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Gene Dmel\AlstR

General Information
Symbol	Dmel\AlstR	Species	D. melanogaster
Name	Allatostatin Receptor	Annotation symbol	CG2872
Feature type	protein_coding_gene	FlyBase ID	FBgn0028961
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	DAR-1
Genomic Location
Chromosome (arm)	X	Recombination map	1-
Cytogenetic map	3D6-3E2	Sequence location	X:3,468,571..3,560,759 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Allatostatin Receptor is referred to in FlyBase by the symbol Dmel\AlstR (CG2872, FBgn0028961). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: galanin receptor activity; allatostatin receptor activity; G-protein coupled receptor activity; neuropeptide receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process: G-protein coupled receptor signaling pathway. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM; Galanin receptor. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain. Comments on Affy2 ProbeSet: ProbeSet 1629186_a_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of AlstR. Gene sequence location is X:3468571..3560759.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Marina et al., 2010, J. Neurosci. 30(37): 12466--12473 Sequence features BKN29042 HFA17727 HFA17278
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3D6-3E2
Experimentally Determined Cytological Location
Cytogenetic map Notes References 4F-5A   (determined by in situ hybridisation)   (Birgul et al., 1999)
Experimentally Determined Recombination Data
Location	1- (Birguel, 1999.6.29, Lenz, 1999.12.30)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AlstR for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AlstR-RB FBtr0070575  NM_079961   3704   394
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AlstR-PB   FBpp0070550   43.3   394   8.35     NP_524700   AAF45884
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) Galanin receptor (IPR000405) GPCR, rhodopsin-like superfamily (IPR017452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140932   AA141124   AA141143   AA141199   AA141234   AA141354   AA141422   AA141464   AA141489   AA141560   AA141562   AA141593   AA141607   AA141611   AA141655   AA141676   AA141707   AA141714   AA141735   AA141834   AA141881   AA141885   AA440163   AE014298 AAF45884   AF163775 AAF05299   AF220216 AAF33781   AI134940   AI386899   AJ783002   AJ783003   AJ783004   AJ783005   AJ783006   AJ783007   AJ783008   AJ783009   AJ783010   AJ783011   AJ783012   AJ783013   AJ783014   AJ889721   AJ889722   AJ889723   AJ889724   AJ889725   AJ889726   AJ889727   AJ889728   AJ889729   AJ889730   AJ889731   AJ889732   AJ889733   AJ889734   AJ889735   AJ889736   AJ889737   AJ889738   AJ889739   AJ889740   AJ889741   AJ889742   AJ889743   AJ889744   AJ889745   AJ889746   AJ889747   AJ889748   AJ889749   AJ889750   AJ889751   AJ889752   AJ889753   AJ889754   AJ889755   AJ889756   AJ889757   AJ889758   AJ889759   AJ889760   AJ889761   AJ889762   AJ889763   AJ889764   AJ889765   AJ889766   AJ889767   AJ889768   AJ889769   AJ889770   AJ889771   AJ889772   AJ889773   AJ889774   AJ889775   AJ889776   AJ889777   AL024454   BF489526   BG632695   BG637093   BI142244   BI165760   BI365387   BI566503   BI571671   BI571679   BI588633   BI589043   BI604852   BI636622   BI639929   BT024202   CK135090   CO153056   CO153494   CO177555   CO178669   CO187484   CO187710   CO190469   CO190773   CO262568   CO265804   CO266208   CO266528   CO267012   CO267454   CO269696   CO271850   CO272166   CO272320   CO275125   CO276551   CO278383   CO279733   CO280947   CO281528   CO281955   CO282275   CO284265   CO284589   CO284981   CO288445   CO290180   CO290759   CO291316   CO291625   CO292457   CO292855   CO293512   CO293878   CO294202   CO299908   CO300478   CO300848   CO302309   CO302349   CO302803   CO303318   CO303448   CO306074   CO307131   CO309805   CO309979   CO311288   CO311693   CO314047   CO319487   CO320331   CO320976   CO321061   CO321607   CO324776   CO325983   CO326143   CO331136   CO331749   CO332242   CO332493   CO337673   CO339030   CO339169   CO340021   CO340387   CO341425   CO341986   CO343580   CO344264   CO344644   CZ469240   CZ486974   CZ490705   DD177531   EC214640   EC215868
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O76873 Q9U721
