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Gene Dmel\Doc1

General Information
Symbol	Dmel\Doc1	Species	D. melanogaster
Name	Dorsocross1	Annotation symbol	CG5133
Feature type	protein_coding_gene	FlyBase ID	FBgn0028789
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Doc, Tb66F2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66F2-66F3	Sequence location	3L:9,034,475..9,038,142 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dorsocross1 is referred to in FlyBase by the symbol Dmel\Doc1 (CG5133, FBgn0028789). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: anterior Malpighian tubule development; positive regulation of transcription from RNA polymerase II promoter; embryonic development via the syncytial blastoderm; determination of wing disc primordium; cardiocyte differentiation. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Transcription factor, Brachyury; Transcription factor, T-box; Transcription factor, T-box, conserved site; p53-like transcription factor, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult hindgut, larval Malpighian tubules, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1631218_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Doc1. Gene sequence location is 3L:9034475..9038142.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66F2-66F3   Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66F-66F     (Hamaguchi et al., 2004) 66F-66F     (Murakami, 1999.12.1)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Doc1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Doc1-RA FBtr0076522  NM_140026   1526   391 Doc1-RB FBtr0331548  NM_001274683   1339   356
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Doc1-PA   FBpp0076249   43.2   391   8.80     NP_648283   AAF50328 Doc1-PB   FBpp0303938   38.9   356   9.04     NP_001261612   AGB94307
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor, T-box (IPR001699) Transcription factor, Brachyury (IPR002070) p53-like transcription factor, DNA-binding (IPR008967) Transcription factor, T-box, conserved site (IPR018186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50328   AB035412 BAA87864   AE014296 AGB94307   AY113519 AAM29524   BI168426   BI213322   BI228323   BI372304   BI372751   BI375052   BI483514   BT025226   CO283900   CO294988   CO326793   CO329019   EC067179   EC083837   EC201582   EC204636   EC234740   EC254437   GH877030
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9U8L5 Q8MYX3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435361 3L:9,022,917..9,023,482 evidence=Reporter construct (in vivo) (Ismat et al., 2010, Halfon, 2012.6.19) regulatory region FBsf0000436117 3L:9,023,860..9,024,486 evidence=Reporter construct (in vivo) (Junion et al., 2012, Halfon, 2012.6.19) regulatory region FBsf0000436227 3L:9,032,001..9,032,591 evidence=Reporter construct (in vivo) (Junion et al., 2012, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) hindgut anlage in statu nascendi   (Fisher et al., 2012) visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 5   dorsal ectoderm anlage   (Stathopoulos et al., 2002) embryonic stage 7 -- 8   amnioserosa anlage   (Fisher et al., 2012) antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal ectoderm   (Fisher et al., 2012) foregut anlage   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) embryonic stage 9 -- 10   amnioserosa   (Fisher et al., 2012) amnioserosa primordium   (Fisher et al., 2012) antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal ectoderm   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   amnioserosa   (Fisher et al., 2012) cardiogenic mesoderm   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) dorsal head epidermis primordium   (Fisher et al., 2012) dorsal vessel primordium   (Fisher et al., 2012) Comment:reported as dorsal vessel specific anlage embryonic inner optic lobe primordium   (Fisher et al., 2012) embryonic optic lobe primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) small intestine primordium   (Fisher et al., 2012) Comment:reported as small intestine specific anlage embryonic stage 13 -- 16   adult eye primordium   (Fisher et al., 2012) amnioserosa   (Fisher et al., 2012) embryonic dorsal apodeme   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic Malpighian tubule   (Fisher et al., 2012) embryonic small intestine   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- pupal stage     (Reim et al., 2003) adult stage | male     (Reim et al., 2003)
