FB2020_02, released Apr 14, 2020

Gene: Dmel\Doc1

Open Close
General Information
Symbol
Dmel\Doc1
Species
D. melanogaster
Name
Dorsocross1
Annotation Symbol
CG5133
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028789
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Dorsocross1 (Doc1) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Doc, Dorsocross, Tb66F2

Key Links
Genomic Location
Cytogenetic map
66F2-66F3
Sequence location
3L:9,041,375..9,045,042 [+]
Recombination map

3-28

RefSeq locus
NT_037436 REGION:9041375..9045042
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding
Predictions / Assertions
DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
T-BOX TRANSCRIPTION FACTORS -
The T-box transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a conserved DNA-binding immunoglobulin-fold domain of 180-200 amino acids, known as T-box, named after its founding member, the mouse T protein. (Adapted from FBrf0218841).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Doc1 or the JBrowse view of Dmel\Doc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Doc1-RA
FBtr0076522
NM_140026
1526
391
Doc1-RB
FBtr0331548
NM_001274683
1339
356
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Doc1-PA
FBpp0076249
43.2
391
8.80
NP_648283
AAF50328
Doc1-PB
FBpp0303938
38.9
356
9.04
NP_001261612
AGB94307
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Doc1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Wang et al., 2005)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from direct assay
(Stöbe et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II activating transcription factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
anterior Malpighian tubule development
inferred from mutant phenotype
(Hatton-Ellis et al., 2007)
cardiocyte differentiation
inferred from mutant phenotype
(Reim and Frasch, 2005)
determination of wing disc primordium
inferred from mutant phenotype
(Hamaguchi et al., 2004)
embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(Hamaguchi et al., 2004)
positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Reim and Frasch, 2005)
regulation of gene expression
inferred from mutant phenotype
(Stöbe et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
cell fate specification
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
heart development
inferred from biological aspect of ancestor with PANTHER:PTN002601330
(assigned by GO_Central )
(Gaudet et al., 2011)
traceable author statement
(Lo and Frasch, 2003)
negative regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
dorsal ectoderm anlage
(Stathopoulos et al., 2002)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
foregut anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
amnioserosa anlage
(Fisher et al., 2012)
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
cardiogenic mesoderm
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
clypeo-labral primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
dorsal head epidermis primordium
(Fisher et al., 2012)
dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)
embryonic inner optic lobe primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic primordium of adult eye
(Fisher et al., 2012)
amnioserosa
(Fisher et al., 2012)
embryonic dorsal apodeme
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic small intestine
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic stage 10
embryonic hindgut | dorsal
(Hamaguchi et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- pupal stage
(Reim et al., 2003)
adult stage | male
(Reim et al., 2003)
Additional Descriptive Data

At stage 10, Doc1 expression is in the dorsal and lateral regions of the embryonic hindgut, complementary to brk.

(Hamaguchi et al., 2012)

Doc1 is expressed in the dorsal region of the embryo corresponding to the presumptive dorsal ectoderm.

(Stathopoulos et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Doc1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Doc1
Transgenic constructs containing regulatory region of Doc1
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TBX6
9 of 15
Yes
No
Hsap\TBX15
4 of 15
No
Yes
Hsap\TBX1
3 of 15
No
No
Hsap\TBX2
3 of 15
No
No
 
Hsap\TBX3
3 of 15
No
No
Hsap\TBX18
3 of 15
No
No
Hsap\TBX20
3 of 15
No
No
Hsap\TBX22
3 of 15
No
Yes
Hsap\EOMES
2 of 15
No
Yes
Hsap\MGA
2 of 15
No
No
Hsap\TBR1
2 of 15
No
Yes
Hsap\TBX4
2 of 15
No
Yes
Hsap\TBX5
2 of 15
No
Yes
 
