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Gene Dmel\Spt6

General Information
Symbol	Dmel\Spt6	Species	D. melanogaster
Name	Spt6	Annotation symbol	CG12225
Feature type	protein_coding_gene	FlyBase ID	FBgn0028982
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Dspt6, l(1)G0063
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	5E4-5E4	Sequence location	X:6,161,847..6,169,019 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Spt6 is referred to in FlyBase by the symbol Dmel\Spt6 (CG12225, FBgn0028982). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: transcription from RNA polymerase II promoter; regulation of antimicrobial peptide biosynthetic process; positive regulation of transcription elongation from RNA polymerase II promoter. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like; RNA-binding domain, S1; Ribosomal protein S1, RNA-binding domain; SH2 motif; Tex RuvX-like domain; Tex-like domain; Transcription elongation factor Spt6; YqgF/RNase H-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634924_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Spt6. Gene sequence location is X:6161847..6169019.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN20281 HFA18836 Controlled Vocabulary Terms nucleus positive regulation of transcription elongation from RNA polymerase II promoter
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 5E4-5E4   Limits computationally determined from genome sequence between P{EP}EP1457EP1457&P{EP}CG5928EP1083 and P{EP}EP1311&P{EP}EP1384
Experimentally Determined Cytological Location
Cytogenetic map Notes References 5E1-5E2   (determined by in situ hybridisation)   (Peter et al., 2002) 5E6-5E8     (Chiang, 1998.11.4) 5E1-5E8     (Chiang et al., 1999) 5E1-5E7   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 5E1-5E2   (determined by in situ hybridisation)   (Schaefer et al., 1999.3.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spt6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD47893 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spt6-RA FBtr0070896  NM_143705   6151   1831
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spt6-PA   FBpp0070861   208.6   1831   4.96     NP_651962   AAF46140
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SH2 motif (IPR000980) Ribosomal protein S1, RNA-binding domain (IPR003029) YqgF/RNase H-like domain (IPR006641) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027) Transcription elongation factor Spt6 (IPR017072) Tex-like domain (IPR023323) RNA-binding domain, S1 (IPR022967) Tex RuvX-like domain (IPR023097)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202206   AA202705   AA391792   AA392166   AA539528   AA539582   AA539603   AA540589   AA540894   AA567281   AA695350   AA802947   AA803404   AA817292   AA820152   AA940994   AA941412   AA941430   AA948960   AA949736   AA951018   AE014298 AAF46140   AF104400 AAF14114   AF104401 AAF14115   AI259265   AI295118   AI455021   AI512258   AI513035   AI514494   AI514504   AI516547   AI533804   AI546339   AJ426714   AW943932   AY052030 AAK93454   BG633583   BG637978   BG638314   BG638372   BG638505   BG639776   BI166941   BI242364   BI352860   BI353787   BI356698   BI484946   BI580110   BI584287   BI612607   BI613095   BI623807   BI636908   BT050408   CO196097   CO196272   CO196480   CO261872   CO273375   CO273920   CO273922   CO274306   CO288150   CO289173   CO290040   CO297934   CO304002   CO311910   EC064988   EC068199   EC078901   EC081529   EC083444   EC085375   EC198004   EC209396   EC219069   EC228681   EC231295   EC232460   EC242201   ES689995   EV579334   EV587388   EV589689   GH740936   GH742188   GH742958   GH747225   GH763473   GH763618
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W420
