FlyBase Gene Report: Dmel\Doc1

General Information

Symbol

Dmel\Doc1

Species

D. melanogaster

Name

Dorsocross1

Annotation Symbol

CG5133

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028789

Gene Model Status

Stock Availability

9 publicly available

Gene Summary

Dorsocross1 (Doc1) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Doc, Dorsocross, Tb66F2

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:9,041,375..9,045,042 [+]

Recombination map

3-28

RefSeq locus

NT_037436 REGION:9041375..9045042

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from direct assay

(Wang et al., 2005)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from direct assay

(Stöbe et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004251338

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004251338

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in anterior Malpighian tubule development

inferred from mutant phenotype

(Hatton-Ellis et al., 2007)

involved_in cardiocyte differentiation

inferred from mutant phenotype

(Reim and Frasch, 2005)

involved_in determination of wing disc primordium

inferred from mutant phenotype

(Hamaguchi et al., 2004)

involved_in embryonic development via the syncytial blastoderm

inferred from mutant phenotype

(Hamaguchi et al., 2004)

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Reim and Frasch, 2005)

involved_in regulation of gene expression

inferred from mutant phenotype

(Stöbe et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell fate specification

inferred from biological aspect of ancestor with PANTHER:PTN000137774

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in heart development

traceable author statement

(Lo and Frasch, 2003)

inferred from biological aspect of ancestor with PANTHER:PTN002601330

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004251338

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR001699, InterPro:IPR002070, InterPro:IPR018186, InterPro:IPR036960

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

T-BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Dorsocross1 (Doc1) encodes one of the three tissue-specific T-box transcription factors encoded by the Dorsocross cluster. It is crucial for completion of differentiation, cell proliferation arrest and survival of amnioserosa cells, as well as for cardiogenesis and the patterning and morphogenesis of particular ectodermal derivatives. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

T-BOX TRANSCRIPTION FACTORS -: The T-box transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a conserved DNA-binding immunoglobulin-fold domain of 180-200 amino acids, known as T-box, named after its founding member, the mouse T protein. (Adapted from FBrf0218841).

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\Doc1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0076522

1526

391

FBtr0331548

1339

356

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0076249

43.2

391

8.80

FBpp0303938

38.9

356

9.04

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Doc1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

dorsal ectoderm anlage

(Stathopoulos et al., 2002)

embryonic stage 7 -- 8

amnioserosa anlage

(Fisher et al., 2012)

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

amnioserosa primordium

(Fisher et al., 2012)

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

embryonic stage 10

embryonic hindgut | dorsal

(Hamaguchi et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

cardiogenic mesoderm

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

(Fisher et al., 2012)

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

embryonic inner optic lobe primordium

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- pupal stage

(Reim et al., 2003)

adult stage | male

(Reim et al., 2003)

Additional Descriptive Data

At stage 10, Doc1 expression is in the dorsal and lateral regions of the embryonic hindgut, complementary to brk.

(Hamaguchi et al., 2012)

Doc1 is expressed in the dorsal region of the embryo corresponding to the presumptive dorsal ectoderm.

(Stathopoulos et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

cardioblast | subset

• nucleus

(Reim et al., 2003)

mesoderm | restricted

• nucleus

(Reim et al., 2003)

embryonic stage 5 -- 11

organism | dorso-lateral

• nucleus

Comment: patch of dorso-lateral expression

(Reim et al., 2003)

procephalic neurogenic region

• nucleus

(Reim et al., 2003)

embryonic stage 5 -- 15

• nucleus

(Reim et al., 2003)

embryonic stage 9 -- 16

parasegment & ectoderm & mesoderm | dorsal | restricted

• nucleus

(Reim et al., 2003)

embryonic stage 15 -- 16

embryonic anterior Malpighian tubule

• nucleus

(Reim et al., 2003)

abdominal lateral pentascolopidial chordotonal organ lch5

• nucleus

(Reim et al., 2003)

• nucleus

(Reim et al., 2003)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Doc1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Doc1

View exonic expression by tissue for Dmel\Doc1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028789

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028789

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5133-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5133