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028961    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028961 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-12 and 18-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028961 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr  105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr  107 embryo 22-24hr  (142) larva L1  (124) larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr  (128) pupae 2d postWPP  (129) pupae 3d postWPP  101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028961 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr  105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr  107 embryo 22-24hr  142 larva L1  124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr  128 pupae 2d postWPP  129 pupae 3d postWPP  101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    10 embryo 04-06hr    35 embryo 06-08hr    105 embryo 08-10hr    71 embryo 10-12hr    26 embryo 12-14hr    22 embryo 14-16hr    27 embryo 16-18hr    57 embryo 18-20hr    81 embryo 20-22hr    107 embryo 22-24hr    142 larva L1    124 larva L2    32 larva L3 12hr old    11 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    30 white prepupae new    28 white prepupae 12hr    19 white prepupae 24hr    128 pupae 2d postWPP    129 pupae 3d postWPP    101 pupae 4d postWPP    52 adult male 01day    51 adult male 05day    42 adult male 30day    48 adult female 01day    34 adult female 05day    14 adult female 30day    10 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028961    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028961 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028961 expression level Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028961 expression level Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    45.05 Larval Midgut    0.8 Larval Hindgut    1.5 Larval Malpighian Tubules    1.4 Larval Fat Body    1.2 Larval Salivary Gland    1.2 Larval Trachea    2.575 Larval Carcass    3.3 Adult Head    47.1 Adult Eye    147.05 Adult Brain    143.3 Adult Thoracic-Abdominal Ganglion    87.8 Adult Crop    2.2 Adult Midgut    1 Adult Hindgut    1 Adult Malpighian Tubules    1.5 Adult Fat Body    3.8 Adult Salivary Gland    4.7 Adult Heart    1.85 Adult VirginFemale Spermatheca    7.7 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1.6 Adult Testis    0.9 Adult Male Accessory Gland    1.3 Adult Carcass    4.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    47.1   NA  Eye    147.05   NA  Brain    143.3   45.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    87.8   NA  Crop    2.2   0.8  Midgut    1   1.5  Hindgut    1   1.4  Malpighian Tubules    1.5   1.2  Fat Body    3.8   1.2  Salivary Gland    4.7   NA  Heart    1.85   2.575  Trachea    NA   NA  VirginFemale Spermatheca    7.7   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1.6   NA  Testis    0.9   NA  Male Accessory Gland    1.3   3.3  Carcass    4.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028961 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2872-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 AlstRGD713 AlstRGD15365 Phenotype manifest in Allele
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of AlstR Class Mutagen Stocks Known lesion AlstRc04426 piggyBac transposase 1 -- AlstRf04440 piggyBac transposase 1 -- AlstRf08011 piggyBac transposase 1 -- AlstRMB01003 1 -- AlstRMB06064 1 -- AlstRMB07922 1 -- AlstRMI01462 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AlstR Class Mutagen Stocks Known lesion AlstRGD15365 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AlstRGD16182 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AlstRGD713 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AlstRJF02578 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AlstRKK109042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD713} NA P{GD15365} NA P{GD16182} NA P{KK109042} NA P{TRiP.JF02578} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}AlstRMI01462 NA PBac{PB}AlstRc04426 NA PBac{WH}AlstRf04440 NA PBac{WH}AlstRf08011 NA insertion of mobile activating element P{EPg}dockHP26308 NA P{Mae-UAS.6.11}PNUTSDP00473 NA insertion of enhancer trap binary system Mi{ET1}AlstRMB01003 No Mi{ET1}AlstRMB06064 No Mi{ET1}AlstRMB07922 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
