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Gene Dmel\βggt-II

General Information
Symbol	Dmel\βggt-II	Species	D. melanogaster
Name	β subunit of type II geranylgeranyl transferase	Annotation symbol	CG18627
Feature type	protein_coding_gene	FlyBase ID	FBgn0028970
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23C1-23C1	Sequence location	2L:2,879,124..2,880,708 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene β subunit of type II geranylgeranyl transferase is referred to in FlyBase by the symbol Dmel\βggt-II (CG18627, FBgn0028970). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: CAAX-protein geranylgeranyltransferase activity. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Prenyltransferase/squalene oxidase; Terpenoid cylases/protein prenyltransferase alpha-alpha toroid. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629084_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of betaggt-II. Gene sequence location is 2L:2879124..2880708.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA00804 BKN28089
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23C1-23C1   Limits computationally determined from genome sequence between P{PZ}oho23B03575 and P{PZ}lilli00632
Experimentally Determined Cytological Location
Cytogenetic map Notes References 23C1-23C2     (Avedisov, 1999.3.5)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\βggt-II for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) βggt-II-RA FBtr0077631  NM_080155   1421   347
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein βggt-II-PA   FBpp0077316   38.5   347   5.21     NP_524894   AAF51183
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prenyltransferase/squalene oxidase (IPR001330) Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (IPR008930)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51183   AF133269 AAD33042   AI405383   AI519532   AW940972   AY060784 AAL28332   BF504605   BG638675   BX009160   CO196580   CO262613   CO341612   EC205794   EC242227   EC242534   EC252210   EC252714   GH944958   GH946339   GH946535   GH953731   GH953931   GH958803   GH966420   GH981898
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9XZ68
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028970    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028970 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028970 expression level Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1425) embryo 02-04hr  (2016) embryo 04-06hr  (2020) embryo 06-08hr  (1632) embryo 08-10hr  (1335) embryo 10-12hr  (1798) embryo 12-14hr  (1159) embryo 14-16hr  (1826) embryo 16-18hr  (1508) embryo 18-20hr  (1995) embryo 20-22hr  (2157) embryo 22-24hr  (1797) larva L1  (2244) larva L2  (2056) larva L3 12hr old  (1455) larva L3 puffstage 1-2  (1098) larva L3 puffstage 3-6  (1210) larva L3 puffstage 7-9  (1209) white prepupae new  (1196) white prepupae 12hr  (1144) white prepupae 24hr  (1166) pupae 2d postWPP  (963) pupae 3d postWPP  (816) pupae 4d postWPP  (1445) adult male 01day  (1359) adult male 05day  (1598) adult male 30day  (1689) adult female 01day  (1999) adult female 05day  (1446) adult female 30day  (1609) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1425 embryo 02-04hr  (2016) embryo 04-06hr  (2020) embryo 06-08hr  (1632) embryo 08-10hr    1335 embryo 10-12hr  (1798) embryo 12-14hr    1159 embryo 14-16hr  (1826) embryo 16-18hr  1508 embryo 18-20hr  (1995) embryo 20-22hr  (2157) embryo 22-24hr  (1797) larva L1  (2244) larva L2  (2056) larva L3 12hr old  1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP  1445 adult male 01day    1359 adult male 05day  (1598) adult male 30day  (1689) adult female 01day  (1999) adult female 05day  1446 adult female 30day  (1609) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028970 expression level Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1425) embryo 02-04hr  (2016) embryo 04-06hr  (2020) embryo 06-08hr  (1632) embryo 08-10hr  (1335) embryo 10-12hr  (1798) embryo 