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0028982    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0028982 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0028982 expression level Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr    13462 embryo 04-06hr    14307 embryo 06-08hr    11032 embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7665) embryo 02-04hr  (13462) embryo 04-06hr  (14307) embryo 06-08hr  (11032) embryo 08-10hr  (8208) embryo 10-12hr  (6056) embryo 12-14hr  (4754) embryo 14-16hr  (5968) embryo 16-18hr  (4136) embryo 18-20hr  (2941) embryo 20-22hr  (5120) embryo 22-24hr  (3700) larva L1  (2872) larva L2  (2164) larva L3 12hr old  (1759) larva L3 puffstage 1-2  (1391) larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2303) white prepupae new  (2876) white prepupae 12hr  (2919) white prepupae 24hr  (3321) pupae 2d postWPP  (1774) pupae 3d postWPP  (1049) pupae 4d postWPP  (1286) adult male 01day  (1595) adult male 05day  (1755) adult male 30day  (1856) adult female 01day  (3235) adult female 05day  (3818) adult female 30day  (4036) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7665) embryo 02-04hr  (13462) embryo 04-06hr  (14307) embryo 06-08hr  (11032) embryo 08-10hr  (8208) embryo 10-12hr  (6056) embryo 12-14hr  (4754) embryo 14-16hr  (5968) embryo 16-18hr  (4136) embryo 18-20hr  (2941) embryo 20-22hr  (5120) embryo 22-24hr  (3700) larva L1  (2872) larva L2  (2164) larva L3 12hr old  (1759) larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2303) white prepupae new  (2876) white prepupae 12hr  (2919) white prepupae 24hr  (3321) pupae 2d postWPP  (1774) pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day  (1595) adult male 05day  (1755) adult male 30day  (1856) adult female 01day  (3235) adult female 05day  (3818) adult female 30day  (4036) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr  (13462) embryo 04-06hr  (14307) embryo 06-08hr  (11032) embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr    13462 embryo 04-06hr    14307 embryo 06-08hr    11032 embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0028982 expression level Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr    13462 embryo 04-06hr    14307 embryo 06-08hr    11032 embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7665) embryo 02-04hr  (13462) embryo 04-06hr  (14307) embryo 06-08hr  (11032) embryo 08-10hr  (8208) embryo 10-12hr  (6056) embryo 12-14hr  (4754) embryo 14-16hr  (5968) embryo 16-18hr  (4136) embryo 18-20hr  (2941) embryo 20-22hr  (5120) embryo 22-24hr  (3700) larva L1  (2872) larva L2  (2164) larva L3 12hr old  (1759) larva L3 puffstage 1-2  (1391) larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2303) white prepupae new  (2876) white prepupae 12hr  (2919) white prepupae 24hr  (3321) pupae 2d postWPP  (1774) pupae 3d postWPP  (1049) pupae 4d postWPP  (1286) adult male 01day  (1595) adult male 05day  (1755) adult male 30day  (1856) adult female 01day  (3235) adult female 05day  (3818) adult female 30day  (4036) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7665) embryo 02-04hr  (13462) embryo 04-06hr  (14307) embryo 06-08hr  (11032) embryo 08-10hr  (8208) embryo 10-12hr  (6056) embryo 12-14hr  (4754) embryo 14-16hr  (5968) embryo 16-18hr  (4136) embryo 18-20hr  (2941) embryo 20-22hr  (5120) embryo 22-24hr  (3700) larva L1  (2872) larva L2  2164 larva L3 12hr old  1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6  2256 larva L3 puffstage 7-9  2303 white prepupae new  (2876) white prepupae 12hr  (2919) white prepupae 24hr  (3321) pupae 2d postWPP  1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day  1595 adult male 05day  1755 adult male 30day  1856 adult female 01day  (3235) adult female 05day  (3818) adult female 30day  (4036) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr  13462 embryo 04-06hr  14307 embryo 06-08hr  11032 embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7665 embryo 02-04hr    13462 embryo 04-06hr    14307 embryo 06-08hr    11032 embryo 08-10hr    8208 embryo 10-12hr    6056 embryo 12-14hr    4754 embryo 14-16hr    5968 embryo 16-18hr    4136 embryo 18-20hr    2941 embryo 20-22hr    5120 embryo 22-24hr    3700 larva L1    2872 larva L2    2164 larva L3 12hr old    1759 larva L3 puffstage 1-2    1391 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2303 white prepupae new    2876 white prepupae 12hr    2919 white prepupae 24hr    3321 pupae 2d postWPP    1774 pupae 3d postWPP    1049 pupae 4d postWPP    1286 adult male 01day    1595 adult male 05day    1755 adult male 30day    1856 adult female 01day    3235 adult female 05day    3818 adult female 30day    4036 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0028982    