Gene Dmel\CG14478

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General Information

Symbol

Dmel\CG14478

Species

D. melanogaster

Name

Annotation symbol

CG14478

Feature type

protein_coding_gene

FlyBase ID

FBgn0028953

Gene Model Status

Current

Stock availability

8 publicly available

Also Known As

gene 4

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

54B16-54B16

Sequence location

2R:13,345,168..13,353,085 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG14478 (FBgn0028953). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; imaginal disc-derived wing morphogenesis. 16 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638359_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG14478. Gene sequence location is 2R:13345168..13353085.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

54B16-54B16

Limits computationally determined from genome sequence between P{EP}l(2)k01209^EP2177&P{lacW}k11012a and P{lacW}l(2)k07433^k07433

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG14478 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG14478-RA

FBtr0086921

NM_166229

3797

512

CG14478-RB

FBtr0086922

NM_137370

3656

512

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG14478-PA

FBpp0086077

56.0

512

8.96

NP_725678

AAF57859

CG14478-PB

FBpp0086078

56.0

512

8.96

NP_611214

AAF57860

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q6NR30

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		(585.9)
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		491.575
Larval Midgut		140.3
Larval Hindgut		208.8
Larval Malpighian Tubules		186
Larval Fat Body		216.7
Larval Salivary Gland		162.5
Larval Trachea		239.45
Larval Carcass		222.85
Adult Head		236.9
Adult Eye		314.725
Adult Brain		585.9
Adult Thoracic-Abdominal Ganglion		428.4
Adult Crop		339.6
Adult Midgut		142.5
Adult Hindgut		215.1
Adult Malpighian Tubules		105.4
Adult Fat Body		181.7
Adult Salivary Gland		243.1
Adult Heart		192.7
Adult VirginFemale Spermatheca		145.1
Adult InseminatedFemale Spermatheca		126.4
Adult Ovary		76.4
Adult Testis		39.5
Adult Male Accessory Gland		123.4
Adult Carcass		171.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	236.9
NA	Eye	314.725
NA	Brain	585.9
491.575	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	428.4
NA	Crop	339.6
140.3	Midgut	142.5
208.8	Hindgut	215.1
186	Malpighian Tubules	105.4
216.7	Fat Body	181.7
162.5	Salivary Gland	243.1
NA	Heart	192.7
239.45	Trachea	NA
NA	VirginFemale Spermatheca	145.1
NA	InseminatedFemale Spermatheca	126.4
NA	Ovary	76.4
NA	Testis	39.5
NA	Male Accessory Gland	123.4
222.85	Carcass	171.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		147
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		119
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		196
ovary, mated 4-day female		231
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(105)
central nervous system, larvae L3		(147)
central nervous system, pupae P8		(76)
head, virgin 1-day female		(51)
head, virgin 4-day female		(54)
head, virgin 20-day female		(43)
head, mated 1-day female		(56)
head, mated 4-day female		(48)
head, mated 20-day female		(40)
head, mated 1-day male		(73)
head, mated 4-day male		(74)
head, mated 20-day male		(69)
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		(97)
digestive system, larvae L3 wandering		(55)
digestive system, 1-day adult		22
digestive system, 4-day adult		(38)
digestive system, 20-day adult		(33)
fat body, larvae L3 wandering		22
fat body, white prepupae		(77)
fat body, pupae P8		(43)
carcass, larvae L3 wandering		(119)
carcass, 1-day adult		(38)
carcass, 4-day adult		(45)
carcass, 20-day adult		(45)
ovary, virgin 4-day female		(196)
ovary, mated 4-day female		(231)
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		(147)
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		(119)
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		(196)
ovary, mated 4-day female		(231)
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		147
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		119
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		196
ovary, mated 4-day female		231
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		147
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		119
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		196
ovary, mated 4-day female		231
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(105)
central nervous system, larvae L3		(147)
central nervous system, pupae P8		(76)
head, virgin 1-day female		(51)
head, virgin 4-day female		(54)
head, virgin 20-day female		(43)
head, mated 1-day female		(56)
head, mated 4-day female		(48)
head, mated 20-day female		(40)
head, mated 1-day male		(73)
head, mated 4-day male		(74)
head, mated 20-day male		(69)
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		(97)