12-14hr  (1159) embryo 14-16hr  (1826) embryo 16-18hr  (1508) embryo 18-20hr  (1995) embryo 20-22hr  (2157) embryo 22-24hr  (1797) larva L1  (2244) larva L2  (2056) larva L3 12hr old  (1455) larva L3 puffstage 1-2  (1098) larva L3 puffstage 3-6  (1210) larva L3 puffstage 7-9  (1209) white prepupae new  (1196) white prepupae 12hr  (1144) white prepupae 24hr  (1166) pupae 2d postWPP  (963) pupae 3d postWPP  (816) pupae 4d postWPP  (1445) adult male 01day  (1359) adult male 05day  (1598) adult male 30day  (1689) adult female 01day  (1999) adult female 05day  (1446) adult female 30day  (1609) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1425 embryo 02-04hr  2016 embryo 04-06hr  2020 embryo 06-08hr  1632 embryo 08-10hr    1335 embryo 10-12hr  1798 embryo 12-14hr    1159 embryo 14-16hr  1826 embryo 16-18hr  1508 embryo 18-20hr  1995 embryo 20-22hr  2157 embryo 22-24hr  1797 larva L1  2244 larva L2  2056 larva L3 12hr old  1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP  1445 adult male 01day    1359 adult male 05day  1598 adult male 30day  1689 adult female 01day  1999 adult female 05day  1446 adult female 30day  1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1425 embryo 02-04hr    2016 embryo 04-06hr    2020 embryo 06-08hr    1632 embryo 08-10hr    1335 embryo 10-12hr    1798 embryo 12-14hr    1159 embryo 14-16hr    1826 embryo 16-18hr    1508 embryo 18-20hr    1995 embryo 20-22hr    2157 embryo 22-24hr    1797 larva L1    2244 larva L2    2056 larva L3 12hr old    1455 larva L3 puffstage 1-2    1098 larva L3 puffstage 3-6    1210 larva L3 puffstage 7-9    1209 white prepupae new    1196 white prepupae 12hr    1144 white prepupae 24hr    1166 pupae 2d postWPP    963 pupae 3d postWPP    816 pupae 4d postWPP    1445 adult male 01day    1359 adult male 05day    1598 adult male 30day    1689 adult female 01day    1999 adult female 05day    1446 adult female 30day    1609 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028970    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028970 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028970 expression level Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028970 expression level Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    335.35 Larval Midgut    209.9 Larval Hindgut    134.8 Larval Malpighian Tubules    184.8 Larval Fat Body    89.5 Larval Salivary Gland    215.6 Larval Trachea    113.65 Larval Carcass    84.65 Adult Head    239.4 Adult Eye    290.575 Adult Brain    377.5 Adult Thoracic-Abdominal Ganglion    459.6 Adult Crop    77.5 Adult Midgut    213.9 Adult Hindgut    138.9 Adult Malpighian Tubules    349.9 Adult Fat Body    118.5 Adult Salivary Gland    239.6 Adult Heart    127.6 Adult VirginFemale Spermatheca    171.7 Adult InseminatedFemale Spermatheca    159.4 Adult Ovary    98.8 Adult Testis    57.6 Adult Male Accessory Gland    177.2 Adult Carcass    130.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    239.4   NA  Eye    290.575   NA  Brain    377.5   335.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    459.6   NA  Crop    77.5   209.9  Midgut    213.9   134.8  Hindgut    138.9   184.8  Malpighian Tubules    349.9   89.5  Fat Body    118.5   215.6  Salivary Gland    239.6   NA  Heart    127.6   113.65  Trachea    NA   NA  VirginFemale Spermatheca    171.7   NA  InseminatedFemale Spermatheca    159.4   NA  Ovary    98.8   NA  Testis    57.6   NA  Male Accessory Gland    177.2   84.65  Carcass    130.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18627-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for βggt-II Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 βggt-IIGD9621 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of βggt-II Class Mutagen Stocks Known lesion βggt-IIG2472 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of βggt-II Class Mutagen Stocks Known lesion βggt-IIGD9621 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes βggt-IIHMS01247 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}βggt-IIG2472 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