Hsap\TBX10
2 of 15
No
No
Hsap\TBX19
2 of 15
No
No
Hsap\TBX21
2 of 15
No
Yes
Hsap\TBXT
2 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tbx6
9 of 15
Yes
No
Mmus\Tbx15
4 of 15
No
Yes
Mmus\Tbx1
3 of 15
No
No
Mmus\Tbx2
3 of 15
No
No
Mmus\Tbx3
3 of 15
No
No
Mmus\Tbx18
3 of 15
No
Yes
Mmus\Tbx20
3 of 15
No
No
Mmus\Tbx22
3 of 15
No
No
Mmus\Eomes
2 of 15
No
Yes
Mmus\Mga
2 of 15
No
No
Mmus\Tbr1
2 of 15
No
Yes
Mmus\Tbx4
2 of 15
No
Yes
Mmus\Tbx5
2 of 15
No
Yes
Mmus\Tbx19
2 of 15
No
No
Mmus\Tbx21
2 of 15
No
Yes
Mmus\T
2 of 15
No
No
 
Mmus\Tbx10
1 of 15
No
No
Rattus norvegicus (Norway rat) (15)
Rnor\Tbx6
7 of 13
Yes
Yes
Rnor\Tbx15
3 of 13
No
Yes
Rnor\Tbx20
3 of 13
No
No
Rnor\Tbx22
3 of 13
No
No
Rnor\Mga
2 of 13
No
No
Rnor\Tbx1
2 of 13
No
No
Rnor\Tbx2
2 of 13
No
No
Rnor\Tbx3
2 of 13
No
No
Rnor\Tbx4
2 of 13
No
Yes
Rnor\Tbx5
2 of 13
No
Yes
Rnor\Tbx18
2 of 13
No
No
Rnor\Tbx19
2 of 13
No
No
Rnor\Tbx21
2 of 13
No
Yes
Rnor\Tbxt
2 of 13
No
No
Rnor\Tbx10
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\vegt
5 of 12
Yes
Yes
Xtro\tbx6
4 of 12
No
No
Xtro\tbx1
3 of 12
No
No
Xtro\tbx2
3 of 12
No
No
Xtro\tbx20
3 of 12
No
No
Xtro\tbx22
3 of 12
No
Yes
Xtro\eomes
2 of 12
No
Yes
Xtro\mga
2 of 12
No
No
Xtro\t2
2 of 12
No
No
Xtro\tbr1
2 of 12
No
Yes
Xtro\tbx3
2 of 12
No
No
Xtro\tbx4
2 of 12
No
Yes
Xtro\tbx5
2 of 12
No
Yes
Xtro\tbx15
2 of 12
No
Yes
Xtro\tbx18
2 of 12
No
Yes
Xtro\tbxt
2 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\tbx6
5 of 15
Yes
No
Drer\tbx16
4 of 15
No
Yes
Drer\tbx1
3 of 15
No
No
Drer\tbx2b
3 of 15
No
No
Drer\tbx3a
3 of 15
No
No
Drer\tbx15
3 of 15
No
Yes
Drer\tbx16l
3 of 15
No
Yes
Drer\eomesa
2 of 15
No
Yes
Drer\eomesb
2 of 15
No
Yes
Drer\mgaa
2 of 15
No
Yes
Drer\tbr1a
2 of 15
No
Yes
Drer\tbr1b
2 of 15
No
Yes
Drer\tbx2a
2 of 15
No
No
Drer\tbx3b
2 of 15
No
No
Drer\tbx4
2 of 15
No
Yes
Drer\tbx5a
2 of 15
No
Yes
Drer\tbx5b
2 of 15
No
Yes
Drer\tbx19
2 of 15
No
No
Drer\tbx20
2 of 15
No
No
Drer\tbx21
2 of 15
No
Yes
Drer\tbx22
2 of 15
No
Yes
Drer\tbxta
2 of 15
No
No
Drer\tbxtb
2 of 15
No
No
Drer\grap2b
1 of 15
No
No
Drer\tbx18
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (23)
Cele\tbx-2
4 of 15
Yes
No
Cele\mab-9
2 of 15
No
No
Cele\mls-1
2 of 15
No
No
Cele\tbx-8
2 of 15
No
Yes
Cele\tbx-9
2 of 15
No
Yes
Cele\tbx-31
2 of 15
No
Yes
Cele\tbx-37
2 of 15
No
Yes
Cele\tbx-38
2 of 15
No
Yes
Cele\sea-1
1 of 15
No
No
Cele\tbx-7
1 of 15
No
No
Cele\tbx-11
1 of 15
No
No
Cele\tbx-30
1 of 15
No
No
Cele\tbx-32
1 of 15
No
No
Cele\tbx-33
1 of 15
No
No
Cele\tbx-34
1 of 15
No
No
Cele\tbx-35
1 of 15
No
No
Cele\tbx-36
1 of 15
No
No
Cele\tbx-39
1 of 15
No
No
Cele\tbx-40
1 of 15
No
No
Cele\tbx-41
1 of 15
No
No
Cele\tbx-42
1 of 15
No
No
Cele\tbx-43
1 of 15
No
No
Cele\ZK328.6
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091909I5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003809
Drosophila simulans
Dsim\GD14149
Drosophila sechellia
Dsec\GM25113
Drosophila erecta
Dere\GG14369
Drosophila yakuba
Dyak\GE20800
Drosophila ananassae
Dana\GF24375
Drosophila pseudoobscura pseudoobscura
Dpse\GA18682
Drosophila persimilis
Dper\GL15034
Drosophila willistoni
Dwil\GK12353
Drosophila virilis
Dvir\GJ11697
Drosophila mojavensis
Dmoj\GI13831
Drosophila grimshawi
Dgri\GH16541
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504R3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012025
Musca domestica
House fly
Mdoa\17012024
Musca domestica
House fly
Mdoa\17015437
Glossina morsitans
Tsetse fly
Gmor\GMOY001041
Glossina morsitans
Tsetse fly
Gmor\GMOY009865
Glossina morsitans
Tsetse fly
Gmor\GMOY005271
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08849
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08850
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08853
Mayetiola destructor
Hessian fly
Mdes\Mdes000976
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013504
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004174
Anopheles darlingi
American malaria mosquito
Adar\ADAC003584
Anopheles darlingi
American malaria mosquito
Adar\ADAC005019
Anopheles gambiae
Malaria mosquito
Agam\AGAP005895
Anopheles gambiae
Malaria mosquito
Agam\AGAP005896
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004921
