FB2020_01, released Feb 12, 2020

Gene: Dmel\γCOP

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General Information
Symbol
Dmel\γCOP
Species
D. melanogaster
Name
Coat Protein (coatomer) γ
Annotation Symbol
CG1528
Feature Type
protein_coding_gene
FlyBase ID
FBgn0028968
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Snapshot
Coat Protein (coatomer) γ (γCOP) encodes a subunit of the coat complex of COPI vesicles, which transport cargo within the Golgi apparatus and from the Golgi apparatus to the endoplasmic reticulum. Its functions include membrane and protein trafficking in the secretory apparatus. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

copg, l(3)S057302

Key Links
Genomic Location
Cytogenetic map
100C6-100C6
Sequence location
3R:31,572,143..31,575,707 [+]
Recombination map

3-102

RefSeq locus
NT_033777 REGION:31572143..31575707
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the COPG family. (Q8I0G5)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
structural molecule activity
Summaries
Gene Group (FlyBase)
COAT PROTEIN COMPLEX I -
The Coat Protein Complex I (COPI or coatomer) is responsible for retrograde transport from the Golgi to ER. It is composed of seven subunits: the α, β, δ and γ subunits form the cargo adaptor and the β', ε and ζ form the vesicle cage. The small Ras GTPase, Arf1 (Arf79F in D.mel) recruits the complex to Golgi membranes in its GTP-bound form. (Adapted from PMID:22160157).
Protein Function (UniProtKB)
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.
(UniProt, Q8I0G5)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\γCOP or the JBrowse view of Dmel\γCOP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
γCOP-RA
FBtr0085793
NM_079869
3057
879
γCOP-RB
FBtr0085794
NM_170553
3276
883
γCOP-RC
FBtr0301290
NM_001170313
3054
878
γCOP-RD
FBtr0330096
NM_001276216
3054
897
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
γCOP-PA
FBpp0085154
97.3
879
4.95
NP_524608
AAF57160
γCOP-PB
FBpp0085155
97.7
883
5.41
NP_733432
AAN14275
γCOP-PC
FBpp0290505
97.2
878
4.95
NP_001163784
ACZ95077
γCOP-PD
FBpp0303129
99.4
897
4.96
NP_001263145
AGB96524
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

(UniProt, Q8I0G5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γCOP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (24 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
structural molecule activity
inferred from electronic annotation with InterPro:IPR013040
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
branch fusion, open tracheal system
inferred from mutant phenotype
(Grieder et al., 2008)
chitin-based embryonic cuticle biosynthetic process
inferred from mutant phenotype
(Grieder et al., 2008)
extracellular matrix organization
inferred from mutant phenotype
(Jayaram et al., 2008)
larval salivary gland morphogenesis
inferred from mutant phenotype
(Jayaram et al., 2008)
lumen formation, open tracheal system
inferred from mutant phenotype
(Grieder et al., 2008)
male meiosis cytokinesis
inferred from mutant phenotype
(Kitazawa et al., 2012)
mitotic cytokinesis
inferred from mutant phenotype
(Echard et al., 2004)
open tracheal system development
inferred from mutant phenotype
(Grieder et al., 2008)
protein secretion
inferred from mutant phenotype
(Grieder et al., 2008, Jayaram et al., 2008)
regulation of lipid storage
inferred from direct assay
(Beller et al., 2008)
regulation of tube diameter, open tracheal system
inferred from mutant phenotype
(Jayaram et al., 2008)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
endoplasmic reticulum to Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
intra-Golgi vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
intracellular protein transport
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
organelle transport along microtubule
inferred from biological aspect of ancestor with PANTHER:PTN000813705
(assigned by GO_Central )
(Gaudet et al., 2011)
protein secretion
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
acroblast
inferred from direct assay
(Kitazawa et al., 2012)
cis-Golgi network
inferred from direct assay
(Jayaram et al., 2008)
endoplasmic reticulum
inferred from direct assay
(Jayaram et al., 2008)
endoplasmic reticulum-Golgi intermediate compartment
inferred from direct assay
(Kitazawa et al., 2012)
Golgi apparatus
inferred from direct assay
(Grieder et al., 2008)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
COPI vesicle coat
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
endoplasmic reticulum-Golgi intermediate compartment
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
Golgi membrane
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
membrane
inferred from biological aspect of ancestor with PANTHER:PTN000029440
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male & spermatogenesis
primary spermatocyte
(Kitazawa et al., 2012)
meiotic primary spermatocyte
(Kitazawa et al., 2012)
onion stage spermatid
(Kitazawa et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

γCOP is localized to the endoplasmic reticulum-Golgi intermediate compartment in premeiotic spermatocytes, to COPI vesicles associated with astral microtubules in meiotic primary spermatocytes, and to the acroblast in onion stage spermatids.