Additional Descriptive Data
	Doc1 is expressed in the dorsal region of the embryo corresponding to the presumptive dorsal ectoderm. (Stathopoulos et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   cardioblast | subset   • nucleus (Reim et al., 2003) mesoderm | restricted   • nucleus (Reim et al., 2003) embryonic stage 5 -- 11   organism | dorso-lateral   • nucleus (Reim et al., 2003) Comment:patch of dorso-lateral expression procephalic neurogenic region   • nucleus (Reim et al., 2003) embryonic stage 5 -- 15   amnioserosa   • nucleus (Reim et al., 2003) embryonic stage 9 -- 16   parasegment & ectoderm & mesoderm | dorsal & restricted   • nucleus (Reim et al., 2003) embryonic stage 15 -- 16   embryonic anterior Malpighian tubule   • nucleus (Reim et al., 2003) abdominal lateral pentascolopidial chordotonal organ lch5   • nucleus (Reim et al., 2003) dorsal pouch   • nucleus (Reim et al., 2003)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult hindgut, larval Malpighian tubules, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    21.225 Larval Midgut    11 Larval Hindgut    371 Larval Malpighian Tubules    252.1 Larval Fat Body    42.8 Larval Salivary Gland    12.2 Larval Trachea    9.85 Larval Carcass    49.8 Adult Head    11.4 Adult Eye    4.625 Adult Brain    3.5 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    10.6 Adult Midgut    11.7 Adult Hindgut    164.7 Adult Malpighian Tubules    119.5 Adult Fat Body    11.5 Adult Salivary Gland    21.9 Adult Heart    8.325 Adult VirginFemale Spermatheca    7.3 Adult InseminatedFemale Spermatheca    8.6 Adult Ovary    6.2 Adult Testis    141.9 Adult Male Accessory Gland    13.5 Adult Carcass    18 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    11.4   NA  Eye    4.625   NA  Brain    3.5   21.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.9   NA  Crop    no informative data   no informative data  Midgut    no informative data   371  Hindgut    164.7   252.1  Malpighian Tubules    no informative data   42.8  Fat Body    no informative data   12.2  Salivary Gland    no informative data   NA  Heart    8.325   9.85  Trachea    NA   NA  VirginFemale Spermatheca    7.3   NA  InseminatedFemale Spermatheca    8.6   NA  Ovary    6.2   NA  Testis    141.9   NA  Male Accessory Gland    no informative data   49.8  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    14 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr  (57) embryo 06-08hr  (53) embryo 08-10hr  (37) embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr  (57) embryo 06-08hr  (53) embryo 08-10hr  (37) embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    24 embryo 04-06hr    57 embryo 06-08hr    53 embryo 08-10hr    37 embryo 10-12hr    19 embryo 12-14hr    13 embryo 14-16hr    6 embryo 16-18hr    5 embryo 18-20hr    6 embryo 20-22hr    8 embryo 22-24hr    8 larva L1    7 larva L2    3 larva L3 12hr old    4 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    7 larva L3 puffstage 7-9    8 white prepupae new    6 white prepupae 12hr    6 white prepupae 24hr    8 pupae 2d postWPP    5 pupae 3d postWPP    3 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    6 adult female 01day    1 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE59988 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5133-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Doc1 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Doc1GD4334 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Doc1 Class Mutagen Stocks Known lesion Doc1MB02443 1 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Doc1 Class Mutagen Stocks Known lesion Doc1GD4334 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Doc1JF02222 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Doc1KK112245 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Doc1a.cRa in vitro construct - RNAi 0 Yes Doc1cRa in vitro construct - RNAi 0 Yes Doc1dsRNA.cHa in vitro construct - RNAi 0 Yes Doc1Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes Doc1Scer\UAS.cRa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6113 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4334} NA P{KK112245} NA P{TRiP.JF02222} NA P{UAS-Doc1.H} NA P{UAS-Doc1.R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Doc1MB02443 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity inferred from direct assay (Wang et al., 2005)