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004922
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MK1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012897
Bombyx mori
Silkmoth
Bmor\BGIBMGA013132
Bombyx mori
Silkmoth
Bmor\BGIBMGA002994
Bombyx mori
Silkmoth
Bmor\BGIBMGA003174
Bombyx mori
Silkmoth
Bmor\BGIBMGA003173
Danaus plexippus
Monarch butterfly
Dple\DPOGS211184-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212701-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211117-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206923-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012426
Heliconius melpomene
Postman butterfly
Hmel\HMEL015536
Heliconius melpomene
Postman butterfly
Hmel\HMEL012427
Heliconius melpomene
Postman butterfly
Hmel\HMEL004265
Apis florea
Little honeybee
Aflo\2154237764
Apis florea
Little honeybee
Aflo\3376454356
Apis florea
Little honeybee
Aflo\2147484449
Apis florea
Little honeybee
Aflo\2147525857
Apis florea
Little honeybee
Aflo\4267726212
Apis florea
Little honeybee
Aflo\2863733812
Apis florea
Little honeybee
Aflo\2417179158
Apis mellifera
Western honey bee
Amel\GB45658
Apis mellifera
Western honey bee
Amel\GB49684
Apis mellifera
Western honey bee
Amel\LOC552311
Apis mellifera
Western honey bee
Amel\GB50858
Apis mellifera
Western honey bee
Amel\GB45715
Apis mellifera
Western honey bee
Amel\GB49683
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18848
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18937
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16076
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23776
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23777
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20447
Bombus terrestris
Buff-tailed bumblebee
Bter\15217017
Bombus terrestris
Buff-tailed bumblebee
Bter\15203409
Bombus terrestris
Buff-tailed bumblebee
Bter\15202535
Bombus terrestris
Buff-tailed bumblebee
Bter\15205792
Bombus terrestris
Buff-tailed bumblebee
Bter\15216568
Bombus terrestris
Buff-tailed bumblebee
Bter\15215615
Linepithema humile
Argentine ant
Lhum\LH10745
Linepithema humile
Argentine ant
Lhum\LH20155
Linepithema humile
Argentine ant
Lhum\LH16418
Linepithema humile
Argentine ant
Lhum\LH20159
Linepithema humile
Argentine ant
Lhum\LH23371
Linepithema humile
Argentine ant
Lhum\LH26168
Linepithema humile
Argentine ant
Lhum\LH20152
Linepithema humile
Argentine ant
Lhum\LH20154
Linepithema humile
Argentine ant
Lhum\LH10744
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000af2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001437
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026b2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001436
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001439
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002b1a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026b0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019950
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009552
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003929
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004177
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00001
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10853
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06270
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10906
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10905
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06268
Tribolium castaneum
Red flour beetle
Tcas\Org-1
Tribolium castaneum
Red flour beetle
Tcas\TC033450
Tribolium castaneum
Red flour beetle
Tcas\mid
Tribolium castaneum
Red flour beetle
Tcas\TC033122
Tribolium castaneum
Red flour beetle
Tcas\Doc1
Pediculus humanus
Human body louse
Phum\PHUM322740
Pediculus humanus
Human body louse
Phum\PHUM147760
Pediculus humanus
Human body louse
Phum\PHUM147770
Pediculus humanus
Human body louse
Phum\PHUM322730
Pediculus humanus
Human body louse
Phum\PHUM625180
Pediculus humanus
Human body louse
Phum\PHUM607490
Pediculus humanus
Human body louse
Phum\PHUM322720
Rhodnius prolixus
Kissing bug
Rpro\RPRC007267
