FlyBase Gene Report: Dmel\γCOP

General Information

Symbol

Dmel\γCOP

Species

D. melanogaster

Name

Coat Protein (coatomer) γ

Annotation Symbol

CG1528

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028968

Gene Model Status

Stock Availability

19 publicly available

Gene Summary

Coat Protein (coatomer) γ (γCOP) encodes a subunit of the coat complex of COPI vesicles, which transport cargo within the Golgi apparatus and from the Golgi apparatus to the endoplasmic reticulum. Its functions include membrane and protein trafficking in the secretory apparatus. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

copg, l(3)S057302

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:31,572,143..31,575,707 [+]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31572143..31575707

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (22 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural molecule activity

inferred from electronic annotation with InterPro:IPR013040

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (14 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in branch fusion, open tracheal system

inferred from mutant phenotype

(Grieder et al., 2008)

involved_in chitin-based embryonic cuticle biosynthetic process

inferred from mutant phenotype

(Grieder et al., 2008)

involved_in extracellular matrix organization

inferred from mutant phenotype

(Jayaram et al., 2008)

involved_in larval salivary gland morphogenesis

inferred from mutant phenotype

(Jayaram et al., 2008)

involved_in lumen formation, open tracheal system

inferred from mutant phenotype

(Grieder et al., 2008)

involved_in male meiosis cytokinesis

inferred from mutant phenotype

(Kitazawa et al., 2012)

involved_in open tracheal system development

inferred from mutant phenotype

(Grieder et al., 2008)

involved_in protein secretion

inferred from mutant phenotype

(Grieder et al., 2008, Jayaram et al., 2008)

involved_in regulation of lipid storage

inferred from direct assay

(Beller et al., 2008)

involved_in regulation of tube diameter, open tracheal system

inferred from mutant phenotype

(Jayaram et al., 2008)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in intra-Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in intracellular protein transport

inferred from electronic annotation with InterPro:IPR002553, InterPro:IPR009028, InterPro:IPR013040, InterPro:IPR015873

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in organelle transport along microtubule

inferred from biological aspect of ancestor with PANTHER:PTN000813705

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein secretion

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in acroblast

inferred from direct assay

(Kitazawa et al., 2012)

located_in cis-Golgi network

inferred from direct assay

(Jayaram et al., 2008)

located_in endoplasmic reticulum-Golgi intermediate compartment

inferred from direct assay

(Kitazawa et al., 2012)

located_in endoplasmic reticulum

inferred from direct assay

(Jayaram et al., 2008)

located_in Golgi apparatus

inferred from direct assay

(Grieder et al., 2008)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in endoplasmic reticulum-Golgi intermediate compartment

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in Golgi membrane

inferred from biological aspect of ancestor with PANTHER:PTN000029440

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I

Protein Family (UniProt)

Belongs to the COPG family. (Q8I0G5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Coat Protein (coatomer) γ (γCOP) encodes a subunit of the coat complex of COPI vesicles, which transport cargo within the Golgi apparatus and from the Golgi apparatus to the endoplasmic reticulum. Its functions include membrane and protein trafficking in the secretory apparatus. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I -: The Coat Protein Complex I (COPI or coatomer) is responsible for retrograde transport from the Golgi to ER. It is composed of seven subunits: the α, β, δ and γ subunits form the cargo adaptor and the β', ε and ζ form the vesicle cage. The small Ras GTPase, Arf1 (Arf79F in D.mel) recruits the complex to Golgi membranes in its GTP-bound form. (Adapted from PMID:22160157).

Protein Function (UniProtKB)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.

(UniProt, Q8I0G5)

Gene Model and Products

Number of Transcripts

4

Number of Unique Polypeptides

4

Please see the JBrowse view of Dmel\γCOP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8I0G5)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0085793

3057

879

FBtr0085794

3276

883

FBtr0301290

3054

878

FBtr0330096

3054

897

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0085154

97.3

879

4.95

FBpp0085155

97.7

883

5.41

FBpp0290505

97.2

878

4.95

FBpp0303129

99.4

897

4.96

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

(UniProt, Q8I0G5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γCOP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

gammaCOP_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male & spermatogenesis

primary spermatocyte

• endoplasmic reticulum-Golgi intermediate compartment

(Kitazawa et al., 2012)

meiotic primary spermatocyte

• COPI-coated vesicle

(Kitazawa et al., 2012)

onion stage spermatid

• acroblast

(Kitazawa et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

γCOP is localized to the endoplasmic reticulum-Golgi intermediate compartment in premeiotic spermatocytes, to COPI vesicles associated with astral microtubules in meiotic primary spermatocytes, and to the acroblast in onion stage spermatids.