allatostatin receptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) non-traceable author statement (Birguel, 1999.6.29, FlyBase, 1992-) galanin receptor activity inferred from electronic annotation with InterPro:IPR000405 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lenz, 1999.12.30) G-protein coupled receptor activity inferred from sequence or structural similarity (Radford et al., 2002) neuropeptide receptor activity inferred from sequence or structural similarity (Hewes and Taghert, 2001)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000405 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000, Hewes and Taghert, 2001)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000405 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000, Hewes and Taghert, 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AlstR allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0028961 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44126
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22643 Dere\GG18661 Dgri\GH24210 Dmoj\GI15835 Dper\GL15947 Dpse\GA15495 Dsec\GM12299 Dsim\GD16646 Dvir\GJ19325 Dwil\GK14796 Dyak\GE16306
Curated drosophilid orthologs	Dpse\GA15495   Dsim\AlstR
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007169-PA Aedes aegypti (mosquito) AGAP003658-PA Anopheles gambiae (mosquito) XP_397024.1 Apis mellifera (honey bee) XP_001952361.1 Acyrthosiphon pisum (pea aphid) 74737 Branchiostoma floridae (lancelet) 74740 Branchiostoma floridae (lancelet) BGIBMGA005708-PA Bombyx mori (silk worm) ENSBTAP00000027969 Bos taurus (bovine) CN07661 Caenorhabditis brenneri (small nematode) CBP35824 Caenorhabditis briggsae (nematode) CE03814 Caenorhabditis elegans (worm) ENSCAFP00000007485 Canis familiaris (dog) ENSCINP00000004475 Ciona intestinalis (sea squirt) JA05951 Caenorhabditis japonica (nematode) ENSCPOP00000000110 Cavia porcellus (guinea pig) RP46237 Caenorhabditis remanei (nematode) ENSCSAVP00000003830 Ciona savignyi (sedentary tunicate) 19607 Capitella spl (polychaete worm) 13548 Daphnia pulex (daphnia) ENSDARP00000088021 Danio rerio (zebra fish) ENSECAP00000012523 Equus caballus (horse) ENSGACP00000018555 Gymnopilus aculeatus (mushroom) ENSGALP00000002895 Gallus gallus (chicken) 64929 Hypsipyla robusta (cedar shoot borer) ENSP00000299727 Homo sapiens (human) ISCW016382-PA Ixodes scapularis (deer tick) 108200 Lottia gigantea (owl limpet) ENSMODP00000015376 Monodelphis domestica (gray opossum) ENSMMUP00000003354 Macaca mulatta (rhesus monkey) ENSMUSP00000054062 Mus musculus (house mouse) 61644 Nematostella vectensis (starlet anemone) XP_001607985.1 Nasonia vitripennis (wasp) ENSOANP00000009519 Ornithorynchus anatinus (platypus) ENSORLP00000006004 Oryzias latipes (japanese killifish) PHUM001517-PA Pediculus humanus (human body louse) ENSPPYP00000010387 Pongo pygmaeus (orangutan) ENSPTRP00000017206 Pan troglodytes (chimpanzee) ENSRNOP00000012523 Rattus norvegicus (norway rat) Smp_011940 Schistosoma mansoni (trematode parasite) XP_001188485.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000021776 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033860 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027636 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10709 NV10415 LH19460 ISCW016381 ISCW016382 ISCW014938 ISCW001334 FBgn0233840 FBgn0228357 FBgn0216801 FBgn0212999 FBgn0211268 FBgn0206469 FBgn0189566 FBgn0188239 FBgn0167236 FBgn0167225 JGI_V11_13548 JGI_V11_60654 JGI_V11_120392 FBgn0075512 FBgn0070060 FBgn0153551 FBgn0151298 FBgn0138584 FBgn0133297 FBgn0039595 FBgn0131666 FBgn0121637 FBgn0110871 FBgn0104350 FBgn0099637 FBgn0093453 CPIJ016163 CPIJ013095 CPIJ011118 BGIBMGA005708 ACYPI008623 GB19021 GPRALS2 GPRALS1 AAEL007169 AAEL006077 PHUM343230
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	22959 w1118 Mi{ET1}AlstRMB01003 25577 w1118 Mi{ET1}AlstRMB07922
Harvard	- PBac{PB}AlstRc04426 - PBac{WH}AlstRf04440 - PBac{WH}AlstRf08011
VDRC	v101395 P{KK109042}VIE-260B v3399 w1118; P{GD713}v3399 v3400 w1118; P{GD713}v3400 v48496 w1118 P{GD16182}v48496 v39221 w1118; P{GD15365}v39221 v39222 w1118; P{GD15365}v39222 v48495 w1118; P{GD16182}v48495
	More stocks available...