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0028982 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0028982 expression level Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (689.825) Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland  (710.4) Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary  (555.1) Adult Testis    50.2 Adult Male Accessory Gland  (674) Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0028982 expression level Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland  710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary  555.1 Adult Testis    50.2 Adult Male Accessory Gland  674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    689.825 Larval Midgut    330.7 Larval Hindgut    367.2 Larval Malpighian Tubules    305.7 Larval Fat Body    203.6 Larval Salivary Gland    710.4 Larval Trachea    332.125 Larval Carcass    347.625 Adult Head    237.6 Adult Eye    258.075 Adult Brain    306.4 Adult Thoracic-Abdominal Ganglion    336.6 Adult Crop    254.8 Adult Midgut    203.4 Adult Hindgut    221.7 Adult Malpighian Tubules    212.9 Adult Fat Body    314.5 Adult Salivary Gland    446.8 Adult Heart    238.75 Adult VirginFemale Spermatheca    358.2 Adult InseminatedFemale Spermatheca    359.6 Adult Ovary    555.1 Adult Testis    50.2 Adult Male Accessory Gland    674 Adult Carcass    284 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    237.6   NA  Eye    258.075   NA  Brain    306.4   689.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    336.6   NA  Crop    254.8   330.7  Midgut    203.4   367.2  Hindgut    221.7   305.7  Malpighian Tubules    212.9   203.6  Fat Body    314.5   710.4  Salivary Gland    446.8   NA  Heart    238.75   332.125  Trachea    NA   NA  VirginFemale Spermatheca    358.2   NA  InseminatedFemale Spermatheca    359.6   NA  Ovary    555.1   NA  Testis    50.2   NA  Male Accessory Gland    674   347.625  Carcass    284 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028982 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12225-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Spt6GD7536 lethal | embryonic stage Spt6G0063 lethal | recessive Spt6G0063 Spt6PL83 viable Spt6CA07692 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Spt6 Class Mutagen Stocks Known lesion Spt6G0063 P-element activity 1 -- Spt6B1-26 ethyl methanesulfonate 0 Yes Spt6CA07692 P-element activity 0 Yes Spt6D1-10 ethyl methanesulfonate 0 -- Spt6PL83 Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spt6 Class Mutagen Stocks Known lesion Spt6GD7536 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Spt6HMS00364 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spt6Act5C.T:Zzzz\FLAG,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)5D (Petruk et al., 2006)
Duplicated in	Dp(1;f)q2 (Petruk et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7536} NA P{TRiP.HMS00364} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Spt6G0063 No P{lacW}Spt6PL83 No miscellaneous insertions P{PTT-GA}Spt6CA07692 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Petruk et al., 2006)
Biological Process
CV term Evidence References
positive regulation of transcription elongation from RNA polymerase II promoter inferred from mutant phenotype (Petruk et al., 2006) regulation of antimicrobial peptide biosynthetic process inferred from mutant phenotype (Valanne et al., 2010) transcription from RNA polymerase II promoter inferred from expression pattern (assigned by UniProtKB) (Kaplan et al., 2000)
Cellular Component
CV term Evidence References
histone locus body inferred from direct assay (White et al., 2011) colocalizes_with nuclear exosome (RNase complex) inferred from direct assay (Andrulis et al., 2002) nucleus inferred from direct assay (Petruk et al., 2006) polytene chromosome interband inferred from direct assay (assigned by UniProtKB) (Kaplan et al., 2000) polytene chromosome puff inferred from direct assay (assigned by UniProtKB) (Kaplan et al., 2000, Andrulis et al., 2000) transcriptionally active chromatin inferred from direct assay (Andrulis et al., 2002)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from sequence or structural similarity (Chiang, 1998.11.4) inferred from sequence or structural similarity with Saccharomyces SPT6 (FlyBase, 1992-) hydrolase activity, acting on ester bonds inferred from electronic annotation with InterPro:IPR006641 (FlyBase Curators et al., 2004-) RNA binding inferred from electronic annotation with InterPro:IPR003029 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spt6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68765 DroID - A comprehensive database of gene and protein interactions. • FBgn0028982 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44000