Rhodnius prolixus
Kissing bug
Rpro\RPRC001899
Rhodnius prolixus
Kissing bug
Rpro\RPRC009188
Rhodnius prolixus
Kissing bug
Rpro\RPRC001598
Cimex lectularius
Bed bug
Clec\CLEC007094
Cimex lectularius
Bed bug
Clec\CLEC006885
Cimex lectularius
Bed bug
Clec\CLEC007098
Cimex lectularius
Bed bug
Clec\CLEC007099
Cimex lectularius
Bed bug
Clec\CLEC004947
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008613
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001903
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000143
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086926
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17383
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15936
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13184
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10669
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12368
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13183
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15935
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12638
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BIS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015389
Strigamia maritima
European centipede
Smar\SMAR009230
Strigamia maritima
European centipede
Smar\SMAR008438
Ixodes scapularis
Black-legged tick
Isca\ISCW019283
Ixodes scapularis
Black-legged tick
Isca\ISCW019280
Ixodes scapularis
Black-legged tick
Isca\ISCW003117
Ixodes scapularis
Black-legged tick
Isca\ISCW019287
Ixodes scapularis
Black-legged tick
Isca\ISCW019692
Ixodes scapularis
Black-legged tick
Isca\ISCW019282
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71503.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74503.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58866.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65879.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66498.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63700.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75925.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66496.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g00890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur33g01070
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g01390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g01430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_16384
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59354
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59366
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_3881
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_13272
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0I8R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx6/16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx20_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021963gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx2-3
Ciona intestinalis
Vase tunicate
Cint\tbx6b
Ciona intestinalis
Vase tunicate
Cint\tbx2/3
Ciona intestinalis
Vase tunicate
Cint\LOC100185942
Ciona intestinalis
Vase tunicate
Cint\tbx15/18/22
Ciona intestinalis
Vase tunicate
Cint\tbx6a
Ciona intestinalis
Vase tunicate
Cint\tbx1
Ciona intestinalis
Vase tunicate
Cint\tbx20
Gallus gallus
Domestic chicken
Ggal\TBX3
Gallus gallus
Domestic chicken
Ggal\TBX10
Gallus gallus
Domestic chicken
Ggal\TBX2
Gallus gallus
Domestic chicken
Ggal\TBX20
Gallus gallus
Domestic chicken
Ggal\TBX5
Gallus gallus
Domestic chicken
Ggal\TBX22
Gallus gallus
Domestic chicken
Ggal\TBX18
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008653
Gallus gallus
Domestic chicken
Ggal\TBX15
Gallus gallus
Domestic chicken
Ggal\TBX4
Gallus gallus
Domestic chicken
Ggal\TBX6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Doc3
6 of 10
Doc2
5 of 10
bi
4 of 10
org-1
4 of 10
H15
3 of 10
mid
3 of 10
ocm
3 of 10
byn
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TBX6; T-box transcription factor 6
    9 of 15
    602427
    TBX15; T-box transcription factor 15
    4 of 15
    604127
      TBX1; T-box transcription factor 1
      3 of 15
      602054
      TBX2; T-box transcription factor 2
      3 of 15
      600747
         