Biological Process
CV term Evidence References
anterior Malpighian tubule development inferred from mutant phenotype (Hatton-Ellis et al., 2007) cardiocyte differentiation inferred from mutant phenotype (Reim and Frasch, 2005) determination of wing disc primordium inferred from mutant phenotype (Hamaguchi et al., 2004) embryonic development via the syncytial blastoderm inferred from mutant phenotype (Hamaguchi et al., 2004) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Reim and Frasch, 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:O73718 (FlyBase, 1992-)
Biological Process
CV term Evidence References
heart development traceable author statement (Lo and Frasch, 2003) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:O73718 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:O73718 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Doc1 - CG11266 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - Doc2 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Doc1 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Doc1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Doc1 allele Gene References Doc1a.cRa Doc2 (Reim et al., 2003) Doc1cRa Doc2 (Reim et al., 2003) Doc1dsRNA.cHa Doc2 (Hamaguchi et al., 2004) unspecified pnr (Reim and Frasch, 2005) tin (Reim and Frasch, 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64443 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028789 DroID - A comprehensive database of gene and protein interactions. • FBgn0028789 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39039
Orthologs
OrthoDB Orthologs (180) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64XK2Q Dipteran inclusive ortholog search EOG61NTVM Insect inclusive ortholog search EOG6NGFK0 Arthropod inclusive ortholog search EOG6GMSFB Metazoa inclusive ortholog search EOG64N9PC
Orthologs in Drosophila Species (EOG64XK2Q)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Doc1     Drosophila simulans   Dsim\GD14149 Y   Drosophila sechellia   Dsec\GM25113 Y   Drosophila erecta   Dere\GG14369 Y   Drosophila yakuba   Dyak\GE20800 Y   Drosophila ananassae   Dana\GF24375 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18682 Y   Drosophila persimilis   Dper\GL15034 Y   Drosophila willistoni   Dwil\GK12353 Y   Drosophila virilis   Dvir\GJ11697 Y   Drosophila mojavensis   Dmoj\GI13831 Y   Drosophila grimshawi   Dgri\GH16541 Y
Orthologs in non-Drosophila Dipterans (EOG61NTVM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013504 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004174 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005895 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005896 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004921 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004922 Y
Orthologs in non-Dipteran Insects (EOG6NGFK0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552311 Y Apis mellifera Western honey bee  Amel\GB50858 Y Apis mellifera Western honey bee  Amel\GB45658 Y Apis mellifera Western honey bee  Amel\GB49684 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009552 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003929 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004177 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019948 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11360 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14240 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14844 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11372 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11369 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22553 Y Atta cephalotes Leafcutter ant  Acep\ACEP18442 Y Atta cephalotes Leafcutter ant  Acep\ACEP18776 Y Atta cephalotes Leafcutter ant  Acep\ACEP21923 Y Atta cephalotes Leafcutter ant  Acep\ACEP16053 Y Atta cephalotes Leafcutter ant  Acep\ACEP16055 Y Atta cephalotes Leafcutter ant  Acep\ACEP16128 Y Atta cephalotes Leafcutter ant  Acep\ACEP16062 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20760 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18881 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22216 