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20387 Dere\GG19580 Dgri\GH24153 Dmoj\GI21714 Dper\GL21315 Dpse\GA11490 Dsim\GD16791 Dvir\GJ15579 Dwil\GK21875 Dyak\GE16740
Curated drosophilid orthologs	Dpse\GA11490
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006956-PA Aedes aegypti (mosquito) AGAP003619-PA Anopheles gambiae (mosquito) XP_001950257.1 Acyrthosiphon pisum (pea aphid) At1g65440.1 Arabidopsis thaliana (wall cress) 89114 Batrachochytrium dendrobatidis (chytrid fungus) 121812 Branchiostoma floridae (lancelet) XP_001895824.1 Brugia malayi (roundworm nematode) BGIBMGA005523-PA Bombyx mori (silk worm) ENSBTAP00000011900 Bos taurus (bovine) CAL0002923 Candida albicans (a form of yeast) CN26440 Caenorhabditis brenneri (small nematode) CBP10840 Caenorhabditis briggsae (nematode) CE13120 Caenorhabditis elegans (worm) ENSCAFP00000027693 Canis familiaris (dog) CAGL0L04774g Candida glabrata (haploid yeast) Chro.60604 Cryptosporidium hominis (obligate parasite) JA04095 Caenorhabditis japonica (nematode) CMB144C Cyanidioschyzon merolae (red alga) cn02139 Cryptococcus neoformans (yeast-like fungus) cgd6_5250 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000001303 Cavia porcellus (guinea pig) 176530 Chlamidomonas reinhardtii (green alga) RP30123 Caenorhabditis remanei (nematode) 160659 Capitella spl (polychaete worm) DDB0231554 Dictyostelium discoideum (amoeba) DEHA2C03344g Debaryomyces Hansenii (yeast) 201385 Daphnia pulex (daphnia) ENSDARP00000013353 Danio rerio (zebra fish) ENSECAP00000018346 Equus caballus (horse) XP_654539 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000027122 Gymnopilus aculeatus (mushroom) ENSGALP00000000199 Gallus gallus (chicken) 161252 Hypsipyla robusta (cedar shoot borer) ENSP00000319104 Homo sapiens (human) ISCW020442-PA Ixodes scapularis (deer tick) KLLA0B11385g Kluyveromyces lactis (yeast) 103494 Lottia gigantea (owl limpet) LmjF33.3090 Leishmania major (virus) 34162 Monocosta brevicollis (choanoflagellate) ENSMODP00000024080 Monodelphis domestica (gray opossum) ENSMMUP00000006255 Macaca mulatta (rhesus monkey) ENSMUSP00000103950 Mus musculus (house mouse) 192816 Nematostella vectensis (starlet anemone) XP_001606226.1 Nasonia vitripennis (wasp) ENSORLP00000003862 Oryzias latipes (japanese killifish) LOC_Os05g41510.1 Oryza sativa (asian rice) 36068 Ostreococcus tauri (green alga) PF14_0059 Plasmodium falciparum (protozoal parasite) PHUM005249-PA Pediculus humanus (human body louse) 118200 Physcomitrella patens (moss) ENSPPYP00000009113 Pongo pygmaeus (orangutan) 73233 Phytophthora ramorum (sudden oak death pathogen) 129800 Phytophthora sojae (root rot pathogen) 560322 Populus trichocarpa (black cottonwood) ENSPTRP00000015240 Pan troglodytes (chimpanzee) PVX_086120 Plasmodium vivax (protozoal parasite) ENSRNOP00000016759 Rattus norvegicus (norway rat) 4895297 Sorghum bicolor (sorghum) YGR116W Saccharomyces cerevisiae (budding yeast) Smp_180420 Schistosoma mansoni (trematode parasite) SPAC1F7.01c Schizosaccharomyces pombe (fission yeast) XP_001182515.1 Strongylocentrotus purpuratus (purple sea urchin) 59208 Trichoplax adhaerens (metazoa) TA18820 Theileria annulata (apicomplexan parasite) XP_967189.2 Tribolium castaneum (red flour beetle) Tc00.1047053510975.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019248 Tetraodon nigroviridis (green spotted pufferfish) TP03_0651 Theileria parva (parasitic protozoan) 269534 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036812 Takifugu rubripes (pufferfish Takifugu) 3806.m00218 Tetrahymena thermophila (ciliate protozoa) 85228.m00095 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0B01224g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13672 NV50222 NV26042 NV21255 NV13499 LH11500 ISCW020442 FBgn0234236 FBgn0223860 FBgn0202772 FBgn0188378 FBgn0167412 JGI_V11_201385 JGI_V11_10253 JGI_V11_10245 JGI_V11_57945 FBgn0071541 FBgn0144444 FBgn0131609 FBgn0111782 FBgn0097394 CPIJ008034 BGIBMGA005523 ACYPI004626 GB11564 AGAP003619 AAEL006956 PHUM116720 GLEAN_05584