Flygut - An atlas of the Drosophila adult midgut

FBgn0028789

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Doc1

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Doc1

Transgenic constructs containing regulatory region of Doc1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Doc1^GD4334

viable, with Scer\GAL4^Mef2.PR

Doc1^GD4334

viable, with Scer\GAL4^pnr-MD237

Doc1^GD4334

viable, with Scer\GAL4^tin.CΔ4

Doc1^GD4334

Other Phenotypes

Allele

visible, with Scer\GAL4^Bx-MS1096

Doc1^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

wing, with Scer\GAL4^Bx-MS1096

Doc1^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

9 of 15

Yes

No

4 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

4

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

1

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

9 of 15

Yes

No

4 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

No

1

1 of 15

No

No

Rattus norvegicus (Norway rat) (15)

7 of 13

Yes

Yes

3 of 13

No

Yes

3 of 13

No

No

3 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

Yes

2 of 13

No

Yes

2 of 13

No

No

2 of 13

No

No

2 of 13

No

Yes

2 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (16)

5 of 12

Yes

Yes

4 of 12

No

No

3 of 12

No

No

3 of 12

No

No

3 of 12

No

No

3 of 12

No

Yes

2 of 12

No

Yes

2 of 12

No

No

2 of 12

No

No

2 of 12

No

Yes

2 of 12

No

No

2 of 12

No

Yes

2 of 12

No

Yes

2 of 12

No

Yes

2 of 12

No

Yes

2 of 12

No

No

Danio rerio (Zebrafish) (25)

5 of 15

Yes

No

4 of 15

No

Yes

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

Yes

3 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (23)

4 of 15

Yes

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091909I5 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00003809

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504R3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY001041

Glossina morsitans

Tsetse fly

Gmor\GMOY009865

Glossina morsitans

Tsetse fly

Gmor\GMOY005271

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08849

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08850

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08853

Mayetiola destructor

Hessian fly

Mdes\Mdes000976

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013504

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004174

Anopheles darlingi

American malaria mosquito

Adar\ADAC003584

Anopheles darlingi

American malaria mosquito

Adar\ADAC005019

Anopheles gambiae

Malaria mosquito

Agam\AGAP005895

Anopheles gambiae

Malaria mosquito

Agam\AGAP005896

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004921

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004922

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MK1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA012897

Bombyx mori

Silkmoth

Bmor\BGIBMGA013132

Bombyx mori

Silkmoth

Bmor\BGIBMGA002994

Bombyx mori

Silkmoth

Bmor\BGIBMGA003174

Bombyx mori

Silkmoth

Bmor\BGIBMGA003173

Danaus plexippus

Monarch butterfly

Dple\DPOGS211184-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS212701-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS211117-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS206923-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012426

Heliconius melpomene

Postman butterfly

Hmel\HMEL015536

Heliconius melpomene

Postman butterfly

Hmel\HMEL012427

Heliconius melpomene

Postman butterfly

Hmel\HMEL004265

Apis florea

Little honeybee

Aflo\2154237764

Apis florea

Little honeybee

Aflo\3376454356

Apis florea

Little honeybee

Aflo\2147484449

Apis florea

Little honeybee

Aflo\2147525857

Apis florea

Little honeybee

Aflo\4267726212

Apis florea

Little honeybee

Aflo\2863733812

Apis florea

Little honeybee

Aflo\2417179158

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000af2

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001437

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0026b2

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001436

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001439

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002b1a

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0026b0

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019950

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019948

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009552

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003929

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004177

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM322740

Pediculus humanus

Human body louse

Phum\PHUM147760

Pediculus humanus

Human body louse

Phum\PHUM147770

Pediculus humanus

Human body louse

Phum\PHUM322730

Pediculus humanus

Human body louse

Phum\PHUM625180

Pediculus humanus

Human body louse

Phum\PHUM607490

Pediculus humanus

Human body louse

Phum\PHUM322720

Rhodnius prolixus

Kissing bug

Rpro\RPRC007267

Rhodnius prolixus

Kissing bug

Rpro\RPRC001899

Rhodnius prolixus

Kissing bug

Rpro\RPRC009188

Rhodnius prolixus

Kissing bug

Rpro\RPRC001598

Cimex lectularius

Bed bug

Clec\CLEC007094

Cimex lectularius

Bed bug

Clec\CLEC006885

Cimex lectularius

Bed bug

Clec\CLEC007098

Cimex lectularius

Bed bug

Clec\CLEC007099

Cimex lectularius

Bed bug

Clec\CLEC004947

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008613

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001903

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000143

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI086926

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17383

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15936

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13184

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10669

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12368

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13183

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15935

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12638

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BIS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR015389