CAAX-protein geranylgeranyltransferase activity non-traceable author statement (Avedisov, 1999.3.5) catalytic activity inferred from electronic annotation with InterPro:IPR001330 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions βggt-II allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 70919 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028970 DroID - A comprehensive database of gene and protein interactions. • FBgn0028970 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47757
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14990 Dere\GG24898 Dgri\GH10686 Dmoj\GI11182 Dper\GL26294 Dpse\GA15021 Dsec\GM18378 Dsim\GD23193 Dvir\GJ18324 Dwil\GK24285 Dyak\GE18191
Curated drosophilid orthologs	Dpse\GA15021
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001334-PA Aedes aegypti (mosquito) XP_001122542.1 Apis mellifera (honey bee) XP_001944304.1 Acyrthosiphon pisum (pea aphid) At5g12210.1 Arabidopsis thaliana (wall cress) 29439 Batrachochytrium dendrobatidis (chytrid fungus) 287963 Branchiostoma floridae (lancelet) BGIBMGA005544-PA Bombyx mori (silk worm) ENSBTAP00000024551 Bos taurus (bovine) CAL0000126 Candida albicans (a form of yeast) CN29997 Caenorhabditis brenneri (small nematode) CBP25039 Caenorhabditis briggsae (nematode) CE24762 Caenorhabditis elegans (worm) ENSCAFP00000030242 Canis familiaris (dog) CAGL0G09823g Candida glabrata (haploid yeast) Chro.60212 Cryptosporidium hominis (obligate parasite) ENSCINP00000013617 Ciona intestinalis (sea squirt) JA04605 Caenorhabditis japonica (nematode) CMT217C Cyanidioschyzon merolae (red alga) cn04472 Cryptococcus neoformans (yeast-like fungus) cgd6_1750 Cryptosporidium parvum (protozoan parasite) CPIJ012819 Culex pipens (mosquito) ENSCPOP00000000587 Cavia porcellus (guinea pig) 190175 Chlamidomonas reinhardtii (green alga) RP29965 Caenorhabditis remanei (nematode) ENSCSAVP00000015845 Ciona savignyi (sedentary tunicate) 118195 Capitella spl (polychaete worm) DDB0233949 Dictyostelium discoideum (amoeba) DEHA2E02860g Debaryomyces Hansenii (yeast) 220648 Daphnia pulex (daphnia) ENSDARP00000090020 Danio rerio (zebra fish) ENSECAP00000017877 Equus caballus (horse) XP_648235 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000021824 Gymnopilus aculeatus (mushroom) ENSGALP00000018552 Gallus gallus (chicken) ENSP00000317473 Homo sapiens (human) KLLA0E04797g Kluyveromyces lactis (yeast) 165337 Lottia gigantea (owl limpet) LmjF34.4030 Leishmania major (virus) 14854 Monocosta brevicollis (choanoflagellate) ENSMODP00000023829 Monodelphis domestica (gray opossum) ENSMMUP00000039896 Macaca mulatta (rhesus monkey) ENSMUSP00000087396 Mus musculus (house mouse) 13474 Nematostella vectensis (starlet anemone) XP_001606562.1 Nasonia vitripennis (wasp) ENSOANP00000008968 Ornithorynchus anatinus (platypus) ENSORLP00000004073 Oryzias latipes (japanese killifish) LOC_Os08g40140.1 Oryza sativa (asian rice) 8811 Ostreococcus tauri (green alga) PFF0120w Plasmodium falciparum (protozoal parasite) PHUM002523-PA Pediculus humanus (human body louse) 191544 Physcomitrella patens (moss) ENSPPYP00000001430 Pongo pygmaeus (orangutan) 95078 Phytophthora ramorum (sudden oak death pathogen) 156787 Phytophthora sojae (root rot pathogen) 806754 Populus trichocarpa (black cottonwood) ENSPTRP00000001509 Pan troglodytes (chimpanzee) PVX_113290 Plasmodium vivax (protozoal parasite) ENSRNOP00000013660 Rattus norvegicus (norway rat) 4764916 Sorghum bicolor (sorghum) YPR176C Saccharomyces cerevisiae (budding yeast) Smp_150160 Schistosoma mansoni (trematode parasite) SPAC167.02 Schizosaccharomyces pombe (fission yeast) XP_001176818.1 Strongylocentrotus purpuratus (purple sea urchin) 53494 Trichoplax adhaerens (metazoa) TA04900 Theileria annulata (apicomplexan parasite) XP_969750.1 Tribolium castaneum (red flour beetle) Tc00.1047053507053.