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Gene Dmel\CG5869

General Information
Symbol	Dmel\CG5869	Species	D. melanogaster
Name		Annotation symbol	CG5869
Feature type	protein_coding_gene	FlyBase ID	FBgn0028894
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	BG:DS02740.9, DS02740.9
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35F1-35F1	Sequence location	2L:16,301,656..16,302,954 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5869 (FBgn0028894). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. Based on sequence similarity, it is predicted to be involved in the biological process: gliogenesis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Actin-binding, cofilin/tropomyosin type; Glia maturation factor beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628987_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5869. Gene sequence location is 2L:16301656..16302954.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35F1-35F1   Limits computationally determined from genome sequence between P{lacW}heixk11403&P{lacW}heixk12401 and P{EP}fzyEP1028&P{lacW}mRpL4k14608
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5869 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5869-RA FBtr0080851  NM_135943   1019   138
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5869-PA   FBpp0080408   16.5   138   4.64     NP_609787   AAF53517
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108) Glia maturation factor beta (IPR011171)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53517   AI532325   AW944327   AY118642 AAM50011   BI171482   BI216781   BI243017   BI362192   BT014645   CK661985   CO152716   CO264960   CO291685   CO293575   CO297852   CO306719   CO312862   CO331254   CO332492   CO340215   EC061340   EC063505   EC063784   EC065879   EC216616   EC218011   EC248399   EC257027   EC265376   GH753368   GH755781   GH757777   GH771547   GH775637   GH789345   GH807233   GH822757   GH828855   GH833641   GH864981   GH865285   GH901972   GH926346   GH933495
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJL6 Q8MSR7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval midgut. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval hindgut, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut  (656.4) Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut  656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    421.325 Larval Midgut    656.4 Larval Hindgut    199.9 Larval Malpighian Tubules    76.2 Larval Fat Body    194.6 Larval Salivary Gland    265.2 Larval Trachea    141.475 Larval Carcass    108.7 Adult Head    79.3 Adult Eye    57.375 Adult Brain    86.3 Adult Thoracic-Abdominal Ganglion    82.7 Adult Crop    71.4 Adult Midgut    323 Adult Hindgut    82.4 Adult Malpighian Tubules    75.8 Adult Fat Body    77.9 Adult Salivary Gland    120.6 Adult Heart    166.875 Adult VirginFemale Spermatheca    143.6 Adult InseminatedFemale Spermatheca    181.6 Adult Ovary    245.1 Adult Testis    146.8 Adult Male Accessory Gland    118.5 Adult Carcass    58.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    79.3   NA  Eye    57.375   NA  Brain    86.3   421.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    82.7   NA  Crop    71.4   656.4  Midgut    323   199.9  Hindgut    82.4   76.2  Malpighian Tubules    75.8   194.6  Fat Body    77.9   265.2  Salivary Gland    120.6   NA  Heart    166.875   141.475  Trachea    NA   NA  VirginFemale Spermatheca    143.6   NA  InseminatedFemale Spermatheca    181.6   NA  Ovary    245.1   NA  Testis    146.8   NA  Male Accessory Gland    118.5   108.7  Carcass    58.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (31) central nervous system, pupae P8  (30) head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (46) digestive system, larvae L3 wandering  (96) digestive system, 1-day adult  (29) digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  31 central nervous system, pupae P8  30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae  (46) digestive system, larvae L3 wandering  (96) digestive system, 1-day adult  29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    31 central nervous system, pupae P8    30 head, virgin 1-day female    6 head, virgin 4-day female    4 head, virgin 20-day female    8 head, mated 1-day female    3 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    16 salivary gland, white prepupae    46 digestive system, larvae L3 wandering    96 digestive system, 1-day adult    29 digestive system, 4-day adult    16 digestive system, 20-day adult    20 fat body, larvae L3 wandering    6 fat body, white prepupae    18 fat body, pupae P8    22 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    8 ovary, virgin 4-day female    20 ovary, mated 4-day female    12 testis, mated 4-day male    23 accessory gland, mated 4-day male    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr    111 embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  (51) embryo 04-06hr  (111) embryo 06-08hr  (69) embryo 08-10hr  (63) embryo 10-12hr  (70) embryo 12-14hr  (54) embryo 14-16hr  26 embryo 16-18hr  (30) embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr  (29) larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (41) white prepupae new  (49) white prepupae 12hr  (37) white prepupae 24hr  (35) pupae 2d postWPP  (28) pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr  (111) embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr    111 embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr    111 embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr  (51) embryo 