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	11680 w67c23 P{lacW}Spt6G0063/FM7c 32373 y1 sc* v1; P{TRiP.HMS00364}attP2
VDRC	v31701 w1118; P{GD7536}v31701/TM3 v31703 w1118; P{GD7536}v31703/TM3
Genomic Clones ( 2 )
	BACR19D03 BACR22D21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 81 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD47893 RE11071
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM02667 GM06618 GM10781 GM21095 GM25118 LD02327 LD03201 LD04335 LD11553 LD17704 LD17780 LD17816 LD20322 LD20753 LD23412 LD25542 LD25565 LD29733 LD31261 LD41020 LD41032 LD42444 LD44036 LD45251 LP02642 LP08655 RE07191 RE39669 RE42893 RE68142 RE74247 RH23365 RH41540 RH42169 RH56155 SD18753
Other clones	10665 10711 11679 11681 53564 104052 191688 CK01.85D.E2 CK01.89C.C4 CK01.93C.H1 CK01.106C.C11 CK01.111D.E1 CK01.116A.E11 Dmel_dig_008032_0623_2255 Dmel_neb_013881_0320_2651 Dmel_neb_014543_0145_2819 EK000913 EK002605 EK004815 EK067849 EK070332 EK072929 EK081012 EK110656 EK112634 EK112638 EK113749 EK170941 EK227208 EK243354 GM02265 LD11061 LD22523 LD23621 LD27675 RC0-DA0003-130700-022-B01 RP001008069 RP001047361 RP001048681 RP001049189 RP001052035 RP001055348 SD05767
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0028982 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44000
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Spt6 l(1)G0063 (Peter et al., 2002)
Additional comments
Other Comments
	Spt6 may be involved in promoter-associated pausing and transcriptional elongation. (Andrulis et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143705 RefSeq (Proteins) • NP_651962 DDBJ / EMBL / GenBank • AA940994 AAF14114 AAF14115 AAF46140 AAK93454 AF104400 AF104401 AI259265 AI512258 AI513035 AI546339 AJ426714 AW943932 AY052030 Entrez Gene - A searchable database of RefSeq genes. • 44000 UniProtKB/TrEMBL • Q9W420
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SH2 motif (IPR000980) Ribosomal protein S1, RNA-binding domain (IPR003029) YqgF/RNase H-like domain (IPR006641) Nucleic acid-binding, OB-fold (IPR012340) Nucleic acid-binding, OB-fold-like (IPR016027) Transcription elongation factor Spt6 (IPR017072) Tex-like domain (IPR023323) RNA-binding domain, S1 (IPR022967) Tex RuvX-like domain (IPR023097)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68765 DroID - A comprehensive database of gene and protein interactions. • FBgn0028982 DRSC - Results from RNAi screens. • FBgn0028982 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0028982 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12225-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0028982 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44000 InParanoid A subset of ortholog calls from InParanoid. • AAEL006956-PA Aedes aegypti (mosquito) AGAP003619-PA Anopheles gambiae (mosquito) XP_001950257.1 Acyrthosiphon pisum (pea aphid) At1g65440.1 Arabidopsis thaliana (wall cress) 89114 Batrachochytrium dendrobatidis (chytrid fungus) 121812 Branchiostoma floridae (lancelet) XP_001895824.1 Brugia malayi (roundworm nematode) BGIBMGA005523-PA Bombyx mori (silk worm) ENSBTAP00000011900 Bos taurus (bovine) CAL0002923 Candida albicans (a form of yeast) CN26440 Caenorhabditis brenneri (small nematode) CBP10840 Caenorhabditis briggsae (nematode) CE13120 Caenorhabditis elegans (worm) ENSCAFP00000027693 Canis familiaris (dog) CAGL0L04774g Candida glabrata (haploid yeast) Chro.60604 Cryptosporidium hominis (obligate parasite) JA04095 Caenorhabditis japonica (nematode) CMB144C Cyanidioschyzon merolae (red alga) cn02139 Cryptococcus neoformans (yeast-like fungus) cgd6_5250 Cryptosporidium parvum (protozoan parasite) ENSCPOP00000001303 Cavia porcellus (guinea pig) 176530 Chlamidomonas reinhardtii (green alga) RP30123 Caenorhabditis remanei (nematode) 160659 Capitella spl (polychaete worm) DDB0231554 Dictyostelium discoideum (amoeba) DEHA2C03344g Debaryomyces Hansenii (yeast) 201385 Daphnia