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20550 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18104 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17418 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22926 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18006 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18000 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18007 Y Linepithema humile Argentine ant  Lhum\LH20152 Y Linepithema humile Argentine ant  Lhum\LH10745 Y Linepithema humile Argentine ant  Lhum\LH10744 Y Linepithema humile Argentine ant  Lhum\LH20154 Y Linepithema humile Argentine ant  Lhum\LH20159 Y Linepithema humile Argentine ant  Lhum\LH23371 Y Linepithema humile Argentine ant  Lhum\LH16418 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB19528 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11912 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24840 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24839 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB26341 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24847 Y Solenopsis invicta Red fire ant  Sinv\SINV20004 Y Solenopsis invicta Red fire ant  Sinv\SINV16744 Y Solenopsis invicta Red fire ant  Sinv\SINV10896 Y Solenopsis invicta Red fire ant  Sinv\SINV19991 Y Solenopsis invicta Red fire ant  Sinv\SINV11021 Y Solenopsis invicta Red fire ant  Sinv\SINV17750 Y Solenopsis invicta Red fire ant  Sinv\SINV11007 Y Solenopsis invicta Red fire ant  Sinv\SINV17864 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008613 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001903 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000143 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002994 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003172 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012897 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003173 Y Bombyx mori Silkmoth  Bmor\BGIBMGA013132 Y Pediculus humanus Human body louse  Phum\PHUM147760 Y Pediculus humanus Human body louse  Phum\PHUM607490 Y Pediculus humanus Human body louse  Phum\PHUM147770 Y Pediculus humanus Human body louse  Phum\PHUM147980 Y Pediculus humanus Human body louse  Phum\PHUM322730 Y Tribolium castaneum Red flour beetle  Tcas\mid Y Tribolium castaneum Red flour beetle  Tcas\Org-1 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_15795 Y Tribolium castaneum Red flour beetle  Tcas\TC013511 Y Tribolium castaneum Red flour beetle  Tcas\Doc1 Y Tribolium castaneum Red flour beetle  Tcas\H15 Y
Orthologs in non-Insect Arthropods (EOG6GMSFB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\EAPA Y Daphnia pulex Water flea  Dpux\JGI_V11_59354 Y Daphnia pulex Water flea  Dpux\rpoC2 Y Daphnia pulex Water flea  Dpux\mod Y Daphnia pulex Water flea  Dpux\rbcL Y Ixodes scapularis Deer tick  Isca\ISCW019283 Y Ixodes scapularis Deer tick  Isca\ISCW003117 Y Ixodes scapularis Deer tick  Isca\ISCW019280 Y Ixodes scapularis Deer tick  Isca\ISCW019287 Y Ixodes scapularis Deer tick  Isca\ISCW019692 Y
Orthologs in non-Arthropod Metazoa (EOG64N9PC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mls-1 Y Caenorhabditis elegans Nematode  Cele\tbx-2 Y Caenorhabditis elegans Nematode  Cele\mab-9 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020346gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021963gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020345gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023386gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006150gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018392gn Y Danio rerio Zebrafish  Drer\ENSDARG00000061509 Y Danio rerio Zebrafish  Drer\tbx24 Y Danio rerio Zebrafish  Drer\tbx1 Y Danio rerio Zebrafish  Drer\ENSDARG00000086287 Y Danio rerio Zebrafish  Drer\mga Y Danio rerio Zebrafish  Drer\tbx5a Y Danio rerio Zebrafish  Drer\CH211-199D18.2 Y Danio rerio Zebrafish  Drer\tbx4 Y Danio rerio Zebrafish  Drer\tbx22 Y Danio rerio Zebrafish  Drer\OTTDARG00000021108 Y Danio rerio Zebrafish  Drer\tbx3 Y Danio rerio Zebrafish  Drer\tbx5b Y Danio rerio Zebrafish  Drer\tbx18 Y Danio rerio Zebrafish  Drer\tbx6l Y Danio rerio Zebrafish  Drer\tbx16 Y Danio rerio Zebrafish  Drer\tbx2b Y Danio rerio Zebrafish  Drer\tbx15 Y Xenopus tropicalis Western clawed frog  Xtro\tbx18 Y Xenopus tropicalis Western clawed frog  Xtro\vegt