Strigamia maritima

European centipede

Smar\SMAR009230

Strigamia maritima

European centipede

Smar\SMAR008438

Ixodes scapularis

Black-legged tick

Isca\ISCW019283

Ixodes scapularis

Black-legged tick

Isca\ISCW019280

Ixodes scapularis

Black-legged tick

Isca\ISCW003117

Ixodes scapularis

Black-legged tick

Isca\ISCW019287

Ixodes scapularis

Black-legged tick

Isca\ISCW019692

Ixodes scapularis

Black-legged tick

Isca\ISCW019282

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71503.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM74503.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58866.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65879.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66498.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63700.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75925.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66496.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g00890

Tetranychus urticae

Two-spotted spider mite

Turt\tetur33g01070

Tetranychus urticae

Two-spotted spider mite

Turt\tetur32g01390

Tetranychus urticae

Two-spotted spider mite

Turt\tetur32g01430

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_16384

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_59354

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_59366

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_3881

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_13272

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0I8R )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tbx6/16

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tbx20_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021963gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Cint\LOC100185942

Ciona intestinalis

Vase tunicate

Cint\tbx15/18/22

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Ciona intestinalis

Vase tunicate

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008653

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

6 of 10

5 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

TBX6; T-box transcription factor 6

model of spondylocostal dysostosis

IEA

(FlyBase, 2019-)

TBX22; T-box transcription factor 22

model of Abruzzo-Erickson syndrome

IEA

(FlyBase, 2019-)

model of X-linked cleft palate with or without ankyloglossia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TBX6; T-box transcription factor 6

9 of 15

SPONDYLOCOSTAL DYSOSTOSIS 5; SCDO5

spondylocostal dysostosis

TBX15; T-box transcription factor 15

4 of 15

COUSIN SYNDROME

TBX1; T-box transcription factor 1

3 of 15

TBX2; T-box transcription factor 2

3 of 15

VERTEBRAL ANOMALIES AND VARIABLE ENDOCRINE AND T-CELL DYSFUNCTION; VETD

vertebral anomalies and variable endocrine and T-cell dysfunction

TBX3; T-box transcription factor 3

3 of 15

ULNAR-MAMMARY SYNDROME; UMS

ulnar-mammary syndrome

TBX18; T-box transcription factor 18

3 of 15

CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 2; CAKUT2

CAKUT2

TBX20; T-box transcription factor 20

3 of 15

ATRIAL SEPTAL DEFECT 4; ASD4

atrial heart septal defect 4

TBX22; T-box transcription factor 22

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

experimental knowledge based

(Guruharsha et al., 2011)

two hybrid array

(Shokri et al., 2019)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

pull down, autoradiography, two hybrid

(Goldstein et al., 2005)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64443

DroID - A comprehensive database of gene and protein interactions.

FBgn0028789

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39039

MIST (genetic) - An integrated Molecular Interaction Database

Doc1

MIST (protein-protein) - An integrated Molecular Interaction Database

Doc1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-28

Cytogenetic map

Sequence location

3L:9,041,375..9,045,042 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66F2-66F3

Limits computationally determined from genome sequence between P{PZ}l(3)01629⁰¹⁶²⁹&P{PZ}mRpL12¹⁰⁵³⁴ and P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66F-66F

(Hamaguchi et al., 2004, Murakami, 1999.12.1)

Experimentally Determined Recombination Data

Location

3-28

(FlyBase, 2016)

3-21.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

31931

y¹ v¹; P{TRiP.JF02222}attP2

59506

y¹ w^*; Mi{MIC}Doc1^MI14350

80216

y¹ sc^* v¹ sev²¹; P{TOE.GS02597}attP40

83786

y¹ sc^* v¹ sev²¹; P{TKO.GS04246}attP40

23568

w¹¹¹⁸; Mi{ET1}Doc1^MB02443/TM3, Sb¹ Ser¹

F003490

M{UAS-Doc1.ORF-CC}ZH-21F

F000225

M{UAS-Doc1.ORF.3xHA.GW}ZH-86Fb

v104927

P{KK112245}VIE-260B

v16746

w¹¹¹⁸; P{GD4334}v16746

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (97)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028789

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028789

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39039

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Reim et al., 2003)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Doc1 Dorsocross

(Reim, 2002.3.19)

Source for database merge of

Additional comments

Other Comments

The amnioserosa was found to be absent or at least reduced in RNAi embryos injected with a dsRNA mix of Doc1, Doc2 and Doc3.