04-06hr  (111) embryo 06-08hr  (69) embryo 08-10hr  (63) embryo 10-12hr  (70) embryo 12-14hr  (54) embryo 14-16hr  26 embryo 16-18hr  30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr  29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (41) white prepupae new  (49) white prepupae 12hr  (37) white prepupae 24hr  (35) pupae 2d postWPP  28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr  111 embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    23 embryo 02-04hr    51 embryo 04-06hr    111 embryo 06-08hr    69 embryo 08-10hr    63 embryo 10-12hr    70 embryo 12-14hr    54 embryo 14-16hr    26 embryo 16-18hr    30 embryo 18-20hr    25 embryo 20-22hr    21 embryo 22-24hr    29 larva L1    15 larva L2    19 larva L3 12hr old    13 larva L3 puffstage 1-2    24 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    41 white prepupae new    49 white prepupae 12hr    37 white prepupae 24hr    35 pupae 2d postWPP    28 pupae 3d postWPP    14 pupae 4d postWPP    9 adult male 01day    12 adult male 05day    11 adult male 30day    12 adult female 01day    11 adult female 05day    17 adult female 30day    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    117 wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (36) embryonic 1182-4H  (54) embryonic GM2    24 embryonic Kc167  (41) embryonic S1  (64) embryonic S3  (30) leg disc CME L1    21 wing disc CME-W2  (31) wing disc ML-DmD8  (39) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (117) wing disc ML-DmD32  (76) haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (89) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  (96) tumorous blood cells mbn2  (78) ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21  (117) wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    117 wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    117 wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (126) Schneider line 2 Sg4  (36) embryonic 1182-4H  (54) embryonic GM2    24 embryonic Kc167  (41) embryonic S1  (64) embryonic S3  30 leg disc CME L1    21 wing disc CME-W2  31 wing disc ML-DmD8  (39) wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (89) wing disc ML-DmD21  (117) wing disc ML-DmD32  (76) haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (89) mixed discs ML-DmD4-c1  (81) CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  (96) tumorous blood cells mbn2  (78) ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  126 Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21  117 wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    126 Schneider line 2 Sg4    36 embryonic 1182-4H    54 embryonic GM2    24 embryonic Kc167    41 embryonic S1    64 embryonic S3    30 leg disc CME L1    21 wing disc CME-W2    31 wing disc ML-DmD8    39 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    89 wing disc ML-DmD21    117 wing disc ML-DmD32    76 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    89 mixed discs ML-DmD4-c1    81 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    78 ovary fGS/OSS    25 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  (28) Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (32) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3  28 Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3  (48) Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3  32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3  (47) Rotenone 8 μg 12 hrs, larvae L3  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    28 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    24 Cadmium 100 mM 48 hrs, 4-day adult    15 Copper 0.5 mM 12 hrs, larvae L3    22 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    13 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    17 Ethanol 5% 3 hrs, larvae L3    48 Ethanol 10% 3 hrs, larvae L3    25 Caffeine 1.5 mg/ml 4 hrs, larvae L3    32 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    15 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    47 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028894 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5869-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5869GD10559 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG5869 Class Mutagen Stocks Known lesion CG5869G2885 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5869 Class Mutagen Stocks Known lesion CG5869GD10559 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5869KK108743 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5869t12.1 in vitro construct - genomic fragment 0 Yes CG5869t14.2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10559} NA P{KK108743} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG5869G2885 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
actin binding inferred from electronic annotation with InterPro:IPR002108 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Ashburner et al., 1999)
Biological Process
CV term Evidence References
gliogenesis inferred from sequence or structural similarity with EMBL:BC005359 (Mi et al., 2001.12.13)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR002108 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5869 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60974 DroID - A comprehensive database of gene and protein interactions. • FBgn0028894 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34963
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6F4SXP Dipteran inclusive ortholog search EOG670TSP Insect inclusive ortholog search EOG6V425J Arthropod inclusive ortholog search EOG6NZSB1 Metazoa inclusive ortholog search EOG6HXHWJ
