 EK110951 EK136343 EK139742 EK154102 EK157812 EK157839 EK163357 EK166762 EK178250 EK196532 EK248323 EK271252 EK299622 EN12736 EP02024 EP18717 FGM235E05 RP004043553 RP004088665 RP004235523 RP004247482 RP004255552 RP004269409 RP004409827 RP004431064 RP004475790 RP004484561 RP004489444
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028734 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37528
Antibody Information
	monoclonal (Wan et al., 2000) polyclonal (Schenck et al., 2002)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Fmr1 BcDNA:GM08679 (FlyBase, 1996-)
Additional comments	Source for merge of Fmr1 BcDNA:GM08679 was a shared cDNA (date:030206). (FlyBase, 1996-)
Other Comments
	Removal of Fmr1 results in the delay of onset of the premature LTF threshold caused by loss of mGluRA signaling at the synapse. (Repicky and Broadie, 2009) Synaptic excitability is increased in the absence of Fmr1 while removal of mGluRA signaling restores synaptic excitability. (Repicky and Broadie, 2009) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) Fmr1 mutants exhibit developmental defects in the mushroom bodies, of which the most common is a failure of β-lobes to stop at the brain midline. (Michel et al., 2004) Fmr1 mutants are highly sensitive to genetic background. (Michel et al., 2004) Fmr1 is a negative regulator of neuronal architecture and synaptic differentiation. (Pan et al., 2004) Fmr1 has a role in dendritic development. (Lee et al., 2003) Mutant flies show normal central clock function, though have arrhythmic circadian activity and erratic patterns of locomotor activity and show failure to maintain courtship interest. Neurons required for normal circadian behavior show subtle abnormalities. (Dockendorff et al., 2002) Fmr1 plays a critical role in the circadian output pathway regulating locomotor activity. (Inoue et al., 2002) Fmr1 is required for normal neurite extension, guidance and branching. Based on mutant analysis Fmr1 differentially regulates diverse targets in the brain. (Morales et al., 2002) Fmr1 mutants show strong eclosion failure and circadian rhythm defects. Different neuronal cell types show different phenotypes. (Morales et al., 2002) Area matching Drosophila ESTS AA438987 and AA264877. These ESTs have sequence similarity to Human FXR1 gene. (Davies, 2001.3.15) Fmr1 protein specifically binds futsch mRNA. (Zhang et al., 2001) Fmr1 acts as a translational repressor of futsch to regulate microtubule-dependent synaptic growth and function. (Zhang et al., 2001) Either loss or overexpression of Fmr1 or futsch have identical effects on synaptic transmission - elevation at the NMJ and suppression in photoreceptor cells. (Zhang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137801 NM_169324 NM_169325 NM_169326 NM_169327 NM_001170109 NM_001260088 NM_001275518 NM_001275519 RefSeq (Proteins) • NP_611645 NP_731443 NP_731444 NP_731445 NP_731446 NP_001163580 NP_001247017 NP_001262447 NP_001262448 DDBJ / EMBL / GenBank • AA264877 AA438987 AA696905 AAF14639 AAF14640 AAF54493 AAG22045 AAL28499 AAL39327 AAN13451 AAN13452 AAN13453 AAN13454 ACZ94877 AF205596 AF205597 AF305881 AFH06335 AGB95829 AGB95830 AI403408 AJ271221 AJ413217 AJ422082 AJ422083 AQ073998 AQ254726 AW940873 AX094234 AY060951 AY069182 BH214570 BI239377 BI355465 CAB66340 CAC88757 CAD19443 CAD19444 CZ480560 CZ480561 Entrez Gene - A searchable database of RefSeq genes. • 37528 UniProtKB/Swiss-Prot • Q9NFU0 UniProtKB/TrEMBL • B3LF78