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005468 Tetraodon nigroviridis (green spotted pufferfish) TP03_0500 Theileria parva (parasitic protozoan) 268859 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017019 Takifugu rubripes (pufferfish Takifugu) 3831.m01454 Tetrahymena thermophila (ciliate protozoa) 87414.m00280 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006506 Xenopus tropicalis (frog) YALI0E28248g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12457 LH16508 ISCW010108 FBgn0235622 FBgn0226246 FBgn0205483 FBgn0194582 FBgn0173285 JGI_V11_220648 FBgn0075046 FBgn0163876 FBgn0133943 FBgn0118167 FBgn0117027 FBgn0092015 CPIJ012819 BGIBMGA005544 ACYPI000514 GB11272 AGAP013277 AAEL001334 PB22829 PB22982 PHUM046130 GLEAN_01418
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	29051 y1 w*; P{EP}βggt-IIG2472 34902 y1 sc* v1; P{TRiP.HMS01247}attP2
VDRC	v33386 w1118; P{GD9621}v33386
Genomic Clones ( 1 )
	BACR42J13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25366
Other clones	DPiM_GH25366
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT06195 LD32702 LD39156
Other clones	EK006231 EK085927 EP12813 RP004022423 RP004121929 RP004125575 RP004219404 RP004221053 RP004226818 RP004234152 RP004480147
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47757
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: βggt-II CG18627 (Misra, 2000.4.6)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against βggt-II that is transfected into S2 treated with Listeria monocytogenes reveals βggt-II to be involved in Listeria monocytogenes entry and vacuolar escape. (Cheng et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080155 RefSeq (Proteins) • NP_524894 DDBJ / EMBL / GenBank • AAD33042 AAF51183 AAL28332 AF133269 AI405383 AW940972 AY060784 Entrez Gene - A searchable database of RefSeq genes. • 47757 UniProtKB/TrEMBL • Q9XZ68
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prenyltransferase/squalene oxidase (IPR001330) Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (IPR008930)
Linkouts
	BioGRID - A database of protein and genetic interactions • 70919 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0028970 DroID - A comprehensive database of gene and protein interactions. • FBgn0028970 DRSC - Results from RNAi screens. • FBgn0028970 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18627-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47757 InParanoid A subset of ortholog calls from InParanoid. • AAEL001334-PA Aedes aegypti (mosquito) XP_001122542.1 Apis mellifera (honey bee) XP_001944304.1 Acyrthosiphon pisum (pea aphid) At5g12210.1 Arabidopsis thaliana (wall cress) 29439 Batrachochytrium dendrobatidis (chytrid fungus) 287963 Branchiostoma floridae (lancelet) BGIBMGA005544-PA Bombyx mori (silk worm) ENSBTAP00000024551 Bos taurus (bovine) CAL0000126 Candida albicans (a form of yeast) CN29997 Caenorhabditis brenneri (small nematode) CBP25039 Caenorhabditis briggsae (nematode) CE24762 Caenorhabditis elegans (worm) ENSCAFP00000030242 Canis familiaris (dog) CAGL0G09823g Candida glabrata (haploid yeast) Chro.60212 Cryptosporidium hominis (obligate parasite) ENSCINP00000013617 Ciona intestinalis (sea squirt) JA04605 Caenorhabditis japonica (nematode) CMT217C Cyanidioschyzon merolae (red alga) cn04472 Cryptococcus neoformans (yeast-like fungus) cgd6_1750 Cryptosporidium parvum (protozoan parasite) CPIJ012819 Culex pipens (mosquito) ENSCPOP00000000587 Cavia porcellus (guinea pig) 190175 Chlamidomonas reinhardtii (green alga) RP29965 Caenorhabditis remanei (nematode) ENSCSAVP00000015845 Ciona savignyi (sedentary tunicate) 118195 Capitella spl (polychaete worm) DDB0233949 Dictyostelium discoideum (amoeba) DEHA2E02860g Debaryomyces Hansenii (yeast) 220648 Daphnia pulex (daphnia) ENSDARP00000090020 Danio rerio (zebra fish) ENSECAP00000017877 Equus caballus (horse) XP_648235 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000021824 Gymnopilus aculeatus (mushroom) ENSGALP00000018552 Gallus gallus (chicken) ENSP00000317473 Homo sapiens (human) KLLA0E04797g