Y Xenopus tropicalis Western clawed frog  Xtro\tbx22 Y Xenopus tropicalis Western clawed frog  Xtro\tbx3 Y Xenopus tropicalis Western clawed frog  Xtro\mga Y Xenopus tropicalis Western clawed frog  Xtro\tbx5 Y Xenopus tropicalis Western clawed frog  Xtro\tbx15 Y Xenopus tropicalis Western clawed frog  Xtro\tbx4 Y Xenopus tropicalis Western clawed frog  Xtro\tbx1 Y Xenopus tropicalis Western clawed frog  Xtro\tbx2 Y Xenopus tropicalis Western clawed frog  Xtro\tbx20 Y Gallus gallus Domestic chicken  Ggal\TBX10 Y Gallus gallus Domestic chicken  Ggal\TBX2 Y Gallus gallus Domestic chicken  Ggal\TBX20 Y Gallus gallus Domestic chicken  Ggal\TBX5 Y Gallus gallus Domestic chicken  Ggal\MGA Y Gallus gallus Domestic chicken  Ggal\TBX22 Y Gallus gallus Domestic chicken  Ggal\TBX18 Y Gallus gallus Domestic chicken  Ggal\TBX15 Y Gallus gallus Domestic chicken  Ggal\TBX4 Y Gallus gallus Domestic chicken  Ggal\TBX6 Y Mus musculus House mouse  Mmus\Tbx22 Y Mus musculus House mouse  Mmus\Tbx1 Y Mus musculus House mouse  Mmus\Tbx3 Y Mus musculus House mouse  Mmus\Tbx20 Y Mus musculus House mouse  Mmus\Mga Y Mus musculus House mouse  Mmus\Tbx18 Y Mus musculus House mouse  Mmus\Tbx15 Y Mus musculus House mouse  Mmus\Tbx4 Y Mus musculus House mouse  Mmus\Tbx6 Y Mus musculus House mouse  Mmus\Tbx10 Y Mus musculus House mouse  Mmus\Tbx5 Y Rattus norvegicus Norway rat  Rnor\Tbx2 Y Rattus norvegicus Norway rat  Rnor\Tbx6 Y Rattus norvegicus Norway rat  Rnor\Tbx5 Y Rattus norvegicus Norway rat  Rnor\Tbx15 Y Rattus norvegicus Norway rat  Rnor\Tbx18 Y Rattus norvegicus Norway rat  Rnor\Tbx22 Y Rattus norvegicus Norway rat  Rnor\Tbx20 Y Rattus norvegicus Norway rat  Rnor\Mga Y Rattus norvegicus Norway rat  Rnor\Tbx10-ps1 Y Rattus norvegicus Norway rat  Rnor\Tbx3 Y Rattus norvegicus Norway rat  Rnor\Tbx1 Y Homo sapiens Human  Hsap\MGA Y Homo sapiens Human  Hsap\TBX22 Y Homo sapiens Human  Hsap\TBX10 Y Homo sapiens Human  Hsap\TBX5 Y Homo sapiens Human  Hsap\TBX15 Y Homo sapiens Human  Hsap\TBX4 Y Homo sapiens Human  Hsap\TBX20 Y Homo sapiens Human  Hsap\TBX18 Y Homo sapiens Human  Hsap\TBX2 Y Homo sapiens Human  Hsap\TBX6 Y Homo sapiens Human  Hsap\ENSG00000135111 Y Homo sapiens Human  Hsap\TBX1 Y
Human Orthologs (12)
Gene OMIM HGNC Hsap\MGA     Hsap\TBX22     Hsap\TBX10     Hsap\TBX5     Hsap\TBX15     Hsap\TBX4     Hsap\TBX20     Hsap\TBX18     Hsap\TBX2     Hsap\TBX6     Hsap\ENSG00000135111     Hsap\TBX1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14149 Drosophila sechellia Dsec\GM25113 Drosophila erecta Dere\GG14369 Drosophila yakuba Dyak\GE20800 Drosophila ananassae Dana\GF24375 Drosophila pseudoobscura pseudoobscura Dpse\GA18682 Drosophila persimilis Dper\GL15034 Drosophila willistoni Dwil\GK12353 Drosophila virilis Dvir\GJ11697 Drosophila mojavensis Dmoj\GI13831 Drosophila grimshawi Dgri\GH16541
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	31931 y1 v1; P{TRiP.JF02222}attP2 23568 w1118; Mi{ET1}Doc1MB02443/TM3, Sb1 Ser1
VDRC	v104927 P{KK112245}VIE-260B v16746 w1118; P{GD4334}v16746 v16747 w1118; P{GD4334}v16747
Genomic Clones ( 2 )
	BACR03E24 BACR10P09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE59988
Other clones	DPiM_FI01016 FI01016
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE09152 RE18703 RE25838 RE59237 RE62770 RE66422
Other clones	30212 58645 78613 177226 179221 214445.69 EK164749 EK208118 EK291848 EP04640 RP003354175
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39039
Antibody Information
	polyclonal (Reim et al., 2003)
Other Information
Discoverer
Etymology
	The gene is named "Dorsocross" because its expression in the cellular blastoderm appears cross-shaped when viewed from the dorsal side. (Hamaguchi et al., 2004)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Doc1 Dorsocross (Reim, 2002.3.19)
Source for database merge of
Additional comments
Other Comments
	The amnioserosa was found to be absent or at least reduced in RNAi embryos injected with a dsRNA mix of Doc1, Doc2 and Doc3. (Reim et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140026 NM_001274683 RefSeq (Proteins) • NP_648283 NP_001261612 DDBJ / EMBL / GenBank • AAF50328 AAM29524 AB035412 AGB94307 AY113519 BAA87864 BI372751 Entrez Gene - A searchable database of RefSeq genes. • 39039 UniProtKB/TrEMBL • Q8MYX3 Q9U8L5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription factor, T-box (IPR001699) Transcription factor, Brachyury (IPR002070) p53-like transcription factor, DNA-binding (IPR008967) Transcription factor, T-box, conserved site (IPR018186) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE59988