(Reim et al., 2002)

Origin and Etymology

Discoverer

Etymology

The gene is named "Dorsocross" because its expression in the cellular blastoderm appears cross-shaped when viewed from the dorsal side.

(Hamaguchi et al., 2004)

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39039

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028789

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028789

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5133

Flygut - An atlas of the Drosophila adult midgut

FBgn0028789

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39039

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG5133

modMine - A data warehouse for the modENCODE project

FBgn0028789

Linkouts

BioGRID - A database of protein and genetic interactions.

64443

DPiM - Drosophila Protein interaction map

FBgn0028789

DroID - A comprehensive database of gene and protein interactions.

FBgn0028789

DRSC - Results frm RNAi screens

FBgn0028789

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0028789

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG5133-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028789

FlyMine - An integrated database for Drosophila genomics

FBgn0028789

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39039

MIST (genetic) - An integrated Molecular Interaction Database

Doc1

MIST (protein-protein) - An integrated Molecular Interaction Database

Doc1

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG5133

(Keleman et al., 2009.8.5, Perkins et al., 2009, Lo and Frasch, 2001, Whitfield, 2000.5.17)

Dm-DOC1

(Prpic et al., 2003)

Doc

(Ruiz-Losada et al., 2018, Frasch, 2016, Mbodj et al., 2016, Archbold et al., 2014, Erceg et al., 2014, Merabet et al., 2011, Oktaba et al., 2008, Monier et al., 2007, Ismat et al., 2006, Nguyen and Frasch, 2006, Goldstein et al., 2005, Hamaguchi et al., 2004, Lim et al., 2004, Nakahara and Carthew, 2004, Murakami, 1999.12.1)

Doc-1

(Requena et al., 2017)

Doc1

(Curt et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Paul et al., 2018, Salazar and Yamamoto, 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Kahn et al., 2016, Peng et al., 2016, Sandler and Stathopoulos, 2016, Sandler and Stathopoulos, 2016, Schertel et al., 2015, Zhao et al., 2015, Lee et al., 2014, Ocorr et al., 2014, Saunders et al., 2013, Ahmad et al., 2012, Amodio et al., 2012, Chintapalli et al., 2012, Hamaguchi et al., 2012, Konikoff et al., 2012, Remolina et al., 2012, Remolina et al., 2012, Sui et al., 2012, Ismat et al., 2010, Neely et al., 2010, Reim and Frasch, 2010, Stöbe et al., 2009, Kwong et al., 2008, Hatton-Ellis et al., 2007, Reim et al., 2007, Davidson and Erwin, 2006, Jacobsen et al., 2006, Zaffran et al., 2006, Copley, 2005, Wang et al., 2005)

ECT2

(Aguilar-Aragon et al., 2020)

Ect2

(Stathopoulos et al., 2002)

TBX6

(Amodio et al., 2012)

Tb66F2

(Hirota et al., 2002, Hirota et al., 2002, Lo and Frasch, 2001)

doc

(Mann et al., 2007)

doc1

(Szuperák et al., 2011, Zeitlinger et al., 2007)

Name Synonyms

Dorsocross

(Chintapalli et al., 2012, Merabet et al., 2011, Ismat et al., 2010, Oktaba et al., 2008, Mann et al., 2007, Ismat et al., 2006, Nguyen and Frasch, 2006, Schwartz et al., 2006, Goldstein et al., 2005, Wang et al., 2005, Hamaguchi et al., 2004, Lo and Frasch, 2003, Cripps and Olson, 2002)

Dorsocross1

(Ocorr et al., 2014, Mann et al., 2009, Hatton-Ellis et al., 2007, Reim et al., 2002)

dorsocross

(Tolhuis et al., 2011, Butler et al., 2003)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (112)