digestive system, larvae L3 wandering		(55)
digestive system, 1-day adult		22
digestive system, 4-day adult		(38)
digestive system, 20-day adult		(33)
fat body, larvae L3 wandering		22
fat body, white prepupae		(77)
fat body, pupae P8		(43)
carcass, larvae L3 wandering		(119)
carcass, 1-day adult		(38)
carcass, 4-day adult		(45)
carcass, 20-day adult		(45)
ovary, virgin 4-day female		(196)
ovary, mated 4-day female		(231)
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		(147)
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		119
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		(196)
ovary, mated 4-day female		(231)
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		147
central nervous system, pupae P8		76
head, virgin 1-day female		51
head, virgin 4-day female		54
head, virgin 20-day female		43
head, mated 1-day female		56
head, mated 4-day female		48
head, mated 20-day female		40
head, mated 1-day male		73
head, mated 4-day male		74
head, mated 20-day male		69
salivary gland, larvae L3 wandering		18
salivary gland, white prepupae		97
digestive system, larvae L3 wandering		55
digestive system, 1-day adult		22
digestive system, 4-day adult		38
digestive system, 20-day adult		33
fat body, larvae L3 wandering		22
fat body, white prepupae		77
fat body, pupae P8		43
carcass, larvae L3 wandering		119
carcass, 1-day adult		38
carcass, 4-day adult		45
carcass, 20-day adult		45
ovary, virgin 4-day female		196
ovary, mated 4-day female		231
testis, mated 4-day male		12
accessory gland, mated 4-day male		13
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		146
embryo 02-04hr		132
embryo 04-06hr		129
embryo 06-08hr		140
embryo 08-10hr		108
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(146)
embryo 02-04hr		(132)
embryo 04-06hr		(129)
embryo 06-08hr		(140)
embryo 08-10hr		(108)
embryo 10-12hr		(57)
embryo 12-14hr		(80)
embryo 14-16hr		(80)
embryo 16-18hr		(72)
embryo 18-20hr		(55)
embryo 20-22hr		(82)
embryo 22-24hr		(71)
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		(29)
larva L3 puffstage 7-9		(48)
white prepupae new		(62)
white prepupae 12hr		(40)
white prepupae 24hr		(38)
pupae 2d postWPP		(32)
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		(40)
adult female 05day		(69)
adult female 30day		(70)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		(146)
embryo 02-04hr		(132)
embryo 04-06hr		(129)
embryo 06-08hr		(140)
embryo 08-10hr		(108)
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		146
embryo 02-04hr		132
embryo 04-06hr		129
embryo 06-08hr		140
embryo 08-10hr		108
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		146
embryo 02-04hr		132
embryo 04-06hr		129
embryo 06-08hr		140
embryo 08-10hr		108
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(146)
embryo 02-04hr		(132)
embryo 04-06hr		(129)
embryo 06-08hr		(140)
embryo 08-10hr		(108)
embryo 10-12hr		(57)
embryo 12-14hr		(80)
embryo 14-16hr		(80)
embryo 16-18hr		(72)
embryo 18-20hr		(55)
embryo 20-22hr		(82)
embryo 22-24hr		(71)
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		(48)
white prepupae new		(62)
white prepupae 12hr		(40)
white prepupae 24hr		(38)
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		(40)
adult female 05day		(69)
adult female 30day		(70)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		(146)
embryo 02-04hr		132
embryo 04-06hr		129
embryo 06-08hr		140
embryo 08-10hr		108
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		146
embryo 02-04hr		132
embryo 04-06hr		129
embryo 06-08hr		140
embryo 08-10hr		108
embryo 10-12hr		57
embryo 12-14hr		80
embryo 14-16hr		80
embryo 16-18hr		72
embryo 18-20hr		55
embryo 20-22hr		82
embryo 22-24hr		71
larva L1		21
larva L2		14
larva L3 12hr old		10
larva L3 puffstage 1-2		12
larva L3 puffstage 3-6		29
larva L3 puffstage 7-9		48
white prepupae new		62
white prepupae 12hr		40
white prepupae 24hr		38
pupae 2d postWPP		32
pupae 3d postWPP		18
pupae 4d postWPP		14
adult male 01day		17
adult male 05day		16
adult male 30day		16
adult female 01day		40
adult female 05day		69
adult female 30day		70
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		159
ovary OSS		71
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(51)
Schneider line 2 Sg4		22
embryonic 1182-4H		(60)
embryonic GM2		(73)
embryonic Kc167		(47)
embryonic S1		(77)
embryonic S3		(50)
leg disc CME L1		(45)
wing disc CME-W2		(47)
wing disc ML-DmD8		(53)
wing disc ML-DmD9		(55)
wing disc ML-DmD16-c3		(58)
wing disc ML-DmD21		14
wing disc ML-DmD32		(37)
haltere disc ML-DmD17-c3		(64)
eye-antennal disc ML-DmD11		(48)
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		(42)
CNS ML-DmBG1-c1		(58)
CNS ML-DmBG2-c2		(94)
tumorous blood cells mbn2		(63)
ovary fGS/OSS		(82)
ovary OSC		(159)
ovary OSS		(71)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		(159)
ovary OSS		71
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		159