Kluyveromyces lactis (yeast) 165337 Lottia gigantea (owl limpet) LmjF34.4030 Leishmania major (virus) 14854 Monocosta brevicollis (choanoflagellate) ENSMODP00000023829 Monodelphis domestica (gray opossum) ENSMMUP00000039896 Macaca mulatta (rhesus monkey) ENSMUSP00000087396 Mus musculus (house mouse) 13474 Nematostella vectensis (starlet anemone) XP_001606562.1 Nasonia vitripennis (wasp) ENSOANP00000008968 Ornithorynchus anatinus (platypus) ENSORLP00000004073 Oryzias latipes (japanese killifish) LOC_Os08g40140.1 Oryza sativa (asian rice) 8811 Ostreococcus tauri (green alga) PFF0120w Plasmodium falciparum (protozoal parasite) PHUM002523-PA Pediculus humanus (human body louse) 191544 Physcomitrella patens (moss) ENSPPYP00000001430 Pongo pygmaeus (orangutan) 95078 Phytophthora ramorum (sudden oak death pathogen) 156787 Phytophthora sojae (root rot pathogen) 806754 Populus trichocarpa (black cottonwood) ENSPTRP00000001509 Pan troglodytes (chimpanzee) PVX_113290 Plasmodium vivax (protozoal parasite) ENSRNOP00000013660 Rattus norvegicus (norway rat) 4764916 Sorghum bicolor (sorghum) YPR176C Saccharomyces cerevisiae (budding yeast) Smp_150160 Schistosoma mansoni (trematode parasite) SPAC167.02 Schizosaccharomyces pombe (fission yeast) XP_001176818.1 Strongylocentrotus purpuratus (purple sea urchin) 53494 Trichoplax adhaerens (metazoa) TA04900 Theileria annulata (apicomplexan parasite) XP_969750.1 Tribolium castaneum (red flour beetle) Tc00.1047053507053.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005468 Tetraodon nigroviridis (green spotted pufferfish) TP03_0500 Theileria parva (parasitic protozoan) 268859 Thalassiosira pseudonana (marine diatom) ENSTRUP00000017019 Takifugu rubripes (pufferfish Takifugu) 3831.m01454 Tetrahymena thermophila (ciliate protozoa) 87414.m00280 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006506 Xenopus tropicalis (frog) YALI0E28248g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47757 modMine - Data generated by the modENCODE project. • FBgn0028970 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12457 LH16508 ISCW010108 FBgn0235622 FBgn0226246 FBgn0205483 FBgn0194582 FBgn0173285 JGI_V11_220648 FBgn0075046 FBgn0163876 FBgn0133943 FBgn0118167 FBgn0117027 FBgn0092015 CPIJ012819 BGIBMGA005544 ACYPI000514 GB11272 AGAP013277 AAEL001334 PB22829 PB22982 PHUM046130 GLEAN_01418
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	betaggt II (Cheng et al., 2005) betaggt-II (Giot et al., 2003) CG18627 (Santos and Lehmann, 2004, Pile et al., 2003, Ni et al., 2011.7.19) GGT-II beta (Avedisov, 1999.3.5) βggt (Wittwer et al., 2001) βggt-II (Kim et al., 2005)
Name Synonym	β subunit of type II geranylgeranyl transferase
Secondary FlyBase IDs
	FBgn0031480
References ( 15 )
Research paper	Cheng et al., 2005, Proc. Natl. Acad. Sci. USA 102(38): 13646--13651 Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen. [FBrf0188255] Kim et al., 2005, Nature Immunology 6(2): 211--218 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules. [FBrf0184193] Santos and Lehmann, 2004, Dev. Cell 6(2): 283--293 Isoprenoids control germ cell migration downstream of HMGCoA reductase. [FBrf0174539] Pile et al., 2003, J. Biol. Chem. 278(39): 37840--37848 The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: Implications for the regulation of energy metabolism. [FBrf0162185] Wittwer et al., 2001, Development 128(5): 791--800 Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth. [FBrf0134580]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Bellen, 2009.10.14, BDGP_2009_1020.GenExel.xml BDGP_2009_1020.GenExel.xml [FBrf0208883] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Misra, 2000.4.6, Annotation identities: Category 4. Annotation identities: Category 4. [FBrf0126711]
DNA/RNA sequence record	Avedisov, 1999.3.5, GenBank/EMBL/DDBJ: AF133269 Drosophila melanogaster geranylgeranyl transferase type II beta-subunit mRNA, complete cds. [FBrf0122488]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]