(Kitazawa et al., 2012)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
acroblast
inferred from direct assay
(Kitazawa et al., 2012)
cis-Golgi network
inferred from direct assay
(Jayaram et al., 2008)
endoplasmic reticulum
inferred from direct assay
(Jayaram et al., 2008)
endoplasmic reticulum-Golgi intermediate compartment
inferred from direct assay
(Kitazawa et al., 2012)
Golgi apparatus
inferred from direct assay
(Grieder et al., 2008)
Expression Deduced from Reporters
Reporter: P{FRT(γCOP-mRFP.Ω38)}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male & spermatogenesis
primary spermatocyte
(Kitazawa et al., 2012)
Reporter: PBac{768.FSVS-0}γCOPCPTI002986
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\γCOP in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of γCOP
Transgenic constructs containing regulatory region of γCOP
Deletions and Duplications ( 4 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
lethal, with Scer\GAL4tin.CΔ4
lethal (with γCOP1b)
lethal (with γCOP5a)
lethal (with γCOP6a)
lethal (with γCOP7a)
lethal (with γCOP8a)
lethal (with γCOP9a)
lethal (with γCOP10a)
lethal (with γCOP11a)
lethal (with γCOP14a)
lethal (with γCOP15a)
lethal (with γCOP16a)
lethal (with γCOP16b)
lethal (with γCOP17b)
lethal (with γCOP20b)
lethal (with γCOP21b)
lethal (with γCOPS057302)
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
small body
some die during embryonic stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
denticle belt
embryonic/first instar larval cuticle
embryonic/larval dorsal branch
embryonic/larval dorsal trunk
embryonic/larval lateral trunk
embryonic/larval salivary gland
endoplasmic reticulum
onion stage spermatid, with Scer\GAL4VP16.bam
onion stage spermatid (with γCOPd06498), with Scer\GAL4VP16.bam
onion stage spermatid (with γCOPKG06383), with Scer\GAL4VP16.bam
presumptive embryonic/larval nervous system
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\COPG1
13 of 15
Yes
Yes
Hsap\COPG2
11 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Copg1
13 of 15
Yes
Yes
Mmus\Copg2
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Copg2
10 of 13
Yes
Yes
Rnor\Copg1
8 of 13
No
Yes
Rnor\Hmces
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\copg2
11 of 12
Yes
Yes
Xtro\copg1
7 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\copg2
14 of 15
Yes
Yes
Drer\si:dkey-117n7.5
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\T14G10.5
14 of 15
Yes
Yes
Cele\T15H9.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT4G34450
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SEC21
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\sec21
12 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919025Y )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\γCOP
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007384
Drosophila simulans
Dsim\GD21583
Drosophila sechellia
Dsec\GM16430
Drosophila erecta
Dere\GG11813
Drosophila yakuba
Dyak\GE10946
Drosophila ananassae
Dana\GF22968
Drosophila pseudoobscura pseudoobscura
Dpse\GA13624
Drosophila persimilis
Dper\GL23633
Drosophila willistoni
Dwil\GK11719
Drosophila virilis
Dvir\GJ23086
Drosophila mojavensis
Dmoj\GI23396
Drosophila grimshawi
Dgri\GH18636
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501AN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020817
Glossina morsitans
Tsetse fly
Gmor\GMOY007037
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00425
Mayetiola destructor
Hessian fly
Mdes\Mdes005207
Anopheles darlingi
American malaria mosquito
Adar\ADAC000679
Anopheles gambiae
Malaria mosquito
Agam\gammaCop
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012523
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01G2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\Bmo.721
Bombyx mori
Silkmoth
Bmor\BGIBMGA011180
Danaus plexippus
Monarch butterfly
Dple\DPOGS203907-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS200469-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004011
Heliconius melpomene
Postman butterfly
Hmel\HMEL009405
Heliconius melpomene
Postman butterfly
Hmel\HMEL008697
Heliconius melpomene
Postman butterfly
Hmel\HMEL003980
Heliconius melpomene
Postman butterfly
Hmel\HMEL010414
Apis florea
Little honeybee
Aflo\2434932932
Apis mellifera
Western honey bee
Amel\gammaCop
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19178
Bombus terrestris
Buff-tailed bumblebee
Bter\15213100
Linepithema humile
Argentine ant
Lhum\LH17855
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00062b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016029
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10166
Tribolium castaneum
Red flour beetle
Tcas\TC011806
Pediculus humanus
Human body louse
Phum\PHUM286750
Rhodnius prolixus
Kissing bug
Rpro\RPRC007538
Cimex lectularius
Bed bug
Clec\CLEC002136
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001622
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00780
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01E9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002291
Ixodes scapularis
Black-legged tick
Isca\ISCW022475
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76767.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g00890
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59845
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_255361
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64511
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_227791
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HWQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Copg2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003439gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Copg2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001800gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007307
Gallus gallus
Domestic chicken
Ggal\COPG
Gallus gallus
Domestic chicken
Ggal\COPG2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    COPG1; COPI coat complex subunit gamma 1
    13 of 15
    615525
        COPG2; COPI coat complex subunit gamma 2
        11 of 15
        604355
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            γCOP - Arf102F
            pull down, peptide massfingerprinting
            (Christis and Munro, 2012)
            γCOP - Arf79F
            pull down, peptide massfingerprinting
            (Christis and Munro, 2012)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            γCOP
            suppressible
            pio
            (Grieder et al., 2008)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Subunit Structure (UniProtKB)
            Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
            (UniProt, Q8I0G5 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-102