Linkouts
	BioGRID - A database of protein and genetic interactions • 64443 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028789 DroID - A comprehensive database of gene and protein interactions. • FBgn0028789 DRSC - Results from RNAi screens. • FBgn0028789 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028789 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5133-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028789 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39039 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/droscro1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39039 modMine - Data generated by the modENCODE project. • FBgn0028789
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG5133 (Lo and Frasch, 2001, Whitfield, 2000.5.17, Keleman et al., 2009.8.5, Perkins et al., 2009) Dm-DOC1 (Prpic et al., 2003) Doc (Nakahara and Carthew, 2004, Lim et al., 2004, Hamaguchi et al., 2004, Murakami, 1999.12.1, Ismat et al., 2006, Nguyen and Frasch, 2006, Monier et al., 2007, Goldstein et al., 2005, Oktaba et al., 2008) doc (Mann et al., 2007) Doc1 (Jacobsen et al., 2006, Chintapalli et al., 2012, Reim et al., 2007, Zaffran et al., 2006, Davidson and Erwin, 2006, Wang et al., 2005, Kwong et al., 2008, Hatton-Ellis et al., 2007, Stöbe et al., 2009, Copley, 2005, Neely et al., 2010, Hamaguchi et al., 2012, Ismat et al., 2010, Amodio et al., 2012, Konikoff et al., 2012, Remolina et al., 2012, Remolina et al., 2012, Ahmad et al., 2012, Sui et al., 2012) doc1 (Szuperák et al., 2011, Zeitlinger et al., 2007) Ect2 (Stathopoulos et al., 2002) Tb66F2 (Hirota et al., 2002, Hirota et al., 2002, Lo and Frasch, 2001) TBX6 (Amodio et al., 2012)
Name Synonym	Dorsocross (Lo and Frasch, 2003, Cripps and Olson, 2002, Hamaguchi et al., 2004, Ismat et al., 2006, Nguyen and Frasch, 2006, Chintapalli et al., 2012, Mann et al., 2007, Wang et al., 2005, Goldstein et al., 2005, Lo et al., 2007, Oktaba et al., 2008, Schwartz et al., 2006, Ismat et al., 2010) dorsocross (Butler et al., 2003, Tolhuis et al., 2011) Dorsocross1 (Reim et al., 2002, Mann et al., 2009, Hatton-Ellis et al., 2007)
Secondary FlyBase IDs
References ( 75 )
Generate a list of	All references relating to this gene ( 75 )
List References by type	Research paper  ( 37 ) Supplementary material  ( 6 ) Review  ( 8 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 10 )
	Ahmad et al., 2012, Dev. Cell 23(1): 97--111 Two forkhead transcription factors regulate the division of cardiac progenitor cells by a polo-dependent pathway. [FBrf0218973] Amodio et al., 2012, Dev. Dyn. 241(1): 190--199 Transactivation in Drosophila of human enhancers by human transcription factors involved in congenital heart diseases. [FBrf0216960] Chintapalli et al., 2012, PLoS ONE 7(3): e32577 Functional correlates of positional and gender-specific renal asymmetry in Drosophila. [FBrf0218070] Hamaguchi et al., 2012, Mech. Dev. 129(9-12): 236--243 Dorsoventral patterning of the Drosophila hindgut is determined by interaction of genes under the control of two independent gene regulatory systems, the dorsal and terminal systems. [FBrf0219771] Junion et al., 2012, Cell 148(3): 473--486 A transcription factor collective defines cardiac cell fate and reflects lineage history. [FBrf0217404] Konikoff et al., 2012, Dev. Dyn. 241(1): 150--160 Comparison of embryonic expression within multigene families using the flyexpress discovery platform reveals more spatial than temporal divergence. [FBrf0216961] Remolina et al., 2012, Evolution 66(11): 3390--3403 GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER. [FBrf0219782] Sui et al., 2012, Development 139(15): 2773--2782 The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc. [FBrf0218841] Szuperák et al., 2011, Development 138(4): 715--724 Feedback regulation of Drosophila BMP signaling by the novel extracellular protein Larval Translucida. [FBrf0212881] Tolhuis et al., 2011, PLoS Genet. 7(3): e1001343 Interactions among Polycomb Domains Are Guided by Chromosome Architecture. [FBrf0213356] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...