(Kitazawa et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in acroblast

inferred from direct assay

(Kitazawa et al., 2012)

located_in cis-Golgi network

inferred from direct assay

(Jayaram et al., 2008)

located_in endoplasmic reticulum-Golgi intermediate compartment

inferred from direct assay

(Kitazawa et al., 2012)

located_in endoplasmic reticulum

inferred from direct assay

(Jayaram et al., 2008)

located_in Golgi apparatus

inferred from direct assay

(Grieder et al., 2008)

Expression Deduced from Reporters

Reporter: P{FRT(γCOP-mRFP.Ω38)}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male & spermatogenesis

primary spermatocyte

• endoplasmic reticulum-Golgi intermediate compartment

(Kitazawa et al., 2012)

Reporter: PBac{768.FSVS-0}γCOP^CPTI002986

Stage

Tissue/Position (including subcellular localization)

Reference

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\γCOP in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\γCOP

View exonic expression by tissue for Dmel\γCOP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43717/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028968

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028968

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028968

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1528

Flygut - An atlas of the Drosophila adult midgut

FBgn0028968

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 29 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 15 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of γCOP

Transgenic constructs containing regulatory region of γCOP

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene not disrupted in

(Salzberg et al., 1997)

Gene partially disrupted in

Df(3R)γCOP⁶⁷⁷

(Grieder et al., 2008)

Df(3R)pygo^11-3

(Grieder et al., 2008)

Gene disrupted in

Df(3R)γCOP⁵⁷⁷

(Grieder et al., 2008)

Inferred from location ( 0 )

Dp(3;2)GV-CH321-70F21

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

γCOP^GD8960

lethal, with Scer\GAL4^tin.CΔ4

γCOP^GD8960

lethal (with γCOP^1b)

γCOP^S057302

lethal (with γCOP^5a)

γCOP^S057302

lethal (with γCOP^6a)

γCOP^S057302

lethal (with γCOP^7a)

γCOP^S057302

lethal (with γCOP^8a)

γCOP^S057302

lethal (with γCOP^9a)

γCOP^S057302

lethal (with γCOP^10a)

γCOP^S057302

lethal (with γCOP^11a)

γCOP^S057302

lethal (with γCOP^14a)

γCOP^S057302

lethal (with γCOP^15a)

γCOP^S057302

lethal (with γCOP^16a)

γCOP^S057302

lethal (with γCOP^16b)

γCOP^S057302

lethal (with γCOP^17b)

γCOP^S057302

lethal (with γCOP^20b)

γCOP^S057302

lethal (with γCOP^21b)

γCOP^S057302

lethal (with γCOP^S057302)

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

γCOP^GD8960

lethal - all die during embryonic stage | recessive

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

γCOP^GD8960

Sterility

Allele

γCOP^A383.2M3

Other Phenotypes

Allele

decreased body size

γCOP^A383.2M3

some die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

γCOP^GD8960

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

γCOP^GD8960

Phenotype manifest in

Allele

embryonic/first instar larval cuticle

embryonic/larval dorsal tracheal branch

γCOP¹⁰

embryonic/larval salivary gland

γCOP^Δ114

embryonic/larval tracheal dorsal trunk

embryonic/larval tracheal lateral trunk

γCOP¹⁰

endoplasmic reticulum

γCOP^Δ114

onion stage spermatid, with Scer\GAL4^VP16.bam

γCOP^GD8960

onion stage spermatid (with γCOP^d06498), with Scer\GAL4^VP16.bam

γCOP^KG06383

onion stage spermatid (with γCOP^KG06383), with Scer\GAL4^VP16.bam

γCOP^d06498

presumptive embryonic/larval nervous system

γCOP^S057302

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

12 of 15

Yes

Yes

11 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

12 of 15

No

Yes

Rattus norvegicus (Norway rat) (3)

11 of 13

Yes

Yes

8 of 13

No

Yes

2 of 13

No

No

Xenopus tropicalis (Western clawed frog) (2)

12 of 12

Yes

Yes

7 of 12

No

Yes

Danio rerio (Zebrafish) (2)

13 of 15

Yes

Yes

Drer\si:dkey-117n7.5

2 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (1)

13 of 15

Yes

Yes

Arabidopsis thaliana (thale-cress) (1)

8 of 9

Yes

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

13 of 15

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

11 of 12

Yes

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COPG1; COPI coat complex subunit gamma 1

12 of 15

COPG2; COPI coat complex subunit gamma 2

11 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Grieder et al., 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

(UniProt, Q8I0G5 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68560

DroID - A comprehensive database of gene and protein interactions.