Orthologs in Drosophila Species (EOG6F4SXP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5869     Drosophila simulans   Dsim\GD21923 Y   Drosophila sechellia   Dsec\GM17913 Y   Drosophila erecta   Dere\GG24175 Y   Drosophila yakuba   Dyak\GE19369 Y   Drosophila ananassae   Dana\GF15327 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19191 Y   Drosophila persimilis   Dper\GL14094 Y   Drosophila willistoni   Dwil\GK24743 Y   Drosophila virilis   Dvir\GJ17165 Y   Drosophila mojavensis   Dmoj\GI14715 Y   Drosophila grimshawi   Dgri\GH11432 Y
Orthologs in non-Drosophila Dipterans (EOG670TSP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007334   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013768   Anopheles gambiae Malaria mosquito  Agam\AGAP009059   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007823
Orthologs in non-Dipteran Insects (EOG6V425J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010634   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005516   Bombyx mori Silkmoth  Bmor\BGIBMGA011372   Pediculus humanus Human body louse  Phum\PHUM348160   Tribolium castaneum Red flour beetle  Tcas\TC014337
Orthologs in non-Insect Arthropods (EOG6NZSB1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\nad5
Orthologs in non-Arthropod Metazoa (EOG6HXHWJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y50D7A.10   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027603gn   Danio rerio Zebrafish  Drer\gmfb   Xenopus tropicalis Western clawed frog  Xtro\gmfb   Mus musculus House mouse  Mmus\Gmfg   Mus musculus House mouse  Mmus\Gmfb   Rattus norvegicus Norway rat  Rnor\Gmfg   Rattus norvegicus Norway rat  Rnor\Gmfb   Homo sapiens Human  Hsap\GMFG
Human Orthologs (1)
Gene OMIM HGNC Hsap\GMFG
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21923 Drosophila sechellia Dsec\GM17913 Drosophila erecta Dere\GG24175 Drosophila yakuba Dyak\GE19369 Drosophila ananassae Dana\GF15327 Drosophila pseudoobscura pseudoobscura Dpse\GA19191 Drosophila persimilis Dper\GL14094 Drosophila willistoni Dwil\GK24743 Drosophila virilis Dvir\GJ17165 Drosophila mojavensis Dmoj\GI14715 Drosophila grimshawi Dgri\GH11432
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	26908 y1 w*; P{EP}CG5869G2885
VDRC	v101994 P{KK108743}VIE-260B v34145 w1118; P{GD10559}v34145/CyO
Genomic Clones ( 1 )
	BACR01N08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE40543 SD03793
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP21858 RE13271 RE24050 RE46693
Other clones	32288 70255 74007 105157 144888 214383.32 276635 473579 CK01.40D.H11 EK141038 EK170706 EK197958 EK203623 EK230255 EK252038 EK298917 EK303636 EN00261 EP10224 RP003034704 RP003064989 RP003167290 RP003170204 RP003192874 RP003198770 RP003228794 RP003263542 RP003278601 RP003349336 RP003394144 RP003430074 RP003471463 RP003503206 RP003641813
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028894 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34963
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: BG:DS02740.9 BcDNA:SD03793 (FlyBase, 1996-)
Additional comments	Source for merge of BG:DS02740.9 BcDNA:SD03793 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135943 RefSeq (Proteins) • NP_609787 DDBJ / EMBL / GenBank • AAF53517 AAM50011 AE003415 AI532325 AW944327 AY118642 BI243017 Entrez Gene - A searchable database of RefSeq genes. • 34963 UniProtKB/TrEMBL • Q8MSR7 Q9VJL6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Actin-binding, cofilin/tropomyosin type (IPR002108) Glia maturation factor beta (IPR011171)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60974 DroID - A comprehensive database of gene and protein interactions. • FBgn0028894 DRSC - Results from RNAi screens. • FBgn0028894 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028894 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5869-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028894 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34963 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34963 modMine - Data generated by the modENCODE project. • FBgn0028894
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:SD03793   BG:DS02740.9 (Ashburner et al., 1999.10.12, Ashburner et al., 1999, Ashburner et al., 1999, Giot et al., 2003, ) CG5869 (Keleman et al., 2009.8.5) DS02740.9 (Reese et al., 2000, Reese et al., 2000)
Name Synonym
Secondary FlyBase IDs
	FBgn0062894
References ( 19 )
Research paper	Willingham and Keil, 2004, Mech. Dev. 121(10): 1289--1297 A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. [FBrf0179737] Reese et al., 2000, Genome Res. 10(4): 483--501 Genome annotation assessment in Drosophila melanogaster. [FBrf0127290] Reese et al., 2000, Genome Res. 10(4): 529--538 Genie - Gene finding in Drosophila melanogaster. [FBrf0127289] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Ashburner et al., 1999, Genetics 153(1): Table S2. Genes, known and predicted, that have been determined on the sequence of the Adh region. All genes are protein coding, unless indicated tscan in the prediction column, these are tRNAs. [FBrf0112151] Ashburner et al., 1999, Genetics 153(1): Table S3. A classified summary of the inferred function of the products of 91 genes in the Adh region. [FBrf0112152]
Personal communication to FlyBase	Bellen, 2009.2.6, BDGP_2009_0206.GenExel.xml BDGP_2009_0206.GenExel.xml [FBrf0206623] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Mi et al., 2001.12.13, Corrections to the assignment of GO terms. Corrections to the assignment of GO terms. [FBrf0141274] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]