pulex (daphnia) ENSDARP00000013353 Danio rerio (zebra fish) ENSECAP00000018346 Equus caballus (horse) XP_654539 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000027122 Gymnopilus aculeatus (mushroom) ENSGALP00000000199 Gallus gallus (chicken) 161252 Hypsipyla robusta (cedar shoot borer) ENSP00000319104 Homo sapiens (human) ISCW020442-PA Ixodes scapularis (deer tick) KLLA0B11385g Kluyveromyces lactis (yeast) 103494 Lottia gigantea (owl limpet) LmjF33.3090 Leishmania major (virus) 34162 Monocosta brevicollis (choanoflagellate) ENSMODP00000024080 Monodelphis domestica (gray opossum) ENSMMUP00000006255 Macaca mulatta (rhesus monkey) ENSMUSP00000103950 Mus musculus (house mouse) 192816 Nematostella vectensis (starlet anemone) XP_001606226.1 Nasonia vitripennis (wasp) ENSORLP00000003862 Oryzias latipes (japanese killifish) LOC_Os05g41510.1 Oryza sativa (asian rice) 36068 Ostreococcus tauri (green alga) PF14_0059 Plasmodium falciparum (protozoal parasite) PHUM005249-PA Pediculus humanus (human body louse) 118200 Physcomitrella patens (moss) ENSPPYP00000009113 Pongo pygmaeus (orangutan) 73233 Phytophthora ramorum (sudden oak death pathogen) 129800 Phytophthora sojae (root rot pathogen) 560322 Populus trichocarpa (black cottonwood) ENSPTRP00000015240 Pan troglodytes (chimpanzee) PVX_086120 Plasmodium vivax (protozoal parasite) ENSRNOP00000016759 Rattus norvegicus (norway rat) 4895297 Sorghum bicolor (sorghum) YGR116W Saccharomyces cerevisiae (budding yeast) Smp_180420 Schistosoma mansoni (trematode parasite) SPAC1F7.01c Schizosaccharomyces pombe (fission yeast) XP_001182515.1 Strongylocentrotus purpuratus (purple sea urchin) 59208 Trichoplax adhaerens (metazoa) TA18820 Theileria annulata (apicomplexan parasite) XP_967189.2 Tribolium castaneum (red flour beetle) Tc00.1047053510975.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019248 Tetraodon nigroviridis (green spotted pufferfish) TP03_0651 Theileria parva (parasitic protozoan) 269534 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036812 Takifugu rubripes (pufferfish Takifugu) 3806.m00218 Tetrahymena thermophila (ciliate protozoa) 85228.m00095 Trichomonas vaginalis (parasitic flagellated protozoan) YALI0B01224g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/spt6.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44000 modMine - Data generated by the modENCODE project. • FBgn0028982 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13672 NV50222 NV26042 NV21255 NV13499 LH11500 ISCW020442 FBgn0234236 FBgn0223860 FBgn0202772 FBgn0188378 FBgn0167412 JGI_V11_201385 JGI_V11_10253 JGI_V11_10245 JGI_V11_57945 FBgn0071541 FBgn0144444 FBgn0131609 FBgn0111782 FBgn0097394 CPIJ008034 BGIBMGA005523 ACYPI004626 GB11564 AGAP003619 AAEL006956 PHUM116720 GLEAN_05584
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG12225 (Bourbon et al., 2002, Ni et al., 2010.12.1) Dspt6 (Chiang and Kurnit, 2003, Chiang et al., 1999, Petruk et al., 2006, Raja et al., 2010) dSpt6 (Andrulis et al., 2002) dspt6 (Mendjan et al., 2006, Buscaino et al., 2006) l(1)G0063 (Schaefer et al., 1999.6.15, Schaefer et al., 1999.3.29) Spt6 (Breiling et al., 2004, Legube et al., 2006, Straub et al., 2005, Zobeck et al., 2010, Buszczak et al., 2007, White et al., 2011, Yokoyama et al., 2007, Ni et al., 2008, Petesch and Lis, 2008, Ayroles et al., 2009, Bhutkar et al., 2007, Avet-Rochex et al., 2010, Valanne et al., 2010, Zobeck et al., 2010) spt 6 (Bourbon et al., 2002) SPT6 (Chiang, 1998.11.4, ) spt6 (Petruk et al., 2006, Petruk et al., 2006)
Name Synonym	Spt6 (Breiling et al., 2004, )
Secondary FlyBase IDs
	FBgn0026691 FBgn0028682
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Avet-Rochex et al., 2010, BMC Dev. Biol. 10: 65 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. [FBrf0211137] Raja et al., 2010, Mol. Cell 38(6): 827--841 The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila. [FBrf0211222] Valanne et al., 2010, J. Immunol. 184(11): 6188--6198 Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. [FBrf0210846] Zobeck et al., 2010, Mol. Cell 40(6): 965--975 Recruitment timing and dynamics of transcription factors at the hsp70 Loci in living cells. [FBrf0212598] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...