FBgn0028968

MIST (protein-protein) - An integrated Molecular Interaction Database

gammaCOP

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028968

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-102

Cytogenetic map

Sequence location

3R:31,572,143..31,575,707 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100C6-100C6

Limits computationally determined from genome sequence between P{PZ}l(3)rM731^rM731 and P{EP}pygo^EP1076

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100C-100C

(determined by in situ hybridisation)

(Grieder et al., 2005)

100C7-100D8

(Mink, 2002.6.28)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-99.1

(Comeron et al., 2012)

3-

(Salzberg et al., 1997)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

29710

w^*; P{UASp-γCOP.Ω31}3

29711

w^*; P{UASp-γCOP.EGFP}3

28889

y¹ v¹; P{TRiP.HM05099}attP2

81745

y¹ v¹; P{TKO.GS04682}attP40

29714

y¹ w^*; Kr^If-1/CyO; P{UASp-γCOP.mRFP}3

29713

y¹ w^*; P{UASp-γCOP.mRFP}2; l(3)*^*/MKRS

29707

y¹ w^*; P{FRT(γCOP-mRFP.Ω38)}i4; MKRS/TM6B, Tb¹

4544

y¹ w^67c23; P{lacW}γCOP^S057302/TM3, Sb¹ Ser¹

14296

y¹; ry⁵⁰⁶ P{SUPor-P}γCOP^KG06383/TM3, Sb¹ Ser¹

F000931

M{UAS-γCOP.ORF.3xHA}ZH-86Fb

115386

w¹¹¹⁸; PBac{768.FSVS-0}γCOP^CPTI002986

v25101

w¹¹¹⁸; P{GD8960}v25101/CyO

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (54)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028968

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028968

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43717

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: γCop CG1528

(Zhao, 1999.11)

Source for identity of: γCOP γCop

(FlyBase, 2009-)

Source for database merge of

Source for merge of: γCop l(3)S057302b

(Ecovoiu et al., 2002)

Source for merge of: γCop anon-WO0118547.334

(FlyBase, 1996-)

Additional comments

Source for merge of γCop anon-WO0118547.334 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against γCop that is transfected into S2 treated with Listeria monocytogenes reveals γCop to be involved in Listeria monocytogenes entry and vacuolar escape.

(Cheng et al., 2005)

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

Area matching Drosophila EST AA697891 (inverted). This EST has sequence similarity to Bovine gamma COP.

(Davies, 2001.3.15)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 72 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43717

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8I0G5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8I0G5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8I0G5

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028968

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43717/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028968

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

gammaCOP_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028968

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028968

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1528

Flygut - An atlas of the Drosophila adult midgut

FBgn0028968

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028968

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43717

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1528

MARRVEL_MODEL - MARRVEL (model organism gene)

43717

modMine - A data warehouse for the modENCODE project

FBgn0028968

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

14296-g-Cop[KG06383]

BioGRID - A database of protein and genetic interactions.

68560

DroID - A comprehensive database of gene and protein interactions.

FBgn0028968

DRSC - Results frm RNAi screens

FBgn0028968

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028968

FlyMine - An integrated database for Drosophila genomics

FBgn0028968

MIST (protein-protein) - An integrated Molecular Interaction Database

gammaCOP

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

0573/02

(Deak et al., 1997)

573.02

(Salzberg et al., 1997)

CG1528

(Kolkhof et al., 2017, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Christis and Munro, 2012, Perkins et al., 2009, Sepp et al., 2008, Derré et al., 2007, Hollien and Weissman, 2006, Nybakken et al., 2005)

COPIγ

(Schlesinger et al., 2004)

Gamma-COP

(Lesch and Page, 2012)

anon-WO0118547.334

copg

(Hahn et al., 2000, Hahn, 1999.10.1)

gamma-COP

(Camelo and Luschnig, 2021)

gamma-cop

(Jiang et al., 2019)

gammaCOP

(Transgenic RNAi Project members, 2017-, Aikin et al., 2012, Lindquist et al., 2011, Cherry et al., 2006)

gammaCop

(Johnson et al., 2020, Aradska et al., 2015, Kwon et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Jungreis et al., 2011, Lindquist et al., 2011, Fox et al., 2010, Sepp et al., 2008, Derré et al., 2007, Giot et al., 2003)

l(3)S057302

(Johannes and Preiss, 2002)

l(3)S057302b

γ-COP

(Echard et al., 2004)

γCOP

(Camelo et al., 2022, Sechi et al., 2021, Yang et al., 2021, Abuin et al., 2019, Singh et al., 2019, Ables et al., 2016, Singh et al., 2016, Sekine et al., 2013, Christis and Munro, 2012, Kitazawa et al., 2012, Beller et al., 2008, Grieder et al., 2008, Jayaram et al., 2008, Bjorklund et al., 2006, Grieder et al., 2005)

γCop

(Yuan et al., 2015, Grieder, 2010.3.8, Grieder, 2010.3.8, Costello et al., 2009, Guo et al., 2008, Sepp et al., 2008, Ecovoiu et al., 2007, Liebl et al., 2006, Stroschein-Stevenson et al., 2006, Nybakken et al., 2005)

Name Synonyms

COPI γ subunit

(Neumann et al., 2010)

Coat Protein (coatomer) γ

gammaCop

(Lindquist et al., 2011, Ecovoiu et al., 2007, Hollien and Weissman, 2006)

lethal (3) S057302b

γ-coatomer protein

(Hahn, 1999.10.1)

Secondary FlyBase IDs

FBgn0041590
FBgn0062085

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (105)