ovary OSS		71
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		159
ovary OSS		71
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(51)
Schneider line 2 Sg4		22
embryonic 1182-4H		(60)
embryonic GM2		(73)
embryonic Kc167		(47)
embryonic S1		(77)
embryonic S3		(50)
leg disc CME L1		(45)
wing disc CME-W2		(47)
wing disc ML-DmD8		(53)
wing disc ML-DmD9		(55)
wing disc ML-DmD16-c3		(58)
wing disc ML-DmD21		14
wing disc ML-DmD32		(37)
haltere disc ML-DmD17-c3		(64)
eye-antennal disc ML-DmD11		(48)
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		(42)
CNS ML-DmBG1-c1		(58)
CNS ML-DmBG2-c2		(94)
tumorous blood cells mbn2		(63)
ovary fGS/OSS		(82)
ovary OSC		(159)
ovary OSS		(71)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		(159)
ovary OSS		71
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		51
Schneider line 2 Sg4		22
embryonic 1182-4H		60
embryonic GM2		73
embryonic Kc167		47
embryonic S1		77
embryonic S3		50
leg disc CME L1		45
wing disc CME-W2		47
wing disc ML-DmD8		53
wing disc ML-DmD9		55
wing disc ML-DmD16-c3		58
wing disc ML-DmD21		14
wing disc ML-DmD32		37
haltere disc ML-DmD17-c3		64
eye-antennal disc ML-DmD11		48
antennal disc ML-DmD20-c5		26
mixed discs ML-DmD4-c1		42
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		94
tumorous blood cells mbn2		63
ovary fGS/OSS		82
ovary OSC		159
ovary OSS		71
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		158
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		111
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		111
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		148
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		111
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(80)
cold shock, 4-day adult		(55)
heat shock, 4-day adult		(54)
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		(69)
Cadmium 100 mM 48 hrs, 4-day adult		(158)
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		(111)
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		(67)
Ethanol 2.5% 3 hrs, larvae L3		(111)
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(148)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(74)
Paraquat 5 mM 48 hrs, 4-day adult		(111)
Paraquat 10 mM 48 hrs, 4-day adult		(78)
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		(158)
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		(111)
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		(111)
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(148)
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		(111)
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		158
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		111
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		111
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		148
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		111
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		158
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		111
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		111
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		148
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		111
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(80)
cold shock, 4-day adult		(55)
heat shock, 4-day adult		(54)
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		(69)
Cadmium 100 mM 48 hrs, 4-day adult		(158)
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		(111)
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		(67)
Ethanol 2.5% 3 hrs, larvae L3		(111)
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(148)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(74)
Paraquat 5 mM 48 hrs, 4-day adult		(111)
Paraquat 10 mM 48 hrs, 4-day adult		(78)
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		(158)
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		111
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		111
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(148)
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		111
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		80
cold shock, 4-day adult		55
heat shock, 4-day adult		54
Cadmium 50 mM 6 hrs, larvae L3		12
Cadmium 50 mM 12 hrs, larvae L3		26
Cadmium 50 mM 48 hrs, 4-day adult		69
Cadmium 100 mM 48 hrs, 4-day adult		158
Copper 0.5 mM 12 hrs, larvae L3		14
Copper 15 mM 48 hrs, 4-day adult		111
Zinc 5 mM 12 hrs, larvae L3		24
Zinc 4.5 mM 48 hrs, 4-day adult		67
Ethanol 2.5% 3 hrs, larvae L3		111
Ethanol 5% 3 hrs, larvae L3		13
Ethanol 10% 3 hrs, larvae L3		12
Caffeine 1.5 mg/ml 4 hrs, larvae L3		21
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		148
Caffeine 25 mg/ml 48 hrs, 4-day adult		74
Paraquat 5 mM 48 hrs, 4-day adult		111
Paraquat 10 mM 48 hrs, 4-day adult		78
Rotenone 2 μg 12 hrs, larvae L3		11
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE38958