        TBX3; T-box transcription factor 3
        3 of 15
        601621
        TBX18; T-box transcription factor 18
        3 of 15
        604613
        TBX20; T-box transcription factor 20
        3 of 15
        606061
        TBX22; T-box transcription factor 22
        3 of 15
        300307
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Doc1 - Ak2
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Doc1 - Doc2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Doc1 - Rel
        two hybrid array
        (Shokri et al., 2019)
        Doc1 - Ubx
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        Doc1 - abd-A
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-28

        Cytogenetic map
        66F2-66F3
        Sequence location
        3L:9,041,375..9,045,042 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        66F2-66F3
        Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        66F-66F
        (Hamaguchi et al., 2004, Murakami, 1999.12.1)
        Experimentally Determined Recombination Data
        Location

        3-28

        (FlyBase, 2016)

        3-21.4

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (10)
        Genomic Clones (13)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (97)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Reim et al., 2003)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Doc1 Dorsocross

        (Reim, 2002.3.19)
        Source for database merge of
        Additional comments
        Other Comments

        The amnioserosa was found to be absent or at least reduced in RNAi embryos injected with a dsRNA mix of Doc1, Doc2 and Doc3.

        (Reim et al., 2002)
        Origin and Etymology
        Discoverer
        Etymology

        The gene is named "Dorsocross" because its expression in the cellular blastoderm appears cross-shaped when viewed from the dorsal side.

        (Hamaguchi et al., 2004)
        Identification
        External Crossreferences and Linkouts ( 45 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (13)
        Reported As
        Symbol Synonym
        CG5133
        (Keleman et al., 2009.8.5, Perkins et al., 2009, Lo and Frasch, 2001, Whitfield, 2000.5.17)
        Dm-DOC1
        (Prpic et al., 2003)
        Doc
        (Ruiz-Losada et al., 2018, Frasch, 2016, Mbodj et al., 2016, Archbold et al., 2014, Erceg et al., 2014, Merabet et al., 2011, Oktaba et al., 2008, Monier et al., 2007, Ismat et al., 2006, Nguyen and Frasch, 2006, Goldstein et al., 2005, Hamaguchi et al., 2004, Lim et al., 2004, Nakahara and Carthew, 2004, Murakami, 1999.12.1)
        Doc-1
        (Requena et al., 2017)
        Doc1
        (Curt et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Paul et al., 2018, Salazar and Yamamoto, 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Kahn et al., 2016, Peng et al., 2016, Sandler and Stathopoulos, 2016, Sandler and Stathopoulos, 2016, Schertel et al., 2015, Zhao et al., 2015, Lee et al., 2014, Ocorr et al., 2014, Saunders et al., 2013, Ahmad et al., 2012, Amodio et al., 2012, Chintapalli et al., 2012, Hamaguchi et al., 2012, Konikoff et al., 2012, Remolina et al., 2012, Remolina et al., 2012, Sui et al., 2012, Ismat et al., 2010, Neely et al., 2010, Reim and Frasch, 2010, Stöbe et al., 2009, Kwong et al., 2008, Hatton-Ellis et al., 2007, Reim et al., 2007, Davidson and Erwin, 2006, Jacobsen et al., 2006, Zaffran et al., 2006, Copley, 2005, Wang et al., 2005)
        Ect2
        (Stathopoulos et al., 2002)
        TBX6
        (Amodio et al., 2012)
        Tb66F2
        (Hirota et al., 2002, Hirota et al., 2002, Lo and Frasch, 2001)
        doc
        (Mann et al., 2007)
        doc1
        (Szuperák et al., 2011, Zeitlinger et al., 2007)
        Name Synonyms
        Dorsocross
        (Chintapalli et al., 2012, Merabet et al., 2011, Ismat et al., 2010, Oktaba et al., 2008, Mann et al., 2007, Ismat et al., 2006, Nguyen and Frasch, 2006, Schwartz et al., 2006, Goldstein et al., 2005, Wang et al., 2005, Hamaguchi et al., 2004, Lo and Frasch, 2003, Cripps and Olson, 2002)
        Dorsocross1
        (Ocorr et al., 2014, Mann et al., 2009, Hatton-Ellis et al., 2007, Reim et al., 2002)
        dorsocross
        (Tolhuis et al., 2011, Butler et al., 2003)
        Secondary FlyBase IDs
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (109)