            Cytogenetic map
            100C6-100C6
            Sequence location
            3R:31,572,143..31,575,707 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            100C6-100C6
            Limits computationally determined from genome sequence between P{PZ}l(3)rM731rM731 and P{EP}pygoEP1076
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            100C-100C
            (determined by in situ hybridisation)
            (Grieder et al., 2005)
            100C7-100D8
            (Mink, 2002.6.28)
            Experimentally Determined Recombination Data
            Location

            3-102

            (FlyBase, 2016)

            3-99.1

            (Comeron et al., 2012)

            3-

            (Salzberg et al., 1997)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (19)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (54)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: γCop CG1528

              (Zhao, 1999.11)

              Source for identity of: γCOP γCop

              (FlyBase, 2009-)
              Source for database merge of

              Source for merge of: γCop l(3)S057302b

              (Ecovoiu et al., 2002)

              Source for merge of: γCop anon-WO0118547.334

              (FlyBase, 1996-)
              Additional comments

              Source for merge of γCop anon-WO0118547.334 was sequence comparison ( date:051113 ).

              (FlyBase, 1996-)
              Other Comments

              S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

              (Stroschein-Stevenson et al., 2006)

              dsRNA made from templates generated with primers directed against γCop that is transfected into S2 treated with Listeria monocytogenes reveals γCop to be involved in Listeria monocytogenes entry and vacuolar escape.

              (Cheng et al., 2005)

              Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

              (Nybakken et al., 2005)

              dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

              (Echard et al., 2004)

              Area matching Drosophila EST AA697891 (inverted). This EST has sequence similarity to Bovine gamma COP.

              (Davies, 2001.3.15)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 67 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              ApoDroso - Functional genomic database for photoreceptor development, survival and function
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (19)
              Reported As
              Symbol Synonym
              0573/02
              (Deak et al., 1997)
              573.02
              (Salzberg et al., 1997)
              CG1528
              (Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Christis and Munro, 2012, Perkins et al., 2009, Sepp et al., 2008, Derré et al., 2007, Hollien and Weissman, 2006, Nybakken et al., 2005)
              COPIγ
              (Schlesinger et al., 2004)
              Gamma-COP
              (Lesch and Page, 2012)
              anon-WO0118547.334
              copg
              (Hahn et al., 2000, Hahn, 1999.10.1)
              gamma-cop
              (Jiang et al., 2019)
              gammaCOP
              (Transgenic RNAi Project members, 2017-, Aikin et al., 2012, Lindquist et al., 2011, Cherry et al., 2006)
              gammaCop
              (Aradska et al., 2015, Kwon et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Jungreis et al., 2011, Lindquist et al., 2011, Fox et al., 2010, Sepp et al., 2008, Derré et al., 2007, Giot et al., 2003)
              l(3)S057302
              (Johannes and Preiss, 2002)
              l(3)S057302b
              γ-COP
              (Echard et al., 2004)
              γCOP
              (Abuin et al., 2019, Singh et al., 2019, Singh et al., 2016, Christis and Munro, 2012, Kitazawa et al., 2012, Beller et al., 2008, Grieder et al., 2008, Jayaram et al., 2008, Bjorklund et al., 2006, Grieder et al., 2005)
              γCop
              (Yuan et al., 2015, Grieder, 2010.3.8, Grieder, 2010.3.8, Costello et al., 2009, Guo et al., 2008, Sepp et al., 2008, Ecovoiu et al., 2007, Liebl et al., 2006, Stroschein-Stevenson et al., 2006, Nybakken et al., 2005)
              Name Synonyms
              COPI γ subunit
              (Neumann et al., 2010)
              Coat Protein (coatomer) γ
              gammaCop
              (Lindquist et al., 2011, Ecovoiu et al., 2007, Hollien and Weissman, 2006)
              lethal (3) S057302b
              γ-coatomer protein
              (Hahn, 1999.10.1)
              Secondary FlyBase IDs
              • FBgn0041590
              • FBgn0062085
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (99)