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0028953

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14478-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG14478^CB02133

Other Phenotypes

Allele

behavior defective | recessive

CG14478^BG02377

Phenotype manifest in

Allele

Classical Alleles ( 13 )

For All Classical Alleles Show

Allele of CG14478	Mutagen	Stocks	Known lesion
CG14478^CB-6372-3		1	--
CG14478^CB-6461-3		1	--
CG14478^d11112	P-element activity	1	--
CG14478^EP2283	P-element activity	1	--
CG14478^EY02186	P-element activity	1	--
CG14478^KG00627	P-element activity	1	--
CG14478^NP5912		1	--
CG14478^BG02377		0	--
CG14478^c03572	piggyBac transposase	0	--
CG14478^CB02133	P-element activity	0	Yes
CG14478^d09297	P-element activity	0	--
CG14478^DG25111	P-element activity	0	--
CG14478^NP6302		0	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG14478	Mutagen	Stocks	Known lesion
CG14478^KK113343	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG14478^GD16714	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes
CG14478^GD8340	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD8340}

P{GD16714}

P{KK113343}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}CG14478^EP2283

P{EPgy2}CG14478^EY02186

P{XP}CG14478^d09297

P{XP}CG14478^d11112

miscellaneous insertions

P{GT1}CG14478^BG02377

P{PTT-GB}CG14478^CB02133

P{RS3}CG14478^CB-6372-3

P{RS3}CG14478^CB-6461-3

P{SUPor-P}CG14478^KG00627

P{wHy}CG14478^DG25111

PBac{PB}CG14478^c03572

insertion of enhancer trap

P{lacW}l(2)SH0369^SH0369

insertion of enhancer trap binary system

P{GawB}CG14478^NP5912

P{GawB}CG14478^NP6302

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

Terms Based on Experimental Evidence ( 2 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Carreira et al., 2011)

inter-male aggressive behavior

inferred from mutant phenotype

(Edwards et al., 2009)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG14478 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

62658

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0028953

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36964

Orthologs

OrthoDB Orthologs (77) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG67DB2D

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

EOG6B2RT6

Arthropod inclusive ortholog search

EOG6GB5PZ

Metazoa inclusive ortholog search

EOG6H7F65

Orthologs in Drosophila Species (EOG67DB2D)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13013

Drosophila persimilis

Dper\GL11427

Drosophila willistoni

Dwil\GK22900

Drosophila virilis

Dvir\GJ20373

Drosophila mojavensis

Dmoj\GI18579

Drosophila grimshawi

Dgri\GH21400

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (EOG6B2RT6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016369

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH24549

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO26740

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO25949

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO23956

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO26698

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO24960

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO24710

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO25292

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO25884

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO25302

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO24518

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO25291

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO23981

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL25952

Tribolium castaneum

Red flour beetle

Tcas\TC002189

Tribolium castaneum

Red flour beetle

Tcas\TC002753

Tribolium castaneum

Red flour beetle

Tcas\TC010751

Tribolium castaneum

Red flour beetle

Tcas\TC012886

Tribolium castaneum

Red flour beetle

Tcas\TC002157

Tribolium castaneum

Red flour beetle

Tcas\TC010292

Tribolium castaneum

Red flour beetle

Tcas\TC016409

Orthologs in non-Insect Arthropods (EOG6GB5PZ)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\cytb