Genomic Clones ( 2 )
	BACR17E02 BACR32E02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 118 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE48774
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25571 GH17272 LD14764 RE05714 RE50674 RH06941 RH06949 RH22177 RH30020 RH30716 RH36065 RH70341 SD14952 SD16292 SD18363 SD22651
Other clones	144463 175550 CK01023 CK01258 CK01331 CK01421 CK01456 CK01617 CK01718 CK01792 CK02010 CK02026 CK02083 CK02102 CK02134 CK02216 CK02256 CK02311 CK02322 CK02564 CK02584 CK02648 CK02684 CK02693 EK030002 EK032025 EK048304 EK049563 EK053809 EK057316 EK068527 EK073259 EK075111 EK077604 EK085812 EK095603 EK104936 EK106046 EK106728 EK116527 EK121312 EK129929 EK135752 EK143704 EK145429 EK146664 EK148339 EK150160 EK155537 EK157360 EK159162 EK160129 EK165624 EK166349 EK167802 EK176904 EK178259 EK179526 EK183856 EK183952 EK184927 EK186020 EK194822 EK197836 EK200229 EK201106 EK203155 EK205033 EK206320 EK219351 EK220109 EK224049 EK225919 EK234764 EK240954 EK241457 EK250221 EK253707 EK278350 EK284052 EK289455 EK290234 EK298525 EK301618 EK302908 EK303642 EN01164 EN02064 EN15045 EP00644 EP01012 EP03024 EP03318 EP09905 EP10540 EP12425 EP13602 EP17315 EP18944 EP19647 GH12528
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028961 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44126
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: GR EG:121E7.2 (FlyBase, 1996-)
Source for database merge of	Source for merge of: AlstR CG2872 (Bayraktaroglu, 2000.4.12)
Additional comments	Source for identity of GR EG:121E7.2 was sequence comparison (date:000327). (FlyBase, 1996-)
Other Comments
	Identification: a reverse physiological method using functionally expressed orphan receptors with peptide fractions purified from Drosophila head extracts. (Birgul et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079961 RefSeq (Proteins) • NP_524700 DDBJ / EMBL / GenBank • AAF05299 AAF33781 AAF45884 AF163775 AF220216 AJ783002 AJ783003 AJ783004 AJ783005 AJ783006 AJ783007 AJ783008 AJ783009 AJ783010 AJ783011 AJ783012 AJ783013 AJ783014 AJ889721 AJ889722 AJ889723 AJ889724 AJ889725 AJ889726 AJ889727 AJ889728 AJ889729 AJ889730 AJ889731 AJ889732 AJ889733 AJ889734 AJ889735 AJ889736 AJ889737 AJ889738 AJ889739 AJ889740 AJ889741 AJ889742 AJ889743 AJ889744 AJ889745 AJ889746 AJ889747 AJ889748 AJ889749 AJ889750 AJ889751 AJ889752 AJ889753 AJ889754 AJ889755 AJ889756 AJ889757 AJ889758 AJ889759 AJ889760 AJ889761 AJ889762 AJ889763 AJ889764 AJ889765 AJ889766 AJ889767 AJ889768 AJ889769 AJ889770 AJ889771 AJ889772 AJ889773 AJ889774 AJ889775 AJ889776 AJ889777 AL024454 CZ469240 CZ486974 CZ490705 DD177531 Entrez Gene - A searchable database of RefSeq genes. • 44126 UniProtKB/TrEMBL • O76873 Q9U721
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GPCR, rhodopsin-like, 7TM (IPR000276) Galanin receptor (IPR000405) GPCR, rhodopsin-like superfamily (IPR017452)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0028961 DRSC - Results from RNAi screens. • FBgn0028961 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028961 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2872-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028961 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44126 InParanoid A subset of ortholog calls from InParanoid. • AAEL007169-PA Aedes aegypti (mosquito) AGAP003658-PA Anopheles gambiae (mosquito) XP_397024.1 Apis