FlyBase Gene Report: Dmel\γCOP

General Information

Symbol

Dmel\γCOP

Species

D. melanogaster

Name

Coat Protein (coatomer) γ

Annotation Symbol

CG1528

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028968

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Snapshot

Coat Protein (coatomer) γ (γCOP) encodes a subunit of the coat complex of COPI vesicles, which transport cargo within the Golgi apparatus and from the Golgi apparatus to the endoplasmic reticulum. Its functions include membrane and protein trafficking in the secretory apparatus. [Date last reviewed: 2019-09-26]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

copg, l(3)S057302

Key Links

Genomic Location

Cytogenetic map

100C6-100C6

Sequence location

3R:31,572,143..31,575,707 [+]

Recombination map

3-102

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I

Protein Family (UniProt)

Belongs to the COPG family. (Q8I0G5)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

Predictions / Assertions

structural molecule activity

Summaries

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I -: The Coat Protein Complex I (COPI or coatomer) is responsible for retrograde transport from the Golgi to ER. It is composed of seven subunits: the α, β, δ and γ subunits form the cargo adaptor and the β', ε and ζ form the vesicle cage. The small Ras GTPase, Arf1 (Arf79F in D.mel) recruits the complex to Golgi membranes in its GTP-bound form. (Adapted from PMID:22160157).

Protein Function (UniProtKB)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.

(UniProt, Q8I0G5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\γCOP or the JBrowse view of Dmel\γCOP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

γCOP-RA

FBtr0085793

NM_079869

3057

879

γCOP-RB

FBtr0085794

NM_170553

3276

883

γCOP-RC

FBtr0301290

NM_001170313

3054

878

γCOP-RD

FBtr0330096

NM_001276216

3054

897

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

γCOP-PA

FBpp0085154

97.3

879

4.95

NP_524608

AAF57160

γCOP-PB

FBpp0085155

97.7

883

5.41

NP_733432

AAN14275

γCOP-PC

FBpp0290505

97.2

878

4.95

NP_001163784

ACZ95077

γCOP-PD

FBpp0303129

99.4

897

4.96

NP_001263145

AGB96524

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

(UniProt, Q8I0G5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\γCOP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

gammaCOP_1

Linkouts

Gene Ontology (23 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

structural molecule activity

inferred from electronic annotation with InterPro:IPR013040

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (15 terms)

Terms Based on Experimental Evidence (11 terms)

CV Term

Evidence

References

branch fusion, open tracheal system