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • K Homology domain (IPR004087) K Homology domain, type 1 (IPR004088) RNA-binding domain, S1 (IPR022967) Agenet-like domain (IPR008395) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM08679
Linkouts
	BioGRID - A database of protein and genetic interactions • 63147 DroID - A comprehensive database of gene and protein interactions. • FBgn0028734 DRSC - Results from RNAi screens. • FBgn0028734 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028734 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6203-RB;CG6203-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028734 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37528 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/fraglxr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37528 modMine - Data generated by the modENCODE project. • FBgn0028734
Synonyms & Secondary IDs ( 44 )
Reported As
Symbol Synonym	AT24755 (Pena-Rangel et al., 2002) BcDNA:GM08679   CG6203 (Duncan et al., 2006, Zhang, 2001.4.24, Cermelli et al., 2006, Holloway et al., 2008, Worringer et al., 2009, Chang et al., 2008, Perkins et al., 2009, Ni et al., 2011.7.19, Kanuka et al., 2005) cg6203 (Lasko, 2000) dFMR (Ling, 2004, Ling et al., 2004, Megosh et al., 2005, Lorbeck et al., 2011, Jepson and Reenan, 2009) dfmr (Pan et al., 2004, Zhang et al., 2004, Mutsuddi et al., 2004, Beerman and Jongens, 2007, Nurminsky, 2007, Tauber et al., 2011, Scantlebury et al., 2010, D'Hulst et al., 2006) dfmr1 (Reeve, 2005, Reeve et al., 2005, Dell, 2005, Zhang and Broadie, 2005, Wang et al., 2005, Xu et al., 2004, Inlow and Restifo, 2004, Reeve et al., 2004, Jin and Warren, 2003, Dockendorff et al., 2002, Gao, 2002, Rusch et al., 2002, Dockendorff et al., 2001, Wan et al., 2000, Wang et al., 2006, Pepper and Jongens, 2006, Jongens et al., 2006, Bhogal and Jongens, 2006, Beerman and Jongens, 2006, Deshpande et al., 2006, Wang et al., 2007, Bhogal and Jongens, 2007, Pepper and Jongens, 2007, Olson et al., 2007, Zaratiegui, 2007, Dolen and Bear, 2005, McBride et al., 2005, Costa et al., 2005, Banerjee et al., 2007, Kelley et al., 2007, Pan et al., 2008, Bettencourt da Cruz et al., 2005, Michel et al., 2004, Bhogal and Jongens, 2008, Banerjee et al., 2008, Monzo et al., 2008, Coffee et al., 2012, Reeve et al., 2008, Sofola et al., 2008, Pan and Broadie, 2007, Xu et al., 2008, Gatto and Broadie, 2008, Yang et al., 2009, Darnell et al., 2009, Yang et al., 2007, Pepper et al., 2009, Monzo et al., 2010, Banerjee et al., 2010, McBride et al., 2010, Tessier and Broadie, 2011, Beerman and Jongens, 2011, Bolduc et al., 2010, Sekine et al., 2008, Zhang et al., 2005, Liu et al., 2012) dFMR1 (Duncan et al., 2006, Tomari, 2005, Govek, 2005, Wang et al., 2005, Schenck et al., 2004, Okamura et al., 2004, Schenck et al., 2003, Costa et al., 2004, Nelson et al., 2003, Billuart and Chelly, 2003, Carthew, 2002, Costa et al., 2003, Ishizuka et al., 2002, Costa et al., 2002, Wan et al., 2000, Wong et al., 2006, Banerjee and Dockendorff, 2007, Siomi et al., 2002, Bhogal et al., 2011, Kwak et al., 2008, Cziko et al., 2009, Xu et al., 2008, Schenck et al., 2002, Coffee et al., 2010) dFmr1 (Zarnescu et al., 2005, Zarnescu et al., 2004, Kirkpatrick et al., 2001, Pinter and Zarnescu, 2006, Estes et al., 2008, Callan and Zarnescu, 2008, Klenov, 2008, Zarnescu et al., 2005, Jin et al., 2004, Epstein et al., 2009, Bushey et al., 2009, Stetler et al., 2006, Yang et al., 2007, Scantlebury et al., 2010, Callan et al., 2010, Bauer et al., 2008, Kanuka et al., 2005, Callan et al., 2012) dFMRP (Pan et al., 2005, Anonymous, 