mellifera (honey bee) XP_001952361.1 Acyrthosiphon pisum (pea aphid) 74737 Branchiostoma floridae (lancelet) 74740 Branchiostoma floridae (lancelet) BGIBMGA005708-PA Bombyx mori (silk worm) ENSBTAP00000027969 Bos taurus (bovine) CN07661 Caenorhabditis brenneri (small nematode) CBP35824 Caenorhabditis briggsae (nematode) CE03814 Caenorhabditis elegans (worm) ENSCAFP00000007485 Canis familiaris (dog) ENSCINP00000004475 Ciona intestinalis (sea squirt) JA05951 Caenorhabditis japonica (nematode) ENSCPOP00000000110 Cavia porcellus (guinea pig) RP46237 Caenorhabditis remanei (nematode) ENSCSAVP00000003830 Ciona savignyi (sedentary tunicate) 19607 Capitella spl (polychaete worm) 13548 Daphnia pulex (daphnia) ENSDARP00000088021 Danio rerio (zebra fish) ENSECAP00000012523 Equus caballus (horse) ENSGACP00000018555 Gymnopilus aculeatus (mushroom) ENSGALP00000002895 Gallus gallus (chicken) 64929 Hypsipyla robusta (cedar shoot borer) ENSP00000299727 Homo sapiens (human) ISCW016382-PA Ixodes scapularis (deer tick) 108200 Lottia gigantea (owl limpet) ENSMODP00000015376 Monodelphis domestica (gray opossum) ENSMMUP00000003354 Macaca mulatta (rhesus monkey) ENSMUSP00000054062 Mus musculus (house mouse) 61644 Nematostella vectensis (starlet anemone) XP_001607985.1 Nasonia vitripennis (wasp) ENSOANP00000009519 Ornithorynchus anatinus (platypus) ENSORLP00000006004 Oryzias latipes (japanese killifish) PHUM001517-PA Pediculus humanus (human body louse) ENSPPYP00000010387 Pongo pygmaeus (orangutan) ENSPTRP00000017206 Pan troglodytes (chimpanzee) ENSRNOP00000012523 Rattus norvegicus (norway rat) Smp_011940 Schistosoma mansoni (trematode parasite) XP_001188485.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000021776 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033860 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000027636 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44126 modMine - Data generated by the modENCODE project. • FBgn0028961 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10709 NV10415 LH19460 ISCW016381 ISCW016382 ISCW014938 ISCW001334 FBgn0233840 FBgn0228357 FBgn0216801 FBgn0212999 FBgn0211268 FBgn0206469 FBgn0189566 FBgn0188239 FBgn0167236 FBgn0167225 JGI_V11_13548 JGI_V11_60654 JGI_V11_120392 FBgn0075512 FBgn0070060 FBgn0153551 FBgn0151298 FBgn0138584 FBgn0133297 FBgn0039595 FBgn0131666 FBgn0121637 FBgn0110871 FBgn0104350 FBgn0099637 FBgn0093453 CPIJ016163 CPIJ013095 CPIJ011118 BGIBMGA005708 ACYPI008623 GB19021 GPRALS2 GPRALS1 AAEL007169 AAEL006077 PHUM343230
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	AlstR (Zhou et al., 2009, Perkins et al., 2009.8.10, Marina et al., 2010) CG2872 (McPartland et al., 2006, Keleman et al., 2009.8.5, Macdonald and Long, 2006) D.AlstR1 (Kreienkamp et al., 2002) DAR-1 (Larsen et al., 2001, Lenz et al., 2000) DGR (Lenz et al., 2000) EG:121E7.2 (Brody and Cravchik, 2000, ) GR (Lenz, 1999.12.30, )
Name Synonym	Allatostatin Receptor (Birgul et al., 1999) Galanin Receptor (Lenz, 1999.12.30, )
Secondary FlyBase IDs
	FBgn0024990 FBgn0040320
References ( 36 )
Generate a list of	All references relating to this gene ( 36 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Marina et al., 2010, J. Neurosci. 30(37): 12466--12473 Essential Role of Phox2b-Expressing Ventrolateral Brainstem Neurons in the Chemosensory Control of Inspiration and Expiration. [FBrf0211853] Show all research papers ...