Daphnia pulex

Water flea

Dpux\JGI_V11_318734

Daphnia pulex

Water flea

Dpux\JGI_V11_242755

Daphnia pulex

Water flea

Dpux\JGI_V11_106728

Daphnia pulex

Water flea

Dpux\JGI_V11_66487

Daphnia pulex

Water flea

Dpux\matK

Daphnia pulex

Water flea

Dpux\C13orf35

Daphnia pulex

Water flea

Dpux\atpD

Ixodes scapularis

Deer tick

Isca\ISCW019375

Orthologs in non-Arthropod Metazoa (EOG6H7F65)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006560gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019910gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006050gn

Danio rerio

Zebrafish

Drer\ENSDARG00000088542

Danio rerio

Zebrafish

Drer\ENSDARG00000086423

Danio rerio

Zebrafish

Drer\BX296538.3

Danio rerio

Zebrafish

Drer\ENSDARG00000087370

Danio rerio

Zebrafish

Drer\CU694385.1

Danio rerio

Zebrafish

Drer\ENSDARG00000087331

Danio rerio

Zebrafish

Drer\ENSDARG00000087246

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000030870

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000033738

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032450

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031868

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000030621

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000030002

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031699

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000030181

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031654

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032603

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000030569

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032804

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000034188

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031448

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000033281

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032765

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000034311

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000002594

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032638

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031667

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000033135

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032530

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031919

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000032828

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA13013

Drosophila persimilis

Dper\GL11427

Drosophila willistoni

Dwil\GK22900

Drosophila virilis

Dvir\GJ20373

Drosophila mojavensis

Dmoj\GI18579

Drosophila grimshawi

Dgri\GH21400

Stocks & Reagents

Stocks Listed in FlyBase ( 8 )

Bloomington

17040

w¹¹¹⁸; P{EP}CG14478^EP2283

15557

y¹ w^67c23; P{EPgy2}CG14478^EY02186

14074

y¹ w^67c23; P{SUPor-P}CG14478^KG00627

Harvard

P{XP}CG14478^d11112

Kyoto

124076

w¹¹¹⁸; P{RS3}CG14478^CB-6372-3

124112

w¹¹¹⁸; P{RS3}CG14478^CB-6461-3

113782

y^* w^*; P{GawB}CG14478^NP5912 / CyO, P{UAS-lacZ.UW14}UW14

VDRC

v104085

P{KK113343}VIE-260B

Genomic Clones ( 1 )

BACR21A09

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 105 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE38958

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0028953

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36964

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: BEST:LD13441 CG14478

(Bayraktaroglu, 2000.11.2)

Additional comments

Other Comments

Identification: transcription unit identified during molecular analysis of the robl genomic region.

(Bowman et al., 1999)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

36964

UniProtKB/TrEMBL

•

Q6NR30

Other Crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE38958

Linkouts

BioGRID - A database of protein and genetic interactions

•

62658

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0028953

DRSC - Results from RNAi screens.

•

FBgn0028953

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0028953

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14478-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0028953

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36964

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36964

modMine - Data generated by the modENCODE project.

•

FBgn0028953

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

BEST:LD13441

(Giot et al., 2003, )

CG14478

(Edwards et al., 2006, Robin et al., 2007, Buszczak et al., 2007, Chen et al., 2012, Quinones-Coello, 2007, Mensch et al., 2008, Keleman et al., 2009.8.5, Edwards et al., 2009, Beckstead et al., 2007, Carreira et al., 2011)

gene 4

(Bowman, 1999.11.11)

GENE 4

(Bowman et al., 1999)

Name Synonym

Secondary FlyBase IDs

FBgn0034222

References ( 27 )

Generate a list of

All references relating to this gene ( 27 )

List References by type

Recent research papers ( 2 )

Chen et al., 2012, Cell Death Differ. 19(10): 1655--1663: Effectors of alcohol-induced cell killing in Drosophila. [FBrf0219410]
Carreira et al., 2011, BMC Dev. Biol. 11: 32: Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273]

Show all research papers ...

Recent reviews (0)

All reviews listed in FlyBase were published before 2011

Show reviews ...