2002, Monzo et al., 2007, Megosh et al., 2006, Nurminsky, 2007, Pan et al., 2008, Monzo et al., 2008, Papoulas et al., 2008, Kim et al., 2007, Gatto and Broadie, 2009, Tauber et al., 2011, Tessier and Broadie, 2008, Gatto and Broadie, 2008, Darnell et al., 2009, Papoulas et al., 2010) dFmrp (Wiggin et al., 2005, Yang et al., 2007) dFXR (Denli and Hannon, 2003, Murchison and Hannon, 2004, Pham et al., 2004, Chakkalakal and Jasmin, 2003, Moine and Mandel, 2001, Zhang et al., 2001, Kim et al., 2007) dfxr (Zhang et al., 2004, Pan et al., 2004, Broadie and Richmond, 2002, Lee et al., 2003, Oostra, 2002, Michel et al., 2003, Morales et al., 2002, Hassan et al., 2002, Zhang et al., 2001, Kaytor and Orr, 2001, Martinez et al., 2007, Zarnescu et al., 2005, Yang et al., 2007) dfxr1 (Shulman and Feany, 2003) dFXR1 (Caudy et al., 2002) dFXRP (Pozdnyakova and Regan, 2005) dmfr1 (Inoue et al., 2002, Tessier and Broadie, 2008) EP(3)3517 (Pena-Rangel et al., 2002) fmr (Klenov et al., 2004) FMR (Zhou et al., 2008, Lim et al., 2011) FMR1 (Maurer-Stroh et al., 2003, Kunda et al., 2003, Jin et al., 2003, Inoue et al., 2002, Hirst et al., 2001, Sofola et al., 2007, Kolaczkowski et al., 2011, Farny et al., 2008, Estes et al., 2008, Worringer et al., 2009, Stetler et al., 2006, Farny et al., 2009, Choi et al., 2010, Bolduc et al., 2010, Schaefer et al., 2010, Papoulas et al., 2010, Khong and Jan, 2011, Sekine et al., 2008) fmr1 (Papoulas et al., 2006, Sofola et al., 2007, Klenov, 2008, Tadros et al., 2007, Nechipurenko and Broihier, 2012, Reich and Papoulas, 2012) Fmr1 (Cermelli et al., 2006, Holloway et al., 2008, Xu et al., 2012, Michel et al., 2004, Haerty et al., 2007, Bushey et al., 2011, Chang et al., 2008, Bushey et al., 2009, Hurt et al., 2009, Bolduc et al., 2008, Bhogal et al., 2011, Magalhaes et al., 2007, Temme et al., 2010, Wasbrough et al., 2010, Wasbrough et al., 2010, Goto et al., 2011, Bianco et al., 2010, Bolduc et al., 2010, Lowery et al., 2010, Chang et al., 2008, Felix et al., 2012) FMRP (Broadie and Pan, 2005, Hieronymus and Silver, 2004, Schenck et al., 2003, Chang et al., 2006, Zarnescu et al., 2007, White-Grindley and Si, 2006, Solecki et al., 2006, Pan and Broadie, 2007, Denman, 2006, Monzo et al., 2006, Zarnescu et al., 2008, Barbee et al., 2006, Repicky and Broadie, 2009, Cziko et al., 2009, Scantlebury et al., 2010, Papoulas et al., 2010) Fmrp (Zarnescu et al., 2005, Zarnescu et al., 2007) FMRp (Meister and Tuschi, 2004, Dorner et al., 2006) FXR (Caudy et al., 2003, Bailey, 1999.11.16, Bailey, 1999.11.16)
Name Synonym	dFMR (Lorbeck et al., 2011) dFmr1 (Jin et al., 2004) Drosophila fragile X mental retardation protein (Monzo et al., 2008) Fmr1 (Wasbrough et al., 2010) Fragile X (Nakahara and Carthew, 2004) fragile X (Sohn, 2001) fragile-X (Martinez et al., 2007) Fragile X mental retardation (Bolduc et al., 2010) fragile X mental retardation 1 (Michel et al., 2004, Bushey et al., 2011, Repicky and Broadie, 2009, Schaefer et al., 2010, Tessier and Broadie, 2011) Fragile X mental retardation gene (Bettencourt da Cruz et al., 2005) Fragile X Mental Retardation Protein (Pan and Broadie, 2007, Scantlebury et al., 2010) Fragile-X Mental Retardation protein (Cziko et al., 2009) fragile X mental retardation protein (Reeve et al., 2008) Fragile X mental retardation protein (Monzo et al., 2010, Papoulas et al., 2010) Fragile X protein (Zarnescu et al., 2007) Fragile X-related (He and Hannon, 2004, Bartel, 2004) Fragile-X-related (Whitfield, 2000.5.16, Dockendorff et al., 2001, Cho et al., 2005) Fragile X related (Bailey, 1999.11.16, Bailey, 1999.11.16) fragile x related (Bhogal and Jongens, 2007) Fragile X related protein (Pozdnyakova and Regan, 2005)
Secondary FlyBase IDs
	FBgn0037787 FBgn0047258
References ( 241 )
Generate a list of	All references relating to this gene ( 241 )
List References by type	Research paper  ( 126 ) Supplementary material  ( 8 ) Review  ( 35 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 48 ) FlyBase analysis  ( 3 ) News article  ( 1 ) DNA/RNA sequence record  ( 6 ) Conference report  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 22 )
	Callan et al., 2012, Brain Res. 1462: 151--161 Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. [FBrf0218552] Coffee et al., 2012, Hum. Mol. Genet. 21(4): 900--915 In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. [FBrf0217253] Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Kanellopoulos et al., 2012, J. Neurosci. 32(38): 13111--13124 Learning and memory deficits consequent to reduction of the fragile x mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila. [FBrf0219485] Liu et al., 2012, Nature 482(7386): 519--523 The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. [FBrf0217556] Liu et al., 2012, Hum. Mol. Genet. 21(21): 4655--4668 Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis. [FBrf0219769] Nechipurenko and Broihier, 2012, J. Cell Biol. 196(3): 345--362 FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. [FBrf0217391] Reich and Papoulas, 2012, PLoS ONE 7(4): e35365 Caprin controls follicle stem cell fate in the Drosophila ovary. [FBrf0217973] Xu et al., 2012, J. Proteome Res. 11(9): 4403--4412 Stable isotope labeling with amino acids in Drosophila for quantifying proteins and modifications. [FBrf0219396] Beerman and Jongens, 2011, Neuroscience 181: 48--66 A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms. [FBrf0213401] Bhogal et al., 2011, Nat. Neurosci. 14(12): 1517--1524 Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. [FBrf0216747] Bushey et al., 2011, Science 332(6037): 1576--1581 Sleep and synaptic homeostasis: structural evidence in Drosophila. [FBrf0213999] Gatto and Broadie, 2011, Dev. Biol. 356(2): 291--307 Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. [FBrf0214459] Goto et al., 2011, J. Neurosci. 31(14): 5454--5459 Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. [FBrf0213400] Khong and Jan, 2011, J. Virol. 85(4): 1439--1451 Modulation of Stress Granules and P Bodies during Dicistrovirus Infection. [FBrf0212847] Kolaczkowski et al., 2011, Mol. Biol. Evol. 28(2): 1033--1042 Recurrent adaptation in RNA interference genes across the Drosophila phylogeny. [FBrf0212798] Lim et al., 2011, Nature 470(7334): 399--403 The novel gene twenty-four defines a critical translational step in the Drosophila clock. [FBrf0213059] Lorbeck et al., 2011, PLoS ONE 6(4): e18412 Microarray analysis uncovers a role for tip60 in nervous system function and general metabolism. [FBrf0213446] Siller and Broadie, 2011, Dis. Model Mech. 4(5): 673--685 Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. [FBrf0215041] Tauber et al., 2011, PLoS ONE 6(11): e27100 Elevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile x syndrome. [FBrf0216766] Tessier and Broadie, 2011, Neurobiol. Disease 41(1): 147--159 The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. [FBrf0212274] Yao et al., 2011, Hum. Mol. Genet. 20(1): 